Abstract:
PURPOSE:Chronic kidney disease (CKD) is an inflammatory process. In addition to increased morbidity and mortality, inflammation also contributes to the progression of CKD. Neutrophil/lymphocyte ratio (NLR) is a marker of inflammation. Some recent data suggest that NLR may predict the progression of CKD. METHODS:In this study, 5-year data of 740 patients with stage 2-4 CKD were reviewed retrospectively. Demographic data, NLR, CRP, albumin, the amount of proteinuria were recorded. At the beginning and the end of follow-up the glomerular filtration rate (GFR) and the annual GFR decline rate were calculated. Patients were divided to high and low NLR group according to median value of their baseline NLR. Reaching stage 5 CKD or initiation of renal replacement therapy was determined as end-point for follow-up. RESULTS:The mean age was 62.8 ± 0.57 years, eGFR 40 ml/min/1.73 m2, median NLR was 2.76. NLR increased as the CKD-stage increased. Mean follow-up time was 51.2 ± 30 months and 21.4% of patients reached the end-point. NLR was significantly increased at follow-up (from 3.22 to 5.68, p < 0.001). Annual GFR loss and baseline CRP were higher but baseline albumin and GFR were lower of patients with high NLR. The percent of patients reaching the end-point was not different between the groups with high and low baseline NLR. Kaplan Meier analysis showed that patients with high NLR had significantly lower mean renal survival (86.5 months) than patients with low NLR (105 months) (p < 0.001). In the Cox-regression analysis NLR was not an independent predictor in reaching the end-point but presence of diabetes mellitus, younger age and low baseline eGFR were found effective. CONCLUSIONS:NLR is an indicator of inflammation in chronic kidney disease. It may not be an independent predictor of CKD progression except that the CKD is in a more advanced stage and reflects the associated inflammation. Classical risk factors such as DM and lower GFR are more powerful predictors of progression.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Altunoren O,Akkus G,Sezal DT,Ciftcioglu M,Guzel FB,Isiktas S,Torun GI,Uyan M,Sokmen MF,Sevim HA,Sarısık FN,Senel ME,Erken E,Gungor Odoi
10.1007/s11255-018-1994-7subject
Has Abstractpub_date
2019-01-01 00:00:00pages
129-137issue
1eissn
0301-1623issn
1573-2584pii
10.1007/s11255-018-1994-7journal_volume
51pub_type
杂志文章abstract:PURPOSE:To suggest a different method for diagnosing vesicoureteral reflux (VUR) in lieu of voiding cystourethrography (VCU), in order to prevent radiation exposure. MATERIALS AND METHODS:Fifty-two ureterorenal units of 26 patients were evaluated ultrasonographically for visualizing the renal collecting systems, both ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550307
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Although sleep complaints are commonly reported in persons with end stage renal disease (ESRD), little is known about the prevalence of sleep complaints in chronic kidney disease (CKD), and the relation of sleep quality to the severity of kidney disease. METHODS:We administered the Kidney Disease Quality of...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-4654-z
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease mineral and bone disorders (CKD-MBD) suffer high rates of morbidity and mortality, in particular related to bone and cardiovascular outcomes. The management of CKD-MBD remains challenging. The objective of this systematic survey is to critically appraise clinical practice...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-016-1436-3
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. METHODS:SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-rea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0233-x
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this work is to determine the long-term therapeutic benefit(s) of daclizumab induction therapy with triple immunosuppressive protocols including prednisolone, cyclosporine microemulsion (CsA), and mycophenolate mofetil (MMF) in the living related donor kidney transplantation. METHODS:Twenty-...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9091-8
更新日期:2007-01-01 00:00:00
abstract:AIM:The aim of this study is to assess whether the haemostatic markers D-dimer, factor VIII (FVIII) and von Willebrand factor (VWF) are predictive of non-dipping status in treated hypertensive patients; so, as easy available laboratory data can predict non-dipping pattern and help with the selection of the patients who...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0288-8
更新日期:2013-06-01 00:00:00
abstract::Eighty-four patients with testicular seminoma were treated at the Northern Israel Oncology Center during the years 1968-1988. Using the staging classification of Hussey, 69 patients (82%) had Stage I, eight (10%) had Stage IIA, four (5%) had Stage IIB, one (1%) had Stage IIIA, and two (2%) had Stage IIIB disease. Sixt...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768019
