Validity of urine neutrophile gelatinase-associated lipocalin in children with primary vesicoureteral reflux.

Abstract:

BACKGROUND:Vesicoureteral reflux (VUR) is the most common congenital urinary tract abnormality in children. The objective of this study was to evaluate the diagnostic value of urine neutrophil gelatinase-associated lipocalin (NGAL) in children with primary vesicoureteral reflux (VUR). MATERIALS AND METHODS:A total of 69 patients were evaluated in 2 groups with (32) and without (37) VUR. Patients with secondary VUR, infectious or inflammatory disorders, obstructive uropathies, and acute or chronic kidney disease were excluded. Urine NGAL level was measured by ELISA kit. RESULTS:Mean age of children with VUR was 36.84 ± 28.16, compared to those without VUR 32.32 ± 29.08, with no significant difference (p = 0.51). Mean urine NGAL (p = 0.012) and urine NGAL/Cr (p = 0.003) were higher in patients with VUR. In addition, urine NGAL/Cr increased significantly in patients with decreased parenchymal function, compared to those with normal DMSA scan. Using the cutoff value of 0.888, urine NGAL had 84% sensitivity and 81% specificity for diagnosis of VUR. Based on AUC (0.86), urine NGAL had acceptable diagnostic accuracy in children with VUR. CONCLUSION:The results of this study support the evidence that urine NGAL/Cr is a sensitive, specific and accurate biomarker for diagnosis of children with primary VUR.

journal_name

Int Urol Nephrol

authors

Nickavar A,Valavi E,Safaeian B,Moosavian M

doi

10.1007/s11255-019-02355-3

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

599-602

issue

4

eissn

0301-1623

issn

1573-2584

pii

10.1007/s11255-019-02355-3

journal_volume

52

pub_type

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