当前位置： SCI文献检索 > JOURNAL OF ENDODONTICS期刊下所有文献 > Can apical periodontitis modify systemic levels of inflammatory markers? A systematic review and meta-analysis.

Can apical periodontitis modify systemic levels of inflammatory markers? A systematic review and meta-analysis.

Abstract：

INTRODUCTION:This systematic review and meta-analysis investigated evidence to support whether apical periodontitis (AP) can modify the systemic levels of inflammatory markers (IM) in humans. METHODS:The MEDLINE, Embase, Cochrane, and PubMed databases were searched between 1948 and 2012, with no language restriction. Additionally, the bibliography of all relevant articles and textbooks were manually searched. Based on inclusion and exclusion criteria, 2 reviewers independently rated the quality of each study based on the Newcastle-Ottawa Scale. The primary outcome variable for meta-analysis was determined by the serum levels of IMs in AP subjects versus healthy controls or in AP subjects before versus after treatment intervention. RESULTS:Among the 531 initially identified articles, 20 comprised the final analysis. Thirty-one different IMs were analyzed, with immunoglobulin (Ig) A, IgM, IgG, and C-reactive protein (CRP) being the most commonly investigated. CRP, interleukin (IL)-1, IL-2, IL-6, asymmetrical dimethylarginine, IgA, IgG, and IgM were shown to be increased in patients with AP compared with controls in most studies. Meta-analyses showed that serum levels of IgA (P = .001), IgG (P = .04), and IgM (P < .00001) were increased in humans with AP compared with healthy controls and serum levels of CRP, IgA, IgE, IgG, and IgM were not significantly different between patients with AP before and after treatment (P > .05). CONCLUSIONS:Available evidence is limited but consistent, suggesting that AP is associated with increased levels of CRP, IL-1, IL-2, IL-6, asymmetrical dimethylarginine, IgA, IgG, and IgM in humans. These findings suggest that AP may contribute to a systemic immune response not confined to the localized lesion, potentially leading to increased systemic inflammation.

journal_name

J Endod

journal_title

Journal of endodontics

authors

Gomes MS,Blattner TC,Sant'Ana Filho M,Grecca FS,Hugo FN,Fouad AF,Reynolds MA

doi

10.1016/j.joen.2013.06.014

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

1205-17

issue

10

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(13)00551-7

journal_volume

39

pub_type

杂志文章,meta分析,评审

相关文献

JOURNAL OF ENDODONTICS文献大全
  • Long-term seal provided by some root-end filling materials.

    abstract：:A tight and long-lasting seal of root-end fillings is of prime clinical importance. A hundred standard bovine root sections, each 3 mm high and with a central pulp lumen of 2.6 mm in diameter, were filled with five commonly used or potential root-end filling materials. At 24 h, or at 3, 6, or 12 months after filling, ...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/S0099-2399(98)80077-0

    authors： Wu MK,Kontakiotis EG,Wesselink PR

    更新日期：1998-08-01 00:00:00

  • Regulation of matrix metalloproteinase-2 production by cytokines and pharmacological agents in human pulp cell cultures.

    abstract：:Type IV matrix metalloproteinases (MMPs) are members of the family of MMPs and are thought to play an important role in degradation of extracellular components. Human pulp cells can secrete and produce these enzymes. Recent evidence shows that MMPs may play a role in pulpal inflammation. To date little is known regard...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1097/00004770-200111000-00007

    authors： Chang YC,Yang SF,Hsieh YS

    更新日期：2001-11-01 00:00:00

  • The Antimicrobial Peptide LL-37 as a Possible Adjunct for the Proliferation and Differentiation of Dental Pulp Stem Cells.

    abstract：INTRODUCTION:This study evaluated the biocompatibility of 5 and 10 μg/mL LL-37 in vitro and its effect on the differentiation of human dental pulp stem cells (DPSCs) into odontoblast-like cells. METHODS:Cell viability, genotoxicity, nitric oxide production, cell cycle, dentine sialophosphoprotein (DSPP) production, an...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2017.08.010

    authors： Milhan NVM,de Barros PP,de Lima Zutin EA,de Oliveira FE,Camargo CHR,Camargo SEA

