Abstract:
OBJECTIVES:To examine the survival effect of treatment delays from the time of confirmed diagnosis of prostate cancer to first treatment in an Australian population. METHODS:Three thousand one hundred and forty patients were identified from the South Australian Prostate Cancer Clinical Outcomes Collaborative database for analysis. Selected patients had dates recorded for both diagnosis and treatment. We examined the effect of treatment delay (the time from diagnosis to date of first treatment) on survival using Cox and competing risks regression and compared quartiles of delay across the cohort. Adjustment was made for age, PSA levels, treatment modality and Gleason score. Outcomes included overall survival (OS) and prostate cancer-specific mortality (PCSM). RESULTS:Quartiles of delay were as follows (days)-Q1: 35, Q2: 86, Q3: 138.0, Q4: 264. Shorter delays were associated with hormonal treatment, high Gleason score and high PSA values. Measuring PCSM with Q2 as reference, age-adjusted associations were-Q1: sHR 4.37 (2.75-6.94), Q3: sHR 1.29 (0.73-2.28), Q4: sHR 1.55 (0.91-2.63). After additional adjustment for treatment type, Gleason score and PSA, Q1 remained at increased risk [sHR 2.46 (1.10-5.54)]. A similar trend was observed for OS. In analysis stratified by Gleason score, delays were not significantly associated with OS. CONCLUSIONS:Factors associated with shorter delay in treatment include high Gleason score, high PSA and hormonal treatment. After adjustment for these variables, increased delays were not associated with OS or PCSM in this cohort. The nonlinear association of delay with risk may explain conflicting reports in the literature.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
O'Callaghan ME,Shi Z,Kopsaftis T,Moretti Kdoi
10.1007/s11255-017-1508-zsubject
Has Abstractpub_date
2017-03-01 00:00:00pages
449-455issue
3eissn
0301-1623issn
1573-2584pii
10.1007/s11255-017-1508-zjournal_volume
49pub_type
杂志文章abstract:INTRODUCTION:Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearanc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9496-7
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:We compared the accuracy of magnetic resonance (MR) urethrography and X-ray urethrography with operative findings for urethral strictures and observed their effects on treatment. MATERIALS AND METHODS:A total of 87 male patients (10-85 years of age) treated from January 2015 to December 2016 were included in t...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02162-w
更新日期:2019-07-01 00:00:00
abstract::Fibrosing cholestatic hepatitis (FCH) is an uncommon complication of renal transplantation. It is usually associated with hepatitis B and C viral infection. It is further rare in renal transplantation in absence of HBV and HCV infection. To the best of our knowledge, only three cases of FCH in renal transplantation, w...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-004-6196-9
更新日期:2004-01-01 00:00:00
abstract::The seasonal prevalence of urinary calculus disease from the records of L.T. Municipal General Hospital, Sion, Bombay, which primarily caters services to poor people of Northeast Bombay, especially Dharavi slum area, is reported. The qualitative and quantitative compositions of stones collected from the patients of Dh...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549827
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Chronic kidney disease (CKD) is an inflammatory process. In addition to increased morbidity and mortality, inflammation also contributes to the progression of CKD. Neutrophil/lymphocyte ratio (NLR) is a marker of inflammation. Some recent data suggest that NLR may predict the progression of CKD. METHODS:In thi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1994-7
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Intravesical prostatic protrusion (IPP) is a type of benign prostatic hyperplasia (BPH) adenoma, and it plays a critical role in the pathogenesis of bladder outlet obstruction in patients with lower urinary tract syndromes (LUTS/BPH). AIMS:The goal of this study was to investigate the effect of a combinatio...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1478-6
更新日期:2017-03-01 00:00:00
abstract::The development of a reno-jejunal fistula following a Roux-en-Y cystojejunostomy for an incorrectly diagnosed pancreatic pseudocyst is described. Up to now, this is the second case of iatrogenic reno-jejunal fistula reported in literature. Reno-jejunal fistulas are exceedingly rare and are usually consequences of urol...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007115605427
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:The study aims to compare the clinical efficacy, complications, and patient satisfaction rates of two open hydrocelectomy techniques, Jaboulay's technique, and sac excision hydrocelectomy using a LigaSure™ device, in a prospective and randomized fashion. METHODS:Eighty-two (82) patients were randomized, one-to...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-019-02342-8
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:Varicocele is among the leading causes of male infertility. Despite decades of research, its pathogenesis is still unclear. S100A12 is a member of the S100 family of calcium-binding proteins with principal extracellular activities. It is secreted by activated neutrophils and interacts with the multiligand recep...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1188-5
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Smoking habit is the major risk factor for bladder cancer (BC), related to about 50% of these tumors; however, the tobacco dose-effect impact on BC immune treatment is underexplored. This study evaluates the impact of smoke load on non-muscle invasive bladder cancer (NMIBC) prognosis after intravesical BCG. ME...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02438-6
更新日期:2020-08-01 00:00:00
abstract::We report on our experience with a new surgical procedure of forming a pseudoneotesticle from indigenous tissues obtained from the existing scrotal contents. This procedure has been performed in 32 patients with a diagnosis of hormone dependent cancer of the prostate as a therapeutic manoeuvre, and in 3 children who h...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550317
更新日期:1998-01-01 00:00:00
abstract::Behcet's disease (BD) is a rare chronic, relapsing, multisystemic disorder characterized by mucocutaneous, ocular, vascular and central nervous system manifestations. However, the etiopathogenesis of the disease remains unknown, and diagnosis is basically dependent on clinical manifestations. Sometimes BD may be diagn...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0519-7
更新日期:2014-02-01 00:00:00
abstract::The present study demonstrated prolonged decreases of phagocytic activity by neutrophils in comparison to transitory neutropenias during haemodialysis with cuprophane membranes, remaining in connection with non-equalization immunological findings as C3 complement levels, circulating immune complexes and lysozyme activ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02559638
更新日期:1989-01-01 00:00:00
abstract::Immunoglobulin A nephropathy (IgAN) is an immune-complex-mediated glomerulonephritis characterized by the presence of IgA deposits in mesangial and paramesangial regions. However, the exact mechanism involved in IgA deposition is still unknown. TGF-β(1) that mediates the progression of IgAN is well established as a cr...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-009-9682-2
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Impaired kidney function is common in kidney-transplanted patients and complications of chronic kidney disease (CKD), such as mineral and bone disorders (MBD) are also prevalent in this population. Similarly to other stages of CKD, increasing evidence supports the association between MBD and cardiovascular...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9631-0
更新日期:2009-12-01 00:00:00
abstract::The best "treatment" of acute kidney injury (AKI) is prevention. Patients who are at high risk of AKI should have an assessment of their volume status and receive appropriate volume expansion. The most effective type of intravenous fluid remains unclear. Innumerable studies have compared sodium bicarbonate and isotoni...