更新日期:1994-01-01 00:00:00
abstract::Disorders in calcium, phosphorus, and parathyroid hormone (PTH) are common in chronic kidney disease (CKD) and may be associated with poor outcomes including a higher rate of CKD progression and increased death risk. Although these abnormalities have been examined extensively in patients with CKD stage 5 who are recei...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-008-9346-7
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Progression of the cell cycle is regulated by the interactions of cyclins, cyclin dependent kinases (CDKs) and CDK inhibitors (CDKIs). p27 is a member of the universal cyclin-dependent kinase inhibitor family. The level of p27 protein expression decreases during tumor development and progression in some epit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000020301.39181.03
更新日期:2003-01-01 00:00:00
abstract::Relationships between plasma testosterone levels and selected parameters of lipid metabolism were studied in a group of young sterile males prior to, during, and after hormone therapy. Initial hypertriacylglycerolaemia and decreased concentrations of HDL cholesterol returned to normal values after 30 days of methyltes...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549731
更新日期:1991-01-01 00:00:00
abstract::The authors present four cases of operatively confirmed anorchism. The plasma levels of testosterone and 11-deoxy-17-ketosteroids and dehydroisoandrosterone in urine were low in all cases. After stimulation with HCG, plasma testosterone levels increased in two cases and did not change in another two. The levels of 11-...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082812
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) secondary to acute tubular necrosis (ATN) is common in critically ill patients, and causes significant morbidity and mortality. The underlying etiology of ATN can be divided into pure ischemic, pure nephrotoxic, and mixed causes. This post-hoc analysis of a prospective cohort study ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9994-x
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:We examined the incidence of myocardial ischemia (MI) in kidney transplant recipients (KTR) using myocardial perfusion imaging (MPI), and its association with long-term outcomes after transplantation. METHODS:A retrospective observational study was conducted of asymptomatic KTRs who underwent post-transplant M...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02542-7
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of α-lipoic acid (α-LA) in the prevention and treatment of ethylene glycol-induced calcium oxalate deposition in a rat model and preliminary exploration of the mechanism. METHODS:Sixty male Wistar rats were divided randomly and equally into six groups including two α-LA prevention g...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02423-z
更新日期:2020-07-01 00:00:00
abstract::In 68 men with benign prostatic hyperplasia, we evaluated the association between obesity and prostatic enlargement, as well as changes in serum levels of oestradiol, testosterone, dihydroepiandrosterone and dihydroepiandrosterone sulphate. Despite the larger adenomas, no increase in the symptom score for BPH was obse...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550138
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of masturbation on the spontaneous expulsion of distal ureteral stones 5-10 mm in size. MATERIAL AND METHODS:A total of 128 men with distal ureteral stones were randomly divided into 3 groups. All patients received standard medical therapy. Patients in group 1 (n = 43) were instructed to...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02672-y
更新日期:2020-10-07 00:00:00
abstract::Platelet count did not significantly decrease after charcoal haemoperfusion in patients with acute poisoning and significantly decreased during regular dialysis treatment. Adherent platelets and leucocytes were found on the surface of granules after haemoperfusion using a scanning electron microscope. Decreased platel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081940
更新日期:1981-01-01 00:00:00
abstract::Three hundred fifteen (315) elderly (> or = 60 years) patients with clinical renal diseases were evaluated for the evidence of glomerular diseases between November 1998 to June 2002. Glomerular diseases (GN) were observed in 20.6% (65/315) of the elderly patients. The age of the patients (male 56; female 9) ranged bet...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000020429.14190.5b
更新日期:2003-01-01 00:00:00