    更新日期：2017-12-01 00:00:00

  • Effect of sodium fluorosilicate on the properties of Portland cement.

    abstract：INTRODUCTION:Mineral trioxide aggregate (MTA) satisfies most of the ideal properties of a surgical root-end filling and perforation repair material. It has been found to be nontoxic, noncarcinogenic, nongenotoxic, biocompatible, insoluble in tissue fluids, and dimensionally stable and promotes cementogenesis. The major...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2012.03.013

    authors： Appelbaum KS,Stewart JT,Hartwell GR

    更新日期：2012-07-01 00:00:00

  • Is a volume of 3.6 mL better than 1.8 mL for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis?

    abstract：INTRODUCTION:The purpose of this retrospective study was to determine the success of the inferior alveolar nerve (IAN) block using either 3.6 mL or 1.8 mL 2% lidocaine with 1:100,000 epinephrine in patients presenting with symptomatic irreversible pulpitis. METHODS:As part of 7 previously published studies, 319 emerge...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2013.04.007

    authors： Fowler S,Reader A

    更新日期：2013-08-01 00:00:00

  • Interleukin-8 is increased in gingival crevicular fluid from patients with acute pulpitis.

    abstract：:Irreversibly inflamed pulp (IIP) constitutes both a pathophysiologic and a diagnostic challenge. Gingival crevicular fluid (GCF) samples were obtained with Periopaper strips from IIP and adjacent and contralateral teeth for interleukin-8 (CXCL8) and tumor necrosis factor-alpha (TNF-alpha) measurements. Pain intensity ...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2007.10.022

    authors： Karapanou V,Kempuraj D,Theoharides TC

    更新日期：2008-02-01 00:00:00

  • Cytokine analysis in lesions refractory to endodontic treatment.

    abstract：INTRODUCTION:Failure in endodontic treatment is often caused by the persistence of microorganisms in the root canal after therapy. When treatment fails, an immune response develops that is characterized by an extensive network of immunologic mechanisms that lead to the production of cytokines and chemokines. METHODS:T...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2011.08.007

    authors： Henriques LC,de Brito LC,Tavares WL,Vieira LQ,Ribeiro Sobrinho AP

    更新日期：2011-12-01 00:00:00

  • Leakage associated with single or multiple increment backfill with the Obtura II gutta-percha system.

    abstract：:The purpose of this in vitro study was to compare dye leakage between canals backfilled in a single increment and canals backfilled in multiple increments using the Obtura II system with two different sealers. Sixty extracted single canal teeth were decoronated, cleaned, and shaped. After master cone fit and placement...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/S0099-2399(99)80320-3

    authors： Johnson BT,Bond MS

    更新日期：1999-09-01 00:00:00

  • Evaluation of ultrasonic and sonic instruments for intraradicular post removal.

    abstract：:Ultrasonic instruments are a valuable asset for removing intraradicular posts from root canals before nonsurgical endodontic therapy. The purpose of this study was to evaluate the relative efficacy of post removal by ultrasonic and sonic devices. Fifty extracted teeth were instrumented and obturated. The canals were p...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/S0099-2399(06)80044-0

    authors： Buoncristiani J,Seto BG,Caputo AA

    更新日期：1994-10-01 00:00:00

  • MMP9 deficiency increased the size of experimentally induced apical periodontitis.

    abstract：INTRODUCTION:Apical periodontitis is an inflammation and destruction of periapical tissues. Matrix metalloproteinase-9 (MMP-9) is thought to be involved in periapical lesion formation and progression. The aim of this study was to evaluate the lesion progression in MMP-9 knockout (KO) mice compared with that in control ...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2014.01.003

    authors： Wan C,Yuan G,Yang J,Sun Q,Zhang L,Zhang J,Zhang L,Chen Z

    更新日期：2014-05-01 00:00:00

  • Success and Survival of Endodontically Treated Cracked Teeth with Radicular Extensions: A 2- to 4-year Prospective Cohort.

