Abstract：
:Neuromuscular blocking agents (NMBAs) inhibit patient-initiated active breath and the risk of high tidal volumes and consequent high transpulmonary pressure swings, and minimize patient/ ventilator asynchrony in acute respiratory distress syndrome (ARDS). Minimization of volutrauma and ventilator-induced lung injury (VILI) results in a lower incidence of barotrauma, improved oxygenation and a decrease in circulating proinflammatory markers. Recent randomized clinical trials did not reveal harmful muscular effects during a short course of NMBAs. The use of NMBAs should be considered during the early phase of severe ARDS for patients to facilitate lung protective ventilation or prone positioning only after optimising mechanical ventilation and sedation. The use of NMBAs should be integrated in a global strategy including the reduction of tidal volume, the rational use of PEEP, prone positioning and the use of a ventilatory mode allowing spontaneous ventilation as soon as possible. Partial neuromuscular blockade should be evaluated in future trials.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Hraiech S,Yoshida T,Annane D,Duggal A,Fanelli V,Gacouin A,Heunks L,Jaber S,Sottile PD,Papazian Ldoi
10.1007/s00134-020-06297-8subject
Has Abstractpub_date
2020-12-01 00:00:00pages
2357-2372issue
12eissn
0342-4642issn
1432-1238pii
10.1007/s00134-020-06297-8journal_volume
46pub_type
杂志文章,评审abstract：OBJECTIVE:To determine the relation of malnutrition and underlying diagnosis to the length of stay in the Intensive Care Unit (ICU) and to mortality after lung transplantation (LTX). DESIGN:Retrospective ICU chart review. SETTING:Cardiothoracic ICU in a University hospital. PATIENTS:Fifty-one consecutive patients wh...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01709333
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVE:Both serum levels of tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6) and blood lactate levels in patients with septic shock have been shown to correlate with prognosis. The aim of the study was to define the relative predictive value of these measures. PATIENTS:38 hospitalized patients with ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01712155
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To evaluate clinical and microbiologic characteristics, modalities of treatment and outcome of patients with cervical necrotizing fasciitis admitted to our institution. DESIGN:Retrospective clinical investigation. PATIENTS AND METHODS:We reviewed the charts of 20 consecutive patients hospitalized in our Int...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050959
更新日期：1999-08-01 00:00:00
abstract：:Diagnosis and treatment of infection is a common procedure in the clinical management of patients in the ICU. Infection in the ICU is an important area for study, but requires well-defined and proven diagnostic criteria. The diagnosis of infection, like any diagnosis, is based on probability, and diagnostic criteria a...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01713977
更新日期：1994-11-01 00:00:00
abstract：:The spread of a multi-resistant glucose-acidifying Acinetobacter calcoaceticus strain in a community hospital was studied. After admission of a colonized patient to the hospital the strain was found in clinical specimens from ICU patients and subsequently from several of these patients after transfer to medical wards....
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01058568
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:To obtain insight into the occurrence of brain death and the potential for brain dead and controlled non-heart-beating organ donors (CNHB) in patients with traumatic brain injury (TBI), subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH) in a large neurosurgical serving area (2.1 million inhabi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-0001-9
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:To compare the ventilation achieved with chest compressions (CC) or ventilation plus compressions (VC) in a pediatric animal model of cardiac arrest. DESIGN:Randomized experimental study. SETTING:Experimental department of a University Hospital. METHODS:Twelve infant pigs with asphyxial cardiac arrest. Seq...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-1777-9
更新日期：2010-04-01 00:00:00
abstract：:Myxoedema coma is a medical emergency with high mortality. In this study, clinical response and plasma variations of thyroid hormones were analysed in 7 patients, 6 presenting with myxoedema coma and one with myxoedema ileus. These patients were treated with intravenous or oral l-thyroxine (l-T4). 1000 mu l-T4 iv were...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01708403
更新日期：1991-01-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 社论
doi：10.1007/s00134-018-5468-2
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Mechanical ventilation with lower tidal volumes (≤6 ml/kg of predicted body weight, PBW) could benefit patients without acute respiratory distress syndrome (ARDS). However, tidal volume reduction could be associated with increased patient discomfort and sedation needs, and consequent longer duration of ventilat...
