Double-blind, placebo-controlled, dose-ranging study of new recombinant hypoallergenic Bet v 1 in an environmental exposure chamber.

abstract：:Two hundred and seventy patients with asthma and/or rhinitis (162 or 60% allergic, 108 or 40% non-allergic) were studied for sinus pathology by means of standard X-rays and tomograms. Sinus pathology was defined as abnormal sinus X-rays, either on standard or tomography. Fifty-four percent of the X-rays were classifie...

journal_title：Allergy

authors： De Cleyn KM,Kersschot EA,De Clerck LS,Ortmanns PM,De Schepper AM,Van Bever HP,Stevens WJ

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Multiple drug hypersensitivity syndrome (MDH) is used to describe persons with a drug hypersensitivity reaction (DHR) to at least two chemically unrelated drugs, confirmed by skin test or in vitro assay. METHODS:Medical records of 25 patients with MDH, tested and confirmed at our allergy division, were retr...

journal_title：Allergy

authors： Jörg L,Yerly D,Helbling A,Pichler W

更新日期：2020-05-01 00:00:00

abstract：:The phenotypes and receptors of the intraepithelial lymphocytes which are a major component of the mucosal immune system are of considerable interest. Intraepithelial lymphocytes, especially those of the intestines, are well documented. The nasal intraepithelial lymphocytes probably play a key role in the immune defen...

journal_title：Allergy

authors： Pawankar R,Okuda M

更新日期：1993-02-01 00:00:00

abstract：:The atopy-predictive value of cord blood (CB) cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP-PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy u...

journal_title：Allergy

authors： Odelram H,Björkstén B,Chan SC,Hanifin JM,Kjellman NI

更新日期：1994-09-01 00:00:00

abstract：:Formoterol and salmeterol are 2 newly developed beta 2-adrenoceptor agonists for inhalation with prolonged duration of effect compared with currently available beta 2-agonists. The clinical duration of effect has been suggested to be correlated to a decreased washability in vitro, i.e. decreased effect due to continuo...

journal_title：Allergy

authors： Ullman A,Bergendal A,Lindén A,Waldeck B,Skoogh BE,Löfdahl CG

更新日期：1992-08-01 00:00:00

abstract：:The diagnosis of food IgE-dependent hypersensitivity is based on the demonstration of specific IgE, completed by provocation tests. Two immunoenzymatic techniques, the Phadezym and the FAST, are compared with the Phadebas RAST, in 86 sera (23 controls, 28 from patients with a reported food allergy and 35 with a positi...

journal_title：Allergy

authors： Moneret-Vautrin DA,Gueant JL,Abdel-Ghani A,Maria Y,Nicolas JP

更新日期：1990-02-01 00:00:00

abstract：:The prevalence and specificity of naturally occurring human IgA anti-IgE autoantibodies (a-E Ab) were studied by ELISA with anti-IgA monoclonal antibodies (mAb) and a purified myeloma IgE as solid-phase protein, i.e., IgE-DES(kappa). Such detected IgA a-E Ab were common among adults, and significantly increased geomet...

journal_title：Allergy

authors： Magnusson CG

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The capacity of inflammatory cells to adhere involves an array of adhesion molecules, and is critical to the inflammatory responses seen in childhood asthma. We aimed to determine the changes of intercellular adhesion molecule-1 (ICAM-1) and L-selectin expressed on peripheral blood (PB) T lymphocytes and nat...

journal_title：Allergy

authors： Lin SJ,Chang LY,Yan DC,Huang YJ,Lin TJ,Lin TY

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Allergy is regarded as a multifactorial condition. Its onset and severity are influenced by both genetic and environmental factors. Identification of genetic factors involved in asthma development and related phenotypes is a major task in understanding the genetic background of asthma. The possible involveme...

journal_title：Allergy

authors： Shin HD,Kim LH,Park BL,Choi YH,Park HS,Hong SJ,Choi BW,Lee JH,Park CS

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Allergy to atracurium is a rare condition with serious consequences of diagnostic error. However, correct diagnosis is not always straightforward. The aim of this study is to assess the utility of the basophil activation test (BAT) in atracurium sensitization and to investigate its role in identifying cross-...

journal_title：Allergy

authors： Uyttebroek AP,Sabato V,Leysen J,Bridts CH,De Clerck LS,Ebo DG

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The importance and specific role(s) of eosinophils in modulating the immune/inflammatory phenotype of allergic pulmonary disease remain to be defined. Established animal models assessing the role(s) of eosinophils as contributors and/or causative agents of disease have relied on congenitally deficient mice w...

