Expression of the cyclin-dependent kinase inhibitor p27 in transitional cell bladder cancers: is it a good predictor for tumor behavior?

Abstract:

OBJECTIVES:Progression of the cell cycle is regulated by the interactions of cyclins, cyclin dependent kinases (CDKs) and CDK inhibitors (CDKIs). p27 is a member of the universal cyclin-dependent kinase inhibitor family. The level of p27 protein expression decreases during tumor development and progression in some epithelial, lymphoid and endocrine tissues. It has been suggested that p27 is an independent prognostic factor in various human cancers. The prognostic value of p27 protein expression is not completely understood in bladder cancer yet. AIMS:To investigate the immunohistochemical expression of p27 in transitional cell bladder cancers and its relationship with clinicopathological data, proliferating cell nuclear antigen (PCNA) and p53 oncoprotein immunoreactivity. METHODS:The expression of p27 protein was immunohistochemically analyzed in paraffin-embedded specimens of 75 patients with transitional cell carcinoma of the bladder. p27 expression was compared with tumor grade, stage, growth pattern, disease-free survival, progression, PCNA and p53 immunoreactivity. RESULTS:Expression of p27 was not significantly related to clinicopathologic parameters, disease-free survival, progression, PCNA and p53 immunoreactivity. CONCLUSION:The results indicate that p27 is not a good predictor for outcome of transitional cell carcinoma of the bladder.

journal_name

Int Urol Nephrol

authors

Doganay L,Altaner S,Bilgi S,Kaya E,Ekuklu G,Kutlu K

doi

10.1023/b:urol.0000020301.39181.03

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

181-8

issue

2

eissn

0301-1623

issn

1573-2584

journal_volume

35

pub_type

杂志文章
  • Influence of luteinizing hormone-releasing hormone analogues on serum levels of prostatic acid phosphatase and prostatic specific antigen in patients with metastatic carcinoma of the prostate.

    abstract::Serum concentrations of luteinizing hormone (LH), testosterone, prostatic acid phosphatase (PAP) and prostatic specific antigen (PSA) were measured in 16 patients with advanced prostatic cancer before and after treatment with luteinizing hormone-releasing hormone (LHRH) analogue. An initial rise of serum LH and testos...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02564863

    authors: Sasagawa I,Kubota Y,Nakada T,Suzuki H,Hirano J,Sugano O,Kato H,Imamura A,Mastushita K,Onmura Y,Saito M,Adachi M

    更新日期:1998-01-01 00:00:00

  • Efficacy of pentoxifylline in prevention of contrast-induced nephropathy in angioplasty patients.

    abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is an adverse consequence of contrast media use that results in significant morbidity and mortality and adds significant costs to diagnostic and interventional cardiology procedures. Various pathophysiological mechanisms have been proposed for CIN and various agents have be...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11255-011-0053-4

    authors: Firouzi A,Eshraghi A,Shakerian F,Sanati HR,Salehi N,Zahedmehr A,Kiani R,Madani M,Pedarzadeh A

    更新日期:2012-08-01 00:00:00

  • Nonobstructive urinary tract dilatation in nephrogenic diabetes insipidus.

    abstract::The follow-up study has been performed in 4 male patients with nephrogenic diabetes insipidus lasting for 4 to 15 years. Hydronephrosis or hydroureter appeared to be caused by polyuria with or without urinary tract obstruction. The efficacy of drainage operation is emphasized when polyuria surpasses the transporting a...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02549772

    authors: Nakada T,Miyauchi T,Sumiya H,Shimazaki J

    更新日期:1990-01-01 00:00:00

  • Intraoperative ultrasound: technique and clinical experience in robotic-assisted renal partial nephrectomy for endophytic renal tumors.

    abstract:OBJECTIVES:Surgical removal of completely endophytic renal tumors has presented great technical difficulties for surgeons. In this study, we aim to introduce the role and use of intraoperative ultrasound (IOUS) performed in robotic-assisted renal partial nephrectomy (RAPN) for endophytic renal tumors. METHODS:We retro...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-020-02664-y

    authors: Sun Y,Wang W,Zhang Q,Zhao X,Xu L,Guo H

    更新日期:2020-10-01 00:00:00

  • Our experience with rituximab therapy for adult-onset primary glomerulonephritis and review of literature.

    abstract:BACKGROUND:B cell-targeted immunosuppression with rituximab as primary treatment or when conventional therapy is contraindicated or unsuccessful can induce remission in idiopathic membranous nephropathy (IMN). We explored the efficacy and safety of rituximab therapy in an adult population with IMN and other primary glo...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s11255-012-0206-0

    authors: Kong WY,Swaminathan R,Irish A

    更新日期:2013-06-01 00:00:00

  • Urinary tract infection and antibiotic susceptibility in malnourished children.

