Thinking outside the liver: induced pluripotent stem cells for hepatic applications.

abstract：AIM:To construct a noninvasive assessment model consisting of routine laboratory data to predict significant fibrosis and cirrhosis in patients with chronic hepatitis B (CHB). METHODS:A total of 137 consecutive patients with CHB who underwent percutaneous liver biopsy were retrospectively analyzed. These patients were...

journal_title：World journal of gastroenterology

authors： Zhang YX,Wu WJ,Zhang YZ,Feng YL,Zhou XX,Pan Q

更新日期：2008-12-14 00:00:00

abstract：AIM:To construct tree models for classification of diffuse large B-cell lymphomas (DLBCL) by chromosome copy numbers, to compare them with cDNA microarray classification, and to explore models of multi-gene, multi-step and multi-pathway processes of DLBCL tumorigenesis. METHODS:Maximum-weight branching and distance-ba...

journal_title：World journal of gastroenterology

authors： Jiang HY,Huang ZX,Zhang XF,Desper R,Zhao T

更新日期：2007-03-21 00:00:00

abstract：AIM:To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS:Using a reverse-transcriptase polymerase chain reaction (RT-PCR), Cx 26, Cx 32 and Cx 43 mRNAs were determined in the liver tissues of 15 controls and in HCC ...

journal_title：World journal of gastroenterology

authors： Sheen IS,Jeng KS,Wang PC,Shih SC,Chang WH,Wang HY,Chen CC,Shyung LR

更新日期：2004-10-01 00:00:00

abstract：AIM:To establish an ideal implantable rat liver tumor model for interventional therapy study and examine its angiographic signs and MRI, CT features before and after embolization. METHODS:Forty male Wistar rats were implanted with Walker-256 tumor in the left lateral lobe of liver. Digital subtraction angiography (DSA...

journal_title：World journal of gastroenterology

authors： Li X,Zheng CS,Feng GS,Zhuo CK,Zhao JG,Liu X

更新日期：2002-12-01 00:00:00

abstract：AIM:To prospectively investigate the effectiveness and patient's tolerance of two low-cost bowel cleansing preparation protocols based on magnesium citrate only or the combination of magnesium citrate and senna. METHODS:A total of 342 patients who were referred for colonoscopy underwent a colon cleansing protocol with...

journal_title：World journal of gastroenterology

authors： Vradelis S,Kalaitzakis E,Sharifi Y,Buchel O,Keshav S,Chapman RW,Braden B

更新日期：2009-04-14 00:00:00

abstract：AIM:To investigate the hepatoprotective effect of manual acupuncture at Yanglingquan (GB34) on CCl4-induced chronic liver damage in rats. METHODS:Rats were injected intraperitoneally with CCl4 (1 mL/kg) and treated with manual acupuncture using reinforcing manipulation techniques at left GB34 (Yanglingquan) 3 times a ...

journal_title：World journal of gastroenterology

authors： Yim YK,Lee H,Hong KE,Kim YI,Lee BR,Kim TH,Yi JY

更新日期：2006-04-14 00:00:00

abstract：:Interferon (IFN) therapy is the only treatment strategy for hepatitis C virus (HCV) infection after liver transplantation (LT), but prophylactic and treatable IFN therapy after LT has been shown to be insufficient due to the adverse effects of IFN and rivabirin. In this paper, we describe the disappearance of HCV afte...

journal_title：World journal of gastroenterology

authors： Ichikawa T,Nakao K,Hamasaki K,Honda T,Shibata H,Akahoshi M,Eguchi S,Takatsuki M,Kanematsu T,Eguchi K

更新日期：2007-08-14 00:00:00

abstract：:The prognosis of patients with HCC still remains dismal. The life expectancy of HCC patients is hard to predict because of the high possibility of postoperative recurrence. Many factors, such as patient's general conditions, macroscopic tumor morphology, as well as tumor histopathology features, have been proven of pr...

journal_title：World journal of gastroenterology

authors： Qin LX,Tang ZY

更新日期：2002-04-01 00:00:00

abstract：:AIM:To discuss the effect of surgical procedures on the prognosis of patients of bile duct cancer and their indications.METHODS:A retrospective analysis was made for 52 cases of hepatoportal bile duct cancer treated from January 1991 to December 1996. All the cases were classified according to the modified Bismuth-Cor...

journal_title：World journal of gastroenterology

authors： He XS,Huang JF,Liang LJ,Lu MD,Cao XH

更新日期：1999-04-01 00:00:00

abstract：AIM:To investigate the distribution pathway of metastatic lymph nodes in gastric carcinoma as a foundation for rational lymphadenectomy. METHODS:We investigated 173 cases with solitary or single station metastatic lymph nodes (LN) from among 2476 gastric carcinoma patients. The location of metastatic LN, histological ...

