Clinical trial of the effects of coenzyme Q10 supplementation on glycemic control and markers of lipid profiles in diabetic hemodialysis patients.

Abstract:

PURPOSE:The current study was conducted to determine the effects of coenzyme Q10 (CoQ10) supplementation on glycemic control and markers of lipid profiles risk in diabetic hemodialysis (HD) patients. METHODS:This randomized, double blind, placebo-controlled clinical trial was performed among 60 diabetic HD patients. Subjects were randomly allocated into two groups to take either 120 mg/day of CoQ10 supplements or placebo (n = 30 each group) for 12 weeks. RESULTS:After 12 weeks of intervention, CoQ10 supplementation, compared with the placebo, resulted in a significant decrease in serum insulin concentrations (- 2.5 ± 4.0 vs. + 2.8 ± 5.3 µIU/mL, P < 0.001), homeostasis model of assessment-estimated insulin resistance (- 0.9 ± 2.1 vs. + 1.2 ± 3.0, P = 0.002), and significant increase in the quantitative insulin sensitivity check index (+ 0.009 ± 0.01 vs. - 0.02 ± 0.05, P = 0.003). In addition, a trend toward a greater decrease in serum triglycerides (- 5 ± 53 vs. + 17 ± 44, P = 0.078) and VLDL-cholesterol levels (- 0.9 ± 10 vs. + 3 ± 9, P = 0.078) was observed in the CoQ10 group compared to the placebo group. We did not observe any significant effect of CoQ10 supplementation on fasting glucose, HbA1c and other lipid profiles compared with the placebo. CONCLUSIONS:Overall, our study supported that CoQ10 supplementation to diabetic HD patients for 12 weeks had beneficial effects on markers of insulin metabolism, but did not affect fasting glucose, HbA1c, and lipid profiles. Clinical registration http://www.irct.ir : IRCT2016081811763N30.

journal_name

Int Urol Nephrol

authors

Fallah M,Askari G,Soleimani A,Feizi A,Asemi Z

doi

10.1007/s11255-018-1973-z

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

2073-2079

issue

11

eissn

0301-1623

issn

1573-2584

pii

10.1007/s11255-018-1973-z

journal_volume

50

pub_type

杂志文章,随机对照试验
  • Testicular seminoma: 20-year experience at the Northern Israel Oncology Center (1968-1988).

    abstract::Eighty-four patients with testicular seminoma were treated at the Northern Israel Oncology Center during the years 1968-1988. Using the staging classification of Hussey, 69 patients (82%) had Stage I, eight (10%) had Stage IIA, four (5%) had Stage IIB, one (1%) had Stage IIIA, and two (2%) had Stage IIIB disease. Sixt...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02768019

    authors: Stein M,Steiner M,Moshkowitz B,Sapir D,Kessel I,Kuten A

    更新日期:1994-01-01 00:00:00

  • Oxybutynin hydrochloride in the management of detrusor instability.

    abstract::The results of an investigation dealing with the therapy of instability of the detrusor using oxybutynin hydrochloride are presented. Out of an unselected group of patients 21 were enrolled in the trial. After therapy 19 patients showed significant improvement of subjective symptoms and objective urodynamic parameters...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02550401

    authors: Primus G,Pummer K

    更新日期:1990-01-01 00:00:00

  • Heme biosynthesis and porphyrin studies in chronic renal failure patients following kidney transplantation.

    abstract::El-Far and Sobh were the first to describe abnormalities in porphyrin metabolism in Egyptian patients with chronic renal failure (CRF). Our results were confirmed by others. The present investigation aims to study and discuss the nature of those abnormalities and changes in porphyrin metabolism in CRF patients followi...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02583996

    authors: el-Far M,Sobh M,Ghoniem M

    更新日期:1991-01-01 00:00:00

  • Outcomes of sirolimus regimens in 65-year-old and older kidney transplant recipients: a registry-based observational study.

    abstract:PURPOSE:In large observational studies of adult kidney transplant recipients (KTRs) where older adults (65 years old and older) were not well represented, the mammalian target of rapamycin inhibitors (mTOR inhibitors) has poorer outcomes than the standard tacrolimus-mycophenolate-steroids (TAC-MPA-S) regimen. We conduc...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-019-02251-w

    authors: Santos AH Jr,Chen C,Alquadan K,Wen X

    更新日期:2019-11-01 00:00:00

  • The relationship between lymphocyte subsets, nutritional status and tuberculin reactivity in continuous ambulatory peritoneal dialysis and hemodialysis patients.

