Abstract:
OBJECTIVES:According to current guidelines, radical cystectomy (RC) should be combined with an extended pelvic lymphadenectomy (PLND) as therapeutic and staging instrument. Objective of this study was to analyze the influence of PLND on survival rates and complication rates in a selected group of elderly patients with a minimum age of 80 years. MATERIALS AND METHODS:In this single-center retrospective analysis, we evaluated 102 patients who underwent RC due to UCB from 2004 to 2015 at our institution. In 74 patients (73%), RC was combined with PLND; in 28 cases (27%), RC was performed without PLND. Impact of PLND on cancer specific survival (CSS), overall survival (OS) and progression-free survival (PFS) was analyzed using log-rank test and COX regression model. RESULTS:In univariate analysis of the data, we were not able to show a significant impact of PLND on CSS (p = 0.606), OS (p = 0.979) or PFS (p = 0.883). Also in multivariate analysis of the data, we were not able to identify PLND as an independent prognostic parameter on survival rates of patients undergoing RC, neither for CSS (p = 0.912) nor OS (p = 0.618) or PFS (p = 0.900). CONCLUSIONS:Our small and single-center study was not able to demonstrate a significant independent influence of PLND on CSS, OS and PFS in octogenarians undergoing RC due to UCB. There is no doubt that RC should usually be combined with PLND, but the results of this small data set with a selected patient cohort indicate that RC without PLND might be an option in selected cases of elderly patients.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Grabbert M,Grimm T,Buchner A,Kretschmer A,Apfelbeck M,Schulz G,Jokisch F,Schneevoigt BS,Stief CG,Karl Adoi
10.1007/s11255-017-1699-3subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2137-2142issue
12eissn
0301-1623issn
1573-2584pii
10.1007/s11255-017-1699-3journal_volume
49pub_type
杂志文章abstract:OBJECTIVE:Recently, we reported that alpha 1A-adrenoceptor (AR) is the main participant in phenylephrine-induced human ureteral contraction. We therefore decided to carry out a prospective randomized study to evaluate the effects of silodosin, a selective alpha 1A AR antagonist, as a medical expulsive therapy (MET) for...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
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abstract::The authors describe various possibilities of using uretero-ureterostomy in cases of healthy bladder an in cases of supracystic urinary diversion. The history and the technique of the operation are described. Attention is called to the direction of anastomosis in cases of ureters differing in the width of their lumen....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082423
更新日期:1981-01-01 00:00:00
abstract::The authors review the experience of total parathyroidectomy with microsurgical autotransplantation with reference to the long-term results. This method--after further control investigations--may be envisaged for making a definitive evaluation of the results. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082771
更新日期:1984-01-01 00:00:00
abstract::Renal oncocytoma represents a special category of renal tumours and accounts for 3-5% of renal neoplasms. Usually they are incidental findings. Most reports have demonstrated their benign nature but a few cases of high-grade oncocytomas were reported to have metastasized. In Poland, between 1971 and 1991, 7 patients (...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768007
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abstract::In an attempt to evaluate renal injury relative to open surgery, percutaneous nephrolithotripsy (PCN) and extracorporeal shock wave lithotripsy (ESWL) were studied in 52 patients with renal calculus disease. Preoperative and postoperative urinary levels of N-acetyl-glycosaminidase (NAG), a sensitive marker of renal tu...
journal_title:International urology and nephrology
pub_type: 杂志文章
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abstract:PURPOSE:To evaluate conservative management of renal echinococcosis in cases with normal renal function and active disease. PATIENTS AND METHODS:From a series of 12 consecutive patients with primary renal echinococcosis, nephrectomy was suggested to 4 patients because of kidney destruction. One patient who denied surg...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014405325703
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abstract::Neurofibromatosis of the urinary tract is estimated to account for 20 per cent of the visceral manifestations of the generalized disease. Among its urological forms involvement of the bladder is the most common. Clinically, neurofibromatosis resembles a tumour, therefore, its early histologic diagnosis is of utmost im...
