Abstract：
:The Limulus amoebocyte lysate assay was used as one of a series of laboratory and clinical investigations on a group of 31 patients suffering from septic shock in order to assess the clinical significance of this assay for the detection of circulating endotoxin in clinical gram-negative sepsis. Four patients with cardiogenic shock served as controls. Endotoxin was detected in the bloodstream of all patients with septic shock during the 24 h following referral and was not detected in the control patients. Eventual clinical recovery was associated with the disappearance of endotoxin from the peripheral blood. Blood cultures were unhelpful as a prognostic indicator in these critically ill patients. A quantitative assay of endotoxin in blood may allow a more precise relationship with the clinical manifestations of major sepsis.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
McCartney AC,Banks JG,Clements GB,Sleigh JD,Tehrani M,Ledingham IMdoi
10.1007/BF01772577subject
Has Abstractpub_date
1983-01-01 00:00:00pages
117-22issue
3eissn
0342-4642issn
1432-1238journal_volume
9pub_type
杂志文章abstract：OBJECTIVE:To determine: (1) the proportion of small (<5 mm) or thrombosed internal jugular veins (IJV) and femoral veins (FV) in which catheter placement would be difficult without ultrasound guidance; (2) which position increases central vein sizes and may facilitate cannulation of these vessels. DESIGN:Prospective s...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0875-9
更新日期：2008-02-01 00:00:00
abstract：:A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented. The diagnostic difficulty at presentation is highlighted. Continuous arteriovenous haemofiltration proved a valuable means of maintaining fluid and electrolyte balance. The patient recovered. ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00262905
更新日期：1988-01-01 00:00:00
abstract：:Controlled mechanical ventilation is an accepted therapy for acute respiratory failure but by virtue of the increase in intrathoracic pressure has a large number of disadvantages. It is to overcome these disadvantages that alternative modes of ventilation have been introduced. These aim to reduce the effects of abnorm...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF00254773
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:To define the mechanisms of the stable and prolonged post-operative plasma volume expansion observed with Hydroxyethyl Starches (HES) and to determine whether a partial intravascular hydrolysis of large molecules contribute to reinforce the colloid-osmotic effect. DESIGN:Prospective, pharmacologic study usin...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF01700163
更新日期：1995-07-01 00:00:00
abstract：:Several different epidemiological typing methods have been used in studies of coagulase-negative staphylococci; these include biotyping, antibiotic susceptibility pattern analysis, serological typing, phage typing, slime production detection, protein profile analysis, immunoblot fingerprinting and DNA typing. The most...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01694703
更新日期：1993-01-01 00:00:00
abstract：:The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4 mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01690768
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:To assess the relationship between the base deficit value in the immediate postoperative period of coronary surgery for cardiopulmonary bypass and the length of stay in the ICU. DESIGN AND SETTING:Prospective descriptive study in the department of anesthesia and cardiovascular surgery of a university hospita...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1587-9
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between cytokines and the inflammatory responses in patients with out-of-hospital cardiac arrest, we examined the changes of cytokines as well as alterations in the markers of neutrophil activation, platelet and endothelial activation, and endothelial injury. DESIGN:Prospectiv...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s001340050907
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:To assess the attitudes of physicians in Milan, Italy, intensive care units (ICUs) regarding end-of-life decisions. DESIGN:Anonymous self-administered questionnaire. SETTING:All 20 ICUs in Milan. PARTICIPANTS:Physicians employed in the ICUs. MEASUREMENTS AND RESULTS:The response rate was 87% (225 of 259)....
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1919-4
更新日期：2003-11-01 00:00:00
abstract：:We report a fatal case of a child presenting Reye's syndrome associated with a variety of arrhythmias and ischemia-like ST-T ECG changes. At autopsy, fatty infiltration and patchy myocytolysis were detected in sections of the heart. This case report emphasizes cardiac involvement in Reye's syndrome and the possible me...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01728333
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVE:To test the feasibility of the transcardiac conductance (TCC) method for continuous, on-line measurement of absolute left ventricular (LV) volume and to validate the method by comparison with biplane angiography. DESIGN AND SETTING:Prospective clinical feasibility and validation study in a cardiac catheteriz...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s00134-004-2300-y
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficiency of a new device developed to remove obstructions from endotracheal tubes (ETT) in mechanically ventilated patients. DESIGN:Open study in mechanically ventilated sedated and paralyzed ICU patients. SETTING:General ICU and Laboratory of Respiratory Mechanics of the University of Rom...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF01705724
更新日期：1994-11-01 00:00:00
abstract：:Specific regulations regarding oversight of research in children vary from country to country, but most share common principles derived from major consensus documents. Whereas the permissibility of research on adults depends heavily upon the informed consent of the subject, the regulation of research in pediatrics is ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0917-3
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:1) To compare saline gastric tonometry monitoring with air tonometry (Tonocap) in a group of general ICU patients. 2) An in vitro investigation of the performance of other fluids used in gastric tonometry and to assess the effects of variation of temperature and carbon dioxide concentration within the range e...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s001340050665
