Abstract:
OBJECTIVE:To evaluate the clinical value of detected prostate-specific antigen (PSA) mRNA expression levels in circulating cells in patients with prostate cancer by quantitative real-time polymerase chain reaction (qRT-PCR) and to determine the effect of surgical manipulation on hematogenous dissemination. METHODS:Blood samples before, during, and after (24 h) surgery were obtained from 34 patients with prostate cancer who underwent radical prostatectomy for detecting PSA mRNA expression levels. PSA mRNA expression levels, PSA levels, and Gleason scores were then compared. RESULTS:PSA mRNA expression levels were detected in 14 of 34 (41%) patients, and biochemical recurrence of blood PSA was observed in 6 of 34 (17%) patients. Differences of PSA mRNA expression levels in pre-, per-, and postoperative periods were statistically significant (P < 0.001) and differences of PSA mRNA expression levels in pre- and peroperative samples (P < 0.008), pre- and postoperative samples (P < 0.031), and per- and postoperative samples (P < 0.001) were also statistically meaningful. There was significant relationship between the detectable PSA mRNA expression levels in preoperative samples and biochemical recurrence of blood PSA levels. We demonstrated that surgical manipulation had no effect on biochemical recurrence of blood PSA. We also showed that there was significant correlation between high Gleason score and the detectable PSA mRNA expression levels (P < 0.027). CONCLUSIONS:Our results suggest that highly detectable PSA mRNA expression levels in preoperative samples seem to be a significant predictable factor for prostate cancer recurrence.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Kalfazade N,Kuskucu AM,Karadag S,Sahin S,Aras B,Midilli K,Yilmaz G,Tasci AIdoi
10.1007/s11255-008-9416-xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
273-9issue
2eissn
0301-1623issn
1573-2584journal_volume
41pub_type
杂志文章abstract::Renal arterial embolization and subsequent nephrectomy or nephrectomy alone were performed in 34 patients with renal cell carcinoma. Renal arterial embolization caused a blood pressure elevation concomitant with an increase in plasma renin activity (PRA), urinary aldosterone excretion or urinary prostaglandin (PGE2) e...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549489
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVES:Progression of the cell cycle is regulated by the interactions of cyclins, cyclin dependent kinases (CDKs) and CDK inhibitors (CDKIs). p27 is a member of the universal cyclin-dependent kinase inhibitor family. The level of p27 protein expression decreases during tumor development and progression in some epit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000020301.39181.03
更新日期:2003-01-01 00:00:00
abstract::Chronic hepatic patients, and particularly those suffering from cirrhosis, are predisposed to different sort of water, electrolyte, acid-base, and trace elements disorders due to their altered liver function, and also to their exposition to infectious, inflammatory, oncologic, and pharmacologic variables whose combina...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-017-1614-y
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Cardiovascular calcifications (CVC) are present in up to 70% of non-diabetic dialysis patients. Sparse data are available on predictors of very long-term outcomes of such patients. The Belgrade Aachen Study on Calcification in Hemodialysis patients (BASCH study) aimed to study this using a comprehensive CVC ass...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1821-1
更新日期:2018-05-01 00:00:00
abstract::We report on our experience with a new surgical procedure of forming a pseudoneotesticle from indigenous tissues obtained from the existing scrotal contents. This procedure has been performed in 32 patients with a diagnosis of hormone dependent cancer of the prostate as a therapeutic manoeuvre, and in 3 children who h...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550317
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Aim of the study is to evaluate the long-term results of tunica albuginea plication in patients with congenital curvature of the penis and to compare them with those obtained with the Nesbit technique. METHODS:Overall, 62 patients underwent surgical correction of congenital curvature of the p...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9976-z
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:To compare the antibiotic prophylaxis based on quinolone administered orally with a combination of cephalosporin administered periprostatically and a fluoroquinolone orally, in terms of post-prostate bioptic infectious complication rates in those men undergoing transrectal ultrasound-guided prostate biopsy (TRU...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-012-0160-x
更新日期:2012-08-01 00:00:00
abstract::Idiopathic Localised Bladder Amyloidosis is a rare cause of haematuria and urinary tract symptoms. A review of the literature highlights the varied presentations and the appropriate investigations for this condition, with emphasise on the exclusion of a secondary cause. In addition, the range of treatment options is f...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1023/a:1021302827755
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In diabetics genetic predisposition, poor glycemic control and arterial hypertension contribute to nephropathy development in patients affected by diabetes mellitus. We set up the hypothesis that diabetic nephropathy and incisional hernia formation may have in common alterations of collagen com...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1229-8
更新日期:2016-05-01 00:00:00
abstract::A 67-year-old Saudi man with poorly controlled diabetes-mellitus underwent orchiectomy for a painful left testicular swelling that did not respond to antibiotics. Clinical diagnosis was testicular malignancy. Histologic workup demonstrated extensive involvement of the testis and epididymis by diffuse infiltrate of lar...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9674-2
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the number of autophagosomes in podocyte from kidney tissue of immunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN). METHODS:The changes in kidney tissue pathology were detected after hematoxylin and eosin, periodic acid-Schiff, Masson's trich...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1398-5
更新日期:2016-12-01 00:00:00
abstract::Children with nephrotic syndrome (NS) are at risk for sinovenous and arterial thrombosis, uncommon but serious complications of the nephrotic syndrome. Multiple factors are involved in the hypercoagulable state of patients with NS, for instance, enhanced platelet reactivity and deficiency of antithrombin III due to ur...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9434-8
更新日期:2009-01-01 00:00:00
