Abstract：
INTRODUCTION:Approximately 20 years have passed since we reported our results of histologically proven cytomegalovirus (CMV) pneumonia in non-immunocompromised ICU patients. Even if there are more recent reports suggesting that CMV may worsen the outcomes for ICU patients, there is no definite answer to this question: is CMV a potential pathogen for ICU patients or is it simply a bystander? METHODS:We will describe the pathophysiology of active CMV infection and the most recent insights concerning the epidemiological aspects of these reactivations. MAJOR FINDINGS:Cytomegalovirus can be pathogenic by a direct organ insult (such as for the lung), by decreasing host defences against other microorganisms and/or by enhancing the body's inflammatory response (as in acute respiratory distress syndrome). The incidence of active CMV infection is dependent on the diagnostic method used. Using the most sophisticated available biological tools, the incidence can reach 15-20% of ICU patients (20-40% in ICU patients with positive CMV serology). In adequately powered cohorts of patients, active CMV infection appears to be associated with worse outcomes for mechanically ventilated ICU patients. DISCUSSION:There is no absolute direct proof of a negative impact of active CMV infection on the health outcomes of mechanically ventilated patients. Prospective randomized trials are lacking. Future trials should examine the potential benefits for health outcomes of using antiviral treatments. Such treatments could be prophylactic, pre-emptive or used only when there is an end-organ disease. CONCLUSION:Cytomegalovirus infection may affect health outcomes for ICU patients. Additional prospective trials are necessary to confirm this hypothesis.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Papazian L,Hraiech S,Lehingue S,Roch A,Chiche L,Wiramus S,Forel JMdoi
10.1007/s00134-015-4066-9subject
Has Abstractpub_date
2016-01-01 00:00:00pages
28-37issue
1eissn
0342-4642issn
1432-1238pii
10.1007/s00134-015-4066-9journal_volume
42pub_type
杂志文章abstract：OBJECTIVE:To determine the prevalence of post traumatic stress disorder in survivors of intensive care treatment. DESIGN:Systematic literature review including Medline, Embase, CINAHL, PsycINFO and references from identified papers. STUDY SELECTION:Studies determining the prevalence of PTSD in adult patients who had ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-007-0730-z
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:Nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in the response to injury and inflammation. Calpain I inhibitor is a potent antioxidant which is an effective inhibitor of NF-kappaB. This study examined whether the postulate that calpain...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2328-z
更新日期：2004-08-01 00:00:00
abstract：:Physicians are increasingly involved in how their critically ill patients die [72]. The more this happens, the more physicians will have to understand not only how their own backgrounds and biases influence their medical management, but also the cultural and religious backgrounds of the patient and surrogate [72, 73]....
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s001340000641
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVES:To develop a simplified Therapeutic Intervention Scoring System (TISS) based on the TISS-28 items and to validate the new score in an independent database. DESIGN:Retrospective statistical analysis of a database and a prospective multicentre study. SETTING:Development in the database of the Foundation for ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050406
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVE:To characterize N-terminal pro-brain natriuretic peptide (N-proBNP) and troponin I (TnI) profile following mitral and/or aortic valve surgery and to evaluate correlations with echocardiography measures and outcome criteria. DESIGN AND SETTING:Prospective cross-controlled study in a university children's hosp...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1025-8
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To assess the effects of the cyclooxygenase inhibitor diclofenac in a canine model of pulmonary occlusion and reperfusion of the left lower lobe (LLL). DESIGN:Twelve adult beagle dogs (13-17 kg) were randomly assigned to a control group (n = 6) and a diclofenac-treated group (n = 6). Animals in the treatment...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01700965
更新日期：1995-10-01 00:00:00
abstract：PURPOSE:We assessed feasibility and safety of extracorporeal carbon dioxide removal (ECCO2R) to facilitate ultra-protective ventilation (VT 4 mL/kg and PPLAT ≤ 25 cmH2O) in patients with moderate acute respiratory distress syndrome (ARDS). METHODS:Prospective multicenter international phase 2 study. Primary endpoint w...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-019-05567-4
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:The pressure-volume (P/V) curve has been proposed as a tool to adjust the ventilatory settings in cases of acute respiratory distress syndrome (ARDS). The aim of this study was to test the influence of P/V tracing methodology on the presence and value of the upper inflection point (UIP). METHODS:In 13 medica...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1293-7
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:Critically ill patients often require CT scans. Adverse events (AE) can occur during intra-hospital transport (IHT). The aim of this prospective study was to determine the diagnostic and therapeutic yield and the safety of CT scans in ICU patients. METHODS:All ICU patients having a CT scan for diagnostic purpo...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-014-3592-1
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:To examine the consequences of administration of norepinephrine on muscle tissue oxygenation in severely hypotensive septic shock patients. METHODS:This was a prospective observational study conducted in a medical intensive care unit of a university hospital. We included 28 septic shock patients that received ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-010-2013-3
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients. DESIGN:Prospective clinical study. SETTING:Medical ICU of a non-university hospital. PATIENTS:Mechanically ventilated patients with sep...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2233-5
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Invasive candidiasis and candidemia are frequently encountered in the nosocomial setting particularly in the intensive care unit (ICU). OBJECTIVE AND METHODS:To review the current management of invasive candidiasis and candidemia in non-neutropenic adult ICU patients based on a review of the literature and ...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-008-1339-6
