当前位置： SCI文献检索 > INTENSIVE CARE MEDICINE期刊下所有文献 > Delayed cerebral thrombosis in bacterial meningitis: a prospective cohort study.

Delayed cerebral thrombosis in bacterial meningitis: a prospective cohort study.

Abstract：

PURPOSE:To study the incidence and clinical characteristics of delayed cerebral thrombosis in bacterial meningitis patients. METHODS:We assessed the incidence and clinical characteristics of delayed cerebral thrombosis in adults with cerebrospinal fluid (CSF) culture-proven community-acquired bacterial meningitis included in a prospective nationwide study in The Netherlands performed from 2006 to 2012. RESULTS:Delayed cerebral thrombosis occurred in 11 of 1,032 episodes (1.1%). CSF culture yielded Streptococcus pneumoniae in ten patients and Listeria monocytogenes in one. Adjunctive dexamethasone therapy was administered before or with the first dose of antibiotics in 9 of 11 patients; two patients were initially not treated with dexamethasone. All patients made good initial recovery, followed by sudden deterioration after 7-42 days. Cranial imaging studies showed multiple cerebral infarctions in all patients. The outcome was unfavorable in all but one patient. In an explorative analysis, patients with delayed cerebral thrombosis had eightfold higher complement C5a CSF concentrations on the diagnostic lumbar puncture as compared in those without delayed cerebral thrombosis (p = 0.04). CONCLUSION:Delayed cerebral thrombosis is a rare but devastating complication of bacterial meningitis. Adjunctive dexamethasone therapy seems to predispose patients with bacterial meningitis to this complication. We found some evidence that this thrombotic complication is associated with activation of the complement system.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Lucas MJ,Brouwer MC,van de Beek D

doi

10.1007/s00134-012-2792-9

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

866-71

issue

5

eissn

0342-4642

issn

1432-1238

journal_volume

39

pub_type

杂志文章

相关文献

INTENSIVE CARE MEDICINE文献大全
  • Lower respiratory rates without decreases in oxygen consumption during neonatal synchronized intermittent mandatory ventilation.

    abstract：OBJECTIVE:We tested the hypothesis that synchronization to patient effort during intermittent mandatory ventilation (SIMV), when compared to conventional unsynchronized intermittent mandatory ventilation (IMV), will decrease energy expenditure, as reflected by decreased oxygen consumption (VO2). DESIGN:We used a four-...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s001340050359

    authors： Smith KM,Wahlig TM,Bing DR,Georgieff MK,Boros SJ,Mammel MC

    更新日期：1997-04-01 00:00:00

  • Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease.

    abstract：OBJECTIVE:To characterize N-terminal pro-brain natriuretic peptide (N-proBNP) and troponin I (TnI) profile following mitral and/or aortic valve surgery and to evaluate correlations with echocardiography measures and outcome criteria. DESIGN AND SETTING:Prospective cross-controlled study in a university children's hosp...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-008-1025-8

    authors： Tissières P,da Cruz E,Habre W,Aggoun Y,Mensi N,Kalangos A,Beghetti M

    更新日期：2008-06-01 00:00:00

  • Interferon gamma in trauma-related infections.

    abstract：OBJECTIVE:The efficacy of interferon gamma therapy in reducing infection and improving outcome from infection in patients sustaining major injury was examined. DESIGN:Randomized double-blind placebo control trial SETTING:Nine level one university affiliated trauma centers in the United States. PATIENTS AND PARTICIPA...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF01743725

    authors： Dries DJ

    更新日期：1996-10-01 00:00:00

  • Quinine-induced disseminated intravascular coagulation: case report and review of the literature.

    abstract：OBJECTIVE:To describe the clinical course of quinine-induced disseminated intravascular coagulation (DIC) and review all previous cases reported in the medical literature. DESIGN:Case report/literature review. SETTING:University teaching hospital medical ICU. PATIENTS:One patient in whom thrombocytopenia, coagulopat...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00134-003-1732-0

    authors： Knower MT,Bowton DL,Owen J,Dunagan DP

    更新日期：2003-06-01 00:00:00

  • Effects of nicotinamide, an inhibitor of PARS activity, on gut and liver O2 exchange and energy metabolism during hyperdynamic porcine endotoxemia.

    abstract：OBJECTIVE:To investigate the effects of nicotinamide (NIC), an inhibitor of poly(ADP-ribose) synthetase (PARS), on intestinal and liver perfusion, O2 kinetics, and energy metabolism over 24 h of hyperdynamic porcine endotoxemia. DESIGN:Prospective, randomized, controlled experimental study with repeated measures. SET...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340000842

    authors： Theisen M,Träger K,Tugtekin I,Stehr A,Ploner F,Georgieff M,Radermacher P,Matĕjovic M

