The prevalence of chronic kidney disease in the general population in Romania: a study on 60,000 persons.

Abstract:

INTRODUCTION:Chronic kidney disease (CKD) is a major public health problem worldwide, due to its epidemic proportions and to its association with high cardiovascular risk. Therefore, screening for CKD is an increasingly important concept, aiming for early detection and prevention of progression and complications of this disease. MATERIALS AND METHODS:We studied the prevalence of CKD in the adult population of Iaşi, the largest county in Romania, based on the results of a national general health screening program from 2007 to 2008. The patients were tested for CKD with serum creatinine and urinary dipstick. We used two different methods to estimate the glomerular filtration rate (eGFR): the simplified Modification of Diet in Renal Disease (MDRD) and the CKD Epidemiology Collaboration (CKD-EPI) equations. Based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria, we defined CKD as the presence of either eGFR < 60 ml/min/1.73 m(2) and/or dipstick proteinuria. The classification of CKD by stage was also done according to the KDIGO criteria. RESULTS:The study population included 60,969 people. The global prevalence of CKD was found to be 6.69% by the MDRD formula and 7.32% when using the CKD-EPI equation. The prevalence of CKD was much higher in women than in men: 9.09% versus 3.7%, by MDRD, and 9.32% versus 4.85%, by CKD-EPI. By age groups, the prevalence of CKD was 0.95% and 0.64% in persons aged 18-44 years old, 4.27% and 3.57% (45-64 years old), 13.36% and 15.34% (65-79 years old), and 23.59% and 34.56% (>80 years old), according to MDRD and CKD-EPI, respectively. By stages, the prevalence of CKD stage 3a (eGFR 59 to 45 ml/min/1.73 m(2)) was 5.72% by MDRD and 5.96% according to CKD-EPI, whereas the prevalence of stages 3b, 4, and 5 taken together (eGFR < 45 ml/min/1.73 m(2)) was 0.96% (MDRD) and 1.35% (CKD-EPI). Patients with CKD were significantly older (71.0 years versus 53.7 years) and had lower levels of serum Hb, total cholesterol, and glutamic pyruvic transaminase, and significantly higher serum creatinine and blood glucose, in comparison with the individuals without CKD. Impaired fasting glucose (106 mg/dl) was found in the CKD population, but not in non-CKD individuals. CONCLUSIONS:Our study is one of the largest ever reported on the prevalence of CKD worldwide, the first one in Romania, and one of the very few of its kind in Europe (particularly in Eastern Europe). The study showed that the prevalence of CKD in our country is around 7%, which is lower than in other countries; however, this could be underestimated due to population selection bias. The prevalence is similar with the MDRD and the CKD-EPI equations; it increases with age and is much higher in women than in men. Impaired fasting glucose was detected in CKD patients, a finding that should probably raise the awareness of the high cardiovascular risk associated with CKD.

journal_name

Int Urol Nephrol

authors

Cepoi V,Onofriescu M,Segall L,Covic A

doi

10.1007/s11255-011-9923-z

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

213-20

issue

1

eissn

0301-1623

issn

1573-2584

journal_volume

44

pub_type

杂志文章
  • Randomized clinical trial of a novel donor-derived cfDNA test to detect rejection in CPV-simulated renal transplant patients.

    abstract:PURPOSE:Five-year kidney graft loss currently stands at about 30%. We evaluate the clinical utility of a blood test measuring donor-derived cell-free DNA that detects rejection earlier and, potentially, improves diagnostic and therapeutic accuracy. METHODS:In a randomized controlled experiment, we measured the clinica...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-020-02491-1

    authors: Peabody J,Billings P,Valdenor C,Demko Z,Moshkevich S,Tran M,Paculdo D

    更新日期:2020-08-01 00:00:00

  • Outcome of early ambulation after renal biopsy using automated biopsy needle by inexperienced trainees.

