An unusual case of extensive epididymotesticular malakoplakia in a diabetic patient.

Abstract:

:A 67-year-old Saudi man with poorly controlled diabetes-mellitus underwent orchiectomy for a painful left testicular swelling that did not respond to antibiotics. Clinical diagnosis was testicular malignancy. Histologic workup demonstrated extensive involvement of the testis and epididymis by diffuse infiltrate of large histiocytes with eosinophilic granular cytoplasm and numerous Michaelis-Gutmann bodies, which were diagnostic of malakoplakia. Very rarely, malakoplakia has been described in association with diabetes mellitus. Such an extensive malakoplakia occurring at an unusual site in association with systemic illness lends support to the view that a compromised immune status could be etiologically important in malakoplakia. We present this case to highlight the importance of diagnosing malakoplakia when it occurs at unusual locations. We also explore the role of diabetes mellitus in the pathogenesis of malakoplakia and compare the relationship between malakoplakia and xanthogranulomatous inflammation, which are closely related to each-other on both clinical and morphologic grounds.

journal_name

Int Urol Nephrol

authors

Mannan AA,Kahvic M,Singh NG,Abu Sara Y,Bharati C

doi

10.1007/s11255-009-9674-2

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

569-73

issue

3

eissn

0301-1623

issn

1573-2584

journal_volume

42

pub_type

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