Interferon gamma in trauma-related infections.

Abstract:

OBJECTIVE:The efficacy of interferon gamma therapy in reducing infection and improving outcome from infection in patients sustaining major injury was examined. DESIGN:Randomized double-blind placebo control trial SETTING:Nine level one university affiliated trauma centers in the United States. PATIENTS AND PARTICIPANTS:Four hundred sixteen patients with injury severity score (ISS) > or = 25 or ISS > or = 20 with evidence of wound contamination. INTERVENTION:Recombinant human interferon gamma 100 ug or placebo was given subcutaneously daily for up to 21 days in addition to standard antibiotic therapy. MEASUREMENTS AND RESULTS:Comparable rates of major and minor infections were observed. Among the patients treated with interferon gamma there were fewer deaths related to major infection regardless of type [7-(3%) vs 18-(9%)]. The results, however, were dominated by one center which had the highest enrollment, infection and death rates. CONCLUSIONS:Further studies are warranted to investigate the role of interferon gamma therapy in improving outcome with major infection.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Dries DJ

doi

10.1007/BF01743725

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

S462-7

eissn

0342-4642

issn

1432-1238

journal_volume

22 Suppl 4

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Muscle perfusion and oxygen consumption by near-infrared spectroscopy in septic-shock and non-septic-shock patients.

    abstract:OBJECTIVE:To measure muscle blood flow (Qtis) and oxygen consumption (VO(2)tis) in septic and non-septic critically ill patients by near-infrared spectroscopy (NIRS). SETTING:Surgical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS:Four patients with septic shock, eight post-surgical criticall...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-003-1805-0

    authors: Girardis M,Rinaldi L,Busani S,Flore I,Mauro S,Pasetto A

    更新日期:2003-07-01 00:00:00

  • Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children.

    abstract:OBJECTIVES:To analyse the clinical value of procalcitonin (PCT), C-reactive protein (CRP) and leucocyte count in the diagnosis of paediatric sepsis and in the stratification of patients according to severity. DESIGN:Prospective, observational study. SETTING:Paediatric intensive care unit (PICU). PATIENTS:Ninety-four...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-006-0509-7

    authors: Rey C,Los Arcos M,Concha A,Medina A,Prieto S,Martinez P,Prieto B

    更新日期:2007-03-01 00:00:00

  • Do centrally pre-prepared solutions achieve more reliable drug concentrations than solutions prepared on the ward?

    abstract:PURPOSE:To compare the concentration conformity of infusion solutions manually prepared on intensive care units (ICU) with solutions from pharmacy-based, automated production. METHODS:A prospective observational study conducted in a university hospital in Germany. Drug concentrations of 100 standardised infusion solut...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-011-2230-4

    authors: Dehmel C,Braune SA,Kreymann G,Baehr M,Langebrake C,Hilgarth H,Nierhaus A,Dartsch DC,Kluge S

    更新日期:2011-08-01 00:00:00

  • The respiratory variation in inferior vena cava diameter as a guide to fluid therapy.

    abstract:OBJECTIVE:To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients. DESIGN:Prospective clinical study. SETTING:Medical ICU of a non-university hospital. PATIENTS:Mechanically ventilated patients with sep...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-004-2233-5

    authors: Feissel M,Michard F,Faller JP,Teboul JL

    更新日期:2004-09-01 00:00:00

  • Psychological burnout and critical care medicine: big threat, big opportunity.

    abstract:: ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-018-5063-6

    authors: Hawryluck L,Brindley PG

    更新日期:2018-12-01 00:00:00

  • Effects of pulmonary blood volume on vascular reactivity in the lung.

    abstract:OBJECTIVE:Pulmonary flow resistance is mainly determined by vessel calibres, resulting from the interaction of volume-passive distension and active vasomotion. However, quantitative information on the interplay between these counteracting forces in the lung is lacking. Therefore, we aimed at quantifying (1) the effects...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s001340051090

    authors: Ding ZP,Scheeren TW,Arndt JO

    更新日期:1999-12-01 00:00:00

  • Impact of the humidification device on intubation rate during noninvasive ventilation with ICU ventilators: results of a multicenter randomized controlled trial.

    abstract:PURPOSE:The use of heat and moisture exchangers (HME) during noninvasive ventilation (NIV) can increase the work of breathing, decrease alveolar ventilation, and deliver less humidity in comparison with heated humidifiers (HH). We tested the hypothesis that the use of HH during NIV with ICU ventilators for patients wit...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00134-013-3145-z

    authors: Lellouche F,L'Her E,Abroug F,Deye N,Rodriguez PO,Rabbat A,Jaber S,Fartoukh M,Conti G,Cracco C,Richard JC,Ricard JD,Mal H,Mentec H,Loisel F,Lacherade JC,Taillé S,Brochard L

