Multiple brown tumors causing spinal cord compression in association with secondary hyperparathyroidism.

Abstract:

BACKGROUND:Brown tumor, a non-neoplastic process resulting from excess osteoclast activity, is found in primary hyperparathyroidism (HPTP) and secondary hyperparathyroidism (HPTS). We report a rare case of multiple spinal cord compression by brown tumors. CASE REPORT:A 47-year-old male with end-stage renal disease caused by hypertensive nephrosclerosis, on hemodialysis for 10 years and diagnosed with severe HPTS, developed back pain and sudden onset of gait difficulties progressing to paraplegia. A previous computed tomography (CT) of the lumbosacral spine demonstrated a solid lesion, located in the body of the sacrum, at S1-S2 level, with fine bone edge sclerosis, suggestive of brown tumor. A magnetic resonance imaging without gadolinium injection was performed. The examination revealed an insufflating bone lesion at thoracic level (T5/T6). Posterior laminectomy was followed by tumor excision. Histopathological analysis showed osteoid tissue streaked by fibroplasia with hemosiderin granulation. CONCLUSION:Differential diagnosis of sudden neurologic deficits and paraplegia in renal patients with secondary HPPT must consider the possibility of brown tumor.

journal_name

Int Urol Nephrol

authors

Araújo SM,Bruin VM,Nunes AS,Pereira EN,Mota AC,Ribeiro MZ,Sobreira CT,Daher EF

doi

10.1007/s11255-012-0123-2

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

913-6

issue

3

eissn

0301-1623

issn

1573-2584

journal_volume

45

pub_type

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