Abstract:
PURPOSE:The aim of this study was to investigate the number of autophagosomes in podocyte from kidney tissue of immunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN). METHODS:The changes in kidney tissue pathology were detected after hematoxylin and eosin, periodic acid-Schiff, Masson's trichrome and immunofluorescence. The autophagosomes of podocyte were analyzed by transmission electron microscopy. Clinical data, including age, gender, edema, serum creatinine, estimated glomerular filtrating rate (eGFR), hematuria, urine protein excretion and serum albumin, were collected from inpatient medical record. RESULTS:It was found that the number of autophagosomes in podocyte of nephropathy group was lower when compared to the control group. At the same time, we did not find the difference of the parameter between these two kinds of nephropathy. Further study showed that the index was affected by two factors: eGFR and gender. The cases with worse eGFR (eGFR < 60 ml/min) and male patients presented more autophagosomes. Furthermore, each nephropathy had its own character. The phenomena of reduced autophagosomes were found in IMN cases, did not change from male to female, and further aggravated from pathological stage I to II. By contrast, IgAN cases with less eGFR exhibited more autophagosomes. CONCLUSIONS:Therefore, the results of the present study indicate that autophagy participates in podocyte injury and the progression of IgAN and IMN.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Liang S,Jin J,Gong J,Lin B,Li Y,He Qdoi
10.1007/s11255-016-1398-5subject
Has Abstractpub_date
2016-12-01 00:00:00pages
2109-2114issue
12eissn
0301-1623issn
1573-2584pii
10.1007/s11255-016-1398-5journal_volume
48pub_type
杂志文章abstract:PURPOSE:To analyse the incidence and management of emphysematous pyelonephritis (EPN) in North West London and examine factors that influence immediate and 6-month outcomes with the aim of guiding future management. METHODS:This work analyses EPN cases from the London North West Healthcare NHS Trust from October 2006 ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1706-8
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:In the present study we have performed a correlation of the most prevailing clinical conditions of multiple sclerosis (MS) with overall drug response and the grade of the disease. MATERIALS AND METHODS:One hundred and ten patients were consecutively and prospectively studied with a clinical syndrome of MS, ran...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017597016622
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:A region of chromosome 22 which includes APOL1 and MYH9 genes was recently identified as a risk locus for non-diabetic forms of kidney disease, including idiopathic and HIV-associated focal segmental glomerular sclerosis and kidney disease clinically attributed to hypertension among African Americans. The purpo...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0263-4
更新日期:2013-04-01 00:00:00
abstract::Authors report on a case of Pseudomonas prostatitis complicated with a prostatoperineal fistula in continuity with the urethra that has been successfully treated with human fibrin sealant (Tissucol). ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564742
更新日期:1995-01-01 00:00:00
abstract::Ureteric stents, a good solution to many urologic problems, can lead to significant morbidity if left in situ longer than required. Our case is that of an elderly male with a history of intractable hypertension presenting with urosepsis, anemia, diabetes and chronic renal failure. His work-up revealed a stent in the r...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0021-3
更新日期:2005-01-01 00:00:00
abstract::Serum renin concentration (SRC) was determined in 97 hypertensive patients under basal conditions and during stimulation of renin secretion. Renin secretion was stimulated by upright posture and by either of the following means: (a) diet containing 20 mEq Na/24 hours for 3 days; (b) 300 mg i.v. diazoxide injections; (...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082246
更新日期:1976-01-01 00:00:00
abstract:AIM:The aim of the present study was to determine whether administration of zolpidem, a nonbenzodiazepine sedative-hypnotic agent, at night would improve the frequency of nocturia unresponsive to alpha-blocker monotherapy in men with lower urinary tract symptoms (LUTS). MATERIALS AND METHODS:The study inclusion criter...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9206-x
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of the calcineurin inhibitors (CNIs) cyclosporine (CyA) and tacrolimus (TAC) in the induction and maintenance treatment of lupus nephritis (LN). METHODS:The Cochrane library, PubMed, Embase, and CENTRAL databases were searched and reviewed up to February 2015. Randomized con...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-015-1201-z
更新日期:2016-05-01 00:00:00
abstract::The seasonal prevalence of urinary calculus disease from the records of L.T. Municipal General Hospital, Sion, Bombay, which primarily caters services to poor people of Northeast Bombay, especially Dharavi slum area, is reported. The qualitative and quantitative compositions of stones collected from the patients of Dh...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549827
更新日期:1990-01-01 00:00:00
abstract::Platelet count did not significantly decrease after charcoal haemoperfusion in patients with acute poisoning and significantly decreased during regular dialysis treatment. Adherent platelets and leucocytes were found on the surface of granules after haemoperfusion using a scanning electron microscope. Decreased platel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081940
更新日期:1981-01-01 00:00:00
abstract::Gonococcal infection of a penile prosthesis is a rare presentation of a common disease. Here we report two cases of penile prosthesis extrusion due to gonococcal infection. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000034631.03070.9c
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:We evaluated the efficacy and safety outcomes of endoscopic intradetrusor botulinum toxin A (BTA) injections for the treatment of children with neuropathic bladder (NB) and non-neuropathic bladder (NNB) with or without detrusor overactivity in a single centre with a retrospective analysis. METHODS:For the peri...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02185-3
更新日期:2019-08-01 00:00:00
abstract::In this report serum apolipoprotein A I (Apo A I) and apolipoprotein B (Apo B) levels were determined in children with chronic renal disease (CRD) during metabolic acidosis, after the correction of metabolic acidosis and in healthy children to look for the effect of metabolic acidosis on Apo A I and B levels. It was f...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552208