    abstract:AIM:Skin test anergy is common in patients with uremia and during maintenance hemodialysis treatment. However, up to date only one study concerning skin test in peritoneal dialysis patients has focused on the issue. Our cross-sectional controlled study was conducted to analyze the correlation of purified protein deriva...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-020-02467-1

    authors: Usta M,Ersoy A,Ayar Y,Budak F

    更新日期:2020-06-01 00:00:00

  • The lack of correlation between mast cells and microvessel density with pathologic feature of renal cell carcinoma.

    abstract:OBJECTIVE:The growth of solid tumors requires angiogenesis. Evidence indicates that mast cells (MCs) play an important role in tumor angiogenesis but results are not definitive. The aim of this study is to investigate the possible effects of angiogenesis and the presence of MCs on the prognosis of renal cell carcinoma ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-009-9577-2

    authors: Mohseni MG,Mohammadi A,Heshmat AS,Kosari F,Meysamie AP

    更新日期:2010-03-01 00:00:00

  • Management of failed hypospadias: choosing the right method and achieving optimal results.

    abstract:OBJECTIVE:Because of the complexity of the abnormalities and limited options for reconstruction of failed hypospadias, creating a neourethra presents a challenge to surgeons. We reviewed our experiences with staged urethroplasty strategies to repair the penis of failed hypospadias. MATERIALS AND METHODS:We retrospecti...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-018-1962-2

    authors: Wu M,Chen F,Xie H,Lv Y,Huang Y,Liu Y,Ye W

    更新日期:2018-10-01 00:00:00

  • Urolithiasis in northeast Bombay: seasonal prevalence and chemical composition of stones.

    abstract::The seasonal prevalence of urinary calculus disease from the records of L.T. Municipal General Hospital, Sion, Bombay, which primarily caters services to poor people of Northeast Bombay, especially Dharavi slum area, is reported. The qualitative and quantitative compositions of stones collected from the patients of Dh...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02549827

    authors: Hussain F,Billimoria FR,Singh PP

    更新日期:1990-01-01 00:00:00

  • Hormonal and hemodynamic changes during percutaneous nephrolithotomy.

    abstract::The aim of this study was to investigate the hormonal and hemodynamic changes during percutaneous nephrolithotomy (PCNL) procedure. Twenty-one patients between 15-65 years of age were included in the study. Invasive blood pressure and heart rate were monitored during PCNL. Serum sodium, potassium, BUN and creatinine l...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1023/a:1017527126481

    authors: Atici S,Zeren S,Ariboğan A

    更新日期:2001-01-01 00:00:00

  • Laparoscopic management for urachal cyst in a 9-year-old boy.

    abstract::We report a boy with urachal cyst managed laparoscopically. A 9-year-old boy was referred from another hospital with a history of low abdominal pain. We laparoscopically excised the urachal cyst, removing all structures within the umbilicovesical fascia, including the urachus and each medial umbilical ligament, as wel...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-006-9132-3

    authors: Kojima Y,Hayashi Y,Yasui T,Itoh Y,Maruyama T,Kohri K

    更新日期:2007-01-01 00:00:00

  • Importance of contraction history on muscle force of porcine urinary bladder smooth muscle.

    abstract:INTRODUCTION:The purpose of this study was to provide a comprehensive dataset of porcine urinary bladder smooth muscle properties. Particularly, the history dependence of force production, namely force depression (FD) following shortening and force enhancement (FE) following stretch, was analysed. During active micturi...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-016-1482-x

    authors: Menzel R,Böl M,Siebert T

    更新日期:2017-02-01 00:00:00

  • GFR estimation in the morbidly obese pre- and postbariatric surgery: one size does not fit all.

    abstract:BACKGROUND:Glomerular hyperfiltration commonly associated with obesity is expected to improve postbariatric surgery. However, formula-based glomerular filtration rate (GFR) estimation in these patients is limited by body size confounders necessitating use of modified equations, the reliability of which remains uncertai...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-012-0131-2

    authors: Abouchacra S,Chaaban A,Gebran N,Hussein Q,Ahmed M,Bernieh B,Torab F,Kayyal Y,Al Omary H,Nagelkerke N

    更新日期:2013-02-01 00:00:00

  • The role of ureteroscopy as a diagnostic and therapeutic tool in various indications.

    abstract::Ureteroscopy is now in routine use for the diagnosis and treatment of various pathologies in the upper urinary tract. We report here on our experience in diagnostic and therapeutic applications of the 11.5 F rigid ureteroscope in 85 patients and 88 ureters. An overall success rate of 68.18% (60/88) was achieved when t...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02767719

    authors: Ilker Y,Dillioğlugil O,Tarcan T,Türkeri L,Akdaş A

    更新日期:1994-01-01 00:00:00

  • A comparative study of cystolithotripsy and extracorporeal shock wave therapy for bladder stones.