    abstract::In this study, 31 (30%) cases of urinary tract infection (UTI) of 103 patients with malnutrition, who were admitted to our hospital, were investigated prospectively. Our purpose was to determine the frequency of UTI, species of bacteria caused to infection and their antibiotic susceptibility in infants with malnutriti...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1023/a:1007104326689

    authors: Caksen H,Cesur Y,Uner A,Arslan S,Sar S,Celebi V,Kuru M

    更新日期:2000-01-01 00:00:00

  • Results of secondary ureteral implantation after kidney transplantation.

    abstract:BACKGROUND:We reviewed our experience with ureteral complications and secondary ureteral implantation after kidney transplantation. METHODS:Between 1997 and 2005, 636 patients underwent kidney transplantation at our transplant center. Ureteral implantation was performed in the Lich-Gregoire technique. Thirty-one patie...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-010-9893-6

    authors: Doehn C,Böse N,Meyer AJ,Jocham D

    更新日期:2011-09-01 00:00:00

  • Unusual cause of obstructive uropathy.

    abstract::We report a case involving a 55-year-old healthy man that presented with urinary retention and a lower abdominal mass. His evaluation revealed a large mucocele arising from the appendix that caused severe bilateral ureteral obstruction and renal failure. Appendiceal mucoceles are rare and insidious entities that can p...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-005-0917-6

    authors: Ilbeigi P,Lombardo S,Sadeghi-Nejad H

    更新日期:2005-01-01 00:00:00

  • Robotic-assisted laparoscopic approach in the treatment for Zinner's Syndrome associated with ipsilateral megaureter and incomplete double-crossed ectopic ureter.

    abstract::To report a rare congenital anomaly of the genitourinary tract, renal dysplasia is associated with ipsilateral incomplete duplicated ectopic ureter and seminal vesicle cyst in an adult, successfully treated with robotic-assisted laparoscopic approach. ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-013-0412-4

    authors: Altobelli E,Bove AM,Falavolti C,Sergi F,Nguyen HT,Buscarini M

    更新日期:2013-06-01 00:00:00

  • Effects of combined treatment of tadalafil and tamsulosin on bladder dysfunction via the inhibition of afferent nerve activities in a rat model of bladder outlet obstruction.

    abstract:PURPOSE:To investigate the effects of combined treatment of tadalafil (a phosphodiesterase-5 inhibitor) and tamsulosin (an α1-adrenoceptor antagonist) on bladder dysfunction in a rat model of bladder outlet obstruction (BOO). METHODS:Cystometry was performed in conscious female BOO rats 6 weeks after partially ligatio...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-018-1835-8

    authors: Furuta A,Suzuki Y,Igarashi T,Koike Y,Egawa S,Yoshimura N

    更新日期:2018-05-01 00:00:00

  • Basiliximab versus rabbit antithymocyte globulin as induction therapy for living-related renal transplantation: a single-center experience.

    abstract:PURPOSE:To compare the long-term effects of the interleukin-2 receptor antagonist basiliximab versus rabbit antithymocyte globulin as an induction therapy for living-related renal transplantation. METHODS:This is a prospective, open-label, nonrandomized, controlled study including 213 cases of renal transplant. Immuno...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-016-1307-y

    authors: Huang HF,Zhou JY,Xie WQ,Wu JY,Deng H,Chen JH

    更新日期:2016-08-01 00:00:00

  • Current epidemiology and practice patterns in prevention and treatment of PD-related infections in Poland.

    abstract:BACKGROUND:Peritoneal dialysis (PD) related infections are associated with technique failure and mortality. The aim of this multicentre study was to examine epidemiology, treatment and outcomes of PD-related infections in Poland as well as practice patterns for prevention of these complications in the context of curren...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-018-2057-9

    authors: Lichodziejewska-Niemierko M,Chmielewski M,Wojtaszek E,Suchowierska E,Gołembiewska E,Grajewska M,Matuszkiewicz-Rowińska J,Naumnik B,Sulikowska B,Niemczyk S,Kłak R,Mosakowska M,Jagodziński P,Marcykiewicz B,Kalita K,Krawczyk R

    更新日期:2019-02-01 00:00:00

  • A case of primary ureteral carcinoma in association with unilateral complete duplication of the ureter.

    abstract::We are presenting a 68-year-old female patient who was diagnosed to have a complete ureteral duplication and adenocarcinoma in the ureter which drained the upper moiety of the right kidney. ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1023/b:urol.0000025627.15113.e3

    authors: Unsal A,Cimentepe E,Koc A,Akbulut Z,Balbay MD

    更新日期:2003-01-01 00:00:00

  • Stamey endoscopic vesical neck suspension in female urinary stress incontinence: results and changes in various urodynamic parameters.