更新日期：1998-08-01 00:00:00
abstract：PURPOSE:This prospective observational study aimed at describing prescription patterns of tigecycline and patient outcomes in 26 French intensive care units (ICU). METHODS:Data of consecutive cases of adult patients treated with tigecycline were collected from the initiation until 7 days after the end of treatment. Re...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-014-3323-7
更新日期：2014-07-01 00:00:00
abstract：INTRODUCTION:A prospective physiological study was performed in 12 paediatric patients with acute moderate hypercapnic respiratory insufficiency to assess the ability of noninvasive positive pressure ventilation (NPPV) to unload the respiratory muscles and improve gas exchange. MATERIALS AND METHODS:Breathing pattern,...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s00134-008-1202-9
更新日期：2008-12-01 00:00:00
abstract：:A case of bilateral pseudoaneurysms of the pulmonary arteries caused by blunt chest injury is presented. Although this is a very rare complication, this entity should always be suspected in a patient with hemoptysis and a radiodensity on chest radiograph following chest injury. Selection of operative procedures should...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01706428
更新日期：1992-01-01 00:00:00
abstract：:One hundred and eighteen 20-g radial artery catheters were prospectively evaluated in 109 cardiovascular surgical patients. 0.024% papaverine in saline was used as a continuous flushing solution. Using the Doppler method, obstruction of the radial artery with the catheter in situ was found in 11 (9.8%) patients. Decan...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00254675
更新日期：1986-01-01 00:00:00
abstract：PURPOSE:Relatives of intensive care unit (ICU) patients suffer emotional distress that impairs their ability to acquire the information they need from the staff. We sought to evaluate whether providing relatives with a list of important questions was associated with better comprehension on day 5. METHODS:Randomized, p...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-018-5423-2
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:To investigate the accuracy of lung ultrasonography (LUS) in the quantification of lung water in critically ill patients by using quantitative computed tomography (CT) as the gold standard for the determination of lung weight. METHODS:Twenty consecutive patients admitted to an intensive care unit who underwe...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2694-x
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:To determine the diagnostic performance of a Bayesian Decision-Support System (BDSS) for ventilator-associated pneumonia (VAP). DESIGN:A previously developed BDSS, automatically obtaining patient data from patient information systems, provides likelihood predictions of VAP. In a prospectively studied cohort ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0728-6
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:To implement delirium monitoring, test reliability, and monitor compliance of performing the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) in trauma patients. DESIGN AND SETTING:Prospective, observational study in a level 1 trauma unit of a tertiary care, university-based medical center. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-008-1031-x
更新日期：2008-07-01 00:00:00
abstract：RATIONALE:Acute respiratory distress syndrome (ARDS) is frequently associated with hemodynamic instability which appears as the main factor associated with mortality. Shock is driven by pulmonary hypertension, deleterious effects of mechanical ventilation (MV) on right ventricular (RV) function, and associated-sepsis. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-016-4326-3
更新日期：2016-05-01 00:00:00
abstract：:Helicobacter pylori is estimated to infect over 50% of the world's population, the majority of whom are asymptomatic. Although most research to date has focused on local gastroduodenal disease manifestations, the potential impact of H. pylori infection and the associated chronic active inflammation on systemic disease...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-003-1838-4
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:Inflammatory markers may have a role in predicting severity of illness of intensive care unit (ICU) patients. The aim of this study is to determine whether low eosinophil count can predict 28-day mortality in medical ICU. METHODS:A prospective study over a 4-month period. To evaluate the prognosis information ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2170-z
更新日期：2011-07-01 00:00:00
abstract：:Breathing pattern was studied non-invasively in 20 coronary artery bypass surgery patients before the operation and post-operatively after weaning from mechanical ventilation. Post-operatively minute ventilation (VE), breathing frequency (Fr) and mean inspiratory flow (VT/TI) increased (28%, 42%, 27%; p less than 0.01...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01716198
更新日期：1991-01-01 00:00:00
abstract：:Neuromuscular blocking agents (NMBAs) inhibit patient-initiated active breath and the risk of high tidal volumes and consequent high transpulmonary pressure swings, and minimize patient/ ventilator asynchrony in acute respiratory distress syndrome (ARDS). Minimization of volutrauma and ventilator-induced lung injury (...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-020-06297-8
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:Neurologic and endothelial injury biomarkers are associated with prolonged delirium during critical illness and may reflect injury pathways that lead to poor long-term outcomes. We hypothesized that blood-brain barrier (BBB), neuronal, and endothelial injury biomarkers measured during critical illness are assoc...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-018-5120-1
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The patients who survive the initial hyper-inflammatory step of septic shock but subsequently die may be those who do not recover from i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0204-8
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To apply the modified pediatric RIFLE criteria for severity of acute kidney injury (AKI) to pediatric burn ICU patients and to evaluate the overall incidence of AKI, risk factors for AKI and influence of AKI on outcome. DESIGN:Retrospective, descriptive cohort study. SETTING:10-bed burn PICU facility. PATI...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-009-1638-6
更新日期：2009-12-01 00:00:00
