Abstract:
PURPOSE:Tolvaptan exerts an aquaretic effect by blocking vasopressin V2 receptor. Although tolvaptan ameliorates body fluid retention even in patients with chronic kidney disease (CKD), predictors of body fluid reduction induced by tolvaptan remain unclear. We, therefore, examined the clinical parameters associated with the effect of tolvaptan on fluid volume in CKD patients. METHODS:Twelve CKD patients (stage 3-5) with fluid retention were treated with tolvaptan in addition to conventional diuretic treatment. Patients were divided into low and high responders by the median change in total body water (TBW) for 1 week measured by a bioimpedance analysis (BIA) device, and clinical parameters were compared between the groups. RESULTS:The body weight significantly decreased by 2.0 ± 2.3 kg (p = 0.005), but the estimated glomerular filtration rate (eGFR) was not significantly changed (16.9 ± 11.9 vs. 17.4 ± 12.4 mL/min/1.73 m2, p = 0.139) after 1 week. The BIA showed that the intracellular water (ICW) decreased by 6.0% ± 4.7% (p < 0.001), the extracellular water (ECW) decreased by 6.7% ± 5.4% (p = 0.001), and the TBW decreased by 6.3% ± 4.9% (median value - 6.02%, p < 0.001). The serum albumin level in the high responders was significantly lower than in the low responders (2.3 ± 0.5 vs. 3.3 ± 0.8 g/dL, p = 0.013). Significant partial correlations adjusted for the eGFR were observed between the baseline serum albumin level and changes in the ICW (r = 0.440, p = 0.048), ECW (r = 0.593, p = 0.009) and TBW (r = 0.520, p = 0.020). CONCLUSIONS:Serum albumin levels predict the body fluid response to tolvaptan in CKD patients. Tolvaptan may be a promising therapeutic option for ameliorating body fluid retention, especially in patients with hypoalbuminemia.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Masuda T,Ohara K,Nagayama I,Matsuoka R,Murakami T,Nakagawa S,Oka K,Asakura M,Igarashi Y,Fukaya Y,Miyazawa Y,Maeshima A,Akimoto T,Saito O,Nagata Ddoi
10.1007/s11255-019-02180-8subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1623-1629issue
9eissn
0301-1623issn
1573-2584pii
10.1007/s11255-019-02180-8journal_volume
51pub_type
杂志文章abstract::The first time in Scandinavia we present a case report of a pure primary low-grade neuroendocrine carcinoma (carcinoid tumor) of the prostate. Our patient is a 34-year-old male with a long history of symptomatic chronic prostatitis/prostatodynia. After developing severe obstructive uropathy, a transurethral resection ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9660-8
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:Androgen replacement therapy is a widely accepted form of treatment worldwide for aging men with late-onset hypogonadism (LOH) syndrome. Urologists have been concerned with the use of androgen supplements due to the possibility of enhancing prostate growth. We performed a systematic review and meta-analysis to ...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-013-0477-0
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To correlate the accuracy of intraoperative and surgical specimen (ex vivo) ultrasound (US) with pathological margin status at partial nephrectomy. MATERIALS AND METHODS:Patients undergoing partial nephrectomy for T1 renal tumours in the period May 2010-January 2014 at a single institution who had intraoperati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1083-0
更新日期:2015-10-01 00:00:00
abstract::A review of 71 cases of horseshoe kidney accounting for 0.12% of the total number of patients seen at the Department of Urology, Semmelweis University Medical School, Budapest, over 25 years is presented. The incidence of the abnormality has been found twice as high in males as in females. The proportion of surgical c...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082128
更新日期:1978-01-01 00:00:00
abstract:PURPOSE:No safe ultrasound (US) parameters have been established to differentiate the causes of graft dysfunction. OBJECTIVES:To define US parameters and identify the predictors of normal graft evolution, delayed graft function (DGF), and rejection at the early period after kidney transplantation. METHODS:Between Jun...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0896-6
更新日期:2015-02-01 00:00:00
abstract::Five cases of spontaneous rupture of the renal parenchyma are reported. Two patients had renal cell cancer, one sustained acute purulent pyelonephritis secondary to stone related ureteral obstruction, one suffered from aposthematous pyelonephritis without obstruction, while one had chronic pyelonephritis and a cortica...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768275
更新日期:1994-01-01 00:00:00
abstract::Register and Multicenter Study for Testicular Tumours Bonn was founded in September 1976. Until August 1981, from 46 institutions participating in Austria and the Federal Republic of Germany the data from a total of 1508 patients with testicular tumours have been collected and evaluated. This paper gives an overview o...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082779
更新日期:1984-01-01 00:00:00
abstract::Gonococcal infection of a penile prosthesis is a rare presentation of a common disease. Here we report two cases of penile prosthesis extrusion due to gonococcal infection. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000034631.03070.9c
更新日期:2004-01-01 00:00:00
abstract:PURPOSE AND METHODS:The accurate estimation of volume status is a central problem in dialysis patients. Recently, a bioimpedance spectroscopy (BIS) device (BCM Body Composition Monitor FMC, Germany) has attained growing interest in this regard. By processing the raw data for extracellular water (ECW) and intracellular ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0216-y
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abstract:OBJECTIVE:To investigate whether stone dimension is a restrictive factor for ureterorenoscopic procedures. MATERIALS AND METHODS:A group of 416 patients who had undergone ureterorenoscopic pneumatic lithotripsy (URS-PL) for lower ureteral stones between January 1999 and June 2006 in our clinic had been evaluated retro...