    更新日期:2014-02-01 00:00:00

  • Quinine-induced disseminated intravascular coagulation: case report and review of the literature.

    abstract:OBJECTIVE:To describe the clinical course of quinine-induced disseminated intravascular coagulation (DIC) and review all previous cases reported in the medical literature. DESIGN:Case report/literature review. SETTING:University teaching hospital medical ICU. PATIENTS:One patient in whom thrombocytopenia, coagulopat...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s00134-003-1732-0

    authors: Knower MT,Bowton DL,Owen J,Dunagan DP

    更新日期:2003-06-01 00:00:00

  • Bolus remifentanil for chest drain removal in ICU: a randomized double-blind comparison of three modes of analgesia in post-cardiac surgical patients.

    abstract:PURPOSE:We compared 1 versus 0.5 microg/kg bolus remifentanil versus placebo in alleviating pain due to chest drain removal. Effects on sedation, respiratory rate (RR), oxygen saturation, heart rate (HR) and blood pressure were also evaluated. METHODS:Sixty patients following cardiac surgery were enrolled in this pros...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00134-010-1836-2

    authors: Casey E,Lane A,Kuriakose D,McGeary S,Hayes N,Phelan D,Buggy D

    更新日期:2010-08-01 00:00:00

  • Thiamine status after major trauma.

    abstract::A prospective study of thiamine status in patients with severe injuries (injury severity scores greater than 12) showed that they all developed signs of severe thiamine deficiency on the basis of transketolase activity, the standard biochemical test for thiamine deficiency. This occurred within the first week after th...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF00256767

    authors: McConachie I,Haskew A

    更新日期:1988-01-01 00:00:00

  • Effect of ornithine alpha-ketoglutarate on glutamine pools in burn injury: evidence of component interaction.

    abstract:BACKGROUND:Ornithine alpha-ketoglutarate (OKG) has proved to be efficient in restoring glutamine (Gln) pools which are strongly depleted in hypercatabolic patients. Since its two components, alpha-ketoglutarate (alphaKG) and ornithine (Orn), give rise to glutamate (Glu), they are both considered as Gln precursors. The ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-006-0511-0

    authors: Cynober L,Lasnier E,Le Boucher J,Jardel A,Coudray-Lucas C

    更新日期:2007-03-01 00:00:00

  • Endotoxin immunity and the development of the systemic inflammatory response syndrome in critically ill children.

    abstract:BACKGROUND:The systemic inflammatory response syndrome (SIRS) may be triggered by endotoxin. Humans have antibodies directed against the core of endotoxin (endotoxin core antibodies, EndoCAb) that appear to be protective following surgery and in sepsis. We hypothesised that children with elevated antibodies to endotoxi...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-005-0019-z

    authors: Stephens RCM,Fidler K,Wilson P,Barclay GR,Mythen MG,Dixon GLJ,Turner MW,Klein NJ,Peters MJ

    更新日期:2006-02-01 00:00:00

  • Urgent bedside endoscopy for clinically significant upper gastrointestinal hemorrhage after admission to the intensive care unit.

    abstract:OBJECTIVE:To investigate the sources of hemorrhage and use of endoscopic hemostasis in patients with clinically significant upper gastrointestinal (UGI) hemorrhage after admission to the intensive care unit (ICU). DESIGN AND SETTING:Prospective study, 123 beds of ICU in a 1,629-bed medical center. MEASUREMENTS AND RE...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-003-1921-x

    authors: Lee YC,Wang HP,Wu MS,Yang CS,Chang YT,Lin JT

    更新日期:2003-10-01 00:00:00

  • Respiratory changes after open-heart surgery.

    abstract::Breathing pattern was studied non-invasively in 20 coronary artery bypass surgery patients before the operation and post-operatively after weaning from mechanical ventilation. Post-operatively minute ventilation (VE), breathing frequency (Fr) and mean inspiratory flow (VT/TI) increased (28%, 42%, 27%; p less than 0.01...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01716198

    authors: Tulla H,Takala J,Alhava E,Huttunen H,Kari A,Manninen H

    更新日期:1991-01-01 00:00:00

  • Evaluation of trauma care: validation of the TRISS method in an Italian ICU.

