Abstract：
:Phosphorylation plays important roles in several processes including synaptic plasticity and memory. The critical role of extracellular signal-regulated kinase (ERK) in these processes is well established. ERK is activated in a sustained manner by different stimuli. However, the mechanisms of sustained ERK activation are not completely understood. Here we show that KCl depolarization-induced sustained ERK activation in the hippocampal slices is critically dependent on protein synthesis and transcription. In addition, the sustained ERK activation requires receptor tyrosine kinase(s) activity. In support of a role for a growth factor in sustained ERK activation, KCl depolarization enhances the level of brain-derived neurotrophic factor (BDNF). Furthermore, BDNF antibody blocks KCl-induced sustained ERK activation. These results suggest a positive feed-back loop in which depolarization-induced BDNF maintains ERK activation in the sustained phase.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Maharana C,Sharma KP,Sharma SKdoi
10.1038/srep01103subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1103issn
2045-2322journal_volume
3pub_type
杂志文章abstract：:Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(ω-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03861
更新日期：2014-01-24 00:00:00
abstract：:Detailed structural analyses of the mushroom body which plays critical roles in olfactory learning and memory revealed that it is directly connected with multiple primary sensory centers in Drosophila. Connectivity patterns between the mushroom body and primary sensory centers suggest that each mushroom body lobe proc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29481
更新日期：2016-07-11 00:00:00
abstract：:In plants, the shikimate pathway generally occurs in plastids and leads to the biosynthesis of aromatic amino acids. Chorismate synthase (CS) catalyses the last step of the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to chorismate, but the role of CS in the metabolism of higher plants has not been reported...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67671-6
更新日期：2020-07-02 00:00:00
abstract：:Known susceptibility loci together can only explain about 6-8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovered. We previously identified IgAN and systemic lupus erythematosus (SLE)/lupus nephritis (LN) shared many loci ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35781
更新日期：2016-11-02 00:00:00
abstract：:Bone marrow and adipose tissue represent the two most commonly exploited sources of adult mesenchymal stem cells for musculoskeletal applications. Unfortunately the sampling of bone marrow and fat tissue is invasive and does not always lead to a sufficient number of cells. The present study describes a novel sampling ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00803-7
更新日期：2017-04-06 00:00:00
abstract：:The objective of this study was to evaluate the clinical ability of Near-Infrared Light-Transillumination (NILT) for approximal dentinal caries detection and to compare with direct digital-radiography (DDR), as well as to determine whether the combination of both techniques improves the diagnostic capacity of the lesi...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-50850-5
更新日期：2019-10-02 00:00:00
abstract：:Ocean acidification and global warming have been shown to significantly affect the physiological performances of marine calcifiers; however, the underlying mechanisms remain poorly understood. In this study, the transcriptome and biomineralization responses of Pinctada fucata to elevated CO2 (pH 7.8 and pH 7.5) and te...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18943
更新日期：2016-01-06 00:00:00
abstract：:Quantifying how close two datasets are to each other is a common and necessary undertaking in scientific research. The Pearson product-moment correlation coefficient r is a widely used measure of the degree of linear dependence between two data series, but it gives no indication of how similar the values of these seri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19401
更新日期：2016-01-14 00:00:00
abstract：:Terrestrial plants typically take up nutrients through roots or mycorrhizae while freshwater plants additionally utilize leaves. Their nutrient uptake may be enhanced by root hairs whose occurrence is often negatively correlated with mycorrhizal colonization. Seagrasses utilize both leaves and roots and often form roo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28989-4
更新日期：2018-07-17 00:00:00
abstract：:Rice lines with slower starch digestibility provide opportunities in mitigating the global rise in type II diabetes and related non-communicable diseases. However, screening for low glycemic index (GI) in rice breeding programs is not possible due to time and cost constraints. This study evaluated the feasibility of u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06026-0
更新日期：2017-07-19 00:00:00
abstract：:Graphene aerogels (GAs) with high mechanical strength, tunable density and volume have been prepared only via soaking graphene hydrogels (GHs) in ammonia solution. The density and volume of the obtained GAs are controlled by adjusting the concentration of ammonia solution. Although volume of the GAs decreases with inc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05025
更新日期：2014-05-22 00:00:00
abstract：:Amphibian skin is rich in mucous glands and poison glands, secreting substances important for gas exchange and playing a fundamental role in chemical defense against predators and microorganisms. In the caecilian Siphonops annulatus (Mikan, 1920) we observed a concentration of enlarged mucous glands in the head region...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22005-5
更新日期：2018-02-23 00:00:00
abstract：:Sunflower see/ds (Helianthus annuus L.) were roasted in an electric forced air oven for 15, 30, 45, and 60 min at 125, 135 and 145 °C. The effect of temperature and time on the flavor profile of the samples were evaluated by headspace solid-phase microextraction coupled with gas chromatography-mass spectroscopy (HS-SP...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47811-3
