Serum neuron specific enolase: can it be a tumour marker for renal cell carcinoma?

Abstract:

:Neuron specific enolase (NSE) is an isoenzyme of the glycolytic enzyme enolase. It is not only a marker for all types of neurons but also for all neuroendocrine or paraneuronal cells and various malignant tumours, even of non-neuroendocrine types. We had studied serum NSE in 25 consecutive patients with renal cell carcinoma (RCC). The study included 10 stage I, 3 stage II, 3 stage III-B and 9 stage IV-B patients. Both pretreatment and posttreatment levels were evaluated. Regardless of stage, overall we observed elevated levels of NSE in 80% (20/25) at diagnosis. After the appropriate treatment, according to the stage, there had been a statistically significant (p < 0.05) decrease in the serum levels in all stage I, II and III-B patients. The posttreatment values were not available for stage IV-B patients because they did not come for follow-up. The preliminary results of our study revealed that serum NSE may be considered as a useful marker in the evaluation and surveillance of RCC.

journal_name

Int Urol Nephrol

authors

Yaman O,Baltaci S,Arikan N,Ozdiler E,Göğüş O,Müftüoğlu YZ

doi

10.1007/BF02550862

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

207-10

issue

2

eissn

0301-1623

issn

1573-2584

journal_volume

28

pub_type

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