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:Erythrocytes influence the magnitude of hypoxia-induced pulmonary artery pressure increase. It is, however, unknown to what extent haemoconcentration and haemodilution affect this response and whether intrapulmonary blood volume (and thus vessel dimensions) alters the magnitude of pressure increase. Furthermo...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340051327
更新日期：2000-08-01 00:00:00
abstract：:Peritonitis has been produced in rabbits by the spreading of 5 ml of caecal contents throughout the peritoneal cavity. After sacrifice at 5 h, electron microscopy revealed a increase of 600% in PMN and 1200% in lymphocytes in the pulmonary capillaries of the test animals when compared to the sham operated group. The p...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00265119
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:Pressure-volume (PV) curves are recorded after induction of complete muscle paralysis, which may limit their clinical use. The feasibility of recording PV curves without paralysis has not been tested. In 19 patients with acute respiratory distress syndrome (ARDS) and no hemodynamic instability we prospectivel...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-006-0265-8
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the influence of changes in alveolar ventilation on the following tonometry-derived variables: gastric intramucosal CO2 tension (PtCO2), gastric arterial CO2 tension difference (PgapCO2), gastric intramucosal pH (pHi) and arterial pH-pHi difference (pHgap). DESIGN:Clinical prospective study. SET...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s001340050834
更新日期：1999-03-01 00:00:00
abstract：OBJECTIVE:To analyze the actual cost of pediatric intensive care and its different components, particularly the differences between various patient groups, with special reference to the variable cost and the elements included in it. DESIGN:Prospective, observational study. SETTING:Multidisciplinary 12-bed pediatric i...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050320
更新日期：1997-02-01 00:00:00
abstract：:Owing to an oversight by the authors, Figure 2 in this article was not the version intended for publication. The correct Figure 2, reproduced here, features footnote symbols and Figure 2b includes three studies as described in the main text. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00134-018-5055-6
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:Controversy over the optimal intravenous fluid for volume resuscitation continues unabated. Our objectives were to characterize the demographics of physicians who prescribe intravenous colloids and determine factors that enter into their decision to choose a colloid. DESIGN:Questionnaire with 61 items. PAR...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1337-z
更新日期：2002-07-01 00:00:00
abstract：:We studied the influence of ventilatory frequency (1-5 Hz), tidal volume, lung volume and body position on the end-expiratory alveolar-to-tracheal pressure difference during high-frequency jet ventilation (HFJV) in Yorkshire piglets. The animals were anesthetized and paralysed. Alveolar pressure was estimated with the...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01706322
更新日期：1990-01-01 00:00:00
abstract：:The process of surgical decision making is based on both general principles that are amenable to evaluation using rigorous techniques of clinical research and the intangible element of surgical judgment that seeks to apply those principles to the care of an individual patient. The role of surgical judgment is inescapa...
journal_title：Intensive care medicine
pub_type： 指南,杂志文章,实务指引,评审
doi：10.1007/pl00003797
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:To investigate the role of the inducible nitric oxide synthase activation-induced excess nitric oxide formation on the rate of hepatic glucose production during fully resuscitated murine septic shock. DESIGN:Prospective, controlled, randomized animal study. SETTING:University animal research laboratory. SU...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-007-0638-7
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:We determined the effects of two antibiotic policies (predominance of either beta-lactam antibiotics or fluroquinolones) on acquisition with third-generation cephalosporin-resistant Enterobacteriaceae (CRE) and fluoroquinolone-resistant CRE (FCRE) in two ICUs, with monitoring of other variables that may infl...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00134-009-1714-y
更新日期：2010-03-01 00:00:00
abstract：PURPOSE:To establish the baseline prescribing error rate in a tertiary paediatric intensive care unit (PICU) and to determine the impact of a zero tolerance prescribing (ZTP) policy incorporating a dedicated prescribing area and daily feedback of prescribing errors. METHODS:A prospective, non-blinded, observational st...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2660-7
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:Evaluating the prevalence, risk factors and prevention of pressure ulcers in Dutch intensive care units (ICUs). DESIGN:Cross-sectional design. SETTING:ICUs of acute care hospitals that participated in the 1998 and 1999 national prevalence surveys. Data were collected on 1 day in each year. PATIENTS:Eight h...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340101061
更新日期：2001-10-01 00:00:00
abstract：:Activation of the complement system within the lung can lead to acute pulmonary damage and dysfunction. Based on a variety of experimental models it is now apparent that lung injury is related to complement-induced generation of oxygen derived free radicals from neutrophils and from macrophages. In addition to the oxy...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF00315362
更新日期：1986-01-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00134-020-06009-2
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:To assess the impact of lung ultrasound (LU) on clinical decision making in mechanically ventilated critically ill patients. METHODS:One hundred and eighty-nine patients took part in this prospective study. The patients were enrolled in the study when LU was requested by the primary physician for (1) unexplain...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-013-3133-3
更新日期：2014-01-01 00:00:00
abstract：:Since the introduction of synchronized intermittent mandatory ventilation (SIMV) several advantages have been attributed to this ventilatory mode, one of them being a more homogeneous distribution of ventilation and perfusion than during controlled mechanical ventilation (CMV). Up to now no data are available to confi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01704716
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:Postoperative pneumonia is a potentially devastating complication associated with high mortality in intensive care unit (ICU)-patients. One of the major predisposing factors is the perioperative occurrence of atelectatic formations in non-dependent lung areas. Perioperative ventilation/perfusion mismatch due ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-008-1122-8
更新日期：2008-10-01 00:00:00
