当前位置： SCI文献检索 > INTERNATIONAL UROLOGY AND NEPHROLOGY期刊下所有文献 > Effect of sirolimus on the regression of peritoneal sclerosis in an experimental rat model.

Effect of sirolimus on the regression of peritoneal sclerosis in an experimental rat model.

Abstract：

PURPOSE:Immunosuppressive and anti-inflammatory agents have recently become increasingly popular in the treatment of encapsulating peritoneal sclerosis (EPS). The aim of our study was to investigate the effects of sirolimus on EPS in a rat model. METHODS:We separated 32 non-uremic rats into four groups: 1 control group, 2 ml isotonic saline injected IP daily for 3 weeks; 2 chlorhexidine gluconate (CG) group, 2 ml 0,1 % CG and 15 % ethanol dissolved in saline injected IP daily for 3 weeks; 3 resting group, CG (weeks 0-3) plus peritoneal rest (weeks 3-6); 4 sirolimus group, CG (weeks 0-3), plus 0.2 ml (1 mg/ml) sirolimus (weeks 3-6). Pathological samples were examined by using hematoxylin eosin (HE) and Masson's trichrome stains. Peritoneal thickness, fibrosis, vascular changes, and inflammation were evaluated by light microscopy. Finally, tissue metalloproteinase (MMP)-2 levels were measured by enzyme-linked immunoassay. RESULTS:In the CG group, there was a significant increase in peritoneal thickness, inflammatory activity, and fibrosis score compared to the control group (p < 0.05). We also observed a lower fibrosis score and less peritoneal thickening in the sirolimus group compared to the resting and CG groups (p < 0.05). There was no difference in histopathologic findings, except for the inflammatory activity in the sirolimus group, compared to the control group. Although the CG group had higher tissue MMP-2 levels than the control group, the tissue MMP-2 levels were not significantly different from the other groups. CONCLUSIONS:Sirolimus has a beneficial effect on peritoneal fibrosis induced by CG. This suggests that sirolimus may have therapeutic value in the management of EPS.

journal_name

Int Urol Nephrol

journal_title

International urology and nephrology

authors

Ceri M,Unverdi S,Dogan M,Unverdi H,Karaca G,Kocak G,Kurultak I,Akbal E,Can M,Duranay M

doi

10.1007/s11255-012-0167-3

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

977-82

issue

3

eissn

0301-1623

issn

1573-2584

journal_volume

44

pub_type

杂志文章

相关文献

INTERNATIONAL UROLOGY AND NEPHROLOGY文献大全
  • The effect of metabolic acidosis on serum apolipoprotein A I and apolipoprotein B levels in children with chronic renal failure.

    abstract：:In this report serum apolipoprotein A I (Apo A I) and apolipoprotein B (Apo B) levels were determined in children with chronic renal disease (CRD) during metabolic acidosis, after the correction of metabolic acidosis and in healthy children to look for the effect of metabolic acidosis on Apo A I and B levels. It was f...

    journal_title：International urology and nephrology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02552208

    authors： Bircan Z,Kaplan A,Soran M,Söker M,Kervancioğlu M,Sahin A,Kilinc M

    更新日期：1997-01-01 00:00:00

  • Wild garlic has a greater effect than regular garlic on blood pressure and blood chemistries of rats.

    abstract：:When groups of 10 Spontaneously Hypertensive Rats (SHR) were fed diets containing either 1% w/w regular garlic (Allium sativum) (AS) or 1% w/w wild garlic (Allium ursinum) (AU) for 45 days, the final mean systolic blood pressure (SBP) was reduced significantly compared to control (C) (C 189; AS 175; Au 173 mm Hg). Com...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1023/a:1014417526290

    authors： Preuss HG,Clouatre D,Mohamadi A,Jarrell ST

    更新日期：2001-01-01 00:00:00

  • A pure primary low-grade neuroendocrine carcinoma (carcinoid tumor) of the prostate.

