Pathophysiology and animal modeling of underactive bladder.

Abstract:

:While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, and much of what is known about the clinical etiology of the condition has been derived from epidemiological data. We hereby review current state of the art in the understanding of the pathophysiology of and animal models used to study the UAB.

journal_name

Int Urol Nephrol

authors

Tyagi P,Smith PP,Kuchel GA,de Groat WC,Birder LA,Chermansky CJ,Adam RM,Tse V,Chancellor MB,Yoshimura N

doi

10.1007/s11255-014-0808-9

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

S11-21

eissn

0301-1623

issn

1573-2584

journal_volume

46 Suppl 1

pub_type

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