Chronic glomerulonephritis with massive IgA deposits.

Abstract:

:A total of 234 patients with chronic glomerulonephritis, detected on the basis of clinical, immunological and pathomorphological criteria, have been examined. A group of 23 chronic glomerulonephritis patients with massive deposits of immunoglobulin A found by immunofluorescent examination, has been separated on the basis of immunohistochemical studies. In this group, occurrence of different morphological forms of glomerulonephritis has been observed: 30.4% mesangial-proliferative glomerulonephritis, 13% submicroscopic glomerulonephritis and one case of membranous glomerulonephritis. Complete haemolytic activity of complement, level of complement components C3 and C4, immunological complexes circulating in blood, properdin and immunoglobulin A levels, fibrin and fibrinogen (FDP) degradation product concentrations and their 24-hour excretions with urine have been determined. Preliminary observations of this group of patients seem to indicate a positive effect of steroid therapy in glomerulonephritis with IgA deposits, irrespective of the morphological form of the disease.

journal_name

Int Urol Nephrol

authors

Steciwko A,Szewczyk Z,Letachowicz W,Steciwko M

doi

10.1007/BF02085414

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

269-79

issue

3

eissn

0301-1623

issn

1573-2584

journal_volume

17

pub_type

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