Abstract:
OBJECTIVE:To investigate the effect of smoking status, cumulative smoking exposure and smoking cessation on the outcomes of patient with non-muscle-invasive bladder cancer (NMIBC). METHODS:We collected smoking data from 484 patients with NMIBC who were treated with transurethral resection (TUR); smoking status was categorized as (never smokers vs current smokers vs former smokers). Cumulative smoking exposure was categorized as high smoking exposure (cigarette index ≥400) versus low smoking exposure (cigarette index <400). Association with outcomes was examined by multivariable analyses after adjusting for the effects of standard clinicopathologic factors, and the Kaplan-Meier method was used to estimate the effect of smoking status and cumulative smoking exposure on RFS. RESULTS:A total of 168 (34.7 %) patients were never smoker, 121 (25 %) patients were current smokers, and 195 (40.3 %) patients were former smokers. The median follow-up was 25 months. By multivariate analysis, pathological grade (p = 0.013), history of recurrence (p < 0.001), number of tumors (p < 0.001) and size of tumors (p = 0.013) were significantly associated with tumor recurrence; nevertheless, smoking status did not influence tumor recurrence (p = 0.063). Among current and former smokers, cumulative smoking exposure was significantly associated with tumor recurrence (p < 0.001), compared to current smokers, patients with smoking cessation ≥10 years had a lower risk of tumor recurrence [hazard ratio (HR) 0.456, p = 0.007]. CONCLUSIONS:Smoking affects the prognosis of patient with NMIBC, which is still controversial; however, among ever smokers, a high cumulative exposure smoking can significantly increase the risk of tumor recurrence. Quitting smoking might be associated with a lower recurrence rate for patients with NMIBC.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Li HM,Azhati B,Rexiati M,Wang WG,Li XD,Liu Q,Wang YJdoi
10.1007/s11255-016-1441-6subject
Has Abstractpub_date
2017-01-01 00:00:00pages
69-76issue
1eissn
0301-1623issn
1573-2584pii
10.1007/s11255-016-1441-6journal_volume
49pub_type
杂志文章abstract:PURPOSE:To perform a systematic review and meta-analysis to evaluate the cardiovascular prevention effect of aspirin among patients with chronic kidney disease (CKD). METHODS:A comprehensive literature search was conducted in Embase, PubMed, and Cochrane library (up to March 2019) without language limitations. Randomi...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析
doi:10.1007/s11255-019-02350-8
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:To investigate the value of proliferating cell nuclear antigen (PCNA), Ki-67 antigen labelling indices and nucleolar organizer region (NOR) score in relation to histological grade, stage, recurrence and progression of the bladder tumor. MATERIALS AND METHODS:Tissue specimens from 77 bladder cancer patients ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014452902976
更新日期:2002-01-01 00:00:00
abstract::The vaginal influx during miction is a frequent phenomenon. In our clinical study it showed a rate of 54 per cent. The significance of pathomorphological substrates is diminishing with the advancing vesical descensus. The posture during miction has but little influence on the vaginal deviation of the urinary stream. T...
journal_title:International urology and nephrology
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doi:10.1007/BF02086819
更新日期:1979-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-016-1436-3
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abstract:PURPOSE:Varicocele is among the leading causes of male infertility. Despite decades of research, its pathogenesis is still unclear. S100A12 is a member of the S100 family of calcium-binding proteins with principal extracellular activities. It is secreted by activated neutrophils and interacts with the multiligand recep...
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-011-0053-4
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abstract::Osmotic diuresis results from urine loss of large amounts of solutes distributed either in total body water or in the extracellular compartment. Replacement solutions should reflect the volume and monovalent cation (sodium and potassium) content of the fluid lost. Whereas the volume of the solutions used to replace lo...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-018-1822-0
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abstract:OBJECTIVE:Some studies have found that prostate cancer (PCa) screening provides little or no change in PCa-related mortality during the 7-10 years following diagnoses. However, most men are diagnosed with PCa at low-stage disease and die of unrelated causes during this period. Men diagnosed at stage IV are at much high...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9799-3
更新日期:2011-06-01 00:00:00
abstract::An unusual case of a 15-year-old male who presented with a characteristic clinical syndrome of testicular torsion one week prior to our observation, is reported. During our intervention the testicle was not removed but, on the contrary, restoration of a satisfactory testicular albugineal appearance was achieved. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007189111613
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abstract::A total of 234 patients with chronic glomerulonephritis, detected on the basis of clinical, immunological and pathomorphological criteria, have been examined. A group of 23 chronic glomerulonephritis patients with massive deposits of immunoglobulin A found by immunofluorescent examination, has been separated on the ba...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085414
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-012-0206-0
更新日期:2013-06-01 00:00:00
abstract::This paper presents a newly developed simple procedure using overlapping vascularized dorsal dartos subcutaneous flaps to cover the neourethra after hypospadias correction. A 3-year old boy with distal hypospadias underwent the tubularized incised plate urethroplasty using this method. Postoperative complications, whi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025610800998
更新日期:2002-01-01 00:00:00
abstract::Search is under way to develop reliable tests for the prediction of stone risk. Several indices and ratios on the basis of urinary excretions have been suggested. In the present study the applicability of some risk indices and ratios in slum dwellers of Dharavi area of Bombay was examined. No significant difference wa...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550432
更新日期:1990-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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journal_title:International urology and nephrology
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doi:10.1007/s11255-014-0845-4
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doi:10.1007/s11255-009-9549-6
更新日期:2009-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02457-3
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550565
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9631-0
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02559622
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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