    abstract：:The first time in Scandinavia we present a case report of a pure primary low-grade neuroendocrine carcinoma (carcinoid tumor) of the prostate. Our patient is a 34-year-old male with a long history of symptomatic chronic prostatitis/prostatodynia. After developing severe obstructive uropathy, a transurethral resection ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-009-9660-8

    authors： Giordano S,Tolonen T,Tolonen T,Hirsimäki S,Kataja V

    更新日期：2010-09-01 00:00:00

  • Does antimicrobial lock solution reduce catheter-related infections in hemodialysis patients with central venous catheters? A Bayesian network meta-analysis.

    abstract：PURPOSE:The purpose of our study is to carry out a Bayesian network meta-analysis comparing the efficacy of different antimicrobial lock solutions (ALS) for prevention of catheter-related infections (CRI) in patients with hemodialysis (HD) and ranking these ALS for practical consideration. METHODS:We searched six elec...

    journal_title：International urology and nephrology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s11255-016-1490-x

    authors： Zhang J,Wang B,Li R,Ge L,Chen KH,Tian J

    更新日期：2017-04-01 00:00:00

  • Correction to: Interleukin 6 is a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in hemodialysis patients using reused low-flux dialyzers.

    abstract：:The article "Interleukin 6 is a better predictor of 5-year cardiovascular mortality than high-sensitivity C-reactive protein in hemodialysis patients using reused low-fux dialyzers". ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s11255-020-02513-y

    authors： Thang LV,Loc ND,Kien NT,Dung NH,Quyen DBQ,Tuan NM,Ha DM,Kien TQ,Dung NTT,Van DT,Van Duc N,Ha NTT,Toan PQ,Nghia VX

    更新日期：2020-08-01 00:00:00

  • The relationship between lymphocyte subsets, nutritional status and tuberculin reactivity in continuous ambulatory peritoneal dialysis and hemodialysis patients.

    abstract：AIM:Skin test anergy is common in patients with uremia and during maintenance hemodialysis treatment. However, up to date only one study concerning skin test in peritoneal dialysis patients has focused on the issue. Our cross-sectional controlled study was conducted to analyze the correlation of purified protein deriva...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-020-02467-1

    authors： Usta M,Ersoy A,Ayar Y,Budak F

    更新日期：2020-06-01 00:00:00

  • Penile prosthesis extrusion due to gonococcal infection.

    abstract：:Gonococcal infection of a penile prosthesis is a rare presentation of a common disease. Here we report two cases of penile prosthesis extrusion due to gonococcal infection. ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1023/b:urol.0000034631.03070.9c

    authors： Yildirim I,Bedir S,Sumer F,Tahmaz L,Seckin B,Peker AF

    更新日期：2004-01-01 00:00:00

  • Clinical analysis of the small kidney associated with VUR.

    abstract：:Analysis was performed on the clinical features of children with VUR who had one or two kidneys that were at least -2 SD smaller than normal for age of its renal ratio. The prevalence of the small kidney was 15.6% (97/623 children). Of 107 small kidneys, 87 (82%) were associated with moderate (grade IV) to severe (gra...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/BF02549509

    authors： Shimada K,Matsui T,Arima M,Ikoma F

    更新日期：1988-01-01 00:00:00

  • Urinary alanine-aminopeptidase (AAP) excretion in patients with urinary tract infection treated with ceftazidime (CAZ) or cefotaxime (CTX) plus tobramycin (TOB).

    abstract：:It is well known that some antibiotics are particularly nephrotoxic. In the present study we investigated kidney function and AAP excretion (as an index of nephrotoxicity) in patients with urinary tract infection treated with CAZ or CTX plus TOB. The main cause of infection was E. coli in both treated groups. After 10...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/BF02550604

    authors： Wiecek A,Kokot F,Grzeszczak W

    更新日期：1988-01-01 00:00:00

  • Evaluation of perioperative prophylaxis with fosfomycin tromethamine in ureteroscopic stone removal: an investigator-driven prospective, multicenter, randomized, controlled study.