    abstract::Percutaneous renal biopsy is a fundamental diagnostic technique. Technical innovations had resulted in an increasing simplicity and safety of the procedure. In this study, 28 kidney biopsies were done using gauge 16 or 18 automated biopsy needle by inexperienced trainees, and patients were allowed full ambulation four...

    journal_title:International urology and nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02550217

    authors: Al-Wakeel JS

    更新日期:1998-01-01 00:00:00

  • Xanthogranulomatous prostatitis.

    abstract::Two cases of rarely observed granulomatous prostatitis are presented. Unspecific clinical symptoms and a close similarity in clinical course to prostatic adenoma or adenocarcinoma may be misleading and produce severe diagnostic difficulties even for an experienced urologist. Close cooperation with a pathomorphologist ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02084115

    authors: Miekoś E,Włodarczyk W,Szram S

    更新日期:1986-01-01 00:00:00

  • Ultrasound image features of intravesical prostatic protrusion indicated failure of medication therapy of finasteride and doxazosin in patients with benign prostatic hyperplasia (LUTS/BPH).

    abstract:BACKGROUND:Intravesical prostatic protrusion (IPP) is a type of benign prostatic hyperplasia (BPH) adenoma, and it plays a critical role in the pathogenesis of bladder outlet obstruction in patients with lower urinary tract syndromes (LUTS/BPH). AIMS:The goal of this study was to investigate the effect of a combinatio...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-016-1478-6

    authors: Liu Q,Zhu Y,Liu J,Qi J,Kang J

    更新日期:2017-03-01 00:00:00

  • Predictors of surgical complications and evaluation of outcomes after surgical correction of adult-acquired buried penis.

    abstract:OBJECTIVE:To determine predictors for surgical complications and assess patient satisfaction after surgical treatment of Adult-Acquired Buried Penis (AABP). METHODS:A retrospective review was performed on all patients diagnosed with AABP who underwent surgical treatment at a single institution from January 2013-Decemb...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-019-02347-3

    authors: Aubé M,Chua M,DeLong J,McCammon K,Tonkin J,Gilbert D,Virasoro R

    更新日期:2020-04-01 00:00:00

  • The lack of correlation between mast cells and microvessel density with pathologic feature of renal cell carcinoma.

    abstract:OBJECTIVE:The growth of solid tumors requires angiogenesis. Evidence indicates that mast cells (MCs) play an important role in tumor angiogenesis but results are not definitive. The aim of this study is to investigate the possible effects of angiogenesis and the presence of MCs on the prognosis of renal cell carcinoma ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-009-9577-2

    authors: Mohseni MG,Mohammadi A,Heshmat AS,Kosari F,Meysamie AP

    更新日期:2010-03-01 00:00:00

  • Results of operative treatment of Fraley's syndrome.

    abstract::Relying on their own observations, the authors describe nine patients in whom Fraley's syndrome was diagnosed and treated operatively. In six of them, calycopyeloneostomy was performed. In three of the patients, because of complications, the upper pole of the kidney was excised together with the changed calyx. In nonc...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02082129

    authors: Fryczkowski M,Zaluczkowski K,Kobierska-Szczepaánska A,Rawski W

    更新日期:1978-01-01 00:00:00

  • Kidney injury molecule-1, a sensitive and specific marker for identifying acute proximal tubular injury, can be used to predict renal functional recovery in native renal biopsies.

    abstract::Kidney injury molecule-1 (KIM-1) staining has been shown to be very useful in identifying acute proximal tubular injury, but its sensitivity, specificity and predicting values for the recovery of renal function after injury in renal biopsies have not been well established. In the first study, we randomly selected 184 ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-019-02311-1

    authors: Yin W,Kumar T,Lai Z,Zeng X,Kanaan HD,Li W,Zhang PL

    更新日期:2019-12-01 00:00:00

  • Chronic glomerulonephritis with massive IgA deposits.