更新日期：2019-08-05 00:00:00
abstract：:Optimal mental workload plays a key role in driving performance. Thus, driver-assisting systems that automatically adapt to a drivers current mental workload via brain-computer interfacing might greatly contribute to traffic safety. To design economic brain computer interfaces that do not compromise driver comfort, it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80477-w
更新日期：2021-01-12 00:00:00
abstract：:Both genetic and environmental factors are suggested to influence overweight and obesity risks. Although individual loci and genes have been frequently shown to be associated with body mass index (BMI), the overall interaction of these genes and their role in BMI remains underexplored. Data were collected in 90 health...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43881-5
更新日期：2019-05-15 00:00:00
abstract：:Streptococcus pneumoniae (pneumococcus) is a principal cause of bacterial middle ear infections, pneumonia, and meningitis. Capsule-targeted pneumococcal vaccines have likely contributed to increased carriage of nonencapsulated S. pneumoniae (NESp). Some NESp lineages are associated with highly efficient DNA uptake an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75988-5
更新日期：2020-11-03 00:00:00
abstract：:One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report he...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23009
更新日期：2016-03-11 00:00:00
abstract：:We conducted extensive molecular dynamics simulations to investigate the thermal conductivity of polycrystalline hexagonal boron-nitride (h-BN) films. To this aim, we constructed large atomistic models of polycrystalline h-BN sheets with random and uniform grain configuration. By performing equilibrium molecular dynam...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13228
更新日期：2015-08-19 00:00:00
abstract：:Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58548-9
更新日期：2020-02-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58752-7
更新日期：2020-01-30 00:00:00
abstract：:Rust fungi are plant pathogens that secrete an arsenal of effector proteins interfering with plant functions and promoting parasitic infection. Effectors are often species-specific, evolve rapidly, and display low sequence similarities with known proteins. How rust fungal effectors function in host cells remains elusi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53816-9
更新日期：2019-12-02 00:00:00
abstract：:The possibility of cluster radioactivity (CR) of the neutron-deficient nuclei in the trans-tin region is explored by using the effective liquid drop model (ELDM), generalized liquid drop model (GLDM), and several sets of analytic formulas. It is found that the minimal half-lives are at Nd = 50 (Nd is the neutron numbe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65585-x
更新日期：2020-06-04 00:00:00
abstract：:The protection of tropical forests is one of the most urgent issues in conservation biology because of the rapid deforestation that has occurred over the last 50 years. Even in protected forests, the anthropogenic effects from newly expanding villages such as harvesting of medicinal plants, pasturing cattle and forest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14689
更新日期：2015-10-05 00:00:00
abstract：:The present study aimed to evaluate the accuracy and repeatability of morphological contour interpolation (MCI)-based semiautomatic segmentation method for volumetric measurements of bone grafts around dental implants. Three in vitro (one with a cylinder and two with a geometrically complex form) and four ex vivo mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71651-1
更新日期：2020-09-10 00:00:00
abstract：:A novel protein, designated as DOI, isolated from the Chinese yam (Dioscorea opposita Thunb.) could be the first protein drug for the treatment of menopausal syndrome and an alternative to hormone replacement therapy (HRT), which is known to have undesirable side effects. DOI is an acid- and thermo-stable protein with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10179
更新日期：2015-07-10 00:00:00
abstract：:Insight refers to the sudden conscious shift in the perception of a situation following a period of unconscious processing. The present study aimed to investigate the implicit neural mechanisms underlying insight-based recognition, and to determine the association between these mechanisms and the extent of pupil dilat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25207-z
更新日期：2018-05-02 00:00:00
abstract：:Diffraction gratings are an essential optical component of high-power, short-pulse lasers. The maximum output of high-power pulsed lasers is always determined by laser resistance of gratings and this resistance is strongly dependent on the local near electric field intensity in the grating structure. We presented a no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22479-3
更新日期：2018-03-27 00:00:00
abstract：:Regional brain sizes of very-preterm infants at term-equivalent age differ from those of term-born peers, which have been linked with later cognitive impairments. However, dependence of regional brain volume loss on gestational age has not been studied in detail. To investigate the spatial pattern of brain growth in n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33995
更新日期：2016-09-23 00:00:00
abstract：:The physiological function of the pancreas is controlled by the circadian clock. The aim of this study was to determine whether aging-induced changes in glucose homeostasis affect properties of the circadian clock in the pancreas and/or its sensitivity to disturbances in environmental lighting conditions. mPer2Luc mic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30225-y
更新日期：2018-08-03 00:00:00
abstract：:The use of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) as a positron emission tomography (PET) tracer for brain tumor imaging might have some limitations because of the relatively low affinity for the L-type amino acid transporter 1 (LAT1). To assess the stereospecificity and evaluate the influence of aromatic ring m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40013-x
更新日期：2019-02-27 00:00:00