    abstract：PURPOSE:To compare efficacy, safety, and cost-effectiveness of fosfomycin tromethamine with other standard-of-care antibiotics in patients undergoing ureteroscopic lithotripsy. METHODS:This study was a prospective, multicenter, randomized, controlled trial. Eligible patients scheduled for ureteroscopic lithotripsy wer...

    journal_title：International urology and nephrology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s11255-017-1776-7

    authors： Qiao LD,Chen S,Lin YH,Li JX,Hu WG,Hou JP,Cui L

    更新日期：2018-03-01 00:00:00

  • Hemangiopericytoma arising from the wall of the urinary bladder.

    abstract：:Hemangiopericytoma (HPC) arising from within the urinary bladder is exceptionally rare. A 45-year-old man having the symptoms of left groin pain, vague suprapubic discomfort and frequency was admitted to our clinic. Pelvic tomography revealed a tumor in the bladder wall measuring 4 x 3 cm and was not clearly distinct ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-006-6673-4

    authors： Kibar Y,Uzar AI,Erdemir F,Ozcan A,Coban H,Seckin B

    更新日期：2006-01-01 00:00:00

  • Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy.

    abstract：PURPOSE:Hypoxia plays a significant role in the pathogenesis of acute kidney injury (AKI). Autophagy protects from AKI. Amino acid deprivation induces autophagy. The effect of L-tryptophan depletion on survival and autophagy in cultures of renal proximal tubular epithelial cells (RPTECs) under hypoxia was evaluated. M...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-017-1596-9

    authors： Eleftheriadis T,Pissas G,Sounidaki M,Antoniadis N,Antoniadi G,Liakopoulos V,Stefanidis I

    更新日期：2017-07-01 00:00:00

  • Laser-capture microdissection for analysis of cell type-specific gene expression of muscarinic receptor subtypes in the rat bladder with cyclophosphamide-induced cystitis.

    abstract：PURPOSE:This study examined whether the laser-capture microdissection (LCM) method can achieve separation of urothelial cells from detrusor cells or superficial urothelial cells from intermediate/basal urothelial cells, using α-smooth muscle actin (SMA) and cytokeratin 20 (CK20). In addition, we investigated the change...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-015-0926-z

    authors： Sugino Y,O'Malley KJ,Wang Z,Tyagi P,Birder LA,Ogawa O,Yoshimura N

    更新日期：2015-04-01 00:00:00

  • Benign prostatic hyperplasia: dietary and metabolic risk factors.

    abstract：:Benign prostatic hyperplasia (BPH) is the most common nonmalignant condition of the prostate occurring in ageing men. Even though BPH is a major public health problem, causing high morbidity and substantial worsening in men's quality of life, little is known about its risk factors. Several studies revealed that it is ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章,评审

    doi：10.1007/s11255-008-9333-z

    authors： Nandeesha H

    更新日期：2008-01-01 00:00:00

  • Aspects concerning posterior urethral valves.

    abstract：:Twenty-six boys were evaluated and treated for posterior urethral valves. At the time the valves were diagnosed unilateral or bilateral vesicoureteral reflux was present in 58% of the ureters and 69% of the children, while dilatation of the upper urinary tract was present in 88% and 92%, respectively. There was a vari...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/BF02549902

    authors： Melekos MD,Asbach HW,Giannoulis S,Perimenis P,Barbalias G

    更新日期：1989-01-01 00:00:00

  • Microvessel density and regulators of angiogenesis in malignant and nonmalignant prostate tissue.

    abstract：:The aim of this study was to investigate the relationship between microvessel density (MVD), positive and negative angiogenic factors, and established prognostic factors in prostate cancer (PC), and, to clarify the effect of angiogenic factors to angiogenesis. The vascularization of neoplastic, non-neoplastic prostate...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-006-9144-z

    authors： Kaygusuz G,Tulunay O,Baltaci S,Gogus O

    更新日期：2007-01-01 00:00:00

  • Wilms' tumour in adults. Review of 10 cases.