    abstract::A total of 234 patients with chronic glomerulonephritis, detected on the basis of clinical, immunological and pathomorphological criteria, have been examined. A group of 23 chronic glomerulonephritis patients with massive deposits of immunoglobulin A found by immunofluorescent examination, has been separated on the ba...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02085414

    authors: Steciwko A,Szewczyk Z,Letachowicz W,Steciwko M

    更新日期:1985-01-01 00:00:00

  • Urolithiasis in northeast Bombay: seasonal prevalence and chemical composition of stones.

    abstract::The seasonal prevalence of urinary calculus disease from the records of L.T. Municipal General Hospital, Sion, Bombay, which primarily caters services to poor people of Northeast Bombay, especially Dharavi slum area, is reported. The qualitative and quantitative compositions of stones collected from the patients of Dh...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02549827

    authors: Hussain F,Billimoria FR,Singh PP

    更新日期:1990-01-01 00:00:00

  • Vaginoplasty and creating labia minora in children with disorders of sex development.

    abstract:PURPOSE:To report current results of vaginoplasty using the mucosa of the prepuce, and creating labia minora by penile skin in children with disorders of sex development (DSD). METHODS:In 10 years, we have performed 22 vaginoplasties using the described technique of vaginoplasty, 21 patients with 46, XX DSD and 1 ovot...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-018-2058-8

    authors: Acimi S,Bessahraoui M,Acimi MA,Abderrahmane N,Debbous L

    更新日期:2019-03-01 00:00:00

  • Hematologic abnormalities following renal transplantation.

    abstract::Recipients of renal allografts are surviving longer and, consequently, may experience a variety of complications related not only to the transplanted kidney, but also to the hematopoietic system. Common hematologic complications in the renal transplant patient include abnormalities of one cell line, such as post-trans...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s11255-009-9558-5

    authors: Marinella MA

    更新日期:2010-03-01 00:00:00

  • The changing pattern of renal tuberculosis.

    abstract::The authors present a series of 2,173 patients with renal tuberculosis seen between 1950 and 1979. This is group 1, serving only to show the incidence of renal tuberculosis during the antibiotic era. The fact is that the incidence of renal tuberculosis is going down slightly but constantly in the last years because th...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02082596

    authors: Petković S,Sumarac Z,Petronić V,Marković V

    更新日期:1986-01-01 00:00:00

  • Effects of combined treatment of tadalafil and tamsulosin on bladder dysfunction via the inhibition of afferent nerve activities in a rat model of bladder outlet obstruction.

    abstract:PURPOSE:To investigate the effects of combined treatment of tadalafil (a phosphodiesterase-5 inhibitor) and tamsulosin (an α1-adrenoceptor antagonist) on bladder dysfunction in a rat model of bladder outlet obstruction (BOO). METHODS:Cystometry was performed in conscious female BOO rats 6 weeks after partially ligatio...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-018-1835-8

    authors: Furuta A,Suzuki Y,Igarashi T,Koike Y,Egawa S,Yoshimura N

    更新日期:2018-05-01 00:00:00

  • Does metabolic syndrome increase the risk of infective complications after prostate biopsy? A critical evaluation.

    abstract:PURPOSE:To evaluate the possible association between metabolic syndrome (MetS) and infectious complications after prostate biopsy. METHODS:A total of 480 men underwent prostatic biopsy due to elevated prostate-specific antigen levels and/or abnormal digital rectal examination. Patients were divided into two subgroups ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-014-0904-x

    authors: Sahin C,Eryildirim B,Cetinel AC,Faydaci G,Narter F,Goktas C,Sarica K

    更新日期:2015-03-01 00:00:00

  • The relation between nutrition indices and age in patients on continuous ambulatory peritoneal dialysis receiving similar small solute clearances.

    abstract:OBJECTIVE:To analyze the effect of age on nutrition indices in subjects on the same continuous ambulatory peritoneal dialysis (CAPD) schedule. METHODS:We analyzed 613 sets of clearance values and nutrition indices in 302 CAPD patients. Small solute clearances included urea clearance (Kt/Vurea) and creatinine clearance...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1023/a:1017579105158

    authors: Tzamaloukas AH,Oreopoulos DG,Murata GH,Servilla K,Rao P,Din S,Malhotra D