    abstract：INTRODUCTION:There are no long-term, prospective clinical studies assessing outcomes of endodontically treated cracked teeth with radicular extensions. The purpose of this prospective study was to examine the 2- to 4-year success and survival rates of endodontically treated, coronally restored, cracked teeth, specifica...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2019.03.015

    authors： Davis MC,Shariff SS

    更新日期：2019-07-01 00:00:00

  • Assessment of the Influence of Different Intracanal Materials on the Detection of Root Fracture in Birooted Teeth by Cone-beam Computed Tomography.

    abstract：INTRODUCTION:The aim of this study was to assess 2 cone-beam computed tomographic systems on the detection of artificially induced vertical root fractures (VRFs) and artifact intensity using birooted teeth restored with different intracanal materials. METHODS:The sample consisted of 20 extracted birooted premolars. Ro...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2019.10.028

    authors： Marinho Vieira LE,Diniz de Lima E,Peixoto LR,Oliveira Pinto MG,Sousa Melo SL,Oliveira ML,Rovaris Silva K,Bento PM,Pita de Melo D

    更新日期：2020-02-01 00:00:00

  • Mineral trioxide aggregate as repair material for furcal perforation: case series.

    abstract：:The purpose of treating furcal perforation is to seal the artificial communication between the endodontic space and the periradicular tissue to prevent alveolar bone resorption and damage to the periodontal ligament. These complications are not infrequent in cases of furcal and/or old perforations, which show a worse ...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2008.05.019

    authors： Pace R,Giuliani V,Pagavino G

    更新日期：2008-09-01 00:00:00

  • Effects of parathyroid hormone, 1,25-dihydroxyvitamin D3, and prostaglandin E2 on alkaline phosphatase activity in cultured dental pulp and gingiva cells of bovine calf.

    abstract：:The effects of parathyroid hormone (PTH), 1,25-dihydroxyvitamin D3, and prostaglandin E2 (PGE2) on alkaline phosphatase activity on cultured dental pulp and gingiva cells of bovine calf were compared. In pulp cells, PTH, 1,25-dihydroxyvitamin D3, and PGE2 significantly increased alkaline phosphatase activity, but no i...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/s0099-2399(06)82009-1

    authors： Kido J,Ishida H,Nagata T,Hamasaki A,Nishikawa S,Wakano Y

    更新日期：1991-04-01 00:00:00

  • Antimicrobial Efficacy of Chlorhexidine and Sodium Hypochlorite in Root Canal Disinfection: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

    abstract：INTRODUCTION:We aimed to compare the antimicrobial efficacy of chlorhexidine (CHX) and sodium hypochlorite (NaOCl), 2 irrigants routinely used in root canal therapy of permanent teeth. METHODS:Electronic databases, including PubMed, EMBASE, Web of Science, and Cochrane Library, were searched for randomized controlled ...

    journal_title：Journal of endodontics

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.joen.2020.05.002

    authors： Ruksakiet K,Hanák L,Farkas N,Hegyi P,Sadaeng W,Czumbel LM,Sang-Ngoen T,Garami A,Mikó A,Varga G,Lohinai Z

    更新日期：2020-08-01 00:00:00

  • Interfacial Characterization of Dentin Conditioned with Chitosan Hydroxyapatite Precursor Nanocomplexes Using Time-of-flight Secondary Ion Mass Spectrometry.

    abstract：INTRODUCTION:The purpose of this study was to evaluate the effect of chitosan-hydroxyapatite precursor (C-HA) nanocomplex conditioning on the chemical modifications at the tricalcium silicate sealer-dentin interface using time-of-flight secondary ion mass spectrometry. METHODS:Dentin slabs from human premolar root den...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2019.08.011

    authors： Hashmi A,Sodhi RNS,Kishen A

    更新日期：2019-12-01 00:00:00

  • Vascular architecture of cat pulp using corrosive resin cast under scanning electron, microscopy.

