Abstract:
:Insulin resistance is characterized by the systemic impairment of insulin action and is usually the result of aging, obesity, chronic inflammation, or another factor that may contribute to the inhibition of the insulin signaling pathway. Insulin resistance is accompanied by defects in lipid metabolism and blood coagulation, hypertension, obesity, and vascular inflammation in a syndrome called syndrome X or metabolic syndrome. Metabolic syndrome is involved in the development of atherosclerosis with consequent cardiovascular complications including acute myocardial infarction, stroke, and vascular disease. Recent data have shown that vitamin D acts as a negative regulator of the renin gene and that vitamin D deficiency is followed by increased renin-angiotensin II expression. The link between the insulin signaling pathway/insulin resistance and the renin-angiotensin system has been well documented in previous studies. The present review focuses on disorders characterized by a reduction in vitamin D concentration or its receptor function and the development of insulin resistance or metabolic syndrome, and discusses also possible therapeutic interventions.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Rammos G,Tseke P,Ziakka Sdoi
10.1007/s11255-007-9244-4subject
Has Abstractpub_date
2008-01-01 00:00:00pages
419-26issue
2eissn
0301-1623issn
1573-2584journal_volume
40pub_type
杂志文章,评审abstract:BACKGROUND:There is evidence that chronic local ischemia may be one possible etiology of prostatic atrophy (PA). Our aim was to study the expression of hypoxia induced factors in areas of PA. DESIGN:The immunohistochemical expression of hypoxia-inducible factor-1 alpha (HIF-1) and vascular endothelial growth factor (V...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-6657-4
更新日期:2006-01-01 00:00:00
abstract::A male with a severe form of congenital nephrogenic diabetes insipidus (diuresis 10 l per day) had megaureters, megavesica, large residuum and a history of three traumatic ruptures of the megavesica and a recurrent urinary tract infection (RUTI). Hemodialysis was introduced at 41 years of age. At age of 42, he underwe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-0093-3
更新日期:2006-01-01 00:00:00
abstract::Immunosuppressed recipients of organ transplants have a higher incidence of carcinoma than the general population. A retrospective analysis was made at the Department of Urology of Bonn University, investigating 236 renal allograft recipients as to the incidence of neoplasms before and after transplantation. Eleven pa...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552189
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Symptomatic urachal remnants are rare benign anomalies affecting young adults. For these patients, both curative treatment and acceptable postoperative aesthetic outcomes are important. Here, we describe a novel transumbilical approach, using Y-shaped incisions and three-flap umbilicoplasty techniques, to impro...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1678-8
更新日期:2017-11-01 00:00:00
abstract::Relationships between plasma testosterone levels and selected parameters of lipid metabolism were studied in a group of young sterile males prior to, during, and after hormone therapy. Initial hypertriacylglycerolaemia and decreased concentrations of HDL cholesterol returned to normal values after 30 days of methyltes...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549731
更新日期:1991-01-01 00:00:00
abstract::Posterior urethral valves are usually detected during infancy by prenatal sonography. Less is known about presentation and outcome in older patients. We are describing a patient who presented with renal stones and was found incidentally on cystoscopy to have Type I urethral valves. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000020294.84579.a4
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To survey long-term outcomes of dialysis patients with urothelial cancers who have undergone complete urinary tract exenteration (bilateral nephroureterectomy and cystectomy). METHODS:We retrospectively reviewed our patients with urinary tract urothelial cancer. Forty-two dialysis patients who underwent comple...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1522-1
更新日期:2017-04-01 00:00:00
abstract::We report a 40-year-old lady who presented with severe headaches, persistent microscopic haematuria and hypertension requiring anti-hypertensive medication. Investigations for secondary hypertension were all normal except for a CT scan. This indicated a complex cystic lesion, measuring 2.4 x 5 x 10 cms , arising from ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9085-6
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The numbers of older people on haemodialysis is rising. As aging and renal failure are risk factors for autonomic failure and haemodialysis involves significant fluid shifts we hypothesized that older patients would be susceptible to hypotensive events between dialysis sessions. Postural hypotension is a ris...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000022866.07751.4a
更新日期:2003-01-01 00:00:00
abstract::A study was carried out to verify the clinical usefulness of the elaborated method for the measurement of antistreptococcal antibody in revealing the streptococcal etiology of glomerulonephritis. In 158 patients with glomerulonephritis antistreptococcal antibody (ASA), circulating immune complexes (CIC) and haemolytic...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082387
更新日期:1982-01-01 00:00:00
abstract:AIM:In this prospective study, we aimed to determine the coagulation parameters in the patients with Fournier's gangrene. METHODS:The study group is consisted of 12 consecutive Fournier's gangrene patients (11 men and 1 woman) and control group is consisted of patients with periurethral abscess (n = 2), scrotal absces...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-8437-y
更新日期:2005-01-01 00:00:00
abstract::Renal osteodystrophy, a frequent complication of chronic renal failure, is usually assessed by periodic X-rays of bone which are both poorly reproducible and expensive. Seeking a better screening test for osteodystrophy, we evaluated the usefulness of serum alkaline phosphatase as a predictor of bone disease and of hy...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085384
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Undescended testis is a common problem, which is prevalent in 3 % of male infants. This study aimed to determine the effect of leaving the deep inguinal ring (DIR) without closure during laparoscopic orchiopexy (LO), with regard to post-operative hernia formation and other outcomes. METHODS:From 2012 to 201...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1438-1
更新日期:2017-01-01 00:00:00