journal_title:International urology and nephrology
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doi:10.1007/s11255-007-9278-7
更新日期:2008-01-01 00:00:00
abstract::In 21 men suffering from acute or chronic epididymitis who underwent scrotal surgical exploration, diagnostic microbiological studies consisting in cultures of the epididymal tissues and mid-stream urine specimens, as well as examination of the urethral swabs--before and after prostatic massage--were performed. Labora...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549519
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abstract:OBJECTIVES:To investigate the value of proliferating cell nuclear antigen (PCNA), Ki-67 antigen labelling indices and nucleolar organizer region (NOR) score in relation to histological grade, stage, recurrence and progression of the bladder tumor. MATERIALS AND METHODS:Tissue specimens from 77 bladder cancer patients ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014452902976
更新日期:2002-01-01 00:00:00
abstract::The development of a reno-jejunal fistula following a Roux-en-Y cystojejunostomy for an incorrectly diagnosed pancreatic pseudocyst is described. Up to now, this is the second case of iatrogenic reno-jejunal fistula reported in literature. Reno-jejunal fistulas are exceedingly rare and are usually consequences of urol...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007115605427
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abstract:PURPOSE:The aim of this study was to examine the usefulness of three GFR-estimating equations (eGFR) compared with measured GFR (mGFR) in potential living kidney donors. METHODS:We compared the performance of the MDRD, CKD-Epi and Cockcroft-Gault equations with mGFR measured using (51)Cr-EDTA in 508 consecutive potent...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0859-y
更新日期:2015-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-4705-5
更新日期:2005-01-01 00:00:00
abstract::In the management of infertility, in case semen quality is found insufficient and could not be improved by medical means, handling the available spermatozoa in the most beneficial way has been aimed. Thus, artificial insemination with low quality semen has become a therapeutic alternative. In this study homologous art...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550148
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:In low and middle- income countries, due to lack of financial resources, the number of patients receiving one or two hemodialysis (HD) sessions a week has increased, leading to a large number of complications. Protein-energy wasting (PEW) and overhydration (OH) are common complications; nevertheless, the eviden...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02697-3
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journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-016-1432-7
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Hemodialysis (HD) patients are at risk of deficiency of essential trace elements and excess of toxic trace elements. The aim of the study was to evaluate the relation between the serum levels of some trace elements and heavy metals (iron, zinc, manganese, copper, magnesium, cobalt, cadmium, and lead) and endo...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0055-2
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1706-8
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552189
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abstract::To evaluate cancer involvement of internal female genitalia of patients undergoing anterior exenteration for clinically organ confined transitional cell carcinoma of the bladder, and identify potential preoperative risk factors. Charts and anterior exenteration specimens from 54 women with clinically organ confined tr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9158-6
更新日期:2007-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9478-9
更新日期:2009-01-01 00:00:00
abstract::To report a rare congenital anomaly of the genitourinary tract, renal dysplasia is associated with ipsilateral incomplete duplicated ectopic ureter and seminal vesicle cyst in an adult, successfully treated with robotic-assisted laparoscopic approach. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0412-4
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:A region of chromosome 22 which includes APOL1 and MYH9 genes was recently identified as a risk locus for non-diabetic forms of kidney disease, including idiopathic and HIV-associated focal segmental glomerular sclerosis and kidney disease clinically attributed to hypertension among African Americans. The purpo...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0263-4
更新日期:2013-04-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1466-x
更新日期:2017-01-01 00:00:00
abstract::The hemodynamic response to ephedrine sulphate were studied in a patient on maintenance hemodialysis therapy with chronic renal failure due to renal amyloidosis. The evaluation (including cardiac catheterization studies) and estimation of responses to Valsalva maneuvers before and after ephedrine administration docume...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082096
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abstract:PURPOSE:Residual diuresis progressively decreases with longer dialysis vintage, and higher incidence of renal and urinary tract cancers was often observed in hemodialyzed patients compared to the general population so we hypothesized that patients without preserved residual diuresis have higher risk of renal and urinar...
journal_title:International urology and nephrology
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更新日期:2017-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-008-9346-7
更新日期:2008-01-01 00:00:00
abstract::In 44 patients (22 females, 22 males, aged 18-61 years, mean 36 years) regular dental screening and treatment were started in January 1982. Two years follow-up revealed that the oral hygiene of these haemodialysis patients was worse than that of the average population. In 42 cases calculus formation and gingivitis, in...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082610
更新日期:1986-01-01 00:00:00