Abstract:
OBJECTIVE:To measure muscle blood flow (Qtis) and oxygen consumption (VO(2)tis) in septic and non-septic critically ill patients by near-infrared spectroscopy (NIRS). SETTING:Surgical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS:Four patients with septic shock, eight post-surgical critically ill patients and ten healthy volunteers. MEASUREMENTS AND RESULTS:Oxyhaemoglobin (HbO(2)) and deoxyhaemoglobin (HbH) variations after venous occlusion were measured by NIRS in the brachioradialis muscle. We calculated Qtis by the rate of HbO(2) and HbH increase in the first 30 s of venous occlusion divided by haemoglobin blood concentration. VO(2)tis was calculated by subtraction of the arterial HbH from the initial increase of HbH after venous occlusion extrapolated to 1 min. Tissue oxygenation index [TOI = HbO(2)/(HbO(2)+HbH)] was also measured before venous occlusion. Two measurements in patients with septic shock, and one measurement in non-septic-shock patients and healthy subjects, were obtained. Of the measurements, 35% were repeated because of low-quality NIRS signal. VO(2)tis and Qtis were two times larger ( P<0.05) in patients with septic shock than in patients without and in healthy subjects. The TOI was very similar among the three groups. CONCLUSION:In septic-shock patients the increase in VO(2)tis was associated with an equivalent increase in Qtis. Therefore, tissue O(2) supply does not seem to be a limiting factor for muscle O(2) consumption. NIRS combined with venous occlusion allows a rapid, non-invasive and simultaneous assessment of regional perfusion and oxygen consumption. In case of microcirculatory shunt occurrence, the TOI should be cautiously used to assess tissue oxygenation state.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Girardis M,Rinaldi L,Busani S,Flore I,Mauro S,Pasetto Adoi
10.1007/s00134-003-1805-0keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1173-6issue
7eissn
0342-4642issn
1432-1238journal_volume
29pub_type
杂志文章abstract:OBJECTIVE:There is considerable heterogeneity among randomized trials comparing high-frequency ventilation (HFV) with conventional mechanical ventilation (CMV) in premature neonates with respiratory distress syndrome. We investigated what factors explained differences in outcome among these trials. DESIGN:Meta-regress...
journal_title:Intensive care medicine
pub_type: 杂志文章,meta分析
doi:10.1007/s00134-007-0545-y
更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Intensive care medicine
pub_type: 杂志文章
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更新日期:1978-07-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-015-4066-9
更新日期:2016-01-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-012-2605-1
更新日期:2012-08-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00134-011-2416-9
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00134-011-2304-3
更新日期:2011-10-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-009-1638-6
更新日期:2009-12-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章
doi:10.1007/s00134-001-1149-6
更新日期:2001-12-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-012-2554-8
更新日期:2012-07-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-003-2028-0
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00134-007-0833-6
更新日期:2007-12-01 00:00:00
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更新日期:2009-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-013-2826-y
更新日期:2013-05-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-012-2503-6
更新日期:2012-04-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00134-003-1956-z
更新日期:2003-11-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01706322
更新日期:1990-01-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章,meta分析
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更新日期:2015-11-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章
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更新日期:1998-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF00254122
更新日期:1988-01-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1007/s001340000635
更新日期:2000-12-01 00:00:00