当前位置： SCI文献检索 > INTENSIVE CARE MEDICINE期刊下所有文献 > Different dosages of dobutamine in septic shock patients: determining oxygen consumption with a metabolic monitor integrated in a ventilator.

Different dosages of dobutamine in septic shock patients: determining oxygen consumption with a metabolic monitor integrated in a ventilator.

Abstract：

OBJECTIVE:Oxygen consumption (VO2) obtained from respiratory gases by indirect calorimetry (VO2,IC) with a metabolic monitor integrated in a ventilator were to be compared to VO2 obtained by the Fick principle (VO2,Fick) in septic patients following an increase in oxygen delivery (DO2) induced by positive inotropic support. DESIGN:Prospective clinical study. SETTING:University Hospital, Surgical Intensive Care Unit (ICU). PATIENTS:Thirty patients suffering from sepsis. INTERVENTIONS:DO2 was increased by dobutamine infusion, starting with an initial dosage of 5 microg x kg x min, increased to a maximum of 10 microg x kg x min. MEASUREMENTS AND MAIN RESULTS:Dobutamine infusion induced a dosage-related increase in DO2 (from 577 +/- 192 to 752 +/- 202 ml x min x m2, p < 0.01), which was associated with a statistically significant increase in VO2,IC (from 173 +/- 30 to 188 +/- 28 ml x min x m2, p < 0.01) and in VO2,Fick (from 140 +/- 25 to 156 +/- 24 ml x min x m2, p < 0.01). The comparison between VO2,IC and VO2,Fick revealed differences (bias and precision--33 +/- 32 ml x min x m2). CONCLUSIONS:With a metabolic monitor integrated in a ventilator it was possible to carry out continuous monitoring of calorimetric data under clinical conditions. In contrast to previous studies using indirect calorimetry, this study showed a moderate correlation between VO2 and DO2 in septic patients using either method. The clinical relevance of this finding requires further investigation. Different factors (e. g. injectant temperature, pulmonary VO2) produced substantial differences between VO2,IC and VO2,Fick as previously shown.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Schaffartzik W,Sanft C,Schaefer JH,Spies C

doi

10.1007/s001340000635

keywords:

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1740-6

issue

12

eissn

0342-4642

issn

1432-1238

journal_volume

26

pub_type

临床试验,杂志文章

相关文献

INTENSIVE CARE MEDICINE文献大全
  • Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients.

    abstract：OBJECTIVE:Real-time measurement of stroke volume variation by arterial pulse contour analysis (SVV) is useful in predicting volume responsiveness and monitoring volume therapy in mechanically ventilated patients. This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of f...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00134-003-1649-7

    authors： Reuter DA,Bayerlein J,Goepfert MS,Weis FC,Kilger E,Lamm P,Goetz AE

    更新日期：2003-03-01 00:00:00

  • Early and late onset bacteremia have different risk factors in trauma patients.

    abstract：OBJECTIVE:The aim of this study was to identify risk factors and to describe epidemiological patterns for early-(EOB) and late-onset bacteremias (LOB) after trauma. DESIGN:A prospective study conducted on 141 consecutive trauma patients. SETTING:A general intensive care unit (ICU) of a university hospital. PATIENTS:...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01709514

    authors： Antonelli M,Moro ML,D'Errico RR,Conti G,Bufi M,Gasparetto A

    更新日期：1996-08-01 00:00:00

  • Fluid leakage past tracheal tube cuffs: evaluation of the new Microcuff endotracheal tube.

    abstract：OBJECTIVE:This study compared the recently introduced Microcuff endotracheal tube HVLP ICU featuring an ultrathin (7-microm) polyurethane cuff membrane with endotracheal tubes from different manufacturers regarding fluid leakage past the tube cuff. DESIGN:In vitro setup. MEASUREMENTS AND RESULTS:The following endotra...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-003-1933-6

    authors： Dullenkopf A,Gerber A,Weiss M

    更新日期：2003-10-01 00:00:00

  • Propofol in the management of refractory status epilepticus: a case report.