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Water intake is important for preventing kidney stones. Small molecules water is a more active restructured water under magnetic field. Here, we studied the relation between small molecules water and crystal formation in the rat kidney. MATERIALS:The small molecules water was prepared by a water machine provid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1769-6
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is the major complication related to contrast media administration in patients after coronary angiography (CAG). However, inconsistent results have been published in the literature regarding the effects of pharmacological drugs on CIN prevention. We conducted a network meta...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-018-1814-0
更新日期:2018-06-01 00:00:00
abstract::Experience in the treatment of urinary bladder cancer based upon observation of 306 cases has been presented. Two hundred and thirteen patients were treated surgically by performing in 151 cases partial cystectomy and in 62 cases total cystectomy. Conservative treatment was applied in 75 patients. In the authors' opin...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082168
更新日期:1977-01-01 00:00:00
abstract::Genitourinary organs are at greater risk for multiple primary malignant neoplasms because of the high incidence of these tumours as primaries among all other organs. We present a case of prostate and bladder carcinoma metastasized to a single pelvic lymph node, called a "collision" metastasis, in a patient with four p...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552140
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:In recent studies, it has been observed that androgen receptors are densely located in pelvic floor muscles. We aimed to investigate the effect of testosterone on urodynamic findings and histopathomorphology of pelvic floor muscles in rats with experimentally induced stress urinary incontinence. MATERIALS AN...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9938-5
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The adequate control of phosphataemia is of major importance in end-stage renal disease patients on maintenance dialysis. Recently, lanthanum carbonate (LC) has been added to the phosphate binder armamentarium. To our knowledge, no studies have yet evaluated the usefulness of this drug in uncontrolled hyperp...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9860-2
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:ADPKD is one of the most common inherited disorders, with high risk for end-stage renal disease. Numerous patients, however, have no relatives in whom this disorder is known and are unsure whether they may transmit the disease to their offsprings. The aim of this study was to evaluate whether germline mutati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0125-0
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to examine the usefulness of three GFR-estimating equations (eGFR) compared with measured GFR (mGFR) in potential living kidney donors. METHODS:We compared the performance of the MDRD, CKD-Epi and Cockcroft-Gault equations with mGFR measured using (51)Cr-EDTA in 508 consecutive potent...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0859-y
更新日期:2015-01-01 00:00:00
abstract::Peyronie's disease is characterized by the formation of a fibrotic plaque in the tunica albugenia of the penis. Two patients with calcified butterfly shaped plaques involving the ventrolateral aspect of the penis are described. These patients were managed by plaque excision and dermal grafting with excellent post-oper...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1021371315460
更新日期:2002-01-01 00:00:00
abstract::Authors describe and discuss cases of massive haemorrhage after percutaneous nephrolithotomy. In 10 (0.3%) of 3080 patients who underwent PCNL massive haemorrhage from renal fistula drain or urinary bladder was observed. Renal arteriography was performed in this group of patients which revealed arteriovenous fistulae ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550492
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Renal physiology is a partially cyclooxygenase (COX)-dependent system. Kidneys express both COX-1 and COX-2 enzymes. In this study, we tried to investigate the effects of diclofenac sodium (D), with or without furosemide (F), on plasma renin activity (PRA), serum and urine electrolytes, creatinine clearanc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9496-7
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:Tolvaptan exerts an aquaretic effect by blocking vasopressin V2 receptor. Although tolvaptan ameliorates body fluid retention even in patients with chronic kidney disease (CKD), predictors of body fluid reduction induced by tolvaptan remain unclear. We, therefore, examined the clinical parameters associated wit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02180-8
更新日期:2019-09-01 00:00:00
abstract::Osmotic diuresis results from urine loss of large amounts of solutes distributed either in total body water or in the extracellular compartment. Replacement solutions should reflect the volume and monovalent cation (sodium and potassium) content of the fluid lost. Whereas the volume of the solutions used to replace lo...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-018-1822-0
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Metformin has been shown to reduce diabetic complications in overweight patients, and is increasingly used to treat this condition. However, this agent is associated with a rare but serious risk of lactic acidosis. METHODS:From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9549-6
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Parental iron is used to optimize hemoglobin and enhance erythropoiesis in end-stage renal disease along with erythropoietin-stimulating agents. Safety of iron has been debated extensively and there is no definite evidence whether parenteral iron increases the risk of infections and mortality. We performed t...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析
doi:10.1007/s11255-019-02273-4
更新日期:2019-10-01 00:00:00
abstract::A series of 28 patients with urethral strictures less than 2 cm length underwent 32 visual optical internal urethrotomy under local urethral anesthesia with lidocaine. The procedure was completed successfully in 26 of 28 (92.9%) patients. Among these 25 of 26 (96%) patients reported mild pain. Visual analogue scale (V...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9046-0
更新日期:2007-01-01 00:00:00
abstract::Type 2 diabetes mellitus (DM2) is a chronic condition that affects more than 400 million individuals worldwide. In DM2 patients, an appropriate glycemic control slows the onset and delays the progression of all its micro and macrovascular complications. Even though there are several glucose-lowering drugs, only approx...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-020-02585-w
更新日期:2020-08-07 00:00:00