Abstract:
PURPOSE:To assess the trends of neoadjuvant chemotherapy (NAC) use since its introduction in our practice pathway in patients with cT2 + bladder cancer over a 20-year period. METHODS:This is a retrospective review of patients with cT2 + bladder cancer who underwent RC between 01/01/1998 and 01/01/2018 that aimed to evaluate the trends of NAC use and associated after implementation of a multidisciplinary treatment pathway. Cohorts were stratified into eras: pre-NAC (1998-2007) to NAC eras (2008-2018). Univariate analysis was conducted using Chi-squared test and Kaplan-Meier estimates were used to evaluate survival. RESULTS:In 904 total patients who underwent RC, there were 493 with cT2 + UCC disease. The rate of NAC peaked at 84.2% in the most recent year of analysis in all patients and was 100% in cT2 + patients eligible for NAC. There was an increased rate of complete response (downstage to pT0) from 8.7% to 15.8% (p = 0.018) between the two eras. Unadjusted survival analysis revealed improved overall survival (OS) between eras with 5-year OS 53.2% vs. 42.7% and 10-year OS 42.7% vs. 26.4% in the NAC vs. pre-NAC cohorts, respectively (p = 0.016). CONCLUSIONS:In this review of 20 years of experience, we report a dramatic rise in the use of NAC after adoption of a multidisciplinary pathway that is associated with expected survival benefits.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Faraj KS,Navaratnam AK,Eversman S,Elias L,Syal A,Tyson MD,Castle EPdoi
10.1007/s11255-020-02752-zsubject
Has Abstractpub_date
2021-01-03 00:00:00eissn
0301-1623issn
1573-2584pii
10.1007/s11255-020-02752-zpub_type
杂志文章abstract:PURPOSE:TNF-α -308G/A polymorphism has been implicated in the susceptibility of diabetic nephropathy, but studies have reported inconclusive results. The present study investigated the relationship between -308G/A polymorphism in the TNF-α gene and diabetic nephropathy risk by meta-analysis. METHODS:Data from PubMed, ...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析
doi:10.1007/s11255-013-0490-3
更新日期:2013-12-01 00:00:00
abstract::In 68 men with benign prostatic hyperplasia, we evaluated the association between obesity and prostatic enlargement, as well as changes in serum levels of oestradiol, testosterone, dihydroepiandrosterone and dihydroepiandrosterone sulphate. Despite the larger adenomas, no increase in the symptom score for BPH was obse...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550138
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To compare the economic burden and cost-utility analysis of the renal replacement therapies, including hemodialysis (HD), peritoneal dialysis (PD), and allograft kidney transplantation (KT) among end-stage renal disease (ESRD) patients from Yunnan Province, China. METHODS:Multistage stratified random sampling ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02394-1
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:Cardiovascular (CV) events are the first cause of death in patients with chronic renal disease (CKD) and in patients with type 2 diabetes mellitus (DM2). The combination of CKD and DM2 elevates the risk of both cardiovascular disease (CVD) and death in this high-risk population. Besides traditional risk factors...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1755-z
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To suggest a different method for diagnosing vesicoureteral reflux (VUR) in lieu of voiding cystourethrography (VCU), in order to prevent radiation exposure. MATERIALS AND METHODS:Fifty-two ureterorenal units of 26 patients were evaluated ultrasonographically for visualizing the renal collecting systems, both ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550307
更新日期:1998-01-01 00:00:00
abstract::Multiple myeloma is characterized by marrow plamacytsois, M spike in serum or urine electrophoresis and skeletal lytic lesions. The M spike may be absent in rare instances. We describe a case of myeloma cast nephropathy with acute renal failure who did not exhibit an M spike. lambda-chain staining was documented on im...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-004-2362-3
更新日期:2005-01-01 00:00:00
abstract::In the course of a disinterment of an ancient Avar burial place at Székkutas-Kápolna near Hódmezövásárhely, Hungary, the archaeologist conducting the excavations, Miss Katalin B. Nagy, noticed a lithoid body of oval shape in the pelvis of a skeleton. The find was identified on morphological and chemo-analytical ground...
