Abstract:
:Disorders in calcium, phosphorus, and parathyroid hormone (PTH) are common in chronic kidney disease (CKD) and may be associated with poor outcomes including a higher rate of CKD progression and increased death risk. Although these abnormalities have been examined extensively in patients with CKD stage 5 who are receiving chronic maintenance dialysis, they have not been studied to the same extent at earlier stages of CKD, in spite of the much larger numbers of patients in the early CKD population. We summarize the available literature on outcomes associated with bone and mineral disorders in patients with CKD not yet receiving maintenance dialysis. We have reviewed novel data linking fibroblast growth factor 23 (FGF-23) to phosphorus and vitamin D homeostasis. More rapid CKD progression is linked to hyperphosphatemia and its associated hyperparathyroidism and vitamin D deficiency. Hence, hyperphosphatemia may play a central role in the diverse disorders characterizing CKD. We provide a brief overview of the available treatment recommendations for bone and mineral disorders, with an emphasis on areas needing further research.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Kovesdy CP,Kalantar-Zadeh Kdoi
10.1007/s11255-008-9346-7subject
Has Abstractpub_date
2008-01-01 00:00:00pages
427-40issue
2eissn
0301-1623issn
1573-2584journal_volume
40pub_type
杂志文章,评审abstract::A 67-year-old Saudi man with poorly controlled diabetes-mellitus underwent orchiectomy for a painful left testicular swelling that did not respond to antibiotics. Clinical diagnosis was testicular malignancy. Histologic workup demonstrated extensive involvement of the testis and epididymis by diffuse infiltrate of lar...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9674-2
更新日期:2010-09-01 00:00:00
abstract::In this report serum apolipoprotein A I (Apo A I) and apolipoprotein B (Apo B) levels were determined in children with chronic renal disease (CRD) during metabolic acidosis, after the correction of metabolic acidosis and in healthy children to look for the effect of metabolic acidosis on Apo A I and B levels. It was f...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552208
更新日期:1997-01-01 00:00:00
abstract::Serum renin concentration (SRC) was determined in 97 hypertensive patients under basal conditions and during stimulation of renin secretion. Renin secretion was stimulated by upright posture and by either of the following means: (a) diet containing 20 mEq Na/24 hours for 3 days; (b) 300 mg i.v. diazoxide injections; (...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082246
更新日期:1976-01-01 00:00:00
abstract:PURPOSE:The age-related decline of the testosterone-to-estrogen (T-to-E2) ratio in serum is associated with the increased prevalence of prostatic inflammation. The goal of the study was to induce prostatic inflammation with E2 and androgen treatment and to explore the inflammatory markers and apoptosis on prostatitis. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0845-4
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To prove that phosphodiesterase type-4 inhibitors could potentially treat obesity-associated overactive bladder through modulation of the systemic inflammatory response. METHODS:In this 12-week study, 90 female Sprague-Dawley rats were divided into three groups: (1) vehicle-treated normal diet (ND)-fed rats; (...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1671-2
更新日期:2017-10-01 00:00:00
abstract::We describe and report two cases of bilateral symptomatic ureterocele with calculi in two young adult women. They were successfully managed endoscopically by a transverse meatotomy and stone extraction done bilaterally in a single operative session. The 6th month postoperative voiding cystourethrogram showed no reflux...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-006-0091-5
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Estimated glomerular filtration rate (GFR) is a useful tool for the detection of chronic kidney disease (CKD). Several methods have been proposed, but findings can vary in specific groups such as patients with diabetes, elderly and high and low body mass index and, also, with the stage of CKD. The objective of ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0607-8
更新日期:2014-06-01 00:00:00
abstract::A total of 32 female patients with urinary stress incontinence who underwent a Stamey endoscopic bladder neck suspension were clinically and urodynamically studied pre- and postoperatively. Complete cure was obtained in 78% of the patients and improvement in 6%, the overall success rate being 84% for a mean follow-up ...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02768212
更新日期:1994-01-01 00:00:00
abstract::Disturbances in purine metabolism with hyperuricaemia and/or hyperuricosuria are a risk factor in uric acid and Ca oxalate stone formation. By way of a competitive xanthine oxidase inhibition, the formation of uric acid is reduced by allopurinol. In investigations on two groups of patients, Milurit could be demonstrat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085441
更新日期:1983-01-01 00:00:00
abstract::It is well known that some antibiotics are particularly nephrotoxic. In the present study we investigated kidney function and AAP excretion (as an index of nephrotoxicity) in patients with urinary tract infection treated with CAZ or CTX plus TOB. The main cause of infection was E. coli in both treated groups. After 10...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550604
更新日期:1988-01-01 00:00:00
abstract::Persistent Mullerian duct syndrome (PMDS) is a rare form of the 46 XY disorders of sexual differentiation, characterized by the presence of a uterus and fallopian tubes due to the failure of Mullerian duct regression in genotypically normal males. More than 150 cases have been recorded, most of them in adults. In most...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0667-4
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:The association between crescents and renal outcomes was inconsistent in a Chinese IgA nephropathy (IgAN) cohort, and limited research has investigated the prognosis of IgAN patients with crescents. METHODS:Between January 2008 and January 2013, 169 consecutive IgAN patients with crescents in the Xijing Hospit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02457-3
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Pulmonary embolism with viable tumor cells developed after surgery for renal cell carcinoma may metastasize to lung. We investigated the incidence and fate of newly developed pulmonary embolism after surgery for renal cell carcinoma with vena cava thrombus. METHODS:Among 4549 renal cell carcinoma patients trea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1583-1
更新日期:2017-07-01 00:00:00