    abstract::A total of 32 female patients with urinary stress incontinence who underwent a Stamey endoscopic bladder neck suspension were clinically and urodynamically studied pre- and postoperatively. Complete cure was obtained in 78% of the patients and improvement in 6%, the overall success rate being 84% for a mean follow-up ...

    journal_title:International urology and nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02768212

    authors: Athanassopoulos A,Melekos MD,Speakman M,Perimenis P,Markou S,Barbalias GA

    更新日期:1994-01-01 00:00:00

  • Influence of charcoal haemoperfusion on platelet count in acute poisoning and during regular dialysis treatment.

    abstract::Platelet count did not significantly decrease after charcoal haemoperfusion in patients with acute poisoning and significantly decreased during regular dialysis treatment. Adherent platelets and leucocytes were found on the surface of granules after haemoperfusion using a scanning electron microscope. Decreased platel...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02081940

    authors: Mydlík M,Bucek J,Derzsiová K,Jarcuska J,Takác M

    更新日期:1981-01-01 00:00:00

  • An unexpected presentation: minimal change disease in an adult with treatment-naïve hepatitis C.

    abstract::Minimal change disease is the most common glomerular disease affecting children; its prevalence among adults, however, is eclipsed by other glomerular pathologies. Each of these diseases has a number of classic associations, such as membranoproliferative glomerulonephritis with hepatitis C. We report the case of a mid...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-012-0285-y

    authors: Stokes AL,Alhamad T,Abendroth CS,Farag HA,Verma N

    更新日期:2013-12-01 00:00:00

  • Impaired tubular reabsorption of magnesium after renal transplantation.

    abstract::Tubular reabsorption of magnesium ( TRMg ) was calculated from the values of plasma ultrafiltrable Mg and urinary Mg in 36 patients with transplanted kidneys. The study revealed a defect in TRMg in all investigated patients. The lowest TRMg values were found in patients with poor function of the transplanted kidneys. ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02082706

    authors: Revúsová V,Gratzlová J,Zvara V,Borosová E,Pribylincová V

    更新日期:1984-01-01 00:00:00

  • Peritoneal dialysis catheter placement in the right lower quadrant is associated with a lower risk of catheter tip migration: a retrospective single-center study.

    abstract:PURPOSE:The aim of this study was to investigate the effect of a modified technique for peritoneal dialysis catheter placement in the right lower quadrant with respect to catheter tip migration. METHODS:This retrospective study included 237 patients with end-stage renal disease who underwent implantation of a two-cuff...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-014-0899-3

    authors: Lan L,Jiang J,Wang P,Ren W,Hu Z

    更新日期:2015-03-01 00:00:00

  • Comparing the anti-inflammatory effects of corticotherapy and non-steroid anti-inflammatory drugs in infertile patients with infectious aetiology.

    abstract::To compare the anti-inflammatory effectiveness of corticotherapy and nonsteroid anti-inflammatory drugs (NSAID), we examined 126 infertile men with infectious aetiology. Seventy-seven patients were on corticotherapy and antibiotherapy (thirty-eight patients on high-dose and thirty-nine patients on low-dose corticother...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1023/a:1007184125900

    authors: Altay B,Girgin C,Cikili N

    更新日期:1999-01-01 00:00:00

  • Lycopene therapy in idiopathic male infertility--a preliminary report.

    abstract::Excessive generation of reactive oxygen species (ROS) containing free oxygen radicals has been identified as one of the causes of male infertility. Lycopene is a component of human redox defence mechanism against free radicals. It is found in high concentrations in the testes and seminal plasma and decreased levels ha...

    journal_title:International urology and nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1023/a:1024483520560

    authors: Gupta NP,Kumar R

    更新日期:2002-01-01 00:00:00

  • Cephalosporins periprostatic injection: are really effective on infections following prostate biopsy?

    abstract:PURPOSE:To compare the antibiotic prophylaxis based on quinolone administered orally with a combination of cephalosporin administered periprostatically and a fluoroquinolone orally, in terms of post-prostate bioptic infectious complication rates in those men undergoing transrectal ultrasound-guided prostate biopsy (TRU...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11255-012-0160-x

    authors: Pace G,Carmignani L,Marenghi C,Mombelli G,Bozzini G

    更新日期:2012-08-01 00:00:00

  • The association of renal tubular inflammatory and injury markers with uric acid excretion in chronic kidney disease patients.