journal_title：Intensive care medicine
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00134-014-3318-4
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:Real-time measurement of stroke volume variation by arterial pulse contour analysis (SVV) is useful in predicting volume responsiveness and monitoring volume therapy in mechanically ventilated patients. This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of f...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00134-003-1649-7
更新日期：2003-03-01 00:00:00
abstract：:Paediatric admissions to a general ITU are briefly reviewed. Although it may not be an ideal arrangement it is suggested that children can be safely cared for in such a unit. The problems created by the child with acute upper airway obstruction are discussed to demonstrate the way in which the unit is organized to rec...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00260356
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:Antithrombin exerts direct effects on neutrophils by inhibiting chemokine-induced migration. This study examined the potency of different pharmaceutical antithrombin preparations in inhibiting neutrophil chemotaxis toward interleukin 8. METHODS:Cell migration was tested by the leading front assay in modified...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1432-1
更新日期：2002-10-01 00:00:00
abstract：PURPOSE:Meconium aspiration syndrome (MAS) is a life-threatening neonatal lung injury, whose pathophysiology has been mainly studied in animal models. In such models, pancreatic secretory phospholipase A2 (sPLA2-IB) and proinflammatory cytokines present in meconium challenge the lungs, catabolising surfactant and harmi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2243-z
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:Comparison of side effects (fever shivering and/or allergic reactions, collapse, symptomatic hypocalcaemia) of the different substitution fluids used during therapeutical plasmapheresis. DESIGN:Multicentric retrospective comparative study designed to explore the side effects due to the replacements fluids (a...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s001340050595
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:There are a number of potential etiologies of severe bleeding encountered in the intensive care unit. Although rare, acquired hemophilia is one such etiology that often presents with major bleeding requiring intensive care. Despite the introduction of effective treatments, the reported mortality rate of patie...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-011-2258-5
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:To assess the effects of the association of positive end-expiratory pressure (PEEP) with different inflation volumes (V(T)'s) on passive lung deflation and alveolar recruitment in ARDS patients. DESIGN:Clinical study using PEEP with two different V(T)'s and analyzing whether passive lung deflation and alveol...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051275
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the usefulness of early transcranial Doppler ultrasound (TCD) goal-directed therapy after severe traumatic brain injury initiated before invasive cerebral monitoring is available. DESIGN:Prospective, observational clinical study. SETTING:Surgical intensive care unit, university hospital. PATIEN...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0558-6
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the sensitivity, specificity and overall accuracy of a model based on the presence or absence of organ dysfunctions and/or infection (ODIN) to predict the outcome for intensive care unit patients. DESIGN:Prospective study. SETTING:General intensive care unit in a university teaching hospital. P...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01720528
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To characterize the perceived utilization of physical restraint (PR) in mechanically ventilated intensive care unit (ICU) patients and to identify clinical and structural factors influencing PR use. METHODS:A questionnaire was personally handed to one intensivist in 130 ICUs in France then collected on-site 2 ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2715-9
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:Candida spp. airway colonization could promote development of ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa, a potentially multidrug-resistant (MDR) bacteria, and worsen the outcome of VAP regardless of pathogen. We therefore address the question of the risk of MDR bacteria isolation ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2584-2
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:Pulmonary endothelial activation caused by high pulmonary capillary pressures may be involved in the pathogenesis of cardiogenic pulmonary edema (CPE). We studied soluble selectins and soluble ICAM-1 as markers of cell activation in the systemic and pulmonary circulation of patients with respiratory failure (...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000843
更新日期：2001-03-01 00:00:00
abstract：:The goals of management of patients with respiratory failure include improving arterial oxygenation with PEEP and red cell transfusion to maintain oxygen carrying capacity, both of which contribute to improving tissue oxygen delivery. However, standard CPD-stored blood is rapidly depleted of 2,3 diphosphoglycerate (2,...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00315364
更新日期：1986-01-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-018-5063-6
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:The Brugada syndrome is a clinical and electrocardiographic familial entity, which may lead to sudden cardiac death. A Brugada pattern ECG may occasionally be caused by conditions such as an overdose of tricyclic antidepressants (TCA). Toxicity of TCA frequently results in the need for critical care support. ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-0007-3
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVES:To assess the markers of perfusion which best discriminate survivors from non-survivors of childhood sepsis and to compare the information derived from gastric tonometry with conventionally measured haemodynamic and laboratory parameters. DESIGN:Prospective clinical study of children with sepsis syndrome or...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050394
更新日期：1997-06-01 00:00:00
abstract：PURPOSE:To provide recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza pandemic or mass disaster with a specific focus on essential equipment, pharmaceuticals and supplies. METHODS:Based on a literature review and expert opinion, a Delphi process was use...
journal_title：Intensive care medicine
pub_type： 指南,杂志文章
doi：10.1007/s00134-010-1763-2
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVE:The primary objective was to test the hypothesis that clinical re-expansion pulmonary edema is predominantly due to increased permeability of the alveolar-capillary barrier. A secondary objective was to determine if the alveolar epithelium was functionally intact in patients with re-expansion pulmonary edema ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2379-1
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To assess the role of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance. DESIGN:Prospective cohort study. SETTING:Two medical intensive care units. PATIENTS AND PARTICIPANTS:346 patients admitted for >or= 48 h. INTERVENTION:Analysis of data from an 8-month study c...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1326-y
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of different infusion pump models on continuity of drug delivery during vertical displacement of syringe pumps. DESIGN:Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same syringe in three different models of syringe pump after l...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000784
更新日期：2001-01-01 00:00:00