    abstract：:Nephroblastoma (Wilms' tumour) is very rarely found in adult patients. We report on 10 cases to demonstrate the diagnostic and therapeutic problems. In case of flank pain, large tumour mass, fast tumour growth and young age, the possibility of Wilms' tumour should be taken into consideration even in adult patients. Th...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/BF02550952

    authors： Winter P,Vahlensieck W Jr,Miersch WD,Vogel J,Gokel JM,Hellerich U

    更新日期：1996-01-01 00:00:00

  • Efficacy of pentoxifylline in prevention of contrast-induced nephropathy in angioplasty patients.

    abstract：BACKGROUND:Contrast-induced nephropathy (CIN) is an adverse consequence of contrast media use that results in significant morbidity and mortality and adds significant costs to diagnostic and interventional cardiology procedures. Various pathophysiological mechanisms have been proposed for CIN and various agents have be...

    journal_title：International urology and nephrology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11255-011-0053-4

    authors： Firouzi A,Eshraghi A,Shakerian F,Sanati HR,Salehi N,Zahedmehr A,Kiani R,Madani M,Pedarzadeh A

    更新日期：2012-08-01 00:00:00

  • Impact of serum albumin and body-mass index on survival in hemodialysis patients.

    abstract：:A low body mass index (BMI) and serum albumin are associated with increased risk of mortality in patients with chronic kidney disease (CKD). The purpose of this study was to evaluate BMI and serum albumin as predictors of all-cause and cardiovascular (CV) mortality in hemodialysed (HD) patients. We describe the result...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-007-9201-2

    authors： Mafra D,Farage NE,Azevedo DL,Viana GG,Mattos JP,Velarde LG,Fouque D

    更新日期：2007-01-01 00:00:00

  • Ultrasonographic urinary tract abnormalities in Schistosoma haematobium infection.

    abstract：OBJECTIVE:Evaluation of ultrasonographic abnormalities with active Schistosoma haematobium infection in Yemeni patients. METHODS:As part of a cooperation between a private hospital and Schistosomiasis Control Project in Yemen, laboratory and ultrasonographic examinations were performed in 158 patients (8 females, 150 ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1023/a:1007168507070

    authors： Salah MA,Böszörményi-Nagy G,Al Absi M,Nagi MA,Alsaaidi AA

    更新日期：1999-01-01 00:00:00

  • J-shaped association of platelet-to-lymphocyte ratio with 5-year mortality among patients with chronic kidney disease in a prospective cohort study.

    abstract：PURPOSE:To examine whether platelet-to-lymphocyte ratio (PLR) is associated with 5-year mortality in patients with chronic kidney disease (CKD), we performed this study using data from the National Health and Nutrition Examination Survey (NHANES) through 1999 to 2006. METHODS:3285 patients with CKD stage 1-5 were incl...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-020-02548-1

    authors： Zeng M,Liu Y,Liu F,Peng Y,Sun L,Xiao L

    更新日期：2020-10-01 00:00:00

  • Establishing a renal management clinic in China: initiative, challenges, and opportunities.

    abstract：BACKGROUND:Chronic kidney disease (CKD) has been identified as a growing global burden and traditional health care systems are inadequate for the management of CKD patients. This paper describes an initiative to establish a renal management clinic (RMC) in China and discusses the challenges and opportunities in the man...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-008-9450-8

    authors： Zhang AH,Zhong H,Tang W,Chen SY,He L,Wang S,Su CY,Lu XH,Wang T

    更新日期：2008-01-01 00:00:00

  • Novel porcine model for calcium oxalate stone formation.

    abstract：BACKGROUND:Mechanisms for calcium-based stone formation are not clearly delineated. Porcine are the most anatomically and physiologically congruent mammal to humans. Our objectives were to develop a cost-effective and easily reproducible porcine model for the study of calcium-based nephrolithiasis. METHODS:Crossbred m...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-017-1657-0

    authors： Trojan BP,Trojan SJ,Navetta A,Staches B,Sutton B,Filleur S,Nelius T

    更新日期：2017-10-01 00:00:00

  • Antegrade endopyelotomy in pelvic kidney.