    abstract：:Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit. Standard treatment includes intravenous barbiturates, benzodiazepines and phenytoin. However, drug coma is sometimes necessary to control refractory status epilepticus. We report such a case, successfully treated by int...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01707672

    authors： Borgeat A,Wilder-Smith OH,Jallon P,Suter PM

    更新日期：1994-01-01 00:00:00

  • Continuous arteriovenous haemofiltration and respiratory function in multiple organ systems failure.

    abstract：OBJECTIVE:To determine what change in respiratory function occurred following prolonged and efficient continuous arteriovenous haemofiltration (CAVH) in a group of patients with multiple organ systems failure (MOSF). DESIGN:A retrospective assessment using patient notes and ICU charts. SETTING:The Intensive Care Unit...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01694361

    authors： Bagshaw ON,Anaes FR,Hutchinson A

    更新日期：1992-01-01 00:00:00

  • Will my patient survive? Look for creatinine in the urine!

    abstract：: ...

    journal_title：Intensive care medicine

    pub_type： 评论,社论

    doi：10.1007/s00134-018-5399-y

    authors： Darmon M,Kashani K,Schetz M

    更新日期：2018-11-01 00:00:00

  • Effects of 15-deoxy-Delta12,14-prostaglandin-J2 during hyperdynamic porcine endotoxemia.

    abstract：OBJECTIVE:To investigate the hemodynamic and metabolic effects of the peroxisome proliferator-activated receptor (PPAR)-gamma ligand and nuclear-factor (NF)-kappa B inhibitor 15-deoxy-Delta12,14-prostaglandin-J2 (15d-PGJ2) during long-term, hyperdynamic porcine endotoxemia. DESIGN:Prospective, randomized, controlled e...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-006-0107-8

    authors： Hauser B,Kick J,Iványi Z,Asfar P,Ehrmann U,Muth CM,Albicini M,Wachter U,Vogt J,Bauer M,Brückner UB,Radermacher P,Bracht H

    更新日期：2006-05-01 00:00:00

  • Influence of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance in critically ill medical patients.

    abstract：OBJECTIVE:To assess the role of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance. DESIGN:Prospective cohort study. SETTING:Two medical intensive care units. PATIENTS AND PARTICIPANTS:346 patients admitted for >or= 48 h. INTERVENTION:Analysis of data from an 8-month study c...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-008-1326-y

    authors： Martínez JA,Delgado E,Martí S,Marco F,Vila J,Mensa J,Torres A,Codina C,Trilla A,Soriano A,Alquezar A,Castro P,Nicolás JM

    更新日期：2009-03-01 00:00:00

  • Prolonged extracorporeal CO2-removal in severe adult respiratory distress syndrome. Neuropathological observations in two cases.

    abstract：:Extracorporeal CO2-removal (EC-CO2-R) using a membrane lung system was applied for 12 and 20 days respectively in two young men with adult respiratory distress syndrome (ARDS). Neuropathological examination revealed only moderate hypoxic changes of unusual distribution. In the first case nerve cell loss in Sommer's se...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF00263553

    authors： Krajewski S,Seitz RJ,Schober R,Breulmann M,Falke KJ

    更新日期：1987-01-01 00:00:00

  • Pneumonia associated with invasive and noninvasive ventilation: an analysis of the German nosocomial infection surveillance system database.

    abstract：PURPOSE:Pneumonia associated with invasive mechanical ventilation (IMV) is one of the indicator infections of the German Nosocomial Infection Surveillance System. In 2005 surveillance was extended to include pneumonia associated with noninvasive ventilation (NIV). The aim of this study was to determine the utilization ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-010-1863-z

    authors： Kohlenberg A,Schwab F,Behnke M,Geffers C,Gastmeier P

    更新日期：2010-06-01 00:00:00

  • Airway occlusion pressure at 0.1 s (P0.1) after extubation: an early indicator of postextubation hypercapnic respiratory insufficiency.

    abstract：OBJECTIVE:To examine variables associated with postextubation respiratory distress in chronic obstructive pulmonary disease (COPD) patients. DESIGN:Prospective, clinical investigation. SETTING:Intensive care unit of a university hospital. PATIENTS:Forty COPD patients, considered ready for extubation. MEASUREMENTS A...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s001340050762

    authors： Hilbert G,Gruson D,Portel L,Vargas F,Gbikpi-Benissan G,Cardinaud JP

    更新日期：1998-12-01 00:00:00

  • Assessment of depth of midazolam sedation using objective parameters.