abstract::Chronic hepatic patients, and particularly those suffering from cirrhosis, are predisposed to different sort of water, electrolyte, acid-base, and trace elements disorders due to their altered liver function, and also to their exposition to infectious, inflammatory, oncologic, and pharmacologic variables whose combina...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-017-1614-y
更新日期:2018-01-01 00:00:00
abstract::In a retrospective study of 522 consecutive patients who were subjected to transurethral resection of the prostate with suprapubic trocar technique, six patients were suspected of having transurethral prostatic resection syndrome. The majority of the transurethral resections were performed by surgical or urological tr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550468
更新日期:1987-01-01 00:00:00
abstract::Non-refluxing non-obstructive megaureter is a rare condition, usually diagnosed in asymptomatic neonates. We present the case of a 39-year-old male, who presented with a 6-month history of recurrent UTIs and intermittent frank haematuria. IVU, flexible cystoscopy and micturating cystogram confirmed characteristically ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9054-0
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To report a case of a 31-year-old woman with renal angiomyolipoma (RAML) who presented with progressive massive haematuria with successive pregnancies. CLINICAL PRESENTATION:A 28-year-old woman presented with mild haematuria in the third trimester of her second pregnancy. This was due to bleeding from a left...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9036-2
更新日期:2007-01-01 00:00:00
abstract::We report a boy with urachal cyst managed laparoscopically. A 9-year-old boy was referred from another hospital with a history of low abdominal pain. We laparoscopically excised the urachal cyst, removing all structures within the umbilicovesical fascia, including the urachus and each medial umbilical ligament, as wel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9132-3
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The prostatitis syndrome is a multifactorial condition of largely unknown etiology. This study is to analyze the relationship between cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) with the chronic nonbacterial prostatitis (CNBP). METHODS:A total of 172 CNBP patients and 151 healthy males were recruite...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0743-9
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:This study examined whether the laser-capture microdissection (LCM) method can achieve separation of urothelial cells from detrusor cells or superficial urothelial cells from intermediate/basal urothelial cells, using α-smooth muscle actin (SMA) and cytokeratin 20 (CK20). In addition, we investigated the change...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-0926-z
更新日期:2015-04-01 00:00:00
abstract:AIM:To determine the effectiveness of transdermal electromotive administration (TEA) of verapamil and dexamethasone in the treatment of Peyronie's disease (PD). METHOD:Totally, 51 patients with PD were prospectively included in the study. All patients were evaluated by history, subjective score scales, physical examin...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s11255-008-9408-x
更新日期:2009-01-01 00:00:00
abstract::Platinum (Pt) concentrations in the kidney and liver were determined in 12 autopsied cases following cisplatin treatment. The Pt level in the liver was generally higher than that in the kidney. Pt concentration in the liver showed a significant correlation with the total dose of cisplatin. However, no dose-dependent P...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Patients with metastatic prostate cancer respond to androgen withdrawal therapy, but progression to androgen independence is frequently observed. To clarify the predictor of response to endocrine therapy, the role of PSA changes and the prognosis of the patients were evaluated in 115 Japanese cases of prostate cancer ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014410026495
更新日期:2001-01-01 00:00:00
abstract::The authors describe an uncommon case of a huge perinephric abscess with a gas-fluid level occupying the upper left abdomen. A rational sequence of radiological diagnostic methods such as plain film, ultrasound, CT, and combined retrograde urogram with contrast filling of percutaneous drainage led to correct managemen...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549707
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Recently, great progress has been made in understanding the pathogenesis of membranous nephropathy (MN) with the discovery of autoantibodies (Abs) to M-type phospholipase A2 receptor (PLA2R) in serum and in immunocomplexes deposited in glomerulus in most adult patients with primary MN. OBJECTIVE:To evaluate...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02682-w
更新日期:2020-10-31 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In diabetics genetic predisposition, poor glycemic control and arterial hypertension contribute to nephropathy development in patients affected by diabetes mellitus. We set up the hypothesis that diabetic nephropathy and incisional hernia formation may have in common alterations of collagen com...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1229-8
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:In the present study we have performed a correlation of the most prevailing clinical conditions of multiple sclerosis (MS) with overall drug response and the grade of the disease. MATERIALS AND METHODS:One hundred and ten patients were consecutively and prospectively studied with a clinical syndrome of MS, ran...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017597016622
更新日期:2001-01-01 00:00:00
abstract::The first time in Scandinavia we present a case report of a pure primary low-grade neuroendocrine carcinoma (carcinoid tumor) of the prostate. Our patient is a 34-year-old male with a long history of symptomatic chronic prostatitis/prostatodynia. After developing severe obstructive uropathy, a transurethral resection ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9660-8
更新日期:2010-09-01 00:00:00
abstract::We report a 49-year-old woman with exstrophy of the bladder. Our living case constitutes a rare example of bladder exstrophy cases, who lived about 50 years without any severe complication or intervention. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550721
更新日期:1996-01-01 00:00:00
abstract::This study was designed to investigate the relationship between the effects of testicular reactive oxygen species (ROS) levels and testicular histology on infertile patients with the aid of xanthine oxidase system and testicular tissue malondialdehyde levels. Forty patients with idiopathic infertility constituted our ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007138522517
更新日期:1999-01-01 00:00:00