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Comparison of air tonometry with gastric tonometry using saline and other equilibrating fluids: an in vivo and in vitro study.

Abstract：

OBJECTIVE:1) To compare saline gastric tonometry monitoring with air tonometry (Tonocap) in a group of general ICU patients. 2) An in vitro investigation of the performance of other fluids used in gastric tonometry and to assess the effects of variation of temperature and carbon dioxide concentration within the range encountered in clinical use. DESIGN:a) A prospective, observational study in ICU patients b) A comparative laboratory study. SETTING:The general Intensive Care Unit (ICU) and the laboratory at Leeds General Infirmary. PATIENTS AND PARTICIPANTS:Nine patients in the general ICU with severe sepsis or septic shock. MEASUREMENTS AND RESULTS:In vivo comparison of saline and air tonometry demonstrated a difference between the two techniques. Bland & Altman analysis showed a mean bias in the measurement of gastric PCO2 of 1.88 kPa with a precision of 1.22 kPa, with saline giving the lower result. In vitro, saline, air (Tonocap), gelatin and heparinised blood were used, at temperatures of 33-42 degrees C and at carbon dioxide concentrations of 4-8 kPa. While gelatin and blood gave unpredictable results, dependent on temperature and carbon dioxide concentration, air tonometry gave highly reproducible results. A consistent bias between the results with saline and air tonometry was seen over the range of temperatures and carbon dioxide (CO2) concentrations studied. The mean bias was 0.85 kPa with a precision of 0.40 kPa, saline consistently giving lower results. CONCLUSIONS:There are clinically significant differences in values for gastric mucosal PCO2 measured by air tonometry and saline tonometry both in vivo and in vitro.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Barry B,Mallick A,Hartley G,Bodenham A,Vucevic M

doi

10.1007/s001340050665

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

777-84

issue

8

eissn

0342-4642

issn

1432-1238

journal_volume

24

pub_type

临床试验,杂志文章

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