The effect of thermochemotherapy with mitomycin C on normal bladder urothelium, an experimental study.


PURPOSE:To investigate the effects of thermochemotherapy with mitomycin C (MMC) on normal rabbit bladder urothelium and to compare it with standard intravesical MMC and hyperthermia with normal saline. METHODS:Twenty-four male New Zealand rabbits, with a mean weight of 2.7 kg (in weight of 2.1–4.3 kg), were divided into three groups, each containing eight rabbits. Thermotherapy with only normal saline was performed in the first group, standard intravesical MMC was performed in the second group, and thermotherapy with MMC was performed in the last group. A week after the primary procedure, total cystectomy was performed and tissue samples were evaluated. RESULTS:The presence of epithelial vacuolar degeneration (p = 0.001), epithelial hyperplasia (p = 0.000), subepithelial fibrosis (p = 0.001) and hemorrhagic areas in the connective tissue (p = 0.002) was observed statistically significantly higher in the standard MMC group than in thermotherapy with normal saline group. There was almost a significant difference among standard MMC and normal saline group in terms of vascular congestion in the connective tissue (p = 0.08). Presence of epithelial vacuolar degeneration (p = 0.002), epithelial hyperplasia (p = 0.002), subepithelial fibrosis (p = 0.030), hemorrhagic areas (p = 0.011) and vascular congestion (p = 0.36) in the connective tissue was observed statistically significantly higher in the thermochemotherapy with MMC group than in standard intravesical MMC group. Polymorphonuclear cell infiltration was not considerable in any of the groups, and there was no significant difference between each groups (p = 0.140). CONCLUSION:Administration of intravesical MMC causes a toxic effect on the normal urothelium of the bladder rather than an inflammatory reaction. Heating MMC significantly increased this effect.


Int Urol Nephrol


Uçar M,Altok M,Umul M,Bayram D,Armağan İ,Güneş M,Çapkin T,Soyupek S




Has Abstract


2016-01-01 00:00:00














  • Serum cadmium levels are independently associated with endothelial function in hemodialysis patients.

    abstract:OBJECTIVE:Hemodialysis (HD) patients are at risk of deficiency of essential trace elements and excess of toxic trace elements. The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, and lead) and endo...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Kaya Y,Ari E,Demir H,Gecit I,Beytur A,Kaspar C

    更新日期:2012-10-01 00:00:00

  • Evaluation of nutritional status with different methods in geriatric hemodialysis patients: impact of gender.

    abstract:PURPOSE:This study investigated the frequency of malnutrition in geriatric hemodialysis patients according to biochemical, anthropometric, bioelectrical impedance analysis (BIA), modified quantitative subjective global assessment (MQSGA), and geriatric nutritional risk index (GNRI) methods, and the effect of gender on ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Kaya T,Sipahi S,Karacaer C,Nalbant A,Varım C,Cinemre H,Tamer A

    更新日期:2014-12-01 00:00:00

  • Infectious complications and mortality associated with the use of IV iron therapy: a systematic review and meta-analysis.

    abstract:BACKGROUND:Parental iron is used to optimize hemoglobin and enhance erythropoiesis in end-stage renal disease along with erythropoietin-stimulating agents. Safety of iron has been debated extensively and there is no definite evidence whether parenteral iron increases the risk of infections and mortality. We performed t...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,meta分析


    authors: Salim SA,Cheungpasitporn W,Elmaraezy A,Jawafi O,Rahman M,Aeddula NR,Tirupathi R,Fülöp T

    更新日期:2019-10-01 00:00:00

  • Glomerular diseases in the elderly in India.

    abstract::Three hundred fifteen (315) elderly (> or = 60 years) patients with clinical renal diseases were evaluated for the evidence of glomerular diseases between November 1998 to June 2002. Glomerular diseases (GN) were observed in 20.6% (65/315) of the elderly patients. The age of the patients (male 56; female 9) ranged bet...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Prakash J,Singh AK,Saxena RK,Usha

    更新日期:2003-01-01 00:00:00

  • Uretero-ureterostomy, transuretero-ureterostomy.

    abstract::The authors describe various possibilities of using uretero-ureterostomy in cases of healthy bladder an in cases of supracystic urinary diversion. The history and the technique of the operation are described. Attention is called to the direction of anastomosis in cases of ureters differing in the width of their lumen....