    abstract::This study compares the safety and efficacy of mechanical cystolithotripsy (MCLT) and extracorporeal shock wave lithotripsy (ESWL) in the treatment of vesical stones. In the last four years we have treated 144 bladder lithiasis patients with MCLT (86; group A) and ESWL (58; group B). All patients in group A were treat...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02768241

    authors: Bhatia V,Biyani CS

    更新日期:1994-01-01 00:00:00

  • Efficacy of tegafur-uracil (UFT) administration in castration-resistant prostate cancer patients with a history of both alternative antiandrogen therapy and estramustine phosphate sodium hydrate therapy.

    abstract:PURPOSE:The purpose of this study was to evaluate the efficacy of tegafur-uracil (UFT) administration as a fourth-line therapy in patients with castration-resistant prostate cancer (CRPC) who had already received combined androgen blockade (CAB) therapy (first-line), alternative antiandrogen therapy (second-line), and ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-013-0634-5

    authors: Hayakawa N,Matsumoto K,Sato A,Sakamoto H,Ezaki T,Maeda T,Ninomiya A,Nakamura S

    更新日期:2014-06-01 00:00:00

  • Urological complications of congenital nephrogenic diabetes insipidus--long-term follow-up of one patient.

    abstract::A male with a severe form of congenital nephrogenic diabetes insipidus (diuresis 10 l per day) had megaureters, megavesica, large residuum and a history of three traumatic ruptures of the megavesica and a recurrent urinary tract infection (RUTI). Hemodialysis was introduced at 41 years of age. At age of 42, he underwe...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-006-0093-3

    authors: Hora M,Reischig T,Hes O,Ferda J,Klecka J

    更新日期:2006-01-01 00:00:00

  • A novel technique for repair of mid-penile hypospadias using a preputial skin flap: results of 110 patients.

    abstract:BACKGROUND:Several techniques have been used to repair mid-penile hypospadias; however, high failure rates and major complications have been reported. In this study, we describe a novel technique using a well-vascularized flap of the inner and outer preputial skin. METHODS:A total of 110 male children with hypospadias...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-016-1416-7

    authors: Elmoghazy H,Hussein MM,Mohamed E,Badawy A,Alsagheer G,Abd Elhamed AM

    更新日期:2016-12-01 00:00:00

  • Importance of hypogonadism and testosterone replacement therapy in current urologic practice: a review.

    abstract::Evaluation of potential candidates for testosterone replacement therapy (TRT) includes a complete medical history, physical examination, and hormonal screening. The choice of testosterone assay is important in clinical decision making. TRT should, in theory, approximate natural endogenous production of the hormone. Th...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s11255-010-9879-4

    authors: Hellstrom WJ,Paduch D,Donatucci CF

    更新日期:2012-02-01 00:00:00

  • Nonobstructive urinary tract dilatation in nephrogenic diabetes insipidus.

    abstract::The follow-up study has been performed in 4 male patients with nephrogenic diabetes insipidus lasting for 4 to 15 years. Hydronephrosis or hydroureter appeared to be caused by polyuria with or without urinary tract obstruction. The efficacy of drainage operation is emphasized when polyuria surpasses the transporting a...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02549772

    authors: Nakada T,Miyauchi T,Sumiya H,Shimazaki J

    更新日期:1990-01-01 00:00:00

  • Impaired tubular reabsorption of magnesium after renal transplantation.

    abstract::Tubular reabsorption of magnesium ( TRMg ) was calculated from the values of plasma ultrafiltrable Mg and urinary Mg in 36 patients with transplanted kidneys. The study revealed a defect in TRMg in all investigated patients. The lowest TRMg values were found in patients with poor function of the transplanted kidneys. ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02082706

    authors: Revúsová V,Gratzlová J,Zvara V,Borosová E,Pribylincová V

    更新日期:1984-01-01 00:00:00

  • Problems unique to microsurgical epididymovasostomy. Comparison of four techniques in a laboratory rat model with review of the literature.

    abstract::The new microsurgical techniques, tubule and loop intussusception, are compared to end-to-end and side-to-end in an experimental rat model. Sixty adult male Sprague-Dawley rats were operated on bilaterally under the same conditions. The four microsurgical techniques differ in approach to the inner mucosal layer, while...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:

    authors: Stefanović KB,Buncke HJ Jr,Clark SA

    更新日期:1993-01-01 00:00:00

  • Benign prostatic hyperplasia: dietary and metabolic risk factors.