journal_title:International urology and nephrology
pub_type: 社论,评审
doi:10.1007/s11255-014-0820-0
更新日期:2015-02-01 00:00:00
abstract::Sex cord stromal tumors are rare and account for approximately 6% of all testicular neoplasms. We report a case of sex cord tumor composed of granulosa cells and Sertoli cells in the adult testis. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000022907.66796.61
更新日期:2003-01-01 00:00:00
abstract::The effect of Ergobromocriptine treatment on serum testosterone and prolactin levels in 15 patients with prostatic carcinoma and 15 patients with benign prostatic hyperplasia was examined. The prolactin levels which were elevated in patients with prostatic carcinoma showed a significant decrease after suppression with...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082651
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:PSA is regarded as the best method in the follow-up of prostate carcinoma. After radical vesiculo-prostatectomy the prostate carcinoma seldom recurs at zero or nearly zero PSA levels. METHODS:The authors have used PSA since 1989 and they have found only one case where metastasis in the tibia came without an...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007142910479
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To assess clinical presentation and outcomes of different treatment strategies in cases of spontaneous renal hemorrhage (SRH). METHODS:A retrospective analysis of patients with SRH between 2000 and 2018 was performed. Patients' demographics, clinical presentation, laboratory and radiological investigations, an...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02333-9
更新日期:2020-03-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess the feasibility of robotic assisted kidney transplantation in graft with multiple vessels. MATERIALS AND METHODS:Eighteen patients underwent RAKT with grafts with multiple vessels (GMVs) from living donor performed by a single surgeon in single institution. The retrospe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02305-z
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:In the present study we have performed a correlation of the most prevailing clinical conditions of multiple sclerosis (MS) with overall drug response and the grade of the disease. MATERIALS AND METHODS:One hundred and ten patients were consecutively and prospectively studied with a clinical syndrome of MS, ran...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017597016622
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical value of detected prostate-specific antigen (PSA) mRNA expression levels in circulating cells in patients with prostate cancer by quantitative real-time polymerase chain reaction (qRT-PCR) and to determine the effect of surgical manipulation on hematogenous dissemination. METHODS:Blo...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9416-x
更新日期:2009-01-01 00:00:00
abstract::Persistent Mullerian duct syndrome (PMDS) is a rare form of the 46 XY disorders of sexual differentiation, characterized by the presence of a uterus and fallopian tubes due to the failure of Mullerian duct regression in genotypically normal males. More than 150 cases have been recorded, most of them in adults. In most...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0667-4
更新日期:2014-08-01 00:00:00
abstract::Primary CNS lymphoma (PCNSL) is a rare B cell variant non-Hodgkins lymphoma that is confined to the brain, leptomeninges, spinal cord and eyes. Its incidence is increasing, primarily due to increase in the number of organ transplantations being undertaken. The majority of the PTLD (post-transplant lymphoproliferative ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-012-0146-8
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED. PA...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3621-7
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. MATERIALS AND METHODS:Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9296-5
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Medication adherence plays an essential role in slowing the progression of chronic kidney disease (CKD). This review aims to summarise factors affecting medication adherence among these pre-dialysis CKD patients. METHODS:A systematic review of the literature was performed in Medline®, Embase®, SCOPUS® and C...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-020-02452-8
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Comorbidity has a significant impact on the health status and treatment outcome of a patient. The Charlson comorbidity index (CCI) is a frequently used scoring system, which evaluates the prognosis based on the patient's comorbid conditions. The aim of this study was to evaluate the usefulness of CCI in predict...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02499-7
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:To assess whether conservative treatment of pediatric patients with neurogenic detrusor overactivity (NDO) results in lower bladder pressure and increased expected bladder volume (EBV), we investigated the clinical and urodynamic effects of long-term intravesical oxybutynin instillation compared with a stand...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0030-y
更新日期:2012-04-01 00:00:00