abstract::The treatment of hyponatremia, especially euvolemic and hypervolemic hyponatremia, has changed with the development of drugs which function as vasopressin receptor antagonists. These agents increase solute-free water excretion by the kidney resulting in an aquaresis. Conivaptan, a vasopressin receptor antagonist, has ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9353-8
更新日期:2008-01-01 00:00:00
abstract::Although brucellosis is an endemic disease in Mediterranean countries, there are few reported cases of Brucella endocarditis and glomerulonephritis. We report a case of Brucella prosthetic mitral valve endocarditis and glomerulonephritis that could be managed by using only antibiotic therapy, including rifampicin, dox...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9895-4
更新日期:2012-04-01 00:00:00
abstract:AIM:To investigate the correlation of renal tubular inflammatory and injury markers with renal uric acid excretion in chronic kidney disease (CKD) patients. METHODS:Seventy-three patients with CKD were enrolled. Fasting blood and morning urine sample were collected for routine laboratory measurements. At the same time...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02447-5
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:To present the experience with the use of a "suction bridge" for removal of bladder clots. METHODS:In all patients presenting with bladder clots, mechanical suction was done using a "suction bridge". This bridge has a luer lock that is fixed to the cystoscope sheath, and the other end is connected to suctio...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-0962-8
更新日期:2015-05-01 00:00:00
abstract::The best "treatment" of acute kidney injury (AKI) is prevention. Patients who are at high risk of AKI should have an assessment of their volume status and receive appropriate volume expansion. The most effective type of intravenous fluid remains unclear. Innumerable studies have compared sodium bicarbonate and isotoni...
journal_title:International urology and nephrology
pub_type: 社论,评审
doi:10.1007/s11255-014-0820-0
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To investigate the effects of combined treatment of tadalafil (a phosphodiesterase-5 inhibitor) and tamsulosin (an α1-adrenoceptor antagonist) on bladder dysfunction in a rat model of bladder outlet obstruction (BOO). METHODS:Cystometry was performed in conscious female BOO rats 6 weeks after partially ligatio...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1835-8
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to provide a comprehensive dataset of porcine urinary bladder smooth muscle properties. Particularly, the history dependence of force production, namely force depression (FD) following shortening and force enhancement (FE) following stretch, was analysed. During active micturi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1482-x
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To report current results of vaginoplasty using the mucosa of the prepuce, and creating labia minora by penile skin in children with disorders of sex development (DSD). METHODS:In 10 years, we have performed 22 vaginoplasties using the described technique of vaginoplasty, 21 patients with 46, XX DSD and 1 ovot...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-2058-8
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:It has been shown that residual renal function but not peritoneal clearance predicted patients' survival in peritoneal dialysis therapy. In the present study, we tried to explore the potential causes resulting in the difference between residual renal function and peritoneal dialysis in continuous ambulatory ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-4011-x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:To examine symptomatology and microbiology of infected lymphocele (LC) post-robotic-assisted radical prostatectomy and pelvic lymph node dissection (PLND) and to assess for potential predictors for LC fluid culture positivity. Secondly, to provide general recommendations about use of select antimicrobial the...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1599-6
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:This study investigated the frequency of malnutrition in geriatric hemodialysis patients according to biochemical, anthropometric, bioelectrical impedance analysis (BIA), modified quantitative subjective global assessment (MQSGA), and geriatric nutritional risk index (GNRI) methods, and the effect of gender on ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0776-0
更新日期:2014-12-01 00:00:00
abstract::Artificial insemination (ADI) has been carried out with donor semen since 1984. Following artificial insemination 14 women out of 27 became pregnant in 1984, 30 women out of 57 in 1985 and 33 women out of 56 until October 1, 1986. The cycles were monitored. Serum LH and oestradiol levels were determined every day from...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549573
更新日期:1988-01-01 00:00:00