journal_title:International urology and nephrology
pub_type: 历史文章,杂志文章
doi:10.1007/BF02550466
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Primary bladder neck obstruction (PBNO) is a nonneurogenic voiding disorder and frequently overlooked in young men. Prior studies have reported the efficacy of α-blockers only in the short-term for male patients with PBNO. We hereby report our long-term results using α1-blocker therapy in young men with PBNO....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0096-6
更新日期:2012-06-01 00:00:00
abstract::During a 3-year period, hundreds of patients underwent ESWL treatment with the Dornier HM-3 and HM-4 lithotriptors operating at our institution. Our experience in 3,500 patients treated with the HM-4 bath-free lithotriptor is reported. Patients with radiolucent or cystine stones, stones larger than 3 cm or staghorn ca...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551334
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) is a worldwide health problem, and promotion of the World Kidney Day has improved general population education and awareness of renal illnesses aimed at ameliorating disease prevention. The Kidney Day was also an opportunity for us to investigate risk factors for CKD in an Italia...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9861-1
更新日期:2011-09-01 00:00:00
abstract::An unusual case of a 15-year-old male who presented with a characteristic clinical syndrome of testicular torsion one week prior to our observation, is reported. During our intervention the testicle was not removed but, on the contrary, restoration of a satisfactory testicular albugineal appearance was achieved. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007189111613
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:We evaluated the bladder oxidative stress in neurogenic bladder children treated with intravesical amikacin for recurrent UTI and whether urinary isoprostane f2 alpha (F2-IsoP) is a good biomarker in this particular condition. METHODS:This prospectively designed controlled study was approved by the Adnan ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1711-y
更新日期:2017-12-01 00:00:00
abstract::Relationships between plasma testosterone levels and selected parameters of lipid metabolism were studied in a group of young sterile males prior to, during, and after hormone therapy. Initial hypertriacylglycerolaemia and decreased concentrations of HDL cholesterol returned to normal values after 30 days of methyltes...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549731
更新日期:1991-01-01 00:00:00
abstract:AIM:To determine the effectiveness of transdermal electromotive administration (TEA) of verapamil and dexamethasone in the treatment of Peyronie's disease (PD). METHOD:Totally, 51 patients with PD were prospectively included in the study. All patients were evaluated by history, subjective score scales, physical examin...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s11255-008-9408-x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The prostatitis syndrome is a multifactorial condition of largely unknown etiology. This study is to analyze the relationship between cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) with the chronic nonbacterial prostatitis (CNBP). METHODS:A total of 172 CNBP patients and 151 healthy males were recruite...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0743-9
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Pulmonary hypertension (PH) in maintenance hemodialysis (MHD) patients has attracted increasing attention. This cross-sectional survey aimed to explore PH prevalence and identify potential risk factors in MHD patients. METHODS:A total of 136 MHD patients were assessed at the Fifth Affiliated Hospital of Sun Ya...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1119-5
更新日期:2015-11-01 00:00:00
abstract::Renal osteodystrophy, a frequent complication of chronic renal failure, is usually assessed by periodic X-rays of bone which are both poorly reproducible and expensive. Seeking a better screening test for osteodystrophy, we evaluated the usefulness of serum alkaline phosphatase as a predictor of bone disease and of hy...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085384
更新日期:1980-01-01 00:00:00
abstract:PURPOSE:The association between crescents and renal outcomes was inconsistent in a Chinese IgA nephropathy (IgAN) cohort, and limited research has investigated the prognosis of IgAN patients with crescents. METHODS:Between January 2008 and January 2013, 169 consecutive IgAN patients with crescents in the Xijing Hospit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02457-3
