Conflicts of interest disclosure forms and management in critical care clinical practice guidelines.


BACKGROUND:Trustworthy clinical practice guidelines (CPGs) require identification and careful management of conflicts of interest (COIs) among all participants in the guideline development. Furthermore, COIs are more common than anticipated. However, there are no universally accepted methods to identify and manage COIs. OBJECTIVE:To describe and summarize the current COI disclosure forms and management policies in selected critical care professional societies that develop high-impact CPGs. In addition, we aim to provide suggestions to guideline developers on how to identify and manage different types of COIs. METHODS:We searched PubMed and MEDLINE for CPGs published between 2013 and 2018 in English language and addressed general critical care topics. We then ranked the CPGs according to the numbers of citations and selected the first five critical care professional societies that sponsored the guidelines. We obtained the most recent COI declaration forms and management policies. Two reviewers abstracted data on different types of COI in each of the disclosure forms and management policies. RESULTS:All selected professional critical care societies require that members declare direct financial COIs; four societies inquire specifically about intellectual COIs (involvement in primary research). Three out of five societies require members to disclose indirect institutional financial COIs; however, none inquire about other forms of institutional COI. We developed, by consensus, a streamlined framework to classify and manage different types of COIs. CONCLUSION:The current COI disclosure forms of selected professional societies provide more attention to financial disclosures and COIs and less attention to detecting and managing intellectual COIs, while rarely addressing institutional COIs. We provide some suggestions for guideline developers on the classification and management of different COIs in the context of CPGs.


Intensive Care Med


Intensive care medicine


Alhazzani W,Lewis K,Jaeschke R,Rochwerg B,Møller MH,Evans L,Wilson KC,Patel S,Coopersmith CM,Cecconi M,Guyatt G,Akl EA




Has Abstract


2018-10-01 00:00:00














  • Lower respiratory rates without decreases in oxygen consumption during neonatal synchronized intermittent mandatory ventilation.

    abstract:OBJECTIVE:We tested the hypothesis that synchronization to patient effort during intermittent mandatory ventilation (SIMV), when compared to conventional unsynchronized intermittent mandatory ventilation (IMV), will decrease energy expenditure, as reflected by decreased oxygen consumption (VO2). DESIGN:We used a four-...

    journal_title:Intensive care medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Smith KM,Wahlig TM,Bing DR,Georgieff MK,Boros SJ,Mammel MC

    更新日期:1997-04-01 00:00:00

  • Ultrasound-guided percutaneous dilatational tracheostomy: a safe method to avoid cranial misplacement of the tracheostomy tube.

    abstract::The aim of this investigation was to evaluate the role of ultrasonography in avoiding cranial misplacement of the tracheostomy tube and tracheal ring fractures during percutaneous dilatational tracheostomy (PDT). The tracheas of 26 consecutive ICU patients who had undergone PDT but who later died were removed en bloc ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Sustić A,Kovac D,Zgaljardić Z,Zupan Z,Krstulović B

    更新日期:2000-09-01 00:00:00

  • Effects of blood glucose transcription mismatches on a computer-based intensive insulin therapy protocol.

    abstract:PURPOSE:Computerized clinical decision support systems (CDSS) for intensive insulin therapy (IIT) generate recommendations using blood glucose (BG) values manually transcribed from testing devices to computers, a potential source of error. We quantified the frequency and effect of blood glucose transcription mismatches...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Campion TR Jr,May AK,Waitman LR,Ozdas A,Gadd CS

    更新日期:2010-09-01 00:00:00

  • Optimisation of positive end-expiratory pressure by forced oscillation technique in a lavage model of acute lung injury.

    abstract:PURPOSE:We evaluated whether oscillatory compliance (C(X5)) measured by forced oscillation technique (FOT) at 5 Hz may be useful for positive end-expiratory pressure (PEEP) optimisation. METHODS:We studied seven pigs in which lung injury was induced by broncho-alveolar lavage. The animals were ventilated in volume con...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Dellacà RL,Zannin E,Kostic P,Olerud MA,Pompilio PP,Hedenstierna G,Pedotti A,Frykholm P

    更新日期:2011-06-01 00:00:00

  • Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study.

    abstract:OBJECTIVE:To test the hypothesis that levosimendan increases systemic and intestinal oxygen delivery (DO(2)) and prevents intramucosal acidosis in septic shock. DESIGN:Prospective, controlled experimental study. SETTING:University-based research laboratory. SUBJECTS:Nineteen anesthetized, mechanically ventilated she...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Dubin A,Murias G,Sottile JP,Pozo MO,Barán M,Edul VS,Canales HS,Etcheverry G,Maskin B,Estenssoro E