    更新日期：2001-03-01 00:00:00

  • Metabolic and respiratory effects of enteral nutrition in patients during mechanical ventilation.

    abstract：:The effect of enteral feeding on O2-consumption (VO2) and CO2-production (VCO2) was studied in 9 ventilator-dependent patients, who were in a stable condition without signs of hypermetabolism. Resting energy expenditure (REE) in postabsorptive state was assessed and enteral feeding was started by continuous drip (480 ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF00717989

    authors： van den Berg B,Stam H

    更新日期：1988-01-01 00:00:00

  • Meningococcal disease: a comparison of eight severity scores in 125 children.

    abstract：OBJECTIVE:To investigate the accuracy of eight different prognostic scores (Stiehm, Niklasson, Leclerc, Garlund, the MOC score, Tesero, the Glasgow Meningococcal Septicaemia Prognostic Score (GMSPS) and Tüyzüs) in the prediction of fatal outcome in meningococcal disease. DESIGN:Combined prospective and retrospective s...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01709565

    authors： Derkx HH,van den Hoek J,Redekop WK,Bijlmer RP,van Deventer SJ,Bossuyt PM

    更新日期：1996-12-01 00:00:00

  • Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients.

    abstract：OBJECTIVE:Although several advantages are attributed to tracheotomy in ICU patients requiring mechanical ventilation (MV), true benefits and the optimal timing of tracheotomy remain controversial. In this study, we compared early tracheotomy (ET) with prolonged intubation (PI) in severely ill patients requiring prolong...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00134-008-1195-4

    authors： Blot F,Similowski T,Trouillet JL,Chardon P,Korach JM,Costa MA,Journois D,Thiéry G,Fartoukh M,Pipien I,Bruder N,Orlikowski D,Tankere F,Durand-Zaleski I,Auboyer C,Nitenberg G,Holzapfel L,Tenaillon A,Chastre J,Laplanch

    更新日期：2008-10-01 00:00:00

  • Comparison of air tonometry with gastric tonometry using saline and other equilibrating fluids: an in vivo and in vitro study.

    abstract：OBJECTIVE:1) To compare saline gastric tonometry monitoring with air tonometry (Tonocap) in a group of general ICU patients. 2) An in vitro investigation of the performance of other fluids used in gastric tonometry and to assess the effects of variation of temperature and carbon dioxide concentration within the range e...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s001340050665

    authors： Barry B,Mallick A,Hartley G,Bodenham A,Vucevic M

    更新日期：1998-08-01 00:00:00

  • Inhaled nitric oxide for a severe respiratory syncytial virus infection in an infant with bronchopulmonary dysplasia.

    abstract：OBJECTIVE:To report the first case of ARDS in children treated with nitric oxide (NO) inhalation. METHODS:A 13-months infant presented with BPD and severe hypoxemia related to RSV infection and ARDS. Inhaled NO was delivered in the ventilatory circuit of a continuous flow ventilator (Babylog 8000, Dräger) in a concent...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01711907

    authors： Leclerc F,Riou Y,Martinot A,Storme L,Hue V,Flurin V,Deschildre A,Sadik A

    更新日期：1994-08-01 00:00:00

  • Evaluation by polymerase chain reaction of cytomegalovirus reactivation in intensive care patients under mechanical ventilation.

    abstract：OBJECTIVE:The study was undertaken to determine if critically ill patients under mechanical ventilation could reactivate latent cytomegalovirus (CMV) in either lung or blood. DESIGN:Prospective study in critically ill patients was performed in a multidisciplinary intensive care unit in a university hospital. PATIENTS...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01709343

    authors： Stéphan F,Méharzi D,Ricci S,Fajac A,Clergue F,Bernaudin JF

    更新日期：1996-11-01 00:00:00

  • The metrics of glycaemic control in critical care.

    abstract：INTRODUCTION:Trials of tight glucose control have compared measures of central tendency, such as average blood glucose, and yielded conflicting results. Other metrics, such as standard deviation, reflect different properties of glucose control and are also associated with changes in outcome. It is possible, therefore, ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-010-2103-2

    authors： Mackenzie IM,Whitehouse T,Nightingale PG

    更新日期：2011-03-01 00:00:00

  • International critical care hospital pharmacist activities.