    更新日期:2001-01-01 00:00:00

  • Glomerular filtration rate is related to severity of obstructive coronary artery disease in patients undergoing coronary angiography.

    abstract:PURPOSE:Chronic kidney disease is independently associated with an increased risk of cardiovascular events; however, the relationship between the glomerular filtration rate (GFR) and coronary artery disease (CAD) in patients undergoing coronary angiography has yet to be fully elucidated. METHODS:This retrospective stu...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-011-0070-3

    authors: Davoodi G,Mehrabi Pari S,Rezvanfard M,Sheikh Fathollahi M,Amini M,Hakki E,Kazemisaeid A,Yaminisharif A

    更新日期:2012-08-01 00:00:00

  • Enzymatic evaluation of renal damage caused by different therapeutic procedures for kidney stone disease.

    abstract::In an attempt to evaluate renal injury relative to open surgery, percutaneous nephrolithotripsy (PCN) and extracorporeal shock wave lithotripsy (ESWL) were studied in 52 patients with renal calculus disease. Preoperative and postoperative urinary levels of N-acetyl-glycosaminidase (NAG), a sensitive marker of renal tu...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02552130

    authors: Sakkas G,Becopoulos T,Karayannis A,Drossos G,Giannopoulou K

    更新日期:1995-01-01 00:00:00

  • Comparison of screening of vesicoureteral reflux with renal ultrasound and voiding cystourethrography.

    abstract:PURPOSE:To suggest a different method for diagnosing vesicoureteral reflux (VUR) in lieu of voiding cystourethrography (VCU), in order to prevent radiation exposure. MATERIALS AND METHODS:Fifty-two ureterorenal units of 26 patients were evaluated ultrasonographically for visualizing the renal collecting systems, both ...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02550307

    authors: Balbay MD,Ozsan O,Ozbek E,Ozkan S,Güneş A

    更新日期:1998-01-01 00:00:00

  • Serum neuron specific enolase: can it be a tumour marker for renal cell carcinoma?

    abstract::Neuron specific enolase (NSE) is an isoenzyme of the glycolytic enzyme enolase. It is not only a marker for all types of neurons but also for all neuroendocrine or paraneuronal cells and various malignant tumours, even of non-neuroendocrine types. We had studied serum NSE in 25 consecutive patients with renal cell car...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02550862

    authors: Yaman O,Baltaci S,Arikan N,Ozdiler E,Göğüş O,Müftüoğlu YZ

    更新日期:1996-01-01 00:00:00

  • Hepatitis C virus related lymphoproliferative disorder in a renal transplant recipient.

    abstract::Posttransplant lymphoproliferative disorders (PTLD) are commonly caused by Ebstein-Barr Virus infection. The role of hepatitis C virus (HCV) in the genesis of lymphomas has been recognized recently. We report a HCV infected renal transplant recipient who developed PTLD 11 months after transplantation. Reduction of imm...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/s11255-006-0050-1

    authors: Aravindan AN,Moger V,Sakhuja V,Kohli HS,Varma N,Jha V

    更新日期:2006-01-01 00:00:00

  • Morbidity of flank incision in 100 renal donors.

    abstract:OBJECTIVE:The purpose of this study is to determine the morbidity of lumbotomy incision used in the last 100 living related donor nephrectomies retrospectively. METHODS:Since March 1991, 100 donor nephrectomies were made to living donors with lumbar incision. Incisions made in lateral decubitus position, subcostally o...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1023/a:1015000328796

    authors: Bayazit Y,Aridoğan IA,Tansuğ Z,Unsal I,Erken U

    更新日期:2001-01-01 00:00:00

  • Diagnosis of urethral strictures: is retrograde urethrography still necessary?

