Abstract：
BACKGROUND:Prolonged cold ischemia time (CIT) has been associated with inferior graft survival in kidney transplantation (KT). The aim of this study was to evaluate the impact of prolonged CIT on short- and long-term outcomes and to determine the possible ways to optimize the use of these organs. METHODS:All kidney transplants from April 2001 to December 2010 with CIT ≥ 20 h were considered. Donor and recipient data were analyzed with uni- and multivariate Cox proportional hazard analyses. Graft and patient survival were calculated using the Kaplan-Meier method. RESULTS:One hundred and eighty-one patients were transplanted with 184 grafts. Median recipient age and waiting time on dialysis were 52.5 and 4.9 years, respectively. After a median follow-up of 4.9 years, 148 of 181 patients are alive, 143 of them with functioning grafts. One-, three, and five-year graft and patient survival rates were 90, 87, and 79 %, and 96, 91, and 85 %, respectively. Donor age (p < 0.0001), retransplantation (p = 0.0025), and induction therapy with interleukin-2 antagonists (p = 0.0487) were predictors of graft survival by univariate analysis. Donor age and retransplantation remained significant by multivariate analysis (p < 0.001 and p = 0.0046, respectively). Donor age (p = 0.0176) and creatinine level at 1-month post-KT (p = 0.0271) were predictors of patient survival by univariate analysis. Only donor age reached multivariate significance (p = 0.0464). The calculated donor age cut off was 60 years. CONCLUSIONS:Satisfactory long-term kidney transplant outcomes in the setting of CIT ≥ 20 h can be achieved with grafts from donors <60 years in first-time recipients. Induction therapy should preferably be with an interleukin-2 antagonist.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Gallinat A,Paul A,Minor T,Treckmann JW,Molmenti EP,Witzke O,Sotiropoulos GCdoi
10.1007/s11255-012-0235-8subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1417-23issue
5eissn
0301-1623issn
1573-2584journal_volume
44pub_type
杂志文章abstract：:We report on our experience with a new surgical procedure of forming a pseudoneotesticle from indigenous tissues obtained from the existing scrotal contents. This procedure has been performed in 32 patients with a diagnosis of hormone dependent cancer of the prostate as a therapeutic manoeuvre, and in 3 children who h...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02550317
更新日期：1998-01-01 00:00:00
abstract：:Experience in the treatment of urinary bladder cancer based upon observation of 306 cases has been presented. Two hundred and thirteen patients were treated surgically by performing in 151 cases partial cystectomy and in 62 cases total cystectomy. Conservative treatment was applied in 75 patients. In the authors' opin...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02082168
更新日期：1977-01-01 00:00:00
abstract：:Hydatid disease of the urinary tract is very rare. We report a case of pure renal hydatid cyst, with its clinical presentation and management. ...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02551409
更新日期：1997-01-01 00:00:00
abstract：:The development of a reno-jejunal fistula following a Roux-en-Y cystojejunostomy for an incorrectly diagnosed pancreatic pseudocyst is described. Up to now, this is the second case of iatrogenic reno-jejunal fistula reported in literature. Reno-jejunal fistulas are exceedingly rare and are usually consequences of urol...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1023/a:1007115605427
更新日期：1999-01-01 00:00:00
abstract：:Nonfunctional carcinomas of the adrenal gland are quite rare. By presenting a 47-year-old woman with such a tumour, a review of the literature is made, with special emphasis on the epidemiology and histologic criteria in predicting malignant behaviour. In addition, the clinical, pathological and radiographic findings,...