journal_title：World journal of gastroenterology

authors： Liu CG,Lu P,Lu Y,Jin F,Xu HM,Wang SB,Chen JQ

更新日期：2007-09-21 00:00:00

abstract：AIM:To evaluate the efficacy and the safety of combined 5-Fluorouracil, irinotecan, bevacizumab and sirolimus in refractory advanced colorectal carcinoma. METHODS:We initiated a regimen with at day 1 an injection (iv) of bevacizumab at 5 mg/kg, followed by 180 mg/m(2) irinotecan, followed by Leucovorin 400 mg/m(2), fo...

journal_title：World journal of gastroenterology

authors： Ghiringhelli F,Guiu B,Chauffert B,Ladoire S

更新日期：2009-09-14 00:00:00

abstract：AIM:Growth factors (GF) that participate in regeneration and apoptosis have an important role in chronic liver diseases. We analyzed serum GF concentration during antiviral treatment and correlated it with morphological liver failure in chronic hepatitis C. METHODS:The levels of GF were determined in sera by ELISA met...

journal_title：World journal of gastroenterology

authors： Anatol P,Robert F,Danuta P

更新日期：2005-03-28 00:00:00

abstract：AIM:To evaluate the inhibition effect of HCV NS5A on p53 transactivation on p21 promoter and explore its possible mechanism for influencing p53 function. METHODS:p53 function of transactivation on p21 promoter was studied with a luciferase reporter system in which the luciferase gene is driven by p21 promoter, and the...

journal_title：World journal of gastroenterology

authors： Gong GZ,Jiang YF,He Y,Lai LY,Zhu YH,Su XS

更新日期：2004-08-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is still the most common cause of hepatocellular carcinoma and liver cirrhosis world wide. Recently, however, there has been quite dramatic improvement in the understanding of HBV associated liver disease and its treatment. It has become clear that high viral replication is a major ri...

journal_title：World journal of gastroenterology

authors： Tillmann HL

更新日期：2007-01-07 00:00:00

abstract：AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by en...

journal_title：World journal of gastroenterology

authors： Ishihara R,Kanzaki H,Iishi H,Nagai K,Matsui F,Yamashina T,Matsuura N,Ito T,Fujii M,Yamamoto S,Hanaoka N,Takeuchi Y,Higashino K,Uedo N,Tatsuta M,Tomita Y,Ishiguro S

更新日期：2013-07-21 00:00:00

abstract：AIM:To investigate the mechanisms of aspirin increasing the susceptibility of Helicobacter pylori (H pylori) to metronidazole. METHODS:H pylori reference strain 26695 and two metronidazole-resistant isolates of H pylori were included in this study. Strains were incubated in Brucella broth with or without aspirin (1 mm...

journal_title：World journal of gastroenterology

authors： Zhang XP,Wang WH,Tian Y,Gao W,Li J

更新日期：2009-02-28 00:00:00

abstract：AIM:To identify the actual clinical management and associated factors of delayed perforation after gastric endoscopic submucosal dissection (ESD). METHODS:A total of 4943 early gastric cancer (EGC) patients underwent ESD at our hospital between January 1999 and June 2012. We retrospectively assessed the actual managem...

journal_title：World journal of gastroenterology

authors： Suzuki H,Oda I,Sekiguchi M,Abe S,Nonaka S,Yoshinaga S,Nakajima T,Saito Y

更新日期：2015-11-28 00:00:00

abstract：:Despite advances in the management of patients with locally advanced, non-metastatic rectal adenocarcinoma (LARC), prognosis remains largely unsatisfactory due to a high rate of distant relapse. In fact, currently available neoadjuvant protocols, represented by fluoropyrimidine-based chemo-radiotherapy (CT-RT) or shor...

journal_title：World journal of gastroenterology

authors： Fornaro L,Caparello C,Vivaldi C,Rotella V,Musettini G,Falcone A,Baldini E,Masi G

更新日期：2014-05-28 00:00:00

abstract：AIM:To investigate whether hepatitis B virus (HBV) infection activates DNA damage response and DNA repair cofactors inhibit HBV infection and replication. METHODS:Human hepatocyte cell line HL7702 was studied. Immunoblotting was performed to test the expression of ataxia telangiectasia-mutated (ATM)-Rad3-related prote...

journal_title：World journal of gastroenterology

authors： Zhao F,Hou NB,Song T,He X,Zheng ZR,Ma QJ,Li L,Zhang YH,Zhong H

更新日期：2008-08-28 00:00:00

abstract：:Several hundred species of bacteria inhabit the gut, and affect its cell biology, morphology and homeostasis. Many bacteria are however potential pathogens, especially if the integrity of the epithelial barrier is physically or functionally breached. Conversely, the interaction between host and commensal microbes can ...