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Borkowski A,Bec A

    更新日期:1981-01-01 00:00:00

  • Modified one-layer microsurgical vasovasostomy in vasectomized patients.

    abstract::Bilateral vasovasostomies were performed in 7 previously vasectomized patients. The method employed was a modification of a one-layer anastomotic technique. There was no correlation between the presence of absence of sperm in the vas fluid, presence or absence of sperm granuloma, and site of vasectomy. No correlation ...

    journal_title:International urology and nephrology

    pub_type: 临床试验,杂志文章


    authors: Fuse H,Kimura H,Katayama T

    更新日期:1995-01-01 00:00:00

  • Vitamin D, the renin-angiotensin system, and insulin resistance.

    abstract::Insulin resistance is characterized by the systemic impairment of insulin action and is usually the result of aging, obesity, chronic inflammation, or another factor that may contribute to the inhibition of the insulin signaling pathway. Insulin resistance is accompanied by defects in lipid metabolism and blood coagul...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审


    authors: Rammos G,Tseke P,Ziakka S

    更新日期:2008-01-01 00:00:00

  • Hepatitis C virus related lymphoproliferative disorder in a renal transplant recipient.

    abstract::Posttransplant lymphoproliferative disorders (PTLD) are commonly caused by Ebstein-Barr Virus infection. The role of hepatitis C virus (HCV) in the genesis of lymphomas has been recognized recently. We report a HCV infected renal transplant recipient who developed PTLD 11 months after transplantation. Reduction of imm...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Aravindan AN,Moger V,Sakhuja V,Kohli HS,Varma N,Jha V

    更新日期:2006-01-01 00:00:00

  • Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease.

    abstract:PURPOSE:Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular events. This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients. MATERIALS AND METHODS:Seventy-one non-dialysis ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Zhang Q,Zhang M,Wang H,Sun C,Feng Y,Zhu W,Cao D,Shao Q,Li N,Xia Y,Tang T,Wan C,Liu J,Jin B,Zhao M,Jiang C

    更新日期:2018-05-01 00:00:00

  • A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies.

    abstract:PURPOSE:In mouse models of prostate cancer, increased epinephrine levels accelerated tumor growth via the beta2-adrenoreceptor/PKA signaling pathway. It is unknown, however, whether men experience increased epinephrine levels sufficient to activate the beta2-adrenoreceptor/PKA pathway in the prostate gland. We measured...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Hassan S,Karpova Y,Flores A,D'Agostino R Jr,Danhauer SC,Hemal A,Kulik G

    更新日期:2014-03-01 00:00:00

  • Pyeloform-aided percutaneous litholapaxy. I. Case study.

    abstract::To remove multiple calyceal stones percutaneously is not a simple task. During the act of dilating the pierced channel the stones are apt to drift away towards other parts of the renal cavitary system. For avoidance we recommend the use of Pyeloform, a bicomponent synthetic compound in which chemical reaction between ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Nagy Z,Bulyovszky I,Székely J

    更新日期:1993-01-01 00:00:00

  • IgG4-related tubulointerstitial nephritis presenting with psychiatric manifestations and skin lesions.

    abstract::We describe a 21-year male with mood disorder on lithium therapy and psoriasis-like skin lesions presenting with rapidly progressive renal failure. The kidney biopsy showed acute tubulointerstitial nephritis with immunoglobulin G4-positive plasma cell infiltration. He was started on oral steroids with a provisional di...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Ramachandran R,Rajakumar V,Rawat A,Nada R,Kumar V,Rathi M,Kohli HS,Sakhuja V,Jha V

    更新日期:2014-01-01 00:00:00

  • The Charlson Comorbidity Index: can it predict the outcome in acute kidney injury?

    abstract:PURPOSE:Comorbidity has a significant impact on the health status and treatment outcome of a patient. The Charlson comorbidity index (CCI) is a frequently used scoring system, which evaluates the prognosis based on the patient's comorbid conditions. The aim of this study was to evaluate the usefulness of CCI in predict...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Yalin SF,Bakir A,Trabulus S,Seyahi N,Altiparmak MR