    更新日期:2007-03-01 00:00:00

  • Endotoxemic pulmonary hypertension is largely mediated by endothelin-induced venous constriction.

    abstract:OBJECTIVE:To analyze the effect of endothelin-1 on pulmonary arterial and venous contractile force in vitro and on up- and downstream pulmonary vascular resistance in vivo under sham and endotoxemic conditions in pigs. MATERIALS AND METHODS:In vitro: paired preparations of pulmonary arteries and veins were mounted in ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Rossi P,Persson B,Boels PJ,Arner A,Weitzberg E,Oldner A

    更新日期:2008-05-01 00:00:00

  • The metrics of glycaemic control in critical care.

    abstract:INTRODUCTION:Trials of tight glucose control have compared measures of central tendency, such as average blood glucose, and yielded conflicting results. Other metrics, such as standard deviation, reflect different properties of glucose control and are also associated with changes in outcome. It is possible, therefore, ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Mackenzie IM,Whitehouse T,Nightingale PG

    更新日期:2011-03-01 00:00:00

  • Autoregulation of ventilation with neurally adjusted ventilatory assist on extracorporeal lung support.

    abstract:PURPOSE:Extracorporeal membrane oxygenation (ECMO) can support oxygenation and carbon dioxide elimination in severe lung failure. Usually it is accompanied by controlled mechanical ventilation. Neurally adjusted ventilatory assist (NAVA) is a new mode of ventilation triggered by the diaphragmatic electrical activity an...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Karagiannidis C,Lubnow M,Philipp A,Riegger GA,Schmid C,Pfeifer M,Mueller T

    更新日期:2010-12-01 00:00:00

  • Trends in sedation practices in Danish intensive care units in 2003: a national survey.

    abstract:OBJECTIVE:The aim of the study was to explore trends and changes in sedation practices for mechanically ventilated patients in Danish intensive care units (ICUs) and to compare sedation practices in 1997 and 2003. DESIGN:The study was a follow-up survey with a descriptive and comparative cross-sectional multicenter de...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,多中心研究


    authors: Egerod I,Christensen BV,Johansen L

    更新日期:2006-01-01 00:00:00

  • Halothane treatment in life-threatening asthma.

    abstract::We analysed the case histories of 22 patients with life threatening asthma retrospectively. Fifteen patients needed mechanical ventilation. Three patients, all of them in cardiac arrest before or at the moment of admission, died. In five patients, halothane therapy was successfully used as a last resort. No major comp...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Rosseel P,Lauwers LF,Baute L

    更新日期:1985-01-01 00:00:00

  • Membranous laryngotracheobronchitis, a complication of measles.

    abstract::Membranous laryngotracheobronchitis is a very serious infection which affects the larynx, trachea and bronchi, requiring aggressive therapeutic measures. It has been recently rediscovered as a cause of disease in children. However, it is a very unusual complication of measles. Two infants with measles and membranous l...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Labay MV,Ramos R,Hervas JA,Reynes J,Gomez B

    更新日期:1985-01-01 00:00:00

  • Use of the oxygen cost of breathing as an index of weaning ability from mechanical ventilation.

    abstract::The oxygen cost of breathing (which is the difference in oxygen consumption measured during controlled ventilation and again during spontaneous ventilation) was measured in 30 patients between the ages of 17 and 96 years at the time of commencement of weaning from mechanical ventilation. There was a significant expone...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: McDonald NJ,Lavelle P,Gallacher WN,Harpin RP

    更新日期:1988-01-01 00:00:00

  • Source control in the management of sepsis.

    abstract::The process of surgical decision making is based on both general principles that are amenable to evaluation using rigorous techniques of clinical research and the intangible element of surgical judgment that seeks to apply those principles to the care of an individual patient. The role of surgical judgment is inescapa...

    journal_title:Intensive care medicine

    pub_type: 指南,杂志文章,实务指引,评审


    authors: Jimenez MF,Marshall JC,International Sepsis Forum.