    abstract:OBJECTIVE:To validate the TRISS method as an audit system on a group of patients with severe trauma admitted to an Italian general intensive care unit (ICU). DESIGN:Prospective, cohort study of consecutive admissions to the ICU. SETTING:A 6-bed general ICU in a 500-bed general hospital. PATIENTS:190 patients with se...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF02044120

    authors: Corbanese U,Possamai C,Casagrande L,Bordino P

    更新日期:1996-09-01 00:00:00

  • Anti-phospholipid antibodies in serum from patients with Guillain-Barré syndrome.

    abstract:OBJECTIVE:The Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy related to autoimmunity. However, no conclusive etiological concept has yet been found. We examined the variation in autoantibodies to lipids in serum of GBS patients in response to the course of the disease but investigated titer modif...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-005-2736-8

    authors: Nakos G,Tziakou E,Maneta-Peyret L,Nassis C,Lekka ME

    更新日期:2005-10-01 00:00:00

  • Albumin supplementation during the first week after a burn does not mobilise tissue oedema in humans.

    abstract:OBJECTIVE:To measure water balance and changes in distribution, and the effect of giving supplementary albumin, early after a burn injury. DESIGN:Consecutive patients (matched groups) and healthy controls. SETTING:National burn unit in a Swedish university hospital. PATIENTS AND SUBJECTS:Eighteen patients with 18%-9...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s001340100935

    authors: Zdolsek HJ,Lisander B,Jones AW,Sjöberg F

    更新日期:2001-05-01 00:00:00

  • Late outcome of percutaneous dilatational tracheostomy in intensive care patients.

    abstract:OBJECTIVE:Percutaneous dilatational tracheostomy is increasingly practiced in intensive care units and has a low incidence of early complications. The late effects of this procedure are still poorly known and were the focus of this study. DESIGN:Prospective descriptive clinical study. SETTING:Interdisciplinary intens...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF01706200

    authors: Fischler MP,Kuhn M,Cantieni R,Frutiger A

    更新日期:1995-06-01 00:00:00

  • Continuous cardiac output monitoring after cardiopulmonary bypass: a comparison with bolus thermodilution measurement.

    abstract:OBJECTIVE:The interchangeability of continuous measurement of cardiac output (CO) with the traditional bolus method in patients after cardiopulmonary bypass (CPB) is uncertain. DESIGN:Prospective observational clinical study. SETTING:A 20-bed surgical ICU at a university hospital. PATIENTS:Fourteen deeply sedated, v...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-006-0161-2

    authors: Bendjelid K,Schütz N,Suter PM,Romand JA

    更新日期:2006-06-01 00:00:00

  • Active transforming growth factor-beta1 activates the procollagen I promoter in patients with acute lung injury.

    abstract:OBJECTIVE:Fibroproliferation markers like procollagen I predict mortality in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). We sought to determine whether bronchoalveolar lavage fluid (BALF) from patients with lung injury contained mediators that would activate procollagen I promo...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-004-2503-2

    authors: Budinger GR,Chandel NS,Donnelly HK,Eisenbart J,Oberoi M,Jain M

    更新日期:2005-01-01 00:00:00

  • The main determinants of nitrogen balance during total parenteral nutrition in critically ill injured patients.

    abstract::Factors influencing nitrogen balance during total parenteral nutrition have been investigated in 34 critically ill injured patients studied during the first 6 days after trauma. Basal nitrogen balance was severely negative (-0.26 +/- 0.12 (SD) g X kg-1), but improved consistently during treatment. Nitrogen intake prov...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/BF00256262

    authors: Iapichino G,Radrizzani D,Solca M,Pesenti A,Gattinoni L,Ferro A,Leoni L,Langer M,Vesconi S,Damia G

    更新日期:1984-01-01 00:00:00

  • High-mobility group box 1 protein plasma concentrations during septic shock.

    abstract:OBJECTIVE:To investigate plasma high-mobility group box 1 protein (HMGB1) concentration and its relationship with organ dysfunction and outcome in septic shock patients. DESIGN AND SETTING:Prospective, noninterventional study. Medical adult intensive care unit at a university hospital in France. PATIENTS:42 criticall...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-007-0691-2

    authors: Gibot S,Massin F,Cravoisy A,Barraud D,Nace L,Levy B,Bollaert PE

    更新日期:2007-08-01 00:00:00

  • Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients.

    abstract:OBJECTIVE:Although several advantages are attributed to tracheotomy in ICU patients requiring mechanical ventilation (MV), true benefits and the optimal timing of tracheotomy remain controversial. In this study, we compared early tracheotomy (ET) with prolonged intubation (PI) in severely ill patients requiring prolong...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00134-008-1195-4

    authors: Blot F,Similowski T,Trouillet JL,Chardon P,Korach JM,Costa MA,Journois D,Thiéry G,Fartoukh M,Pipien I,Bruder N,Orlikowski D,Tankere F,Durand-Zaleski I,Auboyer C,Nitenberg G,Holzapfel L,Tenaillon A,Chastre J,Laplanch

