Abstract:
:Excessive generation of reactive oxygen species (ROS) containing free oxygen radicals has been identified as one of the causes of male infertility. Lycopene is a component of human redox defence mechanism against free radicals. It is found in high concentrations in the testes and seminal plasma and decreased levels have been demonstrated in men suffering from infertility. We evaluated the effect of oral lycopene therapy in men with idiopathic infertility. Beginning March 2000, thirty men with idiopathic non-obstructive oligo/astheno/teratozoospermia were enrolled for the trial. All patients were administered 2000 mcg of Lycopene, twice a day for three months. Semen analysis was performed at three months and sperm concentration, motility and morphology were evaluated. All patients completed the trial without any complications. Twenty patients (66%) showed an improvement in sperm concentration, sixteen (53%) had improved motility and fourteen (46%) showed improvement in sperm morphology. In cases showing an improvement, the median change in concentration was 22 million/ml, motility 25% and morphology 10%. The improvement in concentration and motility were statistically significant. Baseline sperm concentration less than 5 million/ml was associated with no significant improvement. Higher baseline concentrations were associated with significant improvement and resulted in six pregnancies in 26 patients (23%). Oral Lycopene therapy seems to have a role in the management of idiopathic male infertility. Maximum improvement seems to occur in the sperm concentration (66% cases). Patients without severe oligospermia (sperm density > 5 million/ml) may be given a trial of therapy with lycopene. However, larger randomised controlled trials are essential before definitive therapeutic guidelines can be made.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Gupta NP,Kumar Rdoi
10.1023/a:1024483520560keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
369-72issue
3eissn
0301-1623issn
1573-2584journal_volume
34pub_type
临床试验,杂志文章abstract:INTRODUCTION:Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearanc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9496-7
更新日期:2009-12-01 00:00:00
abstract::Sixty patients in Stages I and II of benign prostatic hyperplasia were treated with Peponen capsule. Out of them 26 took the drug for 10 months, 22 for at least 7, and 12 for at least 4 months. The daily dosage was 3 x 2 capsules in the first month and 3 x 1 capsule for the rest of the time. On the ground of urodynami...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549728
更新日期:1991-01-01 00:00:00
abstract::The authors describe various possibilities of using uretero-ureterostomy in cases of healthy bladder an in cases of supracystic urinary diversion. The history and the technique of the operation are described. Attention is called to the direction of anastomosis in cases of ureters differing in the width of their lumen....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082423
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Chronic kidney disease is independently associated with an increased risk of cardiovascular events; however, the relationship between the glomerular filtration rate (GFR) and coronary artery disease (CAD) in patients undergoing coronary angiography has yet to be fully elucidated. METHODS:This retrospective stu...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0070-3
更新日期:2012-08-01 00:00:00
abstract::Serum, corpuscular and renal tissue phosphate (Pi) concentrations in normal and chronic renal failure rats were examined. A significant correlation was found between Pi levels and indications of renal function. In addition, there were significant relationships between phosphate levels and RBC, Hb, Hct, serum Fe, serum...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::A new method of one-stage surgical correction of distal to penoscrotal hypospadias is described. The chordee is released by skin lysis alone and urethroplasty is done by the flip-flap technique while the globular glans is rerolled over the new urethra, all in one stage. The complication rate was minimal (15 per cent),...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082566
更新日期:1984-01-01 00:00:00
abstract::Authors report on a case of Pseudomonas prostatitis complicated with a prostatoperineal fistula in continuity with the urethra that has been successfully treated with human fibrin sealant (Tissucol). ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564742
更新日期:1995-01-01 00:00:00
abstract::To compare the anti-inflammatory effectiveness of corticotherapy and nonsteroid anti-inflammatory drugs (NSAID), we examined 126 infertile men with infectious aetiology. Seventy-seven patients were on corticotherapy and antibiotherapy (thirty-eight patients on high-dose and thirty-nine patients on low-dose corticother...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007184125900
更新日期:1999-01-01 00:00:00
abstract::A male with a severe form of congenital nephrogenic diabetes insipidus (diuresis 10 l per day) had megaureters, megavesica, large residuum and a history of three traumatic ruptures of the megavesica and a recurrent urinary tract infection (RUTI). Hemodialysis was introduced at 41 years of age. At age of 42, he underwe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-0093-3
更新日期:2006-01-01 00:00:00
abstract::The hemodynamic response to ephedrine sulphate were studied in a patient on maintenance hemodialysis therapy with chronic renal failure due to renal amyloidosis. The evaluation (including cardiac catheterization studies) and estimation of responses to Valsalva maneuvers before and after ephedrine administration docume...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082096
更新日期:1976-01-01 00:00:00
abstract:PURPOSE:Water intake is important for preventing kidney stones. Small molecules water is a more active restructured water under magnetic field. Here, we studied the relation between small molecules water and crystal formation in the rat kidney. MATERIALS:The small molecules water was prepared by a water machine provid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1769-6
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:Cardiovascular (CV) events are the first cause of death in patients with chronic renal disease (CKD) and in patients with type 2 diabetes mellitus (DM2). The combination of CKD and DM2 elevates the risk of both cardiovascular disease (CVD) and death in this high-risk population. Besides traditional risk factors...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1755-z
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To compare efficacy, safety, and cost-effectiveness of fosfomycin tromethamine with other standard-of-care antibiotics in patients undergoing ureteroscopic lithotripsy. METHODS:This study was a prospective, multicenter, randomized, controlled trial. Eligible patients scheduled for ureteroscopic lithotripsy wer...
journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s11255-017-1776-7
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To evaluate conservative management of renal echinococcosis in cases with normal renal function and active disease. PATIENTS AND METHODS:From a series of 12 consecutive patients with primary renal echinococcosis, nephrectomy was suggested to 4 patients because of kidney destruction. One patient who denied surg...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014405325703
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To analyze the effect of age on nutrition indices in subjects on the same continuous ambulatory peritoneal dialysis (CAPD) schedule. METHODS:We analyzed 613 sets of clearance values and nutrition indices in 302 CAPD patients. Small solute clearances included urea clearance (Kt/Vurea) and creatinine clearance...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017579105158
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:It is unclear whether any significant changes in the epidemiology of chronic kidney disease (CKD), possibly resulting from the exceedingly rapid economic development and the aggressive prevention and treatment of kidney diseases in the Chinese population, have occurred over the past two decades. METHODS:The...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0194-0
更新日期:2012-08-01 00:00:00
abstract::Indications for operation, immediate postoperative morbidity and complications were recorded in 43 patients circumcised with the Plastibell device. Questionnaires were used in recording late postoperative morbidity and complications during the mean observation period of 29 months, and were followed by a clinical and c...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550667
更新日期:1988-01-01 00:00:00
abstract::Retroperitoneal fibrosis is idiopathic in two thirds of cases and is found most commonly as an isolated fibrotic plaque centered over the lumbar spine and entrapping one or both ureters. It has been postulated that fibrosis in the idiopathic cases results from a hypersensitivity reaction to antigens leaking into the r...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551311
更新日期:1995-01-01 00:00:00
abstract::Platelet count did not significantly decrease after charcoal haemoperfusion in patients with acute poisoning and significantly decreased during regular dialysis treatment. Adherent platelets and leucocytes were found on the surface of granules after haemoperfusion using a scanning electron microscope. Decreased platel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081940
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Uremic toxins produced by gut microbiota (indoxyl sulfate-IS, p-cresyl sulfate-p-CS, and indole-3-acetic acid-IAA) accumulate in hemodialysis (HD) patients and exhibit potent inflammatory effects. However, the impact of these toxins on nuclear E2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) expres...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1748-y
更新日期:2018-02-01 00:00:00
abstract::The authors report on 9 cases of bladder augmentation with detubularized intestinal segments. The capacity of the contracted bladder was increased in 4 cases; care was taken to prevent the development of an hour-glass bladder. In a young female patient a caecal-ileal segment was applied so that in case of a possible f...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02550073
更新日期:1995-01-01 00:00:00
abstract::Peritonitis is a major complication of peritoneal dialysis (PD) and remains the most common cause of PD failure. Micrococci are catalase-positive, coagulase-negative, and gram-positive cocci that are spherical, often found in tetrad, and belong to the family Micrococcaceae. Micrococcus species are commonly found in th...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0302-1
更新日期:2014-01-01 00:00:00
abstract::A case of Itai-itai (ouch-ouch) disease with reduced urinary kallikrein excretion and slightly enhanced renin-angiotensin-aldosterone system is described. Although it is well known that cadmium toxicity frequently affects the renal tubular lesions, this report is the first to demonstrate the impaired urine concentrati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550809
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To evaluate the association of shock-wave lithotripsy (SWL) for kidney stones and hypertension or diabetes. METHODS:Patients with urolithiasis treated by SWL were retrospectively identified. To assess whether shock-wave application to the kidney is associated with long-term adverse effects, patients after SWL ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1857-2
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:Limited numbers of literatures have focused on the association between γ-glutamyltransferase (GGT) and chronic kidney disease (CKD), and their results were controversial. Therefore, in this study, we set up a large-scale cohort of Chinese population to discover and verify the association between serum GGT and C...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1429-2
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Prolonged cold ischemia time (CIT) has been associated with inferior graft survival in kidney transplantation (KT). The aim of this study was to evaluate the impact of prolonged CIT on short- and long-term outcomes and to determine the possible ways to optimize the use of these organs. METHODS:All kidney tr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0235-8
更新日期:2012-10-01 00:00:00
abstract::The white blood cell count (WBC) decreases during haemodialysis and it was investigated as a function of different dialysis membranes. Each of them was used four times, applying different sterilization methods. Twelve chronic haemodialysis patients were studied and dialysed with cuprophan and polyacrylonitrile (PAN) m...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082704
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:Fatigue and depressed mood are considered main impediments to physical activity in haemodialysis (HD) patients. A better understanding of their interrelationships is crucial to develop effective therapies. Moreover, measurement of daily physical activity (DPA) in HD patients is tricky, as it is usually assess...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02578-9
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:The prevalence of progressive chronic kidney disease (CKD) in children and adults with spina bifida is considerable, rising, and entirely preventable. REMOVING THE CAUSE:PREVENTION OF SPINA BIFIDA: The best prevention of CKD in spina bifida is prevention of spina bifida itself throug...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-010-9894-5
更新日期:2012-06-01 00:00:00
abstract::Posterior urethral valves are usually detected during infancy by prenatal sonography. Less is known about presentation and outcome in older patients. We are describing a patient who presented with renal stones and was found incidentally on cystoscopy to have Type I urethral valves. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000020294.84579.a4
更新日期:2003-01-01 00:00:00