    更新日期:2001-01-01 00:00:00

  • End-expiratory lung impedance change enables bedside monitoring of end-expiratory lung volume change.

    abstract:OBJECTIVE:The aim of the study was to investigate the effect of lung volume changes on end-expiratory lung impedance change (ELIC) in mechanically ventilated patients, since we hypothesized that ELIC may be a suitable parameter to monitor lung volume change at the bedside. DESIGN:Clinical trial on patients requiring m...

    journal_title:Intensive care medicine

    pub_type: 临床试验,杂志文章


    authors: Hinz J,Hahn G,Neumann P,Sydow M,Mohrenweiser P,Hellige G,Burchardi H

    更新日期:2003-01-01 00:00:00

  • Added inspiratory work of breathing during CPAP ventilation: comparison of two demand-valve devices with a continuous flow-system.

    abstract::Measurements of added inspiratory work (AIW) of breathing imposed by three different CPAP systems were performed in 10 patients. One system was a continuous flow system while the two others were demand flow systems separated from respirators (Ohmeda VD 101 and Draeger CPAP 800 devices). AIW was calculated from pressur...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Viale JP,Annat G,Percival C,Bertrand O,Motin J

    更新日期:1986-01-01 00:00:00

  • Gender-based differences in children with sepsis and ARDS: the ESPNIC ARDS Database Group.

    abstract::Male gender predisposes to severe sepsis and septic shock. This effect has been ascribed to higher levels of testosterone. The ESPNIC ARDS database was searched, to determine if there was evidence of a similar male preponderance in severe sepsis in prepubertal patients in spite of low levels of male sex hormones at th...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Bindl L,Buderus S,Dahlem P,Demirakca S,Goldner M,Huth R,Kohl M,Krause M,Kühl P,Lasch P,Lewandowski K,Merz U,Moeller J,Mohamad Y,Peters M,Porz W,Vierzig A,Rüchard J,Scharf J,Varnholt V,ESPNIC ARDS Database Group.

    更新日期:2003-10-01 00:00:00

  • Coagulation Day 2010: an Austrian survey on the routine of thromboprophylaxis in intensive care.

    abstract:PURPOSE:Venous thromboembolism (VTE) is a common but often overlooked life-threatening complication of critical illness. The aim of this cross-sectional survey was to assess current practice of thromboprophylaxis as well as adherence to international guidelines. METHODS:After ethics committee approval, all intensive c...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Schaden E,Metnitz PG,Pfanner G,Heil S,Pernerstorfer T,Perger P,Schoechl H,Fries D,Guetl M,Kozek-Langenecker S

    更新日期:2012-06-01 00:00:00

  • Differential ventilation in unilateral lung disease: effects on respiratory mechanics and gas exchange.

    abstract::Conventional PEEP ventilation has been recently reported to be deleterious in some cases of ARF with unilateral pneumonia. In such respect, two cases of unilateral bacterial pneumonia were intubated with a Carlens tracheal tube. Measurement of tidal volume, static compliance, and functional residual capacity of each l...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Rivara D,Bourgain JL,Rieuf P,Harf A,Lemaire F

    更新日期:1979-11-01 00:00:00

  • Bladder epithelial oxygen tension--a new means of monitoring regional perfusion? Preliminary study in a model of exsanguination/fluid repletion.

    abstract:OBJECTIVE:To assess whether monitoring of bladder epithelial oxygen tension (BEOT) would provide an indication of regional (renal) organ perfusion in an exsanguination/fluid repletion animal model. DESIGN:Prospective non-randomized laboratory study. SETTING:Research laboratory. INTERVENTIONS:Eight anaesthetised, spo...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Singer M,Millar C,Stidwill R,Unwin R

    更新日期:1996-04-01 00:00:00

  • Paracetamol-associated coma, metabolic acidosis, renal and hepatic failure.

    abstract::A case of metabolic acidosis, acute renal failure and hepatic failure following paracetamol ingestion is presented. The diagnostic difficulty at presentation is highlighted. Continuous arteriovenous haemofiltration proved a valuable means of maintaining fluid and electrolyte balance. The patient recovered. ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Kritharides L,Fassett R,Singh B

    更新日期:1988-01-01 00:00:00

  • Posterior reversible encephalopathy syndrome in intensive care medicine.

    abstract:BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is a well-recognized clinico-neuroradiological transient condition. Early recognition is of paramount importance for prompt control of blood pressure or removal of precipitating factors and treatment of epileptic seizures or status epilepticus. Delay in the...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审


    authors: Servillo G,Bifulco F,De Robertis E,Piazza O,Striano P,Tortora F,Striano S,Tufano R

    更新日期:2007-02-01 00:00:00

  • Monitoring of neuromuscular blockade: a comparison of train-of-four and the Campbell diagram.

    abstract:: ...

    journal_title:Intensive care medicine

    pub_type: 信件


    authors: Baedorf Kassis E,Train S,MacNeil B,Loring SH,Talmor D

    更新日期:2018-12-01 00:00:00

  • Intracranial hypertension in head injury: management and results.

    abstract:OBJECTIVE:(1) To describe the pattern of intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in a group of severe head-injured patients, (2) to quantify complications of ICP monitoring, and (3) to describe a management protocol and its results. DESIGN:Prospective observational study. SETTING:General int...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Stocchetti N,Rossi S,Buzzi F,Mattioli C,Paparella A,Colombo A