    更新日期:2008-10-01 00:00:00

  • Quantitative versus standard pupillary light reflex for early prognostication in comatose cardiac arrest patients: an international prospective multicenter double-blinded study.

    abstract:PURPOSE:To assess the ability of quantitative pupillometry [using the Neurological Pupil index (NPi)] to predict an unfavorable neurological outcome after cardiac arrest (CA). METHODS:We performed a prospective international multicenter study (10 centers) in adult comatose CA patients. Quantitative NPi and standard ma...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00134-018-5448-6

    authors: Oddo M,Sandroni C,Citerio G,Miroz JP,Horn J,Rundgren M,Cariou A,Payen JF,Storm C,Stammet P,Taccone FS

    更新日期:2018-12-01 00:00:00

  • Family members' experiences of "wait and see" as a communication strategy in end-of-life decisions.

    abstract:PURPOSE:The aim of this study is to examine family members' experiences of end-of-life decision-making processes in Norwegian intensive care units (ICUs) to ascertain the degree to which they felt included in the decision-making process and whether they received necessary information. Were they asked about the patient'...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-011-2253-x

    authors: Lind R,Lorem GF,Nortvedt P,Hevrøy O

    更新日期:2011-07-01 00:00:00

  • Association of social deprivation with 1-year outcome of ICU survivors: results from the FROG-ICU study.

    abstract:PURPOSE:Intensive care unit survivors suffer from prolonged impairment, reduced quality of life, and higher mortality rates after discharge compared to the general population. Socioeconomic status may play a partial but important role in mortality and recovery. Therefore, the detection of factors that are responsible f...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00134-018-5412-5

    authors: Bastian K,Hollinger A,Mebazaa A,Azoulay E,Féliot E,Chevreul K,Fournier MC,Guidet B,Michel M,Montravers P,Pili-Floury S,Sonneville R,Siegemund M,Gayat E,FROG-ICU Study Investigators.

    更新日期:2018-12-01 00:00:00

  • Impact of two different comorbidity measures on the 6-month mortality of critically ill cancer patients.

    abstract:OBJECTIVE:To evaluate the impact of two different comorbidity measures on the 6-month mortality of severely ill cancer patients. DESIGN AND SETTING:Prospective cohort study in a ten-bed oncological medical-surgical intensive care unit (ICU). PATIENTS:A total of 772 consecutive patients were included over a 45-month p...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-005-2554-z

    authors: Soares M,Salluh JI,Ferreira CG,Luiz RR,Spector N,Rocco JR

    更新日期:2005-03-01 00:00:00

  • Diagnosis of bacterial infection in the ICU: general principles.

    abstract::Diagnosis and treatment of infection is a common procedure in the clinical management of patients in the ICU. Infection in the ICU is an important area for study, but requires well-defined and proven diagnostic criteria. The diagnosis of infection, like any diagnosis, is based on probability, and diagnostic criteria a...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/BF01713977

    authors: Langer M,Pifferi S,Peta M

    更新日期:1994-11-01 00:00:00

  • Apoptosis inhibition in P. aeruginosa-induced lung injury influences lung fluid balance.

    abstract:OBJECTIVE:Pseudomonas aeruginosa-induced lung injury is characterized not only by the alteration in lung fluid movement but also by apoptosis of lung epithelial and endothelial cells. We studied whether inhibition of apoptosis using a broad spectrum caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp fluoromethylketone (Z...

    journal_title:Intensive care medicine

    pub_type: 杂志文章

    doi:10.1007/s00134-004-2165-0

    authors: Le Berre R,Faure K,Fauvel H,Viget NB,Ader F,Prangère T,Thomas AM,Leroy X,Pittet JF,Marchetti P,Guery BP

    更新日期:2004-06-01 00:00:00

  • Myorelaxants in ARDS patients.

    abstract::Neuromuscular blocking agents (NMBAs) inhibit patient-initiated active breath and the risk of high tidal volumes and consequent high transpulmonary pressure swings, and minimize patient/ ventilator asynchrony in acute respiratory distress syndrome (ARDS). Minimization of volutrauma and ventilator-induced lung injury (...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审

    doi:10.1007/s00134-020-06297-8

    authors: Hraiech S,Yoshida T,Annane D,Duggal A,Fanelli V,Gacouin A,Heunks L,Jaber S,Sottile PD,Papazian L

    更新日期:2020-12-01 00:00:00