    abstract：:Vascular casts of cat premolar pulps in various stages of growth were made by injection of low-viscosity resin into the pulpal blood vessels. Examination under a scanning electron microscope revealed that, in the young pulp, the main arterioles ascend in the center of the pulp and venules run along the side of the roo...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/s0099-2399(89)80028-7

    authors： Kishi Y,Shimozato N,Takahashi K

    更新日期：1989-10-01 00:00:00

  • Disinfecting and Shaping Type I C-shaped Root Canals: A Correlative Micro-computed Tomographic and Molecular Microbiology Study.

    abstract：INTRODUCTION:This ex vivo study compared the disinfection and shaping abilities of 2 preparation protocols in C-shaped canals. METHODS:Mandibular second molars with type I C-shaped canals were pair matched based on micro-computed tomographic (micro-CT) analysis and distributed into 2 groups. The canals were contaminat...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2020.11.007

    authors： Gazzaneo I,Amoroso-Silva P,Pacheco-Yanes J,Alves FRF,Marceliano-Alves M,Olivares P,Meto A,Mdala I,Siqueira JF Jr,Rôças IN

    更新日期：2020-11-18 00:00:00

  • Gingival squamous cell carcinoma mimicking a dentoalveolar abscess: report of a case.

    abstract：:Because of its close proximity to teeth and periodontium, gingival squamous cell carcinoma (SCC) can sometimes mimic tooth-related benign inflammatory conditions, resulting in misdiagnosis. In this study we report a case of gingival SCC that mimicked a dentoalveolar abscess of endodontic origin in its early presentati...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2006.08.005

    authors： Lee JJ,Cheng SJ,Lin SK,Chiang CP,Yu CH,Kok SH

    更新日期：2007-02-01 00:00:00

  • Endodontic retreatment: an online study guide.

    abstract：:The Editorial Board of the Journal of Endodontics has developed a literature-based study guide of topical areas related to endodontics. This study guide is intended to give the reader a focused review of the essential endodontic literature and does not cite all possible articles related to each topic. Although citing ...

    journal_title：Journal of endodontics

    pub_type： 杂志文章,评审

    doi：10.1016/j.joen.2007.08.012

    authors： JOE Editorial Board.

    更新日期：2008-05-01 00:00:00

  • Prevalence of Middle Mesial Canals and Isthmi in the Mesial Root of Mandibular Molars: An In Vivo Cone-beam Computed Tomographic Study.

    abstract：INTRODUCTION:Many studies have investigated the morphology of the mandibular molar, but the prevalence of the middle mesial (MM) canal in the mesial root of the mandibular molar is still the subject of controversy. In addition, in previous literature, a true MM canal has not been clearly distinguished from an isthmus b...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2017.02.008

    authors： Tahmasbi M,Jalali P,Nair MK,Barghan S,Nair UP

    更新日期：2017-07-01 00:00:00

  • The effect of age on bacterial penetration of radicular dentin.

    abstract：:The aim of this study was to determine the effects of patient's age on the prevalence and depth of bacterial penetration inside dentinal tubules. Fifty-six single-rooted teeth were divided in two groups based on the patient's age: young (ages 18-25) and old (age >or=60). Teeth were instrumented and inoculated with a s...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2008.10.004

    authors： Kakoli P,Nandakumar R,Romberg E,Arola D,Fouad AF

    更新日期：2009-01-01 00:00:00

  • Inflammatory Myofibroblastic Tumor Mimicking Apical Periodontitis.

    abstract：:Inflammatory myofibroblastic tumors (IMTs) are rare. IMTs of the head and neck occur in all age groups, from neonates to old age, with the highest incidence occurring in childhood and early adulthood. An IMT has been defined as a histologically distinctive lesion of uncertain behavior. This article describes an unusua...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2015.09.006

    authors： Adachi M,Kiho K,Sekine G,Ohta T,Matsubara M,Yoshida T,Katsumata A,Tanuma J,Sumitomo S

    更新日期：2015-12-01 00:00:00

  • A 5 yr clinical investigation of second mesiobuccal canals in endodontically treated and retreated maxillary molars.