    更新日期:2020-09-01 00:00:00

  • Microbiological evaluation of infected pelvic lymphocele after robotic prostatectomy: potential predictors for culture positivity and selection of the best empirical antimicrobial therapy.

    abstract:OBJECTIVES:To examine symptomatology and microbiology of infected lymphocele (LC) post-robotic-assisted radical prostatectomy and pelvic lymph node dissection (PLND) and to assess for potential predictors for LC fluid culture positivity. Secondly, to provide general recommendations about use of select antimicrobial the...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Hamada A,Hwang C,Fleisher J,Tuerk I

    更新日期:2017-07-01 00:00:00

  • Ultrasonographic urinary tract abnormalities in Schistosoma haematobium infection.

    abstract:OBJECTIVE:Evaluation of ultrasonographic abnormalities with active Schistosoma haematobium infection in Yemeni patients. METHODS:As part of a cooperation between a private hospital and Schistosomiasis Control Project in Yemen, laboratory and ultrasonographic examinations were performed in 158 patients (8 females, 150 ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Salah MA,Böszörményi-Nagy G,Al Absi M,Nagi MA,Alsaaidi AA

    更新日期:1999-01-01 00:00:00

  • Urinary tract endometriosis: report of 2 cases and a review of the literature.

    abstract::Endometriosis of the urinary tract is a relatively rare condition. Since clinical signs are not specific the diagnosis is difficult and the therapy is not well defined. Two cases and a review of the literature are presented. ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审


    authors: Sepich CA,Cecchi M,Pampaloni S,Notaro M,Ippolito C,Pagni GL,Fiorentini L

    更新日期:1997-01-01 00:00:00

  • Hormonal and hemodynamic changes during percutaneous nephrolithotomy.

    abstract::The aim of this study was to investigate the hormonal and hemodynamic changes during percutaneous nephrolithotomy (PCNL) procedure. Twenty-one patients between 15-65 years of age were included in the study. Invasive blood pressure and heart rate were monitored during PCNL. Serum sodium, potassium, BUN and creatinine l...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Atici S,Zeren S,Ariboğan A

    更新日期:2001-01-01 00:00:00

  • Long-term effects of steroid and cytostatic treatment on the clinical course of idiopathic membranous glomerulonephritis (retrospective study).

    abstract::The clinical course of 30 patients with idiopathic membranous glomerulonephritis has been followed up for 8.1 +/- 3.4 (4-17) years. First, in each case a long-term prednisone treatment was administered. During this therapy 12 (40%) patients improved and 9 had remission. In the 18 (60%) steroid resistant cases the trea...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Mohácsi G,Magori A,Sonkodi S

    更新日期:1988-01-01 00:00:00

  • Correlation between levels of TNF-alpha and IL-6 and hematological involvement in SLE Egyptian patients with lupus nephritis.

    abstract:BACKGROUND:Systemic lupus Erythematosus (SLE) is a rheumatic autoimmune disease characterized by multisystem organ involvement and by high titers of auto antibodies against several nuclear and cytoplasmic antigens. Numerous abnormalities of the cytokine network have been described in patients suffering from SLE. Howeve...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Sabry A,Elbasyouni SR,Sheashaa HA,Alhusseini AA,Mahmoud K,George SK,Kaleek EA,abo-Zena H,Kalil AM,Mohsen T,Rahim MA,El-samanody AZ

    更新日期:2006-01-01 00:00:00

  • Comparison of four different anesthesia methods for relief of all pain during transrectal ultrasound-guided prostate biopsy.

    abstract:INTRODUCTION:To find the most beneficial method, we assessed patient comfort and morbidity rates during prostate biopsy procedures performed using periprostatic nerve blockade, unilateral pudendal nerve blockade, intrarectal lidocaine gel, and a combination of periprostatic nerve blockade and intrarectal lidocaine gel....

