Abstract:
OBJECTIVE:To evaluate the relationship between the expression of E-cadherin (E-CD) and tumor recurrence and progression in patients with high-grade stage T1 urothelial carcinoma of bladder. METHODS:Fifty-two patients who had primary high-grade stage T1 urothelial carcinoma were enrolled to the study. The pathologic specimens of patients were evaluated and staged as T1a and T1b according to muscularis mucosae involvement by the tumor. The immunohistochemical demonstration of E-CD was accomplished by using immunoperoxidase method and all the specimens were examined under light microscope for E-CD level. RESULTS:The mean age of the patients was 64.0 +/- 7.7 (range 36-81) years. The mean follow-up period was 56.4 +/- 19.4 (range 14-84) months. Among 52 patients, 27 (52%) of them were stage T1b and 25 (48%) were T1a tumors. The recurrence rates for T1a and T1b groups were 52% (n = 13) and 92.6% (n = 25), respectively (P < 0.05). The expression of E-CD was homogenous in 52% of pT1a and 14.8% of T1b tumors (P < 0.05). In T1a group with recurrence, homogeneous E-CD staining ratio was 30.7% (n = 4/13), but it was 75% (n = 9/12) in T1a patients without recurrence (P < 0.05). In T1b group with recurrence, the homogenous expression of E-CD was 12% (n = 3/25) and the expression of E-CD was heterogenous in 88% (n = 22/25) of them (P < 0.05). In T1a group, progression of the disease was detected in 28% (n = 7/25) of the patients, but disease progression was seen in 55.5% (n = 15/27) of T1b group patients (P < 0.05). In T1a group with progression, heterogeneous E-CD staining ratio was 85.7% (n = 6/7), but it was 80% (n = 12/15) in T1b patients with progression. The effects of tumor number, tumor size and carcinoma in situ presence on recurrence were evaluated within each group. It was determined that parameters such as tumor number and tumor size had no significant effect on recurrence of the groups. The mean survival rates were statistically different between the groups. On multivariate analysis only E-cadherin expression (P = 0.012, odds ratio 6.291, 95% confidence interval for odds ratio 1.303-4.72) and tumor stage (P = 0.003, odds ratio 11.58, 95% confidence interval for odds ratio 2.446-8.542) remained independently significant as predictors of recurrence. CONCLUSION:E-CD expression was decreased in pathologic specimens of bladder tumor patients with muscularis mucosae involvement and this condition correlated well with tumor recurrence.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Erdemir F,Ozcan F,Kilicaslan I,Parlaktas BS,Uluocak N,Gokce Odoi
10.1007/s11255-006-9159-5subject
Has Abstractpub_date
2007-01-01 00:00:00pages
1031-7issue
4eissn
0301-1623issn
1573-2584journal_volume
39pub_type
杂志文章abstract:PURPOSE:The purpose of this study was to evaluate the efficacy of tegafur-uracil (UFT) administration as a fourth-line therapy in patients with castration-resistant prostate cancer (CRPC) who had already received combined androgen blockade (CAB) therapy (first-line), alternative antiandrogen therapy (second-line), and ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0634-5
更新日期:2014-06-01 00:00:00
abstract::Patients with metastatic prostate cancer respond to androgen withdrawal therapy, but progression to androgen independence is frequently observed. To clarify the predictor of response to endocrine therapy, the role of PSA changes and the prognosis of the patients were evaluated in 115 Japanese cases of prostate cancer ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014410026495
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:Varicocele is among the leading causes of male infertility. Despite decades of research, its pathogenesis is still unclear. S100A12 is a member of the S100 family of calcium-binding proteins with principal extracellular activities. It is secreted by activated neutrophils and interacts with the multiligand recep...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1188-5
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Although sleep complaints are commonly reported in persons with end stage renal disease (ESRD), little is known about the prevalence of sleep complaints in chronic kidney disease (CKD), and the relation of sleep quality to the severity of kidney disease. METHODS:We administered the Kidney Disease Quality of...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-4654-z
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abstract:PURPOSE:To evaluate whether urine transforming growth factor-β1 (TGF-β1) can help identifying kidneys that would recover their function after drainage of unilateral ureteric obstructive. METHODS:Forty-five patients with unilateral ureteral obstruction were included. Glomerular filtration rate (GFR) of the obstructed k...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0846-3
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abstract:PURPOSE:The purpose of the study was to assess safety and efficacy of autologous muscle derived cells for urinary sphincter repair (AMDC-USR) in female subjects with predominant stress urinary incontinence. METHODS:A randomized, double-blind, multicenter trial examined intra-sphincteric injection of 150 × 106 AMDC-USR...
journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s11255-018-2005-8
更新日期:2018-12-01 00:00:00
abstract::To clarify the relative importance of clinicopathological factors potentially affecting the survival of individuals initially diagnosed as having metastatic renal cell carcinoma (RCC), univariate and multivariate analyses using Cox's proportional hazards model were performed for 111 RCC patients who were admitted to f...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550925
更新日期:1997-01-01 00:00:00
abstract::Genitourinary organs are at greater risk for multiple primary malignant neoplasms because of the high incidence of these tumours as primaries among all other organs. We present a case of prostate and bladder carcinoma metastasized to a single pelvic lymph node, called a "collision" metastasis, in a patient with four p...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552140
更新日期:1995-01-01 00:00:00
abstract::Eight patients with benign prostatic hypertrophy (BPH), considered as a high risk for an operation because of severe accompanying disease, were treated with a self-retaining intraurethral catheter set. Two patients were judged unfit for operation (one because of severe cardiac failure, the other because of severe resp...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
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abstract::Two cases of rarely observed granulomatous prostatitis are presented. Unspecific clinical symptoms and a close similarity in clinical course to prostatic adenoma or adenocarcinoma may be misleading and produce severe diagnostic difficulties even for an experienced urologist. Close cooperation with a pathomorphologist ...
journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
abstract::Register and Multicenter Study for Testicular Tumours Bonn was founded in September 1976. Until August 1981, from 46 institutions participating in Austria and the Federal Republic of Germany the data from a total of 1508 patients with testicular tumours have been collected and evaluated. This paper gives an overview o...
journal_title:International urology and nephrology
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doi:10.1007/BF02082779
更新日期:1984-01-01 00:00:00
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journal_title:International urology and nephrology
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更新日期:2011-09-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1099-5
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abstract:OBJECTIVE:It has been shown that coenzyme Q(10) (CoQ(10)) supplementation in men with idiopathic oligoasthenoteratozoospermia (OAT) results in improved semen parameters. In present study, we evaluated the effects of coenzyme CoQ(10) supplementation on semen parameters and pregnancy rates in infertile men with idiopathi...
journal_title:International urology and nephrology
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doi:10.1007/s11255-011-0081-0
更新日期:2012-06-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1633-8
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To investigate the effects of combined treatment of tadalafil (a phosphodiesterase-5 inhibitor) and tamsulosin (an α1-adrenoceptor antagonist) on bladder dysfunction in a rat model of bladder outlet obstruction (BOO). METHODS:Cystometry was performed in conscious female BOO rats 6 weeks after partially ligatio...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1835-8
更新日期:2018-05-01 00:00:00
abstract::Neurofibromatosis of the urinary tract is estimated to account for 20 per cent of the visceral manifestations of the generalized disease. Among its urological forms involvement of the bladder is the most common. Clinically, neurofibromatosis resembles a tumour, therefore, its early histologic diagnosis is of utmost im...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02089403
更新日期:1985-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02708-3
更新日期:2020-11-21 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9024-6
更新日期:2007-01-01 00:00:00
abstract::Segmental cystectomy or total cystectomy was performed in 26 patients with newly diagnosed stage T1, grade 3 transitional cell carcinoma of the bladder. Their histological specimens were assessed with regard to types of tumour cell spread, small vessel involvement and coexistent carcinoma in situ. Patients were follow...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550418
更新日期:1991-01-01 00:00:00
abstract::Non-gonococcal urethritis (NGU) is the most common disease of the genital tract in men. Recent studies have recommended avoiding the empiric antibiotic administrations that constitute the classical treatment approach in NGU and to aim toward treatment of causative pathogens. However, the classification of NGU agents r...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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更新日期:2019-06-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000025617.97048.ae
更新日期:2003-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1755-z
更新日期:2018-02-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082070
更新日期:1981-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02666-w
更新日期:2020-09-28 00:00:00
abstract:PURPOSE:Bone metabolism disorder is often associated with cardiovascular calcification in patients with chronic kidney disease (CKD). Sclerostin, a novel candidate protein, has been identified to be involved in the bone-vascular axis. The aims of the current investigation were to assess vessel sclerostin expression and...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1604-0
更新日期:2017-08-01 00:00:00
abstract::Indications for operation, immediate postoperative morbidity and complications were recorded in 43 patients circumcised with the Plastibell device. Questionnaires were used in recording late postoperative morbidity and complications during the mean observation period of 29 months, and were followed by a clinical and c...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550667
更新日期:1988-01-01 00:00:00
abstract::A study was carried out to verify the clinical usefulness of the elaborated method for the measurement of antistreptococcal antibody in revealing the streptococcal etiology of glomerulonephritis. In 158 patients with glomerulonephritis antistreptococcal antibody (ASA), circulating immune complexes (CIC) and haemolytic...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082387
更新日期:1982-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-04-01 00:00:00
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journal_title:International urology and nephrology
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更新日期:2017-04-01 00:00:00