    abstract：:Antegrade endopyelotomy was performed in a patient with pelvic kidney. Nephrostomy tube had been placed in the patient during a previous open pyelolithotomy. The nephrostomy tract was used for establishing percutaneous access. The ureteropelvic junction (UPJ) was balloon dilated and incised laterally under vision. At ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-004-4701-9

    authors： Aron M,Goel R,Dash SC,Gupta NP

    更新日期：2005-01-01 00:00:00

  • Intradetrusor injection of botulinum toxin A in children: a 10-year single centre experience.

    abstract：PURPOSE:We evaluated the efficacy and safety outcomes of endoscopic intradetrusor botulinum toxin A (BTA) injections for the treatment of children with neuropathic bladder (NB) and non-neuropathic bladder (NNB) with or without detrusor overactivity in a single centre with a retrospective analysis. METHODS:For the peri...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-019-02185-3

    authors： Peeraully R,Lam C,Mediratta N,Patel R,Williams A,Shenoy M,Fraser N

    更新日期：2019-08-01 00:00:00

  • The role of ureteroscopy as a diagnostic and therapeutic tool in various indications.

    abstract：:Ureteroscopy is now in routine use for the diagnosis and treatment of various pathologies in the upper urinary tract. We report here on our experience in diagnostic and therapeutic applications of the 11.5 F rigid ureteroscope in 85 patients and 88 ureters. An overall success rate of 68.18% (60/88) was achieved when t...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/BF02767719

    authors： Ilker Y,Dillioğlugil O,Tarcan T,Türkeri L,Akdaş A

    更新日期：1994-01-01 00:00:00

  • The influence of UV irradiation on vitamin D metabolism in children with chronic renal diseases.

    abstract：:The aim of this study was to find out whether an improvement of vitamin D metabolism and its metabolites and a decrease of parathormones can be reached through a diet and UV irradiation. Forty-eight children with kidney insufficiency were divided into four groups: Group 1--diet according to Bergström with EAA and ceto...

    journal_title：International urology and nephrology

    pub_type： 临床试验,杂志文章

    doi：

    authors： Lemke E

    更新日期：1993-01-01 00:00:00

  • Bulbocavernosus reflex in benign hypertrophy of the prostate.

    abstract：:Electrically induced bulbocavernosus (BC) reflexes were investigated in 47 patients with benign prostatic hypertrophy and the possible harmful effects of prostatectomy on the pudendal nerve branches were followed up in 30 of the patients using the same method. BC reflex obtained by electrical stimulation of the glans ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/BF02082074

    authors： Ertekin C,Yurtseven O,Reel F

    更新日期：1981-01-01 00:00:00

  • Effects of oral testosterone undecanoate treatment for severe hypospadias.

    abstract：PURPOSE:We sought to evaluate the effects of oral testosterone undecanoate treatment based on the temporary growth of penis and the complications of surgery in children with microphallic hypospadias. MATERIALS AND METHODS:A total of 72 randomized consecutive children with microphallic hypospadias were included in the ...

    journal_title：International urology and nephrology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11255-015-0972-6

    authors： Chen C,Gong CX,Zhang WP

    更新日期：2015-06-01 00:00:00

  • The effect of thermochemotherapy with mitomycin C on normal bladder urothelium, an experimental study.

    abstract：PURPOSE:To investigate the effects of thermochemotherapy with mitomycin C (MMC) on normal rabbit bladder urothelium and to compare it with standard intravesical MMC and hyperthermia with normal saline. METHODS:Twenty-four male New Zealand rabbits, with a mean weight of 2.7 kg (in weight of 2.1–4.3 kg), were divided in...

    journal_title：International urology and nephrology

    pub_type： 杂志文章

    doi：10.1007/s11255-015-1139-1

    authors： Uçar M,Altok M,Umul M,Bayram D,Armağan İ,Güneş M,Çapkin T,Soyupek S

    更新日期：2016-01-01 00:00:00