Abstract:
:El-Far and Sobh were the first to describe abnormalities in porphyrin metabolism in Egyptian patients with chronic renal failure (CRF). Our results were confirmed by others. The present investigation aims to study and discuss the nature of those abnormalities and changes in porphyrin metabolism in CRF patients following kidney transplantation. Blood samples and urine were collected from patients (with and without polycythaemia) as well as from normal controls. The activity of heme enzymes such as ALA-S, ALA-D, URO-S, PBGase and URO-D were assayed. Total blood porphyrins as well as enzyme activities such as ALA-S and URO-S were found to be highly significantly increased in all patients, while URO-D activity remained within normal range. The observed elevated erythrocyte porphyrins may be mainly due to increased activity of ALA-S, the rate-limiting enzyme in heme synthesis. The present study is the first of its kind which clearly demonstrates that successful kidney transplantation does not correct or rectify the abnormalities in porphyrin metabolism.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
el-Far M,Sobh M,Ghoniem Mdoi
10.1007/BF02583996subject
Has Abstractpub_date
1991-01-01 00:00:00pages
503-9issue
5eissn
0301-1623issn
1573-2584journal_volume
23pub_type
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085384
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-4654-z
更新日期:2005-01-01 00:00:00
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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更新日期:1984-01-01 00:00:00
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doi:10.1007/s11255-012-0247-4
更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
doi:10.1007/s11255-019-02078-5
更新日期:2019-03-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549839
更新日期:1990-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564742
更新日期:1995-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085344
更新日期:1975-01-01 00:00:00
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pub_type: 杂志文章,评审
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abstract:INTRODUCTION:Factors responsible for the low incidence of clinical prostate cancer (3-8/100,000 men/year) in the Arab population remain unclear, but may be related to changes in steroid hormone metabolism. We compared the levels of serum conjugated and unconjugated steroids between Arab and Caucasian populations, to de...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3619-1
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pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082677
更新日期:1975-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0194-0
更新日期:2012-08-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082706
更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1748-y
更新日期:2018-02-01 00:00:00