    abstract：OBJECTIVE:The role of critical care pharmacists in the United States has recently been documented; however, little information exists about the role of international critical care pharmacists. The objective of this study was to describe the duties and activities of international pharmacists who practice in critical car...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-007-0918-2

    authors： LeBlanc JM,Seoane-Vazquez EC,Arbo TC,Dasta JF

    更新日期：2008-03-01 00:00:00

  • Patients' preferences concerning medical information and surrogacy: results of a prospective study in a French emergency department.

    abstract：OBJECTIVE:To study the wishes of a sample of French patients about medical information and surrogacy, at a time when the French Ministry of Health is supporting increased patient autonomy. DESIGN:A cohort of competent patients with non-critical illnesses or injuries completed an intention-to-act questionnaire on the a...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340050011

    authors： Roupie E,Santin A,Boulme R,Wartel JS,Lepage E,Lemaire F,Lejonc JL,Montagne O

    更新日期：2000-01-01 00:00:00

  • Auto-PEEP and dynamic hyperinflation in COPD patients during controlled mechanical ventilation and high frequency jet ventilation.

    abstract：:We investigated the levels of auto-PEEP and dynamic hyperinflation during high frequency jet ventilation (HFJV) and controlled mechanical ventilation (CMV) in six patients with chronic obstructive pulmonary disease within the first 36 h of acute exacerbation. The comparative evaluation was performed at similar conditi...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF02575298

    authors： Conti G,Bufi M,Rocco M,Calzecchi E,De Blasi RA,Antonelli M,Pelaia P,Gasparetto A

    更新日期：1990-01-01 00:00:00

  • Endotoxaemia in septic shock: clinical and post mortem correlations.

    abstract：:The Limulus amoebocyte lysate assay was used as one of a series of laboratory and clinical investigations on a group of 31 patients suffering from septic shock in order to assess the clinical significance of this assay for the detection of circulating endotoxin in clinical gram-negative sepsis. Four patients with card...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01772577

    authors： McCartney AC,Banks JG,Clements GB,Sleigh JD,Tehrani M,Ledingham IM

    更新日期：1983-01-01 00:00:00

  • Attitudinal patterns determining decision-making in the treatment of the elderly: a comparison between physicians and nurses in Germany and Sweden.

    abstract：OBJECTIVE:Do-not-resuscitate orders (DNR orders) and advance directives (AD) have been developed and their use by patients is increasing. The objective of the study was to evaluate the compliance with patient's wishes and doctors' and nurses' agreement on decision-making in the treatment of elderly patients from a cros...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340000602

    authors： Richter J,Eisemann MR

    更新日期：2000-09-01 00:00:00

  • The influence of labetalol on arterial blood gas data, pulmonary haemodynamics and pulmonary shunting.

    abstract：:The arterial oxygen and carbon dioxide tensions, pulmonary and systemic haemodynamics and pulmonary shunting and mechanics were measured during the first 30 min after intravenous labetalol administration. Thirty patients, recovering in the intensive care unit after neurosurgical interventions were randomly divided in ...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00255635

    authors： De Hert SG,Heytens LG,De Jongh RG,Vercauteren MP,Boeckx EA,Adriaensen HF

    更新日期：1988-01-01 00:00:00

  • Endotoxin immunity and the development of the systemic inflammatory response syndrome in critically ill children.

    abstract：BACKGROUND:The systemic inflammatory response syndrome (SIRS) may be triggered by endotoxin. Humans have antibodies directed against the core of endotoxin (endotoxin core antibodies, EndoCAb) that appear to be protective following surgery and in sepsis. We hypothesised that children with elevated antibodies to endotoxi...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-005-0019-z

    authors： Stephens RCM,Fidler K,Wilson P,Barclay GR,Mythen MG,Dixon GLJ,Turner MW,Klein NJ,Peters MJ

    更新日期：2006-02-01 00:00:00

  • Albumin bolus administration versus continuous infusion in critically ill hypoalbuminemic pediatric patients.

    abstract：OBJECTIVE:To test the hypothesis that the rate of degradation of exogenously administered albumin is faster with bolus administration than with continuous infusion and thus that a bolus administration is less efficacious in restoring blood albumin concentration (BAC) in the hypoalbuminemic critically ill pediatric pati...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01712175

    authors： Greissman A,Silver P,Nimkoff L,Sagy M

    更新日期：1996-05-01 00:00:00

  • Evaluation of the catheter positioning for neurally adjusted ventilatory assist.

    abstract：PURPOSE:During neurally adjusted ventilatory assist (NAVA) the ventilator is driven by the patients electrical activation of the diaphragm (EAdi), detected by a special esophageal catheter. A reliable positioning of the EAdi-catheter is mandatory to trace a representative EAdi signal. We aimed to determine whether a fo...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-009-1587-0

    authors： Barwing J,Ambold M,Linden N,Quintel M,Moerer O

    更新日期：2009-10-01 00:00:00

  • Rescue therapy with C1-esterase inhibitor concentrate after emergency coronary surgery for failed PTCA.