journal_title：World journal of gastroenterology

authors： Limdi JK,O'Neill C,McLaughlin J

更新日期：2006-09-14 00:00:00

abstract：:An appendiceal neurofibroma (ANF) is a rare neoplasm associated with neurofibromatosis type 1(NF-1), an inheritable neurocutaneous disorder that involves multiple systems including the intraabdominal organs. Appendiceal diverticulitis occasionally ruptures in the absence of intense abdominal pain, which can lead to se...

journal_title：World journal of gastroenterology

authors： Ozaki A,Tsukada M,Watanabe K,Tsubokura M,Kato S,Tanimoto T,Kami M,Ohira H,Kanazawa Y

更新日期：2015-09-07 00:00:00

abstract：AIM:To investigate the role of nuclear division cycle (NDC)80 in human hepatocellular carcinogenesis. METHODS:NDC80 gene expression was analyzed by real-time reverse transcription polymerase chain reaction in 47 paired hepatocellular carcinoma (HCC) and adjacent tissues. The HCC cell line SMMC-7721 was transfected wit...

journal_title：World journal of gastroenterology

authors： Ju LL,Chen L,Li JH,Wang YF,Lu RJ,Bian ZL,Shao JG

更新日期：2017-05-28 00:00:00

abstract：AIM:To investigate the effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. METHODS:Fifteen samples of autoantibodies against beta(1)-adrenoceptor positive sera of patients with hepatitis virus myocarditis were obtained and IgGs were puri...

journal_title：World journal of gastroenterology

authors： Liu K,Liao YH,Wang ZH,Li SL,Wang M,Zeng LL,Tang M

更新日期：2004-04-15 00:00:00

abstract：AIM:To study the role of Twist gene in gastric cancer by gene silencing, including the potential of induction of apoptosis, cell cycle arrest, and proliferation inhibition in human malignant gastric SGC7901 cells. METHODS:The expression level of Twist in gastric cancer samples was measured by immunohistochemistry. The...

journal_title：World journal of gastroenterology

authors： Zhang H,Gong J,Kong D,Liu HY

更新日期：2015-03-14 00:00:00

abstract：:Hepatocellular carcinoma (HCC), the fifth most common cancer in the world, shows increasing incidence worldwide. Curative treatments such as hepatectomy, liver transplantation, and radiofrequency ablation are applied in only 30%-60% of cases. Most remaining patients receive transarterial chemoembolization (TACE). Pati...

journal_title：World journal of gastroenterology

authors： Yamakado K,Hirota S

更新日期：2015-10-07 00:00:00

abstract：:Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions are well established biological events which have an important role in not just normal tissue and organ development, but in the pathogenesis of diseases. Increasing evidence has established their presence in the human colon during colorectal carcinoge...

journal_title：World journal of gastroenterology

authors： Sipos F,Galamb O

更新日期：2012-02-21 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a critical risk factor for the carcinogenesis and progression of hepatocellular carcinoma (HCC). It promotes HCC development by inducing liver fibrogenesis, genetic and epigenetic alterations, and the expression of active viral-coded proteins. Effective antiviral treatments...

journal_title：World journal of gastroenterology

authors： Zhang YQ,Guo JS

更新日期：2015-04-07 00:00:00

abstract：AIM:To evaluate the prognosis of type II diabetes mellitus (T2DM) after gastrectomy and related factors in gastric cancer patients. METHODS:403 gastric cancer patients with T2DM were studied, who underwent gastrectomy between May 2003 and September 2009. A review of medical records and telephone interviews was perform...

journal_title：World journal of gastroenterology

authors： Kim JW,Cheong JH,Hyung WJ,Choi SH,Noh SH

更新日期：2012-01-07 00:00:00

abstract：AIM:Tumor angiogenesis has been shown to be promoted by vascular endothelial growth factor (VEGF) via stimulating endothelial cell proliferation, migration, and survival. Blockade of VEGF signaling by different means has been demonstrated to result in reduced tumor growth and suppression of tumor angiogenesis in distin...

journal_title：World journal of gastroenterology

authors： Schmitz V,Kornek M,Hilbert T,Dzienisowicz C,Raskopf E,Rabe C,Sauerbruch T,Qian C,Caselmann WH

更新日期：2005-07-28 00:00:00

abstract：AIM:To describe cases of gut perforation after orthotopic liver transplantation. METHODS:Data were collected from our center database and medical records. Six of 187 patients (3.2%) who underwent orthotopic liver transplantation from January to December 2005 developed gut perforation. All patients were male with an av...

journal_title：World journal of gastroenterology

authors： Xiong J,You S,He XS

更新日期：2007-04-14 00:00:00