Abstract:
PURPOSE:Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular events. This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients. MATERIALS AND METHODS:Seventy-one non-dialysis CKD patients with low vitamin D (serum 25(OH)D < 30 ng/mL) were recruited. Patients received oral cholecalciferol 50,000 units once a week for 12 weeks. Changes in endothelial function by brachial artery flow-mediated dilation (FMD), soluble vascular cell adhesion molecule-1 (sVCAM-1), and sE-selectin were studied. RESULTS:There was a significant increase in serum levels of 25(OH)D after cholecalciferol supplementation (33.7 ± 12.1 vs. 13.2 ± 5.4 ng/mL, P < 0.001). Multivariable regression analysis showed that higher proteinuria (β = - 0.548, P < 0.001) and lower levels of 25(OH)D (β = 0.360, P < 0.001) at baseline were related to lower 25(OH)D level after supplementation. FMD increased significantly from 4.4 ± 1.3 to 5.1 ± 1.5% (P < 0.001), and soluble endothelial biomarkers decreased: sVCAM-1 from 926.9 ± 158.0 to 867.0 ± 129.0 ng/mL (P < 0.001), and sE-selectin 69.7 ± 15.8 to 63.3 ± 14.7 ng/mL (P < 0.001). CONCLUSIONS:Vitamin D supplementation can improve endothelial dysfunction in pre-dialysis CKD patients.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Zhang Q,Zhang M,Wang H,Sun C,Feng Y,Zhu W,Cao D,Shao Q,Li N,Xia Y,Tang T,Wan C,Liu J,Jin B,Zhao M,Jiang Cdoi
10.1007/s11255-018-1829-6subject
Has Abstractpub_date
2018-05-01 00:00:00pages
923-927issue
5eissn
0301-1623issn
1573-2584pii
10.1007/s11255-018-1829-6journal_volume
50pub_type
杂志文章abstract::Fifty-eight patients with urate calculi and 31 patients with other (non-urate) calculi were examined for total-body potassium by means of a total-body counter. The patients with urate calculosis were found to differ significantly in their total-body K from patients with other calculi as well as from normal subjects. T...
journal_title:International urology and nephrology
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更新日期:2001-01-01 00:00:00
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更新日期:2017-10-01 00:00:00
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