Abstract:
OBJECTIVES:To investigate the value of proliferating cell nuclear antigen (PCNA), Ki-67 antigen labelling indices and nucleolar organizer region (NOR) score in relation to histological grade, stage, recurrence and progression of the bladder tumor. MATERIALS AND METHODS:Tissue specimens from 77 bladder cancer patients (43 superficial, 34 invasive) were immunostained with PCNA and Ki-67 and stained with AgNOR. Thirteen specimens of normal bladder mucosa served as controls. RESULTS:In comparison to normal bladder mucosa the values of the three indicators were significantly greater (p < 0.001). There was a significant relationship between PCNA, Ki-67 indices, AgNOR scores and grade and stage of the tumor (p < 0.001). All indicators also correlated with each other (p < 0.001). The Kaplan-Meier curves for recurrence-progression free survival revealed that patients with a PCNA labelling index >36.22%, Ki-67 labelling index >29.68% and AgNOR score > 3.34 had a worse prognosis than those with <36.22%, <29.68% and <3.34, respectively. CONCLUSIONS:PCNA, Ki-67 indices and AgNOR scores correlated with each other and with tumor grade and stage. These proliferation markers may give objective and accurate information about the biological behavior of bladder transitional cell carcinoma.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Bozlu M,Orhan D,Baltaci S,Yaman O,Elhan AH,Tulunay O,Müftüoğlu YZdoi
10.1023/a:1014452902976keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
59-66issue
1eissn
0301-1623issn
1573-2584journal_volume
33pub_type
杂志文章abstract:PURPOSE:Tolvaptan exerts an aquaretic effect by blocking vasopressin V2 receptor. Although tolvaptan ameliorates body fluid retention even in patients with chronic kidney disease (CKD), predictors of body fluid reduction induced by tolvaptan remain unclear. We, therefore, examined the clinical parameters associated wit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02180-8
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:In recent studies, it has been observed that androgen receptors are densely located in pelvic floor muscles. We aimed to investigate the effect of testosterone on urodynamic findings and histopathomorphology of pelvic floor muscles in rats with experimentally induced stress urinary incontinence. MATERIALS AN...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9938-5
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:Recently, we reported that alpha 1A-adrenoceptor (AR) is the main participant in phenylephrine-induced human ureteral contraction. We therefore decided to carry out a prospective randomized study to evaluate the effects of silodosin, a selective alpha 1A AR antagonist, as a medical expulsive therapy (MET) for...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-013-0429-8
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To evaluate all possible risk factors that can cause impairment of overall renal function in patients with unilateral ureteral calculus and a normal contralateral kidney. METHODS:This is a prospective study of 90 patients who presented to our institute complaining of renal colic secondary to unilateral urete...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-0986-0
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:Physical inactivity and sleep disturbance are frequently observed and relate to poor clinical outcomes in maintenance hemodialysis patients. We aimed to investigate the effect of intradialytic exercise on daily physical activity and sleep quality, measured by an accelerometer, in maintenance hemodialysis patien...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-018-1796-y
更新日期:2018-04-01 00:00:00
abstract:UNLABELLED:We examined renal function and urinary drainage of children with primary megaureter (PMU) in dependence on conservative or operative treatment. MATERIAL AND METHODS:The retrospective analysis covering the years 1994 to 2000 comprised children at an age of 0-7 years with 35 PMU. Sonography, dynamic MAG3 reno...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3615-5
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To compare the therapeutic effects and adverse events (AE) of current first-line treatments of advanced RCC, including sorafenib, sunitinib, temsirolimus, and the combination of bevacizumab and IFN-α. METHODS:We performed a meta-analysis of randomized controlled trials of the effectiveness of the five treatmen...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-015-0932-1
更新日期:2015-04-01 00:00:00
abstract::In this report serum apolipoprotein A I (Apo A I) and apolipoprotein B (Apo B) levels were determined in children with chronic renal disease (CRD) during metabolic acidosis, after the correction of metabolic acidosis and in healthy children to look for the effect of metabolic acidosis on Apo A I and B levels. It was f...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552208
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:The recent guidelines recommend using the estimated glomerular filtration rate (eGFR) to evaluate renal function. There are two reported full-age-spectrum (FAS) equations in 2017, which are based on serum cystatin C concentrations with or without accompanying serum creatinine level (FASCr-Cys or FASCys). We ...
journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s11255-018-1997-4
更新日期:2019-01-01 00:00:00
abstract::In 50 patients with terminal renal failure treated by intermittent peritoneal dialysis quantitative and qualitative assessments of peritoneal cells present in six successive changes of dialysate were performed using light microscopy and the Cytur test (Boehringer). The examination was repeated in 25 patients in the co...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549839
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To investigate the role of urinary neutrophil gelatinase-induced lipocalin (uNGAL) measurement in the early diagnosis of acute kidney injury that may occur after intraoperative ischemia in patients undergoing partial nephrectomy (PN). METHODS:This prospective study included 86 patients who underwent open lapar...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02660-2
更新日期:2020-09-26 00:00:00
abstract:PURPOSE:The association between crescents and renal outcomes was inconsistent in a Chinese IgA nephropathy (IgAN) cohort, and limited research has investigated the prognosis of IgAN patients with crescents. METHODS:Between January 2008 and January 2013, 169 consecutive IgAN patients with crescents in the Xijing Hospit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02457-3
更新日期:2020-08-01 00:00:00
abstract::In this study we explored the possible role of arachidonoylethanolamine (AEA) in regulating blood pressure in patients on continuous ambulatory peritoneal dialysis (CAPD). One hundred and five patients on CAPD were enrolled. Volume status was evaluated by the overhydration (OH) value obtained by bioimpedance analysis....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0153-9
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:Preputial bacterial colonisation was investigated in preschool and primary school children with and without phimosis before the circumcision procedure. METHOD:The study group consisted of 32 boys admitted to our clinic consecutively between June 2003 and September 2003 for circumcision. The indication for s...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-4700-x
更新日期:2005-01-01 00:00:00
abstract::To compare the two conventional surgical methods for varicocelectomy, 50 patients with varicocele were operated by using either the retroperitoneal or the inguinal techniques. Compliance with local anaesthesia was found to be poor in the retroperitoneal group. The operative time was significantly shorter (p = 0.00038)...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768286
更新日期:1994-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9994-x
更新日期:2012-12-01 00:00:00
abstract::This is the first prospective study to investigate the association between kidney stones, bone mineral density, serum testosterone, colon cancer and O. formigenes colonization. 40 kidney stone patients and 85 controls were enrolled. O. formigenes colonization was established. BMD was examined from T- and Z-scores usin...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02627-3
更新日期:2021-01-01 00:00:00
abstract::In the course of a disinterment of an ancient Avar burial place at Székkutas-Kápolna near Hódmezövásárhely, Hungary, the archaeologist conducting the excavations, Miss Katalin B. Nagy, noticed a lithoid body of oval shape in the pelvis of a skeleton. The find was identified on morphological and chemo-analytical ground...
journal_title:International urology and nephrology
pub_type: 历史文章,杂志文章
doi:10.1007/BF02550466
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:To report outcomes 5 years after a resident quality initiative incorporated topical rectal antiseptic into our ultrasound-guided prostate needle biopsy (TRUS PNB) protocol. METHODS:A chart review was conducted on 1007 men who underwent TRUS PNB between 2010 and 2017. Comparison groups include those who receive...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1937-3
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0896-6
更新日期:2015-02-01 00:00:00
abstract::The authors review the experience of total parathyroidectomy with microsurgical autotransplantation with reference to the long-term results. This method--after further control investigations--may be envisaged for making a definitive evaluation of the results. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082771
更新日期:1984-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1962-2
更新日期:2018-10-01 00:00:00
abstract::Experience in the treatment of urinary bladder cancer based upon observation of 306 cases has been presented. Two hundred and thirteen patients were treated surgically by performing in 151 cases partial cystectomy and in 62 cases total cystectomy. Conservative treatment was applied in 75 patients. In the authors' opin...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082168
更新日期:1977-01-01 00:00:00
abstract:PURPOSE:There is a need for methods that would enable monitoring of the effects of immunosuppression on the recipient's immune system to avoid rejection, immunodeficiency-related complications and non-immune toxicities of the drugs used in therapy. METHODS:This prospective trial included thirty patients who underwent ...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s11255-013-0413-3
更新日期:2014-01-01 00:00:00
abstract::Sixty patients in Stages I and II of benign prostatic hyperplasia were treated with Peponen capsule. Out of them 26 took the drug for 10 months, 22 for at least 7, and 12 for at least 4 months. The daily dosage was 3 x 2 capsules in the first month and 3 x 1 capsule for the rest of the time. On the ground of urodynami...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549728
更新日期:1991-01-01 00:00:00
abstract:AIM:To determine the effectiveness of transdermal electromotive administration (TEA) of verapamil and dexamethasone in the treatment of Peyronie's disease (PD). METHOD:Totally, 51 patients with PD were prospectively included in the study. All patients were evaluated by history, subjective score scales, physical examin...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s11255-008-9408-x
更新日期:2009-01-01 00:00:00
abstract::Fournier's gangrene (FG) is a rapidly progressive, fulminant infection of the scrotum, perineum and the abdominal wall. FG is caused by synergic aerobic and anaerobic organisms. Modern surgical series report mortality of up to 67%. This originally rare disease has become more frequent. Aggressive treatment including a...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1019554327341
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:It has been shown that coenzyme Q(10) (CoQ(10)) supplementation in men with idiopathic oligoasthenoteratozoospermia (OAT) results in improved semen parameters. In present study, we evaluated the effects of coenzyme CoQ(10) supplementation on semen parameters and pregnancy rates in infertile men with idiopathi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0081-0
更新日期:2012-06-01 00:00:00
abstract::Rhabdomyosarcoma (RMS) is the commonest variety of soft tissue sarcoma in children and young adults. It represents 6.5% of all malignant tumours in paediatrics with an annual incidence of 4 to 7 cases/million children. The primary paratesticular site is considered to have a good prognosis in comparison with other rhab...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0853-x
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To examine whether platelet-to-lymphocyte ratio (PLR) is associated with 5-year mortality in patients with chronic kidney disease (CKD), we performed this study using data from the National Health and Nutrition Examination Survey (NHANES) through 1999 to 2006. METHODS:3285 patients with CKD stage 1-5 were incl...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02548-1
更新日期:2020-10-01 00:00:00