    更新日期:1999-04-01 00:00:00

  • Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients.

    abstract:PURPOSE:To examine the consequences of administration of norepinephrine on muscle tissue oxygenation in severely hypotensive septic shock patients. METHODS:This was a prospective observational study conducted in a medical intensive care unit of a university hospital. We included 28 septic shock patients that received ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Georger JF,Hamzaoui O,Chaari A,Maizel J,Richard C,Teboul JL

    更新日期:2010-11-01 00:00:00

  • Pulse pressure variations adjusted by alveolar driving pressure to assess fluid responsiveness.

    abstract:OBJECTIVE:To evaluate the ability of DeltaPP/DeltaP [pulse pressure variations (DeltaPP) adjusted by alveolar pressure variations (DeltaP = Pplat-PEEPtot)] in predicting fluid responsiveness, to compare its accuracy to that of DeltaPP used alone and to evaluate the influence of tidal volume (Vt) on these two indices. ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Vallée F,Richard JC,Mari A,Gallas T,Arsac E,Verlaan PS,Chousterman B,Samii K,Genestal M,Fourcade O

    更新日期:2009-06-01 00:00:00

  • Effects of alveolar recruitment maneuvers on clinical outcomes in patients with acute respiratory distress syndrome: a systematic review and meta-analysis.

    abstract:PURPOSE:To assess the effects of alveolar recruitment maneuvers (ARMs) on clinical outcomes in patients with acute respiratory distress syndrome (ARDS). METHODS:We conducted a search of the MEDLINE, EMBASE, LILACS, CINAHL, CENTRAL, Scopus, and Web of Science (from inception to July 2014) databases for all (i.e. no lan...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,meta分析,评审


    authors: Suzumura EA,Figueiró M,Normilio-Silva K,Laranjeira L,Oliveira C,Buehler AM,Bugano D,Passos Amato MB,Ribeiro Carvalho CR,Berwanger O,Cavalcanti AB

    更新日期:2014-09-01 00:00:00

  • Effects of helium-oxygen on respiratory mechanics, gas exchange, and ventilation-perfusion relationships in a porcine model of stable methacholine-induced bronchospasm.

    abstract:OBJECTIVE:To explore the consequences of helium/oxygen (He/O(2)) inhalation on respiratory mechanics, gas exchange, and ventilation-perfusion (VA/Q) relationships in an animal model of severe induced bronchospasm during mechanical ventilation. DESIGN:Prospective, interventional study. SETTING:Experimental animal labo...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Watremez C,Liistro G,deKock M,Roeseler J,Clerbaux T,Detry B,Reynaert M,Gianello P,Jolliet P

    更新日期:2003-09-01 00:00:00

  • Impact of two different comorbidity measures on the 6-month mortality of critically ill cancer patients.

    abstract:OBJECTIVE:To evaluate the impact of two different comorbidity measures on the 6-month mortality of severely ill cancer patients. DESIGN AND SETTING:Prospective cohort study in a ten-bed oncological medical-surgical intensive care unit (ICU). PATIENTS:A total of 772 consecutive patients were included over a 45-month p...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Soares M,Salluh JI,Ferreira CG,Luiz RR,Spector N,Rocco JR

    更新日期:2005-03-01 00:00:00

  • Helicobacter pylori in intensive care: why we should be interested.

    abstract::Helicobacter pylori is estimated to infect over 50% of the world's population, the majority of whom are asymptomatic. Although most research to date has focused on local gastroduodenal disease manifestations, the potential impact of H. pylori infection and the associated chronic active inflammation on systemic disease...

    journal_title:Intensive care medicine

    pub_type: 杂志文章,评审


    authors: Robertson MS,Clancy RL,Cade JF

    更新日期:2003-11-01 00:00:00

  • A comparative assessment of two conservative methods for the diagnosis of catheter-related infection in critically ill patients.

    abstract:PURPOSE:To assess the utility of two in situ techniques, differential time to positivity (DTP) and semiquantitative superficial cultures (SQSC) for diagnosing catheter-related bloodstream infection (CR-BSI) in critically ill adults. METHODS:This was a prospective cohort study in patients with suspected CR-BSI arising ...

    journal_title:Intensive care medicine

    pub_type: 杂志文章


    authors: Gowardman JR,Jeffries P,Lassig-Smith M,Stuart J,Jarrett P,Deans R,McGrail M,George NM,Nimmo GR,Rickard CM

    更新日期:2013-01-01 00:00:00