    abstract::Benign prostatic hyperplasia (BPH) is the most common nonmalignant condition of the prostate occurring in ageing men. Even though BPH is a major public health problem, causing high morbidity and substantial worsening in men's quality of life, little is known about its risk factors. Several studies revealed that it is ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s11255-008-9333-z

    authors: Nandeesha H

    更新日期:2008-01-01 00:00:00

  • Prevention of recurrent uric acid and calcium oxalate stones by administration of the xanthine oxidase inhibitors Milurit 100 and Milurit 300.

    abstract::Disturbances in purine metabolism with hyperuricaemia and/or hyperuricosuria are a risk factor in uric acid and Ca oxalate stone formation. By way of a competitive xanthine oxidase inhibition, the formation of uric acid is reduced by allopurinol. In investigations on two groups of patients, Milurit could be demonstrat...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02085441

    authors: Schneider HJ,Brundig P,Balogh A,Traeger A,Stein G,Fünfstück R

    更新日期:1983-01-01 00:00:00

  • Paratesticular pleomorphic rhabdomyosarcoma in an adult.

    abstract::Rhabdomyosarcoma (RMS) is the commonest variety of soft tissue sarcoma in children and young adults. It represents 6.5% of all malignant tumours in paediatrics with an annual incidence of 4 to 7 cases/million children. The primary paratesticular site is considered to have a good prognosis in comparison with other rhab...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-004-0853-x

    authors: Demir A,Onol FF,Türkeri L

    更新日期:2004-01-01 00:00:00

  • Spontaneous right uretero-cutaneous fistula complicated by spontaneous rupture of the urinary bladder.

    abstract::A case of spontaneous right uretero-cutaneous fistula complicated by spontaneous rupture of the urinary bladder is presented. This morbid state is extremely rare and has not been previously reported to the best of our knowledge. ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02564762

    authors: Nishiyama T,Terunuma M,Sugahara S,Yahata K

    更新日期:1995-01-01 00:00:00

  • The effect of testosterone treatment on urodynamic findings and histopathomorphology of pelvic floor muscles in female rats with experimentally induced stress urinary incontinence.

    abstract:OBJECTIVE:In recent studies, it has been observed that androgen receptors are densely located in pelvic floor muscles. We aimed to investigate the effect of testosterone on urodynamic findings and histopathomorphology of pelvic floor muscles in rats with experimentally induced stress urinary incontinence. MATERIALS AN...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-011-9938-5

    authors: Mammadov R,Simsir A,Tuglu I,Evren V,Gurer E,Özyurt C

    更新日期:2011-12-01 00:00:00

  • An unusual profile of endocrine study in a patient with pre-Cushing's syndrome.

    abstract::A unilateral adrenal tumour was incidentally detected in a 39-year-old woman with no characteristic features of Cushing's syndrome. Basal levels of glucocorticoids were within normal limits. However, abnormal pattern of plasma cortisol and ACTH was observed. The dexamethasone suppression test and the metyrapone test s...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:

    authors: Kodama C,Nakada T,Sasagawa I,Ishigooka M,Yamaguchi T,Suzuki H

    更新日期:1993-01-01 00:00:00

  • Prognostic factors and the role of nephrectomy in metastatic renal cell carcinoma.

    abstract::The objective of this study was to evaluate the prognostic factors and role of nephrectomy in metastatic renal cell carcinoma. We reviewed 62 cases of metastatic renal cell carcinoma (RCC) at presentation to document the factors influencing the survival and to evaluate the role of nephrectomy. Sex and age of the patie...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02564853

    authors: Uygur MC,Usubütün A,Ozen H,Ayhan A,Kendi S

    更新日期:1998-01-01 00:00:00

  • Prophylaxis with AT III for thromboembolism in nephrotic syndrome: why should it be done?

    abstract::Children with nephrotic syndrome (NS) are at risk for sinovenous and arterial thrombosis, uncommon but serious complications of the nephrotic syndrome. Multiple factors are involved in the hypercoagulable state of patients with NS, for instance, enhanced platelet reactivity and deficiency of antithrombin III due to ur...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-008-9434-8

    authors: Zaffanello M,Brugnara M,Fanos V,Franchini M

    更新日期:2009-01-01 00:00:00

  • De novo nephrotic syndrome following pegylated interferon alfa 2b/ribavirin therapy for chronic hepatitis C infection.

    abstract::This paper describes the case of a patient with HCV, without previous evidence of nephropathy, who following two well-tolerated cycles of treatment with interferon alone developed nephrotic syndrome after a third attempt with ribavirin associated with peginterferon alfa 2b. The patient exhibited a total remission when...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-007-9241-7

    authors: Tovar JL,Buti M,Segarra A,Majó J,Esteban R

    更新日期:2008-01-01 00:00:00