Abstract:
AIM:To investigate the correlation of renal tubular inflammatory and injury markers with renal uric acid excretion in chronic kidney disease (CKD) patients. METHODS:Seventy-three patients with CKD were enrolled. Fasting blood and morning urine sample were collected for routine laboratory measurements. At the same time, 24 h of urine was collected for urine biochemistry analyses, and 10 ml was extracted from the 24-h urine sample to further detect renal tubular inflammatory and injury markers, including interleukin-18 (IL-18), interleukin 1β (IL-1β), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). The patients were divided into three tertile groups according to their 24-h urinary uric acid (24-h UUA) levels (UUA1: 24-h UUA ≤ 393.12 mg; UUA2: 393.12 < 24-h UUA ≤ 515.76 mg; UUA3: 24-h UUA > 515.76 mg). The general clinical and biochemical indexes were compared. Multivariable linear regression models were used to test the association of IL-18/Urinary creatinine concentration (IL-18/CR), IL-1β/CR, NGAL/CR and KIM-1/CR with renal uric acid excretion indicators. RESULTS:All of tested renal tubular inflammation- and injury-related urinary markers were negatively associated with 24-h UUA and UEUA, and the negative correlation still persisted after adjusting for multiple influencing factors including urinary protein and eGFR. Further group analyses showed that these makers were significantly higher in the UUA1 than in the UUA3 group. CONCLUSIONS:Our findings suggest that markers of urinary interstitial inflammation and injury in CKD patients are significantly correlated with 24-h UUA and Urinary excretion of uric acid (UEUA), and those with high 24-h UUA have lower levels of these markers. Renal uric acid excretion may also reflect the inflammation and injury of renal tubules under certain conditions.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Zheng Y,Guan H,Zhou X,Xu Y,Fu C,Xiao J,Ye Zdoi
10.1007/s11255-020-02447-5subject
Has Abstractpub_date
2020-05-01 00:00:00pages
923-932issue
5eissn
0301-1623issn
1573-2584pii
10.1007/s11255-020-02447-5journal_volume
52pub_type
杂志文章abstract:AIM:To evaluate the infectious complications, microorganism distribution and antibacterial treatment in patients who underwent percutaneous nephrolithotomy (PCNL). PATIENTS AND METHODS:Three hundred and thirty-eight patients who were 17 years age or older who underwent PCNL between January 2001 and December 2002 have ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9147-9
更新日期:2007-01-01 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is the most common nonmalignant condition of the prostate occurring in ageing men. Even though BPH is a major public health problem, causing high morbidity and substantial worsening in men's quality of life, little is known about its risk factors. Several studies revealed that it is ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-008-9333-z
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Estimated glomerular filtration rate (GFR) is a useful tool for the detection of chronic kidney disease (CKD). Several methods have been proposed, but findings can vary in specific groups such as patients with diabetes, elderly and high and low body mass index and, also, with the stage of CKD. The objective of ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0607-8
更新日期:2014-06-01 00:00:00
abstract::A case of Itai-itai (ouch-ouch) disease with reduced urinary kallikrein excretion and slightly enhanced renin-angiotensin-aldosterone system is described. Although it is well known that cadmium toxicity frequently affects the renal tubular lesions, this report is the first to demonstrate the impaired urine concentrati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550809
更新日期:1989-01-01 00:00:00
abstract::A patient with bladder carcinoma, subjected to cystectomy and bilateral ureterosigmoidostomy, survived for the length of 31 years. The Coffey method of anastomosis was applied in a form modified by the authors. The patient succumbed to acute circulatory insufficiency at the age of 85. Metastases were not discovered ei...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081864
更新日期:1984-01-01 00:00:00
abstract::Renal oncocytoma represents a special category of renal tumours and accounts for 3-5% of renal neoplasms. Usually they are incidental findings. Most reports have demonstrated their benign nature but a few cases of high-grade oncocytomas were reported to have metastasized. In Poland, between 1971 and 1991, 7 patients (...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768007
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:Water intake is important for preventing kidney stones. Small molecules water is a more active restructured water under magnetic field. Here, we studied the relation between small molecules water and crystal formation in the rat kidney. MATERIALS:The small molecules water was prepared by a water machine provid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1769-6
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To assess the trends of neoadjuvant chemotherapy (NAC) use since its introduction in our practice pathway in patients with cT2 + bladder cancer over a 20-year period. METHODS:This is a retrospective review of patients with cT2 + bladder cancer who underwent RC between 01/01/1998 and 01/01/2018 that aimed to ev...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02752-z
更新日期:2021-01-03 00:00:00
abstract::In a retrospective study of 522 consecutive patients who were subjected to transurethral resection of the prostate with suprapubic trocar technique, six patients were suspected of having transurethral prostatic resection syndrome. The majority of the transurethral resections were performed by surgical or urological tr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550468
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:In this prospective study we aimed to describe our new technique; dehydrated human dura mater as an interposition graft in patients undergoing benign vesicovaginal fistula repair (VVF). PATIENTS AND METHODS:Eleven patients with benign VVFs aged 38-73 years were operated with dura mater interposition technique ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000032682.84973.e9
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:Frailty is a multicausal syndrome characterized by a decrease in strength, resistance and physiological function, which makes the individual vulnerable and dependent, and increases his/her mortality. This syndrome is more prevalent among older individuals, and chronic kidney disease patients, particularly ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02757-8
更新日期:2021-01-30 00:00:00
abstract::Pure testicular rhabdomyosarcoma is a very rare tumor and 7 cases have been reported in literature. A 20-year-old male patient presented with a painless right testicular swelling who underwent inguinal orchiectomy with suspicion of testicular malignancy. The case was regarded as an embryonal rhabdomyosarcoma according...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000032671.74121.d3