journal_title：International urology and nephrology
pub_type： 杂志文章,评审
doi：10.1007/BF02550852
更新日期：1996-01-01 00:00:00
abstract：:The authors have elaborated a biochemical technique for the assessment of the selectivity of proteinuria by means of the clearances of ceruloplasmin, haptoglobin and albumin. The results obtained in 69 patients were compared to those established by the method of Cameron and Blanford, as well as by the clearance of alp...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02082033
更新日期：1978-01-01 00:00:00
abstract：PURPOSE:Non-adherence (NA) to medication is a major contributor to treatment failure in hypertensive patients. Factors of the ecological model, at family/healthcare professional, service, and system levels, are rarely evaluated as correlates of NA in hypertensive patients. METHODS:This crossectional study assessed the...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-020-02755-w
更新日期：2021-01-16 00:00:00
abstract：PURPOSE:To analyse the incidence and management of emphysematous pyelonephritis (EPN) in North West London and examine factors that influence immediate and 6-month outcomes with the aim of guiding future management. METHODS:This work analyses EPN cases from the London North West Healthcare NHS Trust from October 2006 ...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-017-1706-8
更新日期：2017-12-01 00:00:00
abstract：:A 67-year-old Saudi man with poorly controlled diabetes-mellitus underwent orchiectomy for a painful left testicular swelling that did not respond to antibiotics. Clinical diagnosis was testicular malignancy. Histologic workup demonstrated extensive involvement of the testis and epididymis by diffuse infiltrate of lar...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-009-9674-2
更新日期：2010-09-01 00:00:00
abstract：PURPOSE AND METHODS:The accurate estimation of volume status is a central problem in dialysis patients. Recently, a bioimpedance spectroscopy (BIS) device (BCM Body Composition Monitor FMC, Germany) has attained growing interest in this regard. By processing the raw data for extracellular water (ECW) and intracellular ...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-012-0216-y
更新日期：2013-02-01 00:00:00
abstract：:Immunosuppressed recipients of organ transplants have a higher incidence of carcinoma than the general population. A retrospective analysis was made at the Department of Urology of Bonn University, investigating 236 renal allograft recipients as to the incidence of neoplasms before and after transplantation. Eleven pa...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02552189
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:To compare the therapeutic effects and adverse events (AE) of current first-line treatments of advanced RCC, including sorafenib, sunitinib, temsirolimus, and the combination of bevacizumab and IFN-α. METHODS:We performed a meta-analysis of randomized controlled trials of the effectiveness of the five treatmen...
journal_title：International urology and nephrology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11255-015-0932-1
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:We evaluated the efficacy and safety outcomes of endoscopic intradetrusor botulinum toxin A (BTA) injections for the treatment of children with neuropathic bladder (NB) and non-neuropathic bladder (NNB) with or without detrusor overactivity in a single centre with a retrospective analysis. METHODS:For the peri...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-019-02185-3
更新日期：2019-08-01 00:00:00
abstract：:Angiomyolipoma with extrarenal involvement is very uncommon. Herein we report a case of angiomyolipoma with lymph node involvement in a 17-year-old female. The diagnosis and treatment of the case is discussed. ...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1023/a:1020518315280
更新日期：2001-01-01 00:00:00
abstract：:Considering the aging dialysis population of today, increasing our knowledge about the nature, diagnosis and the treatment of bone mineral density (BMD) problems in end-stage renal disease (ESRD) patients deserves more attention. Osteoporosis is basicly defined as a decrease in bone mass. Large epidemiological studies...
journal_title：International urology and nephrology
pub_type： 杂志文章,评审
doi：10.1007/s11255-006-9109-2
更新日期：2007-01-01 00:00:00
abstract：:One hundred patients with recurrent calcium nephrolithiasis were submitted to the Pak test. At fasting state hypercalciuria was found in 27 cases, while a group of 16 further patients became hypercalciuric after oral calcium load. Only measurement of urinary cAMP excretion in both conditions made it possible to diagno...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02083499
更新日期：1985-01-01 00:00:00
abstract：:Serum, corpuscular and renal tissue phosphate (Pi) concentrations in normal and chronic renal failure rats were examined. A significant correlation was found between Pi levels and indications of renal function. In addition, there were significant relationships between phosphate levels and RBC, Hb, Hct, serum Fe, serum...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Transitional cell carcinoma (TCC) of ureteral stump after radical nephrectomy is rare. Following nephrectomy patients with a prior history of bladder cancer must have their ureteral stumps evaluated. Furthermore, the presence of hematuria should alert the urologist to a possible TCC in the ureteral stump. We present a...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-004-0745-0
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:Primary bladder neck obstruction (PBNO) is a nonneurogenic voiding disorder and frequently overlooked in young men. Prior studies have reported the efficacy of α-blockers only in the short-term for male patients with PBNO. We hereby report our long-term results using α1-blocker therapy in young men with PBNO....