abstract::Cyproterone acetate was given as monotherapy to 18 patients with advanced prostatic carcinoma at a weekly dose of 300 mg. Progression was observed in all of the patients; median time to progression was 35 months and median survival time was 48 months. Partial response, stabilization, progression and exitus rates by ye...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551344
更新日期:1997-01-01 00:00:00
abstract::El-Far and Sobh were the first to describe abnormalities in porphyrin metabolism in Egyptian patients with chronic renal failure (CRF). Our results were confirmed by others. The present investigation aims to study and discuss the nature of those abnormalities and changes in porphyrin metabolism in CRF patients followi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02583996
更新日期:1991-01-01 00:00:00
abstract::Relying on their own observations, the authors describe nine patients in whom Fraley's syndrome was diagnosed and treated operatively. In six of them, calycopyeloneostomy was performed. In three of the patients, because of complications, the upper pole of the kidney was excised together with the changed calyx. In nonc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082129
更新日期:1978-01-01 00:00:00
abstract::Idiopathic Localised Bladder Amyloidosis is a rare cause of haematuria and urinary tract symptoms. A review of the literature highlights the varied presentations and the appropriate investigations for this condition, with emphasise on the exclusion of a secondary cause. In addition, the range of treatment options is f...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1023/a:1021302827755
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Previous studies on the association between extracorporeal shock wave lithotripsy (SWL) and new onset hypertension have only illustrated contradictory results. In order to illustrate the association between SWL and new onset hypertension, a meta-analysis of case-control and cohort studies was conducted. METH...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-013-0588-7
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Some studies have found that prostate cancer (PCa) screening provides little or no change in PCa-related mortality during the 7-10 years following diagnoses. However, most men are diagnosed with PCa at low-stage disease and die of unrelated causes during this period. Men diagnosed at stage IV are at much high...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9799-3
更新日期:2011-06-01 00:00:00
abstract::A case of Itai-itai (ouch-ouch) disease with reduced urinary kallikrein excretion and slightly enhanced renin-angiotensin-aldosterone system is described. Although it is well known that cadmium toxicity frequently affects the renal tubular lesions, this report is the first to demonstrate the impaired urine concentrati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550809
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Vesicoureteral reflux (VUR) is the most common congenital urinary tract abnormality in children. The objective of this study was to evaluate the diagnostic value of urine neutrophil gelatinase-associated lipocalin (NGAL) in children with primary vesicoureteral reflux (VUR). MATERIALS AND METHODS:A total of ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02355-3
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:So far, studies have not clearly identified infectious agents as an etiological factor for interstitial cystitis (IC). Specific microbiological diagnosis for detecting the pathogen with higher sensitivity in IC may decrease the treatment costs and increase psychosocial health of the patients. METHODS:A prospec...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02248-5
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:Anastomotic stricture (AS) is a well-described complication of radical retropubic prostatectomy (RRP) despite all the refinements in surgical technique. We aimed to define and discuss the role of postoperative urinary drainage on AS development. PATIENTS AND METHODS:A total of 136 patients with localized pr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9309-4
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To compare the performance of prostate-specific antigen (PSA) density in the diagnosis of prostate cancer in obese and non-obese Chinese men. METHODS:The results of transrectal ultrasound-guided (TRUS) prostate biopsies of Chinese men with PSA <20 ng/mL were reviewed. Parameters including age, body mass index ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0826-7
更新日期:2014-12-01 00:00:00
abstract::In an attempt to evaluate renal injury relative to open surgery, percutaneous nephrolithotripsy (PCN) and extracorporeal shock wave lithotripsy (ESWL) were studied in 52 patients with renal calculus disease. Preoperative and postoperative urinary levels of N-acetyl-glycosaminidase (NAG), a sensitive marker of renal tu...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552130
更新日期:1995-01-01 00:00:00
abstract::A clinical study was designed to investigate whether extracorporeal shock waves altered the urinary excretion of glycosaminoglycans and if they have a diagnostic value in determining the extent of the renal tissue damage. A total of 25 consecutive patients were treated for renal stone by extracorporeal shock wave lith...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To investigate the effect of intradialytic resistance exercise on inflammation markers and sarcopenia indices in maintenance hemodialysis (MHD) patients with sarcopenia. METHODS:Forty-one MHD patients with sarcopenia were divided into an intervention group (group E, n = 21) and a control group (group C, n = 20...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-019-02200-7
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:Progression of the cell cycle is regulated by the interactions of cyclins, cyclin dependent kinases (CDKs) and CDK inhibitors (CDKIs). p27 is a member of the universal cyclin-dependent kinase inhibitor family. The level of p27 protein expression decreases during tumor development and progression in some epit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000020301.39181.03
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To investigate the value of proliferating cell nuclear antigen (PCNA), Ki-67 antigen labelling indices and nucleolar organizer region (NOR) score in relation to histological grade, stage, recurrence and progression of the bladder tumor. MATERIALS AND METHODS:Tissue specimens from 77 bladder cancer patients ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014452902976
更新日期:2002-01-01 00:00:00
abstract::Gleason score has been identified as an important variable to predict disease extent and biologic behaviour of prostate cancer. However, the correlation between Gleason score of needle biopsy and surgical specimen is often poor. We studied 72 patients who underwent needle biopsy and radical prostatectomy to correlate ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550548
更新日期:1998-01-01 00:00:00