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship between the expression of E-cadherin (E-CD) and tumor recurrence and progression in patients with high-grade stage T1 urothelial carcinoma of bladder. METHODS:Fifty-two patients who had primary high-grade stage T1 urothelial carcinoma were enrolled to the study. The pathologic sp...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9159-5
更新日期:2007-01-01 00:00:00
abstract::During a 3-year period, hundreds of patients underwent ESWL treatment with the Dornier HM-3 and HM-4 lithotriptors operating at our institution. Our experience in 3,500 patients treated with the HM-4 bath-free lithotriptor is reported. Patients with radiolucent or cystine stones, stones larger than 3 cm or staghorn ca...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551334
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Significantly increased cardiovascular mortality in patients with chronic kidney (CKD) disease cannot be explained by traditional risk factors. Recent studies revealed that the quality of HDL and LDL cholesterol may be more important than their serum levels. The aim of this study was to assess which LDL and ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1466-x
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Mechanisms for calcium-based stone formation are not clearly delineated. Porcine are the most anatomically and physiologically congruent mammal to humans. Our objectives were to develop a cost-effective and easily reproducible porcine model for the study of calcium-based nephrolithiasis. METHODS:Crossbred m...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1657-0
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In diabetics genetic predisposition, poor glycemic control and arterial hypertension contribute to nephropathy development in patients affected by diabetes mellitus. We set up the hypothesis that diabetic nephropathy and incisional hernia formation may have in common alterations of collagen com...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1229-8
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:The present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD. METHODS:We conducted an observational, cross-sectional study in our outpatient diabetic nephropathy clinic from 2014 to 2016, enrolling...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1646-3
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The present study investigated the inhibitory effects of a novel minimally invasive implanted tibial nerve stimulation device on non-nociceptive bladder reflexes in cats. MATERIALS AND METHODS:A wireless minimally invasive implanted nerve stimulator was implanted adjacent to the left tibial nerve in seven ca...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02666-w
更新日期:2020-09-28 00:00:00
abstract:PURPOSE:Hypoxia plays a significant role in the pathogenesis of acute kidney injury (AKI). Autophagy protects from AKI. Amino acid deprivation induces autophagy. The effect of L-tryptophan depletion on survival and autophagy in cultures of renal proximal tubular epithelial cells (RPTECs) under hypoxia was evaluated. M...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1596-9
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:The authors aimed to establish a rat model of catheter-associated UTIs using a complete urethral catheter. Bacterial growth in biofilms on urethral catheters was analyzed using standard culture methods to validate this model. METHODS:A total of 15 rats were divided into the following three groups according to ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1038-5
更新日期:2015-08-01 00:00:00
abstract::One hundred patients with recurrent calcium nephrolithiasis were submitted to the Pak test. At fasting state hypercalciuria was found in 27 cases, while a group of 16 further patients became hypercalciuric after oral calcium load. Only measurement of urinary cAMP excretion in both conditions made it possible to diagno...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02083499
更新日期:1985-01-01 00:00:00
abstract::Leptospirosis is an infectious disease caused by pathogenic leptospires and is characterized by a broad spectrum of clinical manifestations, varying from inappearent infection to fulminant, fetal disease. Eighty-five to 90% of leptospirosis infections are self-limiting. However, 5-10% of infection by L. interrogans ca...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014494012062
更新日期:2002-01-01 00:00:00
abstract::An analysis of the ultrastructural features of 35 canine kidneys after hypothermic preservation in Rheomacrodex, Collins3 and Sacks II solutions, and subsequent autologous reperfusion for 2 to 3 hours is presented. Signs of irreversibility (intramitochondrial crista fragmentation, cell membrane rupture, detachment of ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02089353
更新日期:1980-01-01 00:00:00
abstract:AIMS:Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED. METHODS:We designed a strate...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-017-1644-5
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND/AIMS:Detection of circulating tumor cells (CTCs) in cancer patients has diagnostic and prognostic importance. However, the clinical implications of CTC detection in patients with renal cell carcinoma (RCC) are still unclear. In this study, we investigated the clinical significance of CTCs using two detection...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1954-2
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To determine predictors for surgical complications and assess patient satisfaction after surgical treatment of Adult-Acquired Buried Penis (AABP). METHODS:A retrospective review was performed on all patients diagnosed with AABP who underwent surgical treatment at a single institution from January 2013-Decemb...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02347-3
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Preserving renal function and controlling oncological outcomes are pertinent while managing renal tumours. We compared outcomes of percutaneous cryoablation (PCA) and retroperitoneoscopic cryoablation (RCA) in patients with renal neoplasms. METHODS:We identified 108 patients with renal tumours at two medical c...
journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s11255-018-1925-7
更新日期:2018-08-01 00:00:00
abstract::Cardiovascular disease (CVD) begins early in the course of chronic kidney disease (CKD) and is the leading cause of death in patients with CKD. Preventing the development of CVD and establishing new clinical tools for identifying high-risk individuals, particularly those with an increased risk for cardiac death, is of...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-013-0421-3
更新日期:2014-01-01 00:00:00
abstract::A 67-year-old Saudi man with poorly controlled diabetes-mellitus underwent orchiectomy for a painful left testicular swelling that did not respond to antibiotics. Clinical diagnosis was testicular malignancy. Histologic workup demonstrated extensive involvement of the testis and epididymis by diffuse infiltrate of lar...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9674-2
更新日期:2010-09-01 00:00:00