    abstract:AIM:To investigate the correlation of renal tubular inflammatory and injury markers with renal uric acid excretion in chronic kidney disease (CKD) patients. METHODS:Seventy-three patients with CKD were enrolled. Fasting blood and morning urine sample were collected for routine laboratory measurements. At the same time...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-020-02447-5

    authors: Zheng Y,Guan H,Zhou X,Xu Y,Fu C,Xiao J,Ye Z

    更新日期:2020-05-01 00:00:00

  • The effect of vasectomy on the production of plasma luteinizing hormone and follicle stimulating hormone in man.

    abstract::A prospective study of plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) in 51 men before vasectomy and 10 days and 3 months after vasectomy revealed a trend to rise in LH 10 days after vasectomy normalizing after 3 months. The literature concerning alterations in LH and FSH after vasectomy is rev...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02549744

    authors: Glavind K,Lauritsen NR,Kløve-Mogensen M,Carl J

    更新日期:1990-01-01 00:00:00

  • Leukopenia with different regenerated haemodialysis membranes.

    abstract::The white blood cell count (WBC) decreases during haemodialysis and it was investigated as a function of different dialysis membranes. Each of them was used four times, applying different sterilization methods. Twelve chronic haemodialysis patients were studied and dialysed with cuprophan and polyacrylonitrile (PAN) m...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02082704

    authors: Ksiaźek A,Sokołowska G,Marczewski K,Solski J

    更新日期:1984-01-01 00:00:00

  • Estimating the effectiveness of various methods of evacuation of kidney stones, on the basis of data obtained on percentage of "stone free" and recurrent stone formation.

    abstract::Using the materials of more than 200 scientific papers of recent years in this review it has been carried out analysis of the effectiveness and also discussed the merits and demerits of various methods of treatment of urinary stone diseases (USD). With this purpose, for the first time it has been carried out analysis ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1015282526252

    authors: Bilobrov VM,Roy A,Bilobrov SV

    更新日期:2001-01-01 00:00:00

  • Emergency hospital admissions attributable to infective complications of prostate biopsy despite appropriate prophylaxis: need for additional infection prevention strategies?

    abstract:PURPOSE:To report the incidence of emergency admissions attributable to infective complications of transrectal ultrasound-guided prostate biopsy (TGB) and evaluate appropriateness of antimicrobial prophylaxis. METHODS:Retrospective cross-sectional study of patients undergoing TGB at the North West London Hospitals in ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-013-0529-5

    authors: Gopal Rao G,Batura D

    更新日期:2014-02-01 00:00:00

  • A pure primary low-grade neuroendocrine carcinoma (carcinoid tumor) of the prostate.

    abstract::The first time in Scandinavia we present a case report of a pure primary low-grade neuroendocrine carcinoma (carcinoid tumor) of the prostate. Our patient is a 34-year-old male with a long history of symptomatic chronic prostatitis/prostatodynia. After developing severe obstructive uropathy, a transurethral resection ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-009-9660-8

    authors: Giordano S,Tolonen T,Tolonen T,Hirsimäki S,Kataja V

    更新日期:2010-09-01 00:00:00

  • Spectrum of renal failure in elderly patients.

    abstract::This prospective study was undertaken to study the spectrum of renal failure and the outcome in elderly patients. Patients included in the study group were elderly (age>60 years) who either attended outpatient renal clinic and or were hospitalized. Renal failure was classified as acute renal failure (ARF), rapidly pro...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-006-0089-z

    authors: Kohli HS,Bhat A,Aravindan,Sud K,Jha V,Gupta KL,Sakhuja V

    更新日期:2006-01-01 00:00:00

  • Second malignancies in long-term testicular cancer survivors.

    abstract:PURPOSE:The objective of the present study is to analyze long-term testicular cancer (TC) survivors focusing on the correlation of therapeutic modalities used, the age of patients and second malignancy (SM) occurrence. PATIENTS AND METHODS:A total of 1,367 patients with TC and different subsequent therapeutic procedur...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-013-0554-4

    authors: Ondrus D,Ondrusova M,Friedova L

    更新日期:2014-04-01 00:00:00

  • Metabolic syndrome is a predictor of decreased renal function among community-dwelling middle-aged and elderly Japanese.

    abstract:PURPOSE:Metabolic syndrome (MetS) is increasing worldwide with the continuous increase in obesity prevalence. Chronic kidney disease (CKD) is also a major public health problem, but there is controversy over whether baseline MetS is a predictor of decreased renal function among Japanese community-dwelling middle-aged a...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-019-02320-0

    authors: Kawamoto R,Akase T,Ninomiya D,Kumagi T,Kikuchi A

    更新日期:2019-12-01 00:00:00