当前位置： SCI文献检索 > INTENSIVE CARE MEDICINE期刊下所有文献 > Lower respiratory rates without decreases in oxygen consumption during neonatal synchronized intermittent mandatory ventilation.

Lower respiratory rates without decreases in oxygen consumption during neonatal synchronized intermittent mandatory ventilation.

Abstract：

OBJECTIVE:We tested the hypothesis that synchronization to patient effort during intermittent mandatory ventilation (SIMV), when compared to conventional unsynchronized intermittent mandatory ventilation (IMV), will decrease energy expenditure, as reflected by decreased oxygen consumption (VO2). DESIGN:We used a four-period crossover design. Each patient was studied over four 30-min continuous time intervals. Patients were randomized to receive initially IMV or SIMV, then crossed over such that each patient was treated twice with each modality. Data were analyzed using an analysis of variance technique. SETTING:Patients were receiving treatment in the newborn intensive care unit of Children's Hospital, St. Paul. PATIENTS:We studied 17 patients, who ranged from 23 to 37 weeks gestation, were < or = 14 days old, and had study weights from 623 to 3015 g. All were mechanically ventilated for hyaline membrane disease. MEASUREMENTS AND RESULTS:We measured and compared VO2, carbon dioxide consumption (VCO2), minute ventilation (VE), total respiratory rate, heart rate, arterial blood pressure, and arterial oxygen saturation (SaO2) values during IMV and SIMV. Total respiratory rate fell significantly during SIMV (73 +/- 26 during IMV, 57 +/- 17 during SIMV, p < 0.01) in spite of no significant change in VO2 (0.6 +/- 0.16% fall in VO2 during SIMV) or VCO2 (4.2 +/- 0.19% increase in VCO2 during SIMV) values. Moreover, there were no significant differences in heart rate, blood pressure, VE, or SaO2 values with either form of therapy. CONCLUSIONS:Though total respiratory rate fell, these data do not support the hypothesis that SIMV significantly reduces respiratory rate by decreasing oxygen consumption and carbon dioxide production during infant mechanical ventilation. Rather, the marked fall in respiratory rate may be due to a more efficient respiratory pattern.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Smith KM,Wahlig TM,Bing DR,Georgieff MK,Boros SJ,Mammel MC

doi

10.1007/s001340050359

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

463-8

issue

eissn

0342-4642

issn

1432-1238

journal_volume

pub_type

临床试验,杂志文章,随机对照试验

在线工具

Lower respiratory rates without decreases in oxygen consumption during neonatal synchronized intermittent mandatory ventilation.