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-011-0096-6
更新日期：2012-06-01 00:00:00
abstract：:Neuron specific enolase (NSE) is an isoenzyme of the glycolytic enzyme enolase. It is not only a marker for all types of neurons but also for all neuroendocrine or paraneuronal cells and various malignant tumours, even of non-neuroendocrine types. We had studied serum NSE in 25 consecutive patients with renal cell car...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02550862
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND AND AIM:Fungal peritonitis is a rare but serious complication in patients undergoing peritoneal dialysis (PD). We aimed to analyze the predisposing factors, clinical aspects, etiological agents, and treatment of fungal peritonitis in patients with PD in our hospital. PATIENTS AND METHODS:The data of all pat...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-010-9763-2
更新日期：2011-03-01 00:00:00
abstract：PURPOSE:Five-year kidney graft loss currently stands at about 30%. We evaluate the clinical utility of a blood test measuring donor-derived cell-free DNA that detects rejection earlier and, potentially, improves diagnostic and therapeutic accuracy. METHODS:In a randomized controlled experiment, we measured the clinica...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-020-02491-1
更新日期：2020-08-01 00:00:00
abstract：:The hemodynamic response to ephedrine sulphate were studied in a patient on maintenance hemodialysis therapy with chronic renal failure due to renal amyloidosis. The evaluation (including cardiac catheterization studies) and estimation of responses to Valsalva maneuvers before and after ephedrine administration docume...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02082096
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVES:To study the possible renoprotective effect of sildenafil against renal ischemia/reperfusion (I/R) injury and its effect on the expression of some antioxidant, antiapoptotic gene and proinflammatory cytokine genes in rat model of renal I/R injury. MATERIALS AND METHODS:One hundred and twenty male Sprague Da...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-015-1099-5
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Several techniques have been used to repair mid-penile hypospadias; however, high failure rates and major complications have been reported. In this study, we describe a novel technique using a well-vascularized flap of the inner and outer preputial skin. METHODS:A total of 110 male children with hypospadias...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-016-1416-7
更新日期：2016-12-01 00:00:00
abstract：:Chronic hepatic patients, and particularly those suffering from cirrhosis, are predisposed to different sort of water, electrolyte, acid-base, and trace elements disorders due to their altered liver function, and also to their exposition to infectious, inflammatory, oncologic, and pharmacologic variables whose combina...
journal_title：International urology and nephrology
pub_type： 杂志文章,评审
doi：10.1007/s11255-017-1614-y
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:Physical inactivity and sleep disturbance are frequently observed and relate to poor clinical outcomes in maintenance hemodialysis patients. We aimed to investigate the effect of intradialytic exercise on daily physical activity and sleep quality, measured by an accelerometer, in maintenance hemodialysis patien...
journal_title：International urology and nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11255-018-1796-y
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:To evaluate whether urine transforming growth factor-β1 (TGF-β1) can help identifying kidneys that would recover their function after drainage of unilateral ureteric obstructive. METHODS:Forty-five patients with unilateral ureteral obstruction were included. Glomerular filtration rate (GFR) of the obstructed k...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-014-0846-3
更新日期：2015-01-01 00:00:00
abstract：:Ageing is characterised by a decline in renal function and by a higher susceptibility to renal diseases. This has been defined by Fliser as the "myth of the inexorable decline of renal function with senescence" and is a consequence of multiple factors that predispose to renal damage. These include physiological factor...
journal_title：International urology and nephrology
pub_type： 杂志文章,评审
doi：10.1007/s11255-011-0063-2
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION:Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED. PA...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/s11255-005-3621-7
更新日期：2005-01-01 00:00:00
