Abstract:
:Immunosuppressed recipients of organ transplants have a higher incidence of carcinoma than the general population. A retrospective analysis was made at the Department of Urology of Bonn University, investigating 236 renal allograft recipients as to the incidence of neoplasms before and after transplantation. Eleven patients developed malignant tumours after transplantation. In 4 out of these 11 patients, case history showed pre-existing malignancies. Two of the 4 patients developed a second tumour, while the other two had tumour progression (latency period 21-77 months). Three of the 4 patients died of their tumours 21, 42 and 77 months after transplantation, whereas one female patient is still alive and free of neoplasms 32 months after transplantation. In 7 out of these 11 patients de novo tumours were diagnosed (latency period 3-88 months). All of them are still alive (NED between 15 and 85 months), six of them with good transplant function. There was no difference to be seen in the incidence of malignancies between kidneys supplied by Eurotransplant (n = 40) and ABO compatible kidneys from our own donors (n = 196). The higher incidence rate of neoplasms in transplant recipients requires high standards in preventive measures. Any suspicious change that may occur in the course of a thorough follow-up of transplant recipients must be removed and examined histologically. Patients with previous malignant diseases must be payed special attention, since they frequently tend to develop another malignant tumour and progression of existing tumours, respectively. As far as immunosuppression is concerned, therapeutic guidelines for the treatment of transplant recipients do not differ from those set up for patients on haemodialysis. Since immunosuppression with increased rates of tumour incidence can also be observed in dialysis patients, the mere fact of increased incidence of neoplasms cannot be taken as an argument against transplantation. With a more or less equal risk of tumour incidence the crucial factor should be the higher quality of life for transplant recipients.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Winter P,Schoeneich G,Miersch WD,Klehr HUdoi
10.1007/BF02552189subject
Has Abstractpub_date
1997-01-01 00:00:00pages
701-9issue
6eissn
0301-1623issn
1573-2584journal_volume
29pub_type
杂志文章abstract::The objective of this study was to evaluate the prognostic factors and role of nephrectomy in metastatic renal cell carcinoma. We reviewed 62 cases of metastatic renal cell carcinoma (RCC) at presentation to document the factors influencing the survival and to evaluate the role of nephrectomy. Sex and age of the patie...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564853
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:The development of a symptomatic lymphocele (SL) is a frequent postoperative surgical complication after kidney transplantation. It may lead to pain and discomfort and cause transplant malfunction or even secondary graft loss. A large cohort of renal recipients was investigated to identify the possible risk fac...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02269-0
更新日期:2019-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-7976-y
更新日期:2005-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549707
更新日期:1991-01-01 00:00:00
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journal_title:International urology and nephrology
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doi:10.1007/s11255-017-1755-z
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
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journal_title:International urology and nephrology
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更新日期:1991-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1019502903833
更新日期:2001-01-01 00:00:00
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017565520257
更新日期:2001-01-01 00:00:00
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journal_title:International urology and nephrology
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doi:10.1007/BF02767654
更新日期:1994-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:International urology and nephrology
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更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Duplication of the vas deferens is the identification of a second vas deferens within the spermatic cord; it is a rarely reported congenital anomaly. Duplicate vas deferens should not be confused with double vas deferens that describes ipsilateral renal agenesis with a blind ureter ending in the ejaculatory ...
journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:International urology and nephrology
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doi:10.1007/s11255-020-02594-9
更新日期:2021-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11255-015-0926-z
更新日期:2015-04-01 00:00:00
abstract::Chronic hepatic patients, and particularly those suffering from cirrhosis, are predisposed to different sort of water, electrolyte, acid-base, and trace elements disorders due to their altered liver function, and also to their exposition to infectious, inflammatory, oncologic, and pharmacologic variables whose combina...
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pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0904-x
更新日期:2015-03-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00