abstract::Minimal change disease is the most common glomerular disease affecting children; its prevalence among adults, however, is eclipsed by other glomerular pathologies. Each of these diseases has a number of classic associations, such as membranoproliferative glomerulonephritis with hepatitis C. We report the case of a mid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0285-y
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:The use of interactive voting systems in continuing education helps to evaluate the alteration in the audience's views after a presentation. This study was designed to evaluate whether urologists' attitude towards management of benign prostate hyperplasia can be changed, and to estimate objectively the achievem...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9183-0
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To determine predictors for surgical complications and assess patient satisfaction after surgical treatment of Adult-Acquired Buried Penis (AABP). METHODS:A retrospective review was performed on all patients diagnosed with AABP who underwent surgical treatment at a single institution from January 2013-Decemb...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02347-3
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to examine the usefulness of three GFR-estimating equations (eGFR) compared with measured GFR (mGFR) in potential living kidney donors. METHODS:We compared the performance of the MDRD, CKD-Epi and Cockcroft-Gault equations with mGFR measured using (51)Cr-EDTA in 508 consecutive potent...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0859-y
更新日期:2015-01-01 00:00:00
abstract::Electrically induced bulbocavernosus (BC) reflexes were investigated in 47 patients with benign prostatic hypertrophy and the possible harmful effects of prostatectomy on the pudendal nerve branches were followed up in 30 of the patients using the same method. BC reflex obtained by electrical stimulation of the glans ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082074
更新日期:1981-01-01 00:00:00
abstract::A surgical case of coexisting renal cyst and tumour is reported, diagnosis having been made preoperatively with the aid of two recent diagnostic procedures. Electron microscopic study of the surgical specimen revealed virus-like intranuclear particles in the malignant tissue. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081944
更新日期:1977-01-01 00:00:00
abstract::Renal inflammatory pseudotumor is a very rare benign condition of unknown etiology characterized by proliferative myofibroblasts, fibroblasts, histiocytes, and plasma cells. We report a case of inflammatory pseudotumor of the kidney. A 42-year-old female was admitted with the complaint of right flank pain. Computerize...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000034661.52215.a3
更新日期:2004-01-01 00:00:00
abstract::A modified method of retropubic radical prostatectomy was devised. The root of the penis was compressed and the bilateral internal iliac arteries were clamped before the dissection of the prostate. The urethra was divided at the junction of the prostate and bladder so that the bladder stump thus created has the size o...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549537
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Hand-assisted laparoscopy was first performed in the 1990s by inserting the surgeon's finger or hand through a small tight wound. Although leakage of gas from the incision initially limited the usefulness of the technique, the hand-assisted procedures have advanced extensively since the introduction of the...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9027-3
更新日期:2007-01-01 00:00:00
abstract::The effects of haemodialysate and its three peptide fractions on acetylcholinesterase (AChE, E.C. 3.1.1.7) activity in erythrocytes from healthy subjects and patients with terminal renal insufficiency treated by repeated haemodialyses have been studied. It was shown that erythrocytes from haemodialysed patients displa...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is the major complication related to contrast media administration in patients after coronary angiography (CAG). However, inconsistent results have been published in the literature regarding the effects of pharmacological drugs on CIN prevention. We conducted a network meta...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-018-1814-0
更新日期:2018-06-01 00:00:00
abstract::A case of spontaneous right uretero-cutaneous fistula complicated by spontaneous rupture of the urinary bladder is presented. This morbid state is extremely rare and has not been previously reported to the best of our knowledge. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564762
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:We reviewed our experience with ureteral complications and secondary ureteral implantation after kidney transplantation. METHODS:Between 1997 and 2005, 636 patients underwent kidney transplantation at our transplant center. Ureteral implantation was performed in the Lich-Gregoire technique. Thirty-one patie...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9893-6
更新日期:2011-09-01 00:00:00
abstract::Authors describe and discuss cases of massive haemorrhage after percutaneous nephrolithotomy. In 10 (0.3%) of 3080 patients who underwent PCNL massive haemorrhage from renal fistula drain or urinary bladder was observed. Renal arteriography was performed in this group of patients which revealed arteriovenous fistulae ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550492
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:In this prospective study we aimed to describe our new technique; dehydrated human dura mater as an interposition graft in patients undergoing benign vesicovaginal fistula repair (VVF). PATIENTS AND METHODS:Eleven patients with benign VVFs aged 38-73 years were operated with dura mater interposition technique ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000032682.84973.e9
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:Type 2 diabetes mellitus (T2DM) patients treated with metformin are predisposed to develop contrast-induced nephropathy (CIN) after received emergency contrast-enhanced computed tomography (CT) examination. We evaluated the protective effects of alprostadil on CIN in T2DM patients treated with metformin after c...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-017-1639-2
更新日期:2017-11-01 00:00:00
abstract::Hemangiopericytoma (HPC) arising from within the urinary bladder is exceptionally rare. A 45-year-old man having the symptoms of left groin pain, vague suprapubic discomfort and frequency was admitted to our clinic. Pelvic tomography revealed a tumor in the bladder wall measuring 4 x 3 cm and was not clearly distinct ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-6673-4
更新日期:2006-01-01 00:00:00
abstract::The absorption, distribution and excretion of piromidic acid and its ethyl ester were investigated in the rat. When administered orally the ethyl ester was well absorbed and subsequently hydrolysed, giving much higher blood and tissue concentration than a corresponding dose of the parent compound. The antimicrobial ac...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081992
更新日期:1976-01-01 00:00:00