Conservative management of post-transplant central nervous system lymphoma.

Abstract:

:Primary CNS lymphoma (PCNSL) is a rare B cell variant non-Hodgkins lymphoma that is confined to the brain, leptomeninges, spinal cord and eyes. Its incidence is increasing, primarily due to increase in the number of organ transplantations being undertaken. The majority of the PTLD (post-transplant lymphoproliferative disorder) is seen in kidney transplant recipients simply because they constitute a larger group of transplant recipients each year as compared to other solid organ transplantations. Primary infection of previously infected EBV seronegative patients and immunosuppression are found to be the main etiologic factors in the development of PTLD-PCNSL. There are no clear guidelines on treatment regimens, and it should be individualized according to patient comorbidities. We report a case of PCNS lymphoproliferative disorder in a kidney transplant recipient, which underwent complete remission with decreasing immunosuppression. The patient could not undergo chemotherapy/radiotherapy due to underlying comorbidities. We highlight the available treatment modalities for PTLD-PCNSL.

journal_name

Int Urol Nephrol

authors

Valavoor SH,Ashraf Z,Narwal R,Ratnam S

doi

10.1007/s11255-012-0146-8

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

1219-22

issue

4

eissn

0301-1623

issn

1573-2584

journal_volume

45

pub_type

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