journal_title：Allergy

authors： Jacobsen EA,Lesuer WE,Willetts L,Zellner KR,Mazzolini K,Antonios N,Beck B,Protheroe C,Ochkur SI,Colbert D,Lacy P,Moqbel R,Appleton J,Lee NA,Lee JJ

更新日期：2014-03-01 00:00:00

abstract：:The relation between platelet counts (PCT) and IgE was studied in cord blood from 136 European newborns. PCT was significantly lower (P = 0.0014) when cord-IgE was superior to 1.20 IU/ml (n = 29; 245,000/microliter) than when it was inferior to this value (n = 107; 284,080/microliter) which resulted in a significant n...

journal_title：Allergy

authors： Magnusson CG,de Weck AL

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Quantitative ELISA kits used for the measurement of indoor allergens are time-consuming. Therefore, an immunodot assay (Dustscreen) has been introduced, so that results can be obtained within 4 h. In order to assess the potential applications of the new method, we compared quantitative ELISA methods and Dust...

journal_title：Allergy

authors： Lau S,Schulz G,Sommerfeld C,Wahn U

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Elevated levels of CD23, a natural regulator of IgE production, have been shown to decrease the signs of lung inflammation in mice. The aim of this study was to study the involvement of ADAM10, the primary CD23 sheddase, in experimental asthma. METHODS:ADAM10 was blocked either by using mice with a B-cell-s...

journal_title：Allergy

authors： Mathews JA,Ford J,Norton S,Kang D,Dellinger A,Gibb DR,Ford AQ,Massay H,Kepley CL,Scherle P,Keegan AD,Conrad DH

更新日期：2011-09-01 00:00:00

abstract：:The prevalence of chronic immune and metabolic disorders is increasing rapidly. In particular, inflammatory bowel diseases, obesity, diabetes, asthma and chronic obstructive pulmonary disease have become major healthcare and economic burdens worldwide. Recent advances in microbiome research have led to significant dis...

journal_title：Allergy

authors： Alemao CA,Budden KF,Gomez HM,Rehman SF,Marshall JE,Shukla SD,Donovan C,Forster SC,Yang IA,Keely S,Mann ER,El Omar EM,Belz GT,Hansbro PM

更新日期：2020-08-06 00:00:00

abstract：:It is suggested that eosinophils (Eos) play an important role in the pathogenesis of bronchial asthma by releasing cytotoxic cationic eosinophil granule proteins and damaging bronchial epithelial cells. However, the exact nature of the actual inducer of eosinophil degranulation in vivo is unclear. We examined eosinoph...

journal_title：Allergy

authors： Takafuji S,Tadokoro K,Ito K

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:As in vitro diagnosis of wasp venom sensitization by specific serum IgE has a sensitivity of only 60-80%, additional in vitro tests are desirable. Basophil activation is associated with the expression of CD63 and its measurement has been proposed as a novel in vitro test for immediate-type allergy. Furthermo...

journal_title：Allergy

authors： Erdmann SM,Sachs B,Kwiecien R,Moll-Slodowy S,Sauer I,Merk HF

更新日期：2004-10-01 00:00:00

abstract：:It is debatable whether beta 2-receptor agonists produce antiallergic effects in human airways. This question has been addressed in the present study by examination of both mast-cell indices and the physiologic response to allergen challenge in human nasal airways. Twelve asymptomatic patients with seasonal allergic r...

journal_title：Allergy

authors： Svensson C,Greiff L,Andersson M,Alkner U,Grönneberg R,Persson CG

更新日期：1995-11-01 00:00:00

abstract：:The possible dependence of the dual cutaneous reaction (DCR) on activation of the complement and coagulation systems was further elucidated. Heterologous whole anti-human IgE was injected intradermally (i.d.) on the volar aspect of the forearms of 17 drug-free healthy volunteers and venous samples for the selected lab...

journal_title：Allergy

authors： Grönneberg R

更新日期：1985-11-01 00:00:00

abstract：:House dust mite D. farinae and Der f II-specific IgG and IgG subclass responses were evaluated in 32 adults with perennial rhinitis undergoing immunotherapy for 1 year by means of IgG-RAST and ELISA. The ELISA method, which is based on subclass-specific monoclonal antibodies, could detect 0.5-1.5 ng/ml of specific ant...