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Hippocampus plays an important role in spatial learning and memory. Ghrelin, a brain-gut peptide, participates in the mnestic functions of hippocampus through its receptor growth hormone secretagogue receptor (GHS-R) distributed in hippocampus. This study was to investigate whether there was a correlation betwe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1228-9
更新日期:2016-05-01 00:00:00
abstract::This study compares the safety and efficacy of mechanical cystolithotripsy (MCLT) and extracorporeal shock wave lithotripsy (ESWL) in the treatment of vesical stones. In the last four years we have treated 144 bladder lithiasis patients with MCLT (86; group A) and ESWL (58; group B). All patients in group A were treat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768241
更新日期:1994-01-01 00:00:00
abstract::Primary squamous cell carcinoma of seminal vesicle is extremely rare, and most cases regarding seminal vesicle tumors failed to address this kind of tumor. A 54-year-old male patient presented with intermittent painless visual hematuria for 6 months was hospitalized. Ultrasonography, computerized tomography and magnet...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-012-0373-z
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:No safe ultrasound (US) parameters have been established to differentiate the causes of graft dysfunction. OBJECTIVES:To define US parameters and identify the predictors of normal graft evolution, delayed graft function (DGF), and rejection at the early period after kidney transplantation. METHODS:Between Jun...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0896-6
更新日期:2015-02-01 00:00:00
abstract::Eight patients with benign prostatic hypertrophy (BPH), considered as a high risk for an operation because of severe accompanying disease, were treated with a self-retaining intraurethral catheter set. Two patients were judged unfit for operation (one because of severe cardiac failure, the other because of severe resp...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::This study presents a view of the knowledge the authors have gathered during 11 years of work with radioisotope examinations of the kidneys and ureteral urine passage performed in 34 children. As an important indication field they consider the conditions where excretory urography or separate functional examination, re...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02217144
更新日期:1980-01-01 00:00:00
abstract::Cyclophosphamide was introduced in 1958 in an effort to minimize the side effects of nitrogen mustard. Cyclophosphamide (Cytoxan, Endoxan) is not an alkylating agent which has been used for the treatment of a variety of non-malignant as well as malignant diseases. It has also recently been the focus of considerable in...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082484
更新日期:1985-01-01 00:00:00
abstract::The advent of new diagnostic procedures has made it possible for urologists to detect chlamydial presence in genital infections. Many studies have shown chlamydial association with urethritis. However, its presence in prostatitis and epididymitis has not been clearly defined yet. In this study we investigated the pres...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549645
更新日期:1992-01-01 00:00:00
abstract::We report a case of penile incarceration in a 53-year-old impotent man. The base of the penis was encircled by a metal ring in order to achieve better erection. There was marked oedema of the entire penis distal to the constricting ring. The metal ring was removed successfully by cutting it with a steel saw. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564752
更新日期:1995-01-01 00:00:00
abstract::Excessive generation of reactive oxygen species (ROS) containing free oxygen radicals has been identified as one of the causes of male infertility. Lycopene is a component of human redox defence mechanism against free radicals. It is found in high concentrations in the testes and seminal plasma and decreased levels ha...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1023/a:1024483520560
更新日期:2002-01-01 00:00:00
abstract::Prostate cancer coexisting with asymptomatic Paget's disease (osteitis deformans) may be difficult to stage. The skeletal lesions of both prostate cancer and Paget's disease may closely resemble each other, as appearing on imaging. A case of clinically localized prostate cancer coexisting with incidental Paget's disea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1019502903833
更新日期:2001-01-01 00:00:00
abstract::Disorders in calcium, phosphorus, and parathyroid hormone (PTH) are common in chronic kidney disease (CKD) and may be associated with poor outcomes including a higher rate of CKD progression and increased death risk. Although these abnormalities have been examined extensively in patients with CKD stage 5 who are recei...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-008-9346-7
更新日期:2008-01-01 00:00:00