    abstract：:An examination of 5616 endodontically treated and retreated maxillary first and second molars was made in an attempt to determine the percentage of MB2 canals that could be located routinely, and evaluate if there were any significant differences between initial treatments and retreatments. The teeth examined were 357...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1097/01.don.0000140581.38492.8b

    authors： Wolcott J,Ishley D,Kennedy W,Johnson S,Minnich S,Meyers J

    更新日期：2005-04-01 00:00:00

  • DIAGNOdent laser fluorescence assessment of endodontic infection.

    abstract：INTRODUCTION:Real-time assessment of the microbial status of the root canal system would be useful in clinical endodontic practice for determining endpoints of biomechanical treatment. This laboratory study used an existing laser fluorescence device, the DIAGNOdent (KaVo, Biberach, Germany), in a proof-of-concept study...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2009.07.006

    authors： Sainsbury AL,Bird PS,Walsh LJ

    更新日期：2009-10-01 00:00:00

  • In vitro cytotoxicity evaluation of a self-adhesive, methacrylate resin-based root canal sealer.

    abstract：:This study compared the cytotoxicity of MetaSEAL (Parkell Inc, Farmington, NY), a methacrylate resin-based sealer with an epoxy resin-based (AH Plus Jet; Dentsply Caulk, Milford, DE) and a zinc oxide-eugenol-based sealer (Pulp Canal Sealer; SybronEndo, Orange, CA). Five-millimeter diameter disks prepared from the resp...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2008.06.020

    authors： Pinna L,Brackett MG,Lockwood PE,Huffman BP,Mai S,Cotti E,Dettori C,Pashley DH,Tay FR

    更新日期：2008-09-01 00:00:00

  • Treatment of a mandibular molar with perforating internal resorption.

    abstract：:A case is presented in which a previous partial root canal treatment on a mandibular molar developed internal resorption of the distal canal. The case was followed at the University of Oklahoma student clinic and endodontic treatment completed in the mesial canals, with calcium hydroxide placed in the distal canal for...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1097/00004770-200107000-00010

    authors： Benenati FW

    更新日期：2001-07-01 00:00:00

  • The effect of newly developed root canal sealers on rat dental pulp cells in primary culture.

    abstract：:Cytotoxicity was compared between new root canal sealers (New A, New B, and New B-2) and conventional root canal sealers (AH26, Diaket, Canals, Tubi-Seal, and Sealapex). Dental pulp cells of rats, obtained through primary cell culture, were used. In the experiments with the freshly prepared sealers, the incorporation ...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/S0099-2399(89)80109-8

    authors： Matsumoto K,Inoue K,Matsumoto A

    更新日期：1989-02-01 00:00:00

  • Cross-sectional configuration of endodontic files compared with manufacturers' design.

    abstract：:The cross-sectional configuration of seven files at coronal and apical levels were compared with diagrams presented by manufacturers. The presence of cutting edges was also examined. Ground-twisted (K-file, K-Reamer, and K-flex) and machined files (Flex-R, Unifile, S-file, and Hedstrom) were included in #10, #25, and ...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/S0099-2399(06)81111-8

    authors： D'Souza JE,Walton RE,Maixner D

    更新日期：1995-12-01 00:00:00

  • Effect of modified nonequilibrium plasma with chlorhexidine digluconate against endodontic biofilms in vitro.

    abstract：INTRODUCTION:Nonequilibrium plasma has been reported to effectively kill Enterococcus faecalis in endodontic biofilm compared with chlorhexidine digluconate (CHX). The purpose of this study was to evaluate the antimicrobial in vitro activity of modified nonequilibrium plasma with CHX against E. faecalis and multispecie...

    journal_title：Journal of endodontics

    pub_type： 杂志文章

    doi：10.1016/j.joen.2013.06.027

    authors： Du T,Shi Q,Shen Y,Cao Y,Ma J,Lu X,Xiong Z,Haapasalo M

    更新日期：2013-11-01 00:00:00