journal_title:International urology and nephrology
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doi:10.1007/BF02089403
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abstract::Non-refluxing non-obstructive megaureter is a rare condition, usually diagnosed in asymptomatic neonates. We present the case of a 39-year-old male, who presented with a 6-month history of recurrent UTIs and intermittent frank haematuria. IVU, flexible cystoscopy and micturating cystogram confirmed characteristically ...
journal_title:International urology and nephrology
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doi:10.1007/s11255-006-9054-0
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journal_title:International urology and nephrology
pub_type: 杂志文章
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abstract::A review of 71 cases of horseshoe kidney accounting for 0.12% of the total number of patients seen at the Department of Urology, Semmelweis University Medical School, Budapest, over 25 years is presented. The incidence of the abnormality has been found twice as high in males as in females. The proportion of surgical c...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082128
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abstract::Segmental cystectomy or total cystectomy was performed in 26 patients with newly diagnosed stage T1, grade 3 transitional cell carcinoma of the bladder. Their histological specimens were assessed with regard to types of tumour cell spread, small vessel involvement and coexistent carcinoma in situ. Patients were follow...
journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
abstract:PURPOSE:Chronic kidney disease (CKD) is associated with a high incidence of obstructive sleep apnea (OSA). We assessed the effect of continuous positive airway pressure (CPAP) on renal function in patients with CKD and OSA. METHODS:In this retrospective cohort study, 42 patients with Stage 3-5 CKD and OSA were stratif...
journal_title:International urology and nephrology
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:International urology and nephrology
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-04-01 00:00:00
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更新日期:2021-01-04 00:00:00
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abstract::We are presenting a 68-year-old female patient who was diagnosed to have a complete ureteral duplication and adenocarcinoma in the ureter which drained the upper moiety of the right kidney. ...
journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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doi:10.1007/s11255-008-9353-8
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and will lead some unfavorable outcomes such as end-stage renal disease. The efficacy of tonsillectomy remains controversial in both Asian and Caucasian ethnicity. Our meta-analysis was aiming at exploring its long-term efficacy and providin...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-01-01 00:00:00
abstract::Relying on their own observations, the authors describe nine patients in whom Fraley's syndrome was diagnosed and treated operatively. In six of them, calycopyeloneostomy was performed. In three of the patients, because of complications, the upper pole of the kidney was excised together with the changed calyx. In nonc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082129
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Recently, there have been a few reports on the decrease in the incidence of severe Henoch-Schönlein purpura nephritis (HSPN) in Japan. To evaluate the incidence and the severity of HSPN, we examined the epidemiology and clinical manifestations of HSPN in Fukushima Prefecture over a 22-year period. METHODS:W...
journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章,评审
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abstract:PURPOSE:To prove that phosphodiesterase type-4 inhibitors could potentially treat obesity-associated overactive bladder through modulation of the systemic inflammatory response. METHODS:In this 12-week study, 90 female Sprague-Dawley rats were divided into three groups: (1) vehicle-treated normal diet (ND)-fed rats; (...
journal_title:International urology and nephrology
pub_type: 杂志文章
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doi:10.1007/s11255-013-0412-4
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abstract::Posttransplant lymphoproliferative disorders (PTLD) are commonly caused by Ebstein-Barr Virus infection. The role of hepatitis C virus (HCV) in the genesis of lymphomas has been recognized recently. We report a HCV infected renal transplant recipient who developed PTLD 11 months after transplantation. Reduction of imm...
journal_title:International urology and nephrology
pub_type: 杂志文章
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abstract::A study was carried out to verify the clinical usefulness of the elaborated method for the measurement of antistreptococcal antibody in revealing the streptococcal etiology of glomerulonephritis. In 158 patients with glomerulonephritis antistreptococcal antibody (ASA), circulating immune complexes (CIC) and haemolytic...
journal_title:International urology and nephrology
pub_type: 杂志文章
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