journal_title：Allergy

authors： Einarsson R,Dreborg S,Hammarström L,Löfkvist T,Smith CI,Svensson G

更新日期：1992-04-01 00:00:00

abstract：:This multicentre, randomized, double-blind, parallel-group study was designed to compare the efficacy and tolerability of fluticasone propionate aqueous nasal spray 200 micrograms once daily (FPANS 200 micrograms od) with FPANS 200 micrograms twice daily (bd) in patients whose seasonal rhinitis symptoms were not compl...

journal_title：Allergy

authors： Pedersen B,Dahl R,Richards DH,Jacques LA,Larsen BB,Pichler W,Nykanen KN

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Anaphylaxis to insect venom (Hymenoptera) is most severe in patients with mastocytosis and may even lead to death. However, not all patients with mastocytosis suffer from anaphylaxis. The aim of the study was to analyze differences in gene expression between patients with indolent systemic mastocytosis (ISM)...

journal_title：Allergy

authors： Niedoszytko M,Bruinenberg M,van Doormaal JJ,de Monchy JG,Nedoszytko B,Koppelman GH,Nawijn MC,Wijmenga C,Jassem E,Elberink JN

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Venom immunotherapy (VIT) is regarded as an established and efficient treatment of Hymenoptera venom allergy. Different frequencies of side-effects have been reported in the literature, depending on the hyposensitization regimen (conventional outpatient programme, rush immunotherapy, ultra rush immunotherapy...

journal_title：Allergy

authors： Wenzel J,Meissner-Kraemer M,Bauer R,Bieber T,Gerdsen R

更新日期：2003-11-01 00:00:00

abstract：:A one-day intensive educational course on allergy and immunology theory and diagnostic procedure significantly increased the competency of allergy and immunology fellows-in-training. ...

journal_title：Allergy

authors： Elizalde A,Perez EE,Sriaroon P,Nguyen D,Lockey RF,Dorsey MJ

更新日期：2012-09-01 00:00:00

abstract：:Bronchial allergen challenge was performed on 12 allergic asthmatics during a stable phase of their disease. After resolution of the immediate bronchial response, fractional lung lavage was performed twice, two and 24 h post-challenge. The recovery of eosinophils, eosinophil cationic protein (ECP), eosinophil chemotac...

journal_title：Allergy

authors： Schmekel B,Venge P

更新日期：1993-01-01 00:00:00

abstract：:Two methods of relating daily pollen counts to patients' symptom scores in clinical trials of hyposensitisation in hay fever are described. The problems involved in comparing results from different centres and years of a trial are discussed with particular reference to symptoms which are not pollen related. The Normal...

journal_title：Allergy

authors： Wilkinson P,Taudorf E

更新日期：1984-08-01 00:00:00

abstract：:A double-blind parallel trial of astemizole, pheniramine and placebo was carried out in 51 patients with hay fever. Astemizole is a new potent H1-antihistamine with long duration of action but devoid of central activity. Evaluation criteria were daily symptom- and side effect score cards, daily nasal peak flow measure...

journal_title：Allergy

authors： Malmberg H,Holopainen E,Grahne B,Binder E,Savolainen S,Sundberg S

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:The reported association of allergy and sinusitis varies greatly between study, and the exact role of allergy in predisposing to sinusitis is not clear. We attempted to determine whether patients with perennial allergic rhinitis are at greater risk of developing sinusitis with respect to a control group, and...

journal_title：Allergy

authors： Berrettini S,Carabelli A,Sellari-Franceschini S,Bruschini L,Abruzzese A,Quartieri F,Sconosciuto F

更新日期：1999-03-01 00:00:00

abstract：:Quantiative immunoelectrophoresis used for the analysis of a dialysed, centrifuged and freeze-dried extract from cow hair and dander revealed 17 antigens. Five of these were identified as serum proteins. Partial identity to antigens of serum and extract from hair and dander of goat, sheep, swine, horse, dog, cat and g...

journal_title：Allergy

authors： Prahl P,Weeke B,Løwenstein H

更新日期：1978-10-01 00:00:00

abstract：:Effects of a thromboxane synthetase inhibitor (OKY-046) and a cyclooxygenase inhibitor (indomethacin) on bronchial hyperresponsiveness induced by subthreshold concentration of aerosolized thromboxane A2 analogue (STA2) were investigated in anesthetized, artificially ventilated guinea pigs in order to examine the role ...

journal_title：Allergy

authors： Saito M,Fujimura M,Sakamoto S,Miyake Y,Shintani H,Yasui M,Matsuda T

更新日期：1992-04-01 00:00:00