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Inal G,Adsan O,Ugurlu O,Kaygisiz O,Kosan M,Cetinkaya M

    更新日期:2008-01-01 00:00:00

  • Albumin-stimulated TGFbeta-1 in renal tubular cells is associated with activation of MAP kinase.

    abstract:BACKGROUND:Proteinuric renal diseases are often associated with progressive tubulointerstitial fibrosis that usually defines the degree and rate of progression of renal failure. Glomerular filtration of excess albumin, the dominant protein in proteinuria, into proximal tubule could provide the stimulus to induce certai...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Zhao J,Tramontano A,Makker SP

    更新日期:2007-01-01 00:00:00

  • 31-year survival following total cystectomy and bilateral ureterosigmoidal anastomosis in a case of vesical carcinoma.

    abstract::A patient with bladder carcinoma, subjected to cystectomy and bilateral ureterosigmoidostomy, survived for the length of 31 years. The Coffey method of anastomosis was applied in a form modified by the authors. The patient succumbed to acute circulatory insufficiency at the age of 85. Metastases were not discovered ei...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Bandurski A,Czyz A,Orzolkiewicz F,Sobotkiewicz S

    更新日期:1984-01-01 00:00:00

  • Stepwise shock wave lithotripsy: results of initial study for the treatment of urinary stones in childhood.

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    journal_title:International urology and nephrology

    pub_type: 临床试验,杂志文章


    authors: Demirci D,Altiok E,Gülmez I,Ekmekçioğlu O,Poyrazoğlu HM

    更新日期:2006-01-01 00:00:00

  • Recurrent atrioventricular nodal re-entrant tachycardia treated with percutaneous ablation in a 75-year old patient undergoing intermittent hemodialysis.

    abstract::A 75-year old man with long-term arterial hypertension was diagnosed in 1998 with stage 3 chronic kidney disease due to hypertensive nephropathy. Since May 2004 the patient has been treated with intermittent hemodialysis. Since 1998 he has been hospitalized several times because of palpitations in the course of paroxy...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Ratajewska AM,Banachowicz WW,Grzegorzewska AE

    更新日期:2009-01-01 00:00:00

  • Long-term efficacy of tonsillectomy as a treatment in patients with IgA nephropathy: a meta-analysis.

    abstract:PURPOSE:IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and will lead some unfavorable outcomes such as end-stage renal disease. The efficacy of tonsillectomy remains controversial in both Asian and Caucasian ethnicity. Our meta-analysis was aiming at exploring its long-term efficacy and providin...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,meta分析,评审


    authors: Duan J,Liu D,Duan G,Liu Z

    更新日期:2017-01-01 00:00:00

  • Establishing a renal management clinic in China: initiative, challenges, and opportunities.

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    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Zhang AH,Zhong H,Tang W,Chen SY,He L,Wang S,Su CY,Lu XH,Wang T

    更新日期:2008-01-01 00:00:00

  • How to manage total avulsion of the ureter from both ends: our experience and literature review.

    abstract:OBJECTIVES:To evaluate the treatment alternatives of total avulsion of the ureter from both ends including ureteropelvic junction (UPJ) and ureterovesical junction (UVJ). METHODS:Total ureteral avulsion on both ends of the ureter was examined in 4 cases performing ureteroscopy. In two male patients of the four cases, ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审


    authors: Unsal A,Oguz U,Tuncel A,Bozkurt OF,Aslan Y,Eraslan A,Senocak Ç,Atan A

    更新日期:2013-12-01 00:00:00

  • Validity of urine neutrophile gelatinase-associated lipocalin in children with primary vesicoureteral reflux.

    abstract:BACKGROUND:Vesicoureteral reflux (VUR) is the most common congenital urinary tract abnormality in children. The objective of this study was to evaluate the diagnostic value of urine neutrophil gelatinase-associated lipocalin (NGAL) in children with primary vesicoureteral reflux (VUR). MATERIALS AND METHODS:A total of ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Nickavar A,Valavi E,Safaeian B,Moosavian M

    更新日期:2020-04-01 00:00:00

  • Robotic-assisted laparoscopic approach in the treatment for Zinner's Syndrome associated with ipsilateral megaureter and incomplete double-crossed ectopic ureter.

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    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Altobelli E,Bove AM,Falavolti C,Sergi F,Nguyen HT,Buscarini M

    更新日期:2013-06-01 00:00:00

  • Expression of the cyclin-dependent kinase inhibitor p27 in transitional cell bladder cancers: is it a good predictor for tumor behavior?

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    journal_title:International urology and nephrology

    pub_type: 杂志文章


    authors: Doganay L,Altaner S,Bilgi S,Kaya E,Ekuklu G,Kutlu K

    更新日期:2003-01-01 00:00:00