    abstract：:Administration of C1-esterase inhibitor (C1-INH) attenuates myocardial necrosis and sustains normal cardiac performance after myocardial ischemia and reperfusion in animal experiments. We report on our first experience of C1-INH application as rescue therapy in patients undergoing emergency surgical revascularization ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340050629

    authors： Bauernschmitt R,Böhrer H,Hagl S

    更新日期：1998-06-01 00:00:00

  • To-and-fro veno-venous extracorporeal lung assist for newborns with severe respiratory distress.

    abstract：:A veno-venous to-and-fro bypass method through a single blood access for extracorporeal lung assist with an artificial membrane lung is introduced. A premature newborn with severe respiratory distress was treated with this method. A 12 Fr. single lumen catheter with a spiral-embedded thin-wall, 0.25 mm in wall thickne...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF00271065

    authors： Tsuno K,Terasaki H,Tsutsumi R,Sadanaga M,Higashi K,Morioka T

    更新日期：1989-01-01 00:00:00

  • Correction to: Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review.

    abstract：:The article "Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review", written by Christian J. Wiedermann and Michael Joannidis, was originally published Online First without Open Access. ...

    journal_title：Intensive care medicine

    pub_type： 已发布勘误

    doi：10.1007/s00134-020-06269-y

    authors： Wiedermann CJ,Joannidis M

    更新日期：2020-10-14 00:00:00

  • In vitro validation of a novel method for continuous intra-abdominal pressure monitoring.

    abstract：OBJECTIVE:Intra-abdominal pressure (IAP) measurement is important in daily clinical practice. Most measurement techniques vary in automaticity and reproducibility. This study tested a new fully automated continuous technique for IAP measurement, the CiMON. METHODS:Three IAP measurement catheters (a Foley manometer and...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-007-0952-0

    authors： Malbrain ML,De laet I,Viaene D,Schoonheydt K,Dits H

    更新日期：2008-04-01 00:00:00

  • Research priorities in critical care medicine in the UK.

    abstract：OBJECTIVES:To establish priorities for research in critical care medicine in the UK using survey and nominal group (NG) techniques. DESIGN:The senior doctor and nurse from 325 intensive care units (ICUs) in the UK were invited to contribute up to ten research questions relevant to intensive care organisation, practice...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340000628

    authors： Goldfrad C,Vella K,Bion JF,Rowan KM,Black NA

    更新日期：2000-10-01 00:00:00

  • Respiratory mechanics by least squares fitting in mechanically ventilated patients: applications during paralysis and during pressure support ventilation.

    abstract：OBJECTIVE:To evaluate a least squares fitting technique for the purpose of measuring total respiratory compliance (Crs) and resistance (Rrs) in patients submitted to partial ventilatory support, without the need for esophageal pressure measurement. DESIGN:Prospective, randomized study. SETTING:A general ICU of a Univ...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF01707409

    authors： Iotti GA,Braschi A,Brunner JX,Smits T,Olivei M,Palo A,Veronesi R

    更新日期：1995-05-01 00:00:00

  • Intensive care management of children following heart and heart-lung transplantation.

    abstract：:We report the intensive care management of 23 children (age 3-15 years) following orthotopic heart (HT) and combined heart and lung transplantation (HLT) performed at our 2 institutes between February 1985 and August 1989. Cyclosporin A, azathioprine and steroids were given as routine immunosuppression, whilst anti-th...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01711219

    authors： Whitehead B,James I,Helms P,Scott JP,Smyth R,Higenbottam TW,McGoldrick J,English TA,Wallwork J,Elliott M

    更新日期：1990-01-01 00:00:00

  • Detecting traumatic internal carotid artery dissection using transcranial Doppler in head-injured patients.

    abstract：PURPOSE:The early diagnosis of traumatic internal carotid artery dissection (TICAD) is essential for initiating appropriate treatment and improving outcome. We searched for criteria from transcranial Doppler (TCD) measurements on admission that could be associated with subsequent TICAD diagnosis in patients with trauma...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-010-1919-0

    authors： Bouzat P,Francony G,Brun J,Lavagne P,Picard J,Broux C,Declety P,Jacquot C,Albaladejo P,Payen JF

    更新日期：2010-09-01 00:00:00

  • Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats.

    abstract：PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-010-1913-6

    authors： Fathali N,Lekic T,Zhang JH,Tang J

    更新日期：2010-09-01 00:00:00