    abstract::Different methods are available in the diagnosis and treatment of urethral strictures. True diagnosis is necessary for choosing the most suitable method of treatment and to inform the patient about the method, complications, recurrence rate and costs. In this study we aimed to compare the efficiency, complications and...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02550731

    authors: Bircan MK,Sahin H,Korkmaz K

    更新日期:1996-01-01 00:00:00

  • Stepwise shock wave lithotripsy: results of initial study for the treatment of urinary stones in childhood.

    abstract:OBJECTIVE:To assess the effectiveness of stepwise extracorporeal shock wave lithotripsy in the treatment of upper urinary stones in childhood. PATIENTS AND METHODS:Between August 1998 and August 2003, 31 patients were treated for renal or ureteric stones. All treatments were performed with Dornier Compact Delta lithot...

    journal_title:International urology and nephrology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11255-005-4971-x

    authors: Demirci D,Altiok E,Gülmez I,Ekmekçioğlu O,Poyrazoğlu HM

    更新日期:2006-01-01 00:00:00

  • Neurofibromatosis of the bladder.

    abstract::Neurofibromatosis of the urinary tract is estimated to account for 20 per cent of the visceral manifestations of the generalized disease. Among its urological forms involvement of the bladder is the most common. Clinically, neurofibromatosis resembles a tumour, therefore, its early histologic diagnosis is of utmost im...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02089403

    authors: Merksz M,Tóth J,Király L

    更新日期:1985-01-01 00:00:00

  • Osteoporosis in the elderly with chronic kidney disease.

    abstract::Considering the aging dialysis population of today, increasing our knowledge about the nature, diagnosis and the treatment of bone mineral density (BMD) problems in end-stage renal disease (ESRD) patients deserves more attention. Osteoporosis is basicly defined as a decrease in bone mass. Large epidemiological studies...

    journal_title:International urology and nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s11255-006-9109-2

    authors: Ersoy FF

    更新日期:2007-01-01 00:00:00

  • Wilms' tumour in adults. Review of 10 cases.

    abstract::Nephroblastoma (Wilms' tumour) is very rarely found in adult patients. We report on 10 cases to demonstrate the diagnostic and therapeutic problems. In case of flank pain, large tumour mass, fast tumour growth and young age, the possibility of Wilms' tumour should be taken into consideration even in adult patients. Th...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02550952

    authors: Winter P,Vahlensieck W Jr,Miersch WD,Vogel J,Gokel JM,Hellerich U

    更新日期:1996-01-01 00:00:00

  • Failure of artificial insemination of husband's semen in the treatment of male infertility.

    abstract::In the management of infertility, in case semen quality is found insufficient and could not be improved by medical means, handling the available spermatozoa in the most beneficial way has been aimed. Thus, artificial insemination with low quality semen has become a therapeutic alternative. In this study homologous art...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02550148

    authors: Aydin S,Inci O,Alagöl B,Hüseyin I,Kaya E,Dellaloğlu G

    更新日期:1996-01-01 00:00:00

  • Cyproterone acetate monotherapy in advanced prostatic carcinoma.

    abstract::Cyproterone acetate was given as monotherapy to 18 patients with advanced prostatic carcinoma at a weekly dose of 300 mg. Progression was observed in all of the patients; median time to progression was 35 months and median survival time was 48 months. Partial response, stabilization, progression and exitus rates by ye...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02551344

    authors: Kayigil O,Atahan O,Metin A

    更新日期:1997-01-01 00:00:00

  • The effect of uraemic "middle-sized molecules" on T lymphocyte functions.

    abstract::The activity of the leucocyte inhibitory factor (LIF) stimulated with Concanavalin A was examined in chronic uraemic, haemodialysed patients. It was found that the LIF activity decreased in chronic uraemic patients as compared with the normal controls. The absolute T lymphocyte count and active E rosette formation als...

    journal_title:International urology and nephrology

    pub_type: 杂志文章

    doi:10.1007/BF02082475

    authors: Kálmán K,Löcsey L,Hauck M,Leövey A

    更新日期:1980-01-01 00:00:00