Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease.

Abstract:

PURPOSE:Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular events. This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients. MATERIALS AND METHODS:Seventy-one non-dialysis CKD patients with low vitamin D (serum 25(OH)D < 30 ng/mL) were recruited. Patients received oral cholecalciferol 50,000 units once a week for 12 weeks. Changes in endothelial function by brachial artery flow-mediated dilation (FMD), soluble vascular cell adhesion molecule-1 (sVCAM-1), and sE-selectin were studied. RESULTS:There was a significant increase in serum levels of 25(OH)D after cholecalciferol supplementation (33.7 ± 12.1 vs. 13.2 ± 5.4 ng/mL, P < 0.001). Multivariable regression analysis showed that higher proteinuria (β = - 0.548, P < 0.001) and lower levels of 25(OH)D (β = 0.360, P < 0.001) at baseline were related to lower 25(OH)D level after supplementation. FMD increased significantly from 4.4 ± 1.3 to 5.1 ± 1.5% (P < 0.001), and soluble endothelial biomarkers decreased: sVCAM-1 from 926.9 ± 158.0 to 867.0 ± 129.0 ng/mL (P < 0.001), and sE-selectin 69.7 ± 15.8 to 63.3 ± 14.7 ng/mL (P < 0.001). CONCLUSIONS:Vitamin D supplementation can improve endothelial dysfunction in pre-dialysis CKD patients.

journal_name

Int Urol Nephrol

authors

Zhang Q,Zhang M,Wang H,Sun C,Feng Y,Zhu W,Cao D,Shao Q,Li N,Xia Y,Tang T,Wan C,Liu J,Jin B,Zhao M,Jiang C

doi

10.1007/s11255-018-1829-6

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

923-927

issue

5

eissn

0301-1623

issn

1573-2584

pii

10.1007/s11255-018-1829-6

journal_volume

50

pub_type

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