    abstract：OBJECTIVE:To determine the relationship between the clinically evaluated depth of midazolam-induced sedation and the cardiac beat-to-beat variability (RR variability) in ICU patients in the intensive care unit (ICU). DESIGN:Prospective study. SETTING:ICU of a university hospital. PATIENTS:20 consecutive patients stu...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01709555

    authors： Haberthür C,Lehmann F,Ritz R

    更新日期：1996-12-01 00:00:00

  • Influence of parenteral fat administration on the pulmonary vascular system in man.

    abstract：:In 16 patients with multiple injuries the effect of parenteral administration of a fat emulsion on the pulmonary vascular system has been studied. Using the Hewlett Packard 5600 A Intensive Care System, which allows vital parameters to be sampled at a rate of two values per min, pulmonary artery pressure (PAP) was mon...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01699260

    authors： van Deyk K,Hempel V,Münch F,Kopp M,Graf H,Epple E

    更新日期：1983-01-01 00:00:00

  • Academic conflict of interest.

    abstract：PURPOSE:We set out to summarize the current challenges in academic conflict of interest. METHODS:This is a narrative review by a multidisciplinary, multinational panel of academic officers including deans of medical/pharmacy schools. RESULTS AND CONCLUSIONS:Disclosing conflict of interest has become the appropriate p...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00134-018-5458-4

    authors： Annane D,Lerolle N,Meuris S,Sibilla J,Olsen KM

    更新日期：2019-01-01 00:00:00

  • Acute respiratory distress syndrome among trauma patients: trends in ICU mortality, risk factors, complications and resource utilization.

    abstract：OBJECTIVE:To evaluate trends in mortality and related factors among trauma patients who developed acute respiratory distress syndrome (ARDS). STUDY:Observational study based on data prospectively gathered in computerized trauma registry. SETTING:Trauma intensive care unit (ICU) of 48 beds in level I trauma center. P...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340100955

    authors： Navarrete-Navarro P,Rodriguez A,Reynolds N,West R,Habashi N,Rivera R,Chiu WC,Scalea T

    更新日期：2001-07-01 00:00:00

  • Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study.

    abstract：PURPOSE:To determine the global metabolomic profile as measured in circulating plasma from surviving and non-surviving patients with community-acquired pneumonia (CAP) and sepsis. METHODS:Random, outcome-stratified case-control sample from a prospective study of 1,895 patients hospitalized with CAP and sepsis. Cases (...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00134-013-2935-7

    authors： Seymour CW,Yende S,Scott MJ,Pribis J,Mohney RP,Bell LN,Chen YF,Zuckerbraun BS,Bigbee WL,Yealy DM,Weissfeld L,Kellum JA,Angus DC

    更新日期：2013-08-01 00:00:00

  • Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats.

    abstract：PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-010-1913-6

    authors： Fathali N,Lekic T,Zhang JH,Tang J

    更新日期：2010-09-01 00:00:00

  • Evaluation of two processed EEG analyzers for assessment of sedation after coronary artery bypass grafting.

    abstract：OBJECTIVES:Processed EEG monitoring has been suggested for sedation depth evaluation in intensive care unit (ICU) patients. The present study investigated the efficacy of two processed EEG monitors using SEF90% or SEF95% and BIS to differentiate between conscious (Ramsay score 4) and unconscious sedation (Ramsay score ...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s001340000761

    authors： Walder B,Suter PM,Romand JA

    更新日期：2001-01-01 00:00:00

  • Multinational development and validation of an early prediction model for delirium in ICU patients.

    abstract：RATIONALE:Delirium incidence in intensive care unit (ICU) patients is high and associated with poor outcome. Identification of high-risk patients may facilitate its prevention. PURPOSE:To develop and validate a model based on data available at ICU admission to predict delirium development during a patient's complete I...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00134-015-3777-2

    authors： Wassenaar A,van den Boogaard M,van Achterberg T,Slooter AJ,Kuiper MA,Hoogendoorn ME,Simons KS,Maseda E,Pinto N,Jones C,Luetz