Urinary TGF-1 has a supplementary value in predicting renal function recovery post unilateral ureteral obstruction.

Abstract:

PURPOSE:To evaluate whether urine transforming growth factor-β1 (TGF-β1) can help identifying kidneys that would recover their function after drainage of unilateral ureteric obstructive. METHODS:Forty-five patients with unilateral ureteral obstruction were included. Glomerular filtration rate (GFR) of the obstructed kidney was <10 ml/min, and all patients were treated with percutaneous nephrostomy. TGF-β1 level was measured in the urine from the obstructed kidney at the time of drainage. GFR before nephrostomy insertion and 3 months after were calculated. RESULTS:Patients with renal function improvement (significant increase in GFR) after nephrostomy insertion had significantly lower concentration of urine TGF-β1 (p<0.05) compared with the group that showed no change in GFR (non-functioning kidneys) The sensitivity, specificity and accuracy of urine TGF-β1 in identifying non-functioning kidney was 82, 82 and 82%, respectively. CONCLUSIONS:Urine TGF-β1 is a cytokine leading to renal fibrosis and has a supplementary value in differentiating, at early stage, between kidneys that would recover function after releasing unilateral ureteral obstruction from those which will not (non-functioning kidneys).

journal_name

Int Urol Nephrol

authors

Chen X,Zhu W,Al-Hayek S,Yan X,Jiang C,Zheng X,Guo H

doi

10.1007/s11255-014-0846-3

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

33-7

issue

1

eissn

0301-1623

issn

1573-2584

journal_volume

47

pub_type

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