Abstract:
BACKGROUND/AIMS:Detection of circulating tumor cells (CTCs) in cancer patients has diagnostic and prognostic importance. However, the clinical implications of CTC detection in patients with renal cell carcinoma (RCC) are still unclear. In this study, we investigated the clinical significance of CTCs using two detection systems, the CellSearch system (CSS) and isolation by size of epithelial tumor cells (ISET), among RCC patients. METHODS:We recruited 36 RCC patients and 22 healthy volunteers as controls. Blood was drawn before treatment. Samples were analyzed using the CSS and ISET. We prospectively followed the RCC patients to determine overall and progression-free survival. RESULTS:We did not detect CTCs in the control group using either the CSS or ISET. CTCs were detected in 7/36 patients (19.4%) using the CSS and in 13/36 patients (36.1%) using ISET, while circulating microemboli (CTMs) were detected in three patients (8.3%). The presence of ISET-detected CTCs correlated with clinical tumor node metastasis (TNM) stages, while the CSS-detected CTCs did not. After 36 months (median), CTCs detected by both methods failed to correlate with overall and progression-free survival among RCC patients. CONCLUSION:We discovered that ISET is more suitable than the CSS for detecting CTCs in RCC patients. The presence of CTCs/CTMs in RCC patients correlated with higher TNM stages, suggesting that the presence of CTCs could be a prognostic marker in RCC patients.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Bai M,Zou B,Wang Z,Li P,Wang H,Ou Y,Cui K,Bian J,Li S,Xu Xdoi
10.1007/s11255-018-1954-2subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1801-1809issue
10eissn
0301-1623issn
1573-2584pii
10.1007/s11255-018-1954-2journal_volume
50pub_type
杂志文章abstract:PURPOSE:This study investigated the clinical characteristics and symptomatology of ESRD patients in Jordan taking a multidimensional approach. METHODS:This was a cross-sectional study that included a cohort of 620 patients undergoing maintenance hemodialysis (HD). Data were retrieved via patient survey administration ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02458-2
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Some studies have found that prostate cancer (PCa) screening provides little or no change in PCa-related mortality during the 7-10 years following diagnoses. However, most men are diagnosed with PCa at low-stage disease and die of unrelated causes during this period. Men diagnosed at stage IV are at much high...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9799-3
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:Organ-sparing surgery (OSS) for the kidney and adrenals has emerged as the need for preservation of function is paramount in patients with poor functional reserve. As reports increasingly showed that oncological outcomes were equivalent to radical excision, elective OSS became a viable alternative in patients w...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-02070-5
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:The current study was conducted to determine the effects of coenzyme Q10 (CoQ10) supplementation on glycemic control and markers of lipid profiles risk in diabetic hemodialysis (HD) patients. METHODS:This randomized, double blind, placebo-controlled clinical trial was performed among 60 diabetic HD patients. S...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-018-1973-z
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To evaluate the association of shock-wave lithotripsy (SWL) for kidney stones and hypertension or diabetes. METHODS:Patients with urolithiasis treated by SWL were retrospectively identified. To assess whether shock-wave application to the kidney is associated with long-term adverse effects, patients after SWL ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1857-2
更新日期:2018-07-01 00:00:00
abstract::The studies were aimed at the evaluation of the usefulness of non-invasive diagnostic methods including inquiry, clinical examination, transabdominal ultrasonography, cytologic examination of the urinary sediment, determination of blood serum concentrations of certain neoplastic markers, and urinalysis for early detec...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550626
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Our aim was to compare the different characteristics and outcomes of the Amplatz sheaths and single-step metallic dilators which were used for mini-PCNL procedure in a single institution. METHODS:Retrospective medical records of 236 patients who underwent mini-PCNL were reviewed and divided into Amplatz (n = 1...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1516-z
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To investigate the effects of thermochemotherapy with mitomycin C (MMC) on normal rabbit bladder urothelium and to compare it with standard intravesical MMC and hyperthermia with normal saline. METHODS:Twenty-four male New Zealand rabbits, with a mean weight of 2.7 kg (in weight of 2.1–4.3 kg), were divided in...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1139-1
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the results and complications in 170 patients with symptomatic benign hyperplasia who underwent laser prostatectomy focusing on six month and long-term results. METHODS:A total of 170 patients underwent side firing Neodymium:Yag laser prostatectomy between January 1995 and February 2001 of whom ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025948028530
更新日期:2003-01-01 00:00:00
abstract::While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, an...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-014-0808-9
更新日期:2014-09-01 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is the most common nonmalignant condition of the prostate occurring in ageing men. Even though BPH is a major public health problem, causing high morbidity and substantial worsening in men's quality of life, little is known about its risk factors. Several studies revealed that it is ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-008-9333-z
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To evaluate in an experimental model, the mobility of a novel peritoneal dialysis catheter with a metallic tip (Mag-Cath) using an extra-corporeal magnet. MATERIALS AND METHODS:The Mag-Cath was installed in a porcine model under general anesthesia using laparoscopic access. A senior urologist, a urology reside...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02594-9
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To assess the trends of neoadjuvant chemotherapy (NAC) use since its introduction in our practice pathway in patients with cT2 + bladder cancer over a 20-year period. METHODS:This is a retrospective review of patients with cT2 + bladder cancer who underwent RC between 01/01/1998 and 01/01/2018 that aimed to ev...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02752-z
更新日期:2021-01-03 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In diabetics genetic predisposition, poor glycemic control and arterial hypertension contribute to nephropathy development in patients affected by diabetes mellitus. We set up the hypothesis that diabetic nephropathy and incisional hernia formation may have in common alterations of collagen com...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1229-8
更新日期:2016-05-01 00:00:00
abstract::Percutaneous renal biopsy is a fundamental diagnostic technique. Technical innovations had resulted in an increasing simplicity and safety of the procedure. In this study, 28 kidney biopsies were done using gauge 16 or 18 automated biopsy needle by inexperienced trainees, and patients were allowed full ambulation four...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02550217
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:We examined the incidence of myocardial ischemia (MI) in kidney transplant recipients (KTR) using myocardial perfusion imaging (MPI), and its association with long-term outcomes after transplantation. METHODS:A retrospective observational study was conducted of asymptomatic KTRs who underwent post-transplant M...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02542-7
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to assess the influence of anemia on the risk of developing contrast-induced nephropathy after percutaneous coronary angioplasty. METHODS:Serum creatinine values were measured before and within 48 h after the administration of contrast agents. Contrast-induced nephropathy (C...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0340-8
更新日期:2013-08-01 00:00:00
abstract::Two groups of 50 consecutive patients each, with distal ureteric calculi, were treated by ureteroscopy or in situ ESWL (Dornier HM-4 lithotriptor) in order to establish the effectiveness of ESWL at the distal portion of the ureter. In comparison to ureteroscopy, ESWL for distal ureteral calculi was performed on an out...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552156
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) secondary to acute tubular necrosis (ATN) is common in critically ill patients, and causes significant morbidity and mortality. The underlying etiology of ATN can be divided into pure ischemic, pure nephrotoxic, and mixed causes. This post-hoc analysis of a prospective cohort study ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9994-x
更新日期:2012-12-01 00:00:00
abstract::We report a case of penile incarceration in a 53-year-old impotent man. The base of the penis was encircled by a metal ring in order to achieve better erection. There was marked oedema of the entire penis distal to the constricting ring. The metal ring was removed successfully by cutting it with a steel saw. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564752
更新日期:1995-01-01 00:00:00
abstract::Five characteristics of neonate renal physiology, namely glomerular hypofiltration, low renal blood flow and alterations in water, sodium and potassium management, disappear during the first year of life but reoccur during senescence. However, the underlying mechanisms are different during the two periods. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000034681.60457.84
更新日期:2004-01-01 00:00:00
abstract::We report a case of a urothelial carcinoma with trophoblastic differentiation of the bladder that occured in a 23-year-old man. The patient presented with hematuria. Multiple papillary masses were resected transurethrally. Histopathologically, grade III urothelial cell carcinoma contained giant cells that were positiv...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-004-0859-4
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of smoking status, cumulative smoking exposure and smoking cessation on the outcomes of patient with non-muscle-invasive bladder cancer (NMIBC). METHODS:We collected smoking data from 484 patients with NMIBC who were treated with transurethral resection (TUR); smoking status was cat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1441-6
更新日期:2017-01-01 00:00:00
abstract::The present study demonstrated prolonged decreases of phagocytic activity by neutrophils in comparison to transitory neutropenias during haemodialysis with cuprophane membranes, remaining in connection with non-equalization immunological findings as C3 complement levels, circulating immune complexes and lysozyme activ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02559638
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:So far, studies have not clearly identified infectious agents as an etiological factor for interstitial cystitis (IC). Specific microbiological diagnosis for detecting the pathogen with higher sensitivity in IC may decrease the treatment costs and increase psychosocial health of the patients. METHODS:A prospec...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02248-5
更新日期:2019-11-01 00:00:00
abstract::Three cases of ureteral duplication with blind-ending branch are described. Clinical observations are supplemented with a survey of the literature pertaining to the statistics, embryology, method of diagnosis and treatment of this urological developmental anomaly. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082550
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:To find the most beneficial method, we assessed patient comfort and morbidity rates during prostate biopsy procedures performed using periprostatic nerve blockade, unilateral pudendal nerve blockade, intrarectal lidocaine gel, and a combination of periprostatic nerve blockade and intrarectal lidocaine gel....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9237-3
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:The impact of radical surgery for urothelial carcinoma is significant on patient's quality of life. Organ-sparing surgery (OSS) can provide comparable oncological outcomes and with improved quality of life. In this review, we summarize the indications, techniques and outcomes of OSS for these tumors. METHODS:P...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-019-02232-z
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:Water intake is important for preventing kidney stones. Small molecules water is a more active restructured water under magnetic field. Here, we studied the relation between small molecules water and crystal formation in the rat kidney. MATERIALS:The small molecules water was prepared by a water machine provid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1769-6
更新日期:2018-02-01 00:00:00
abstract::Search is under way to develop reliable tests for the prediction of stone risk. Several indices and ratios on the basis of urinary excretions have been suggested. In the present study the applicability of some risk indices and ratios in slum dwellers of Dharavi area of Bombay was examined. No significant difference wa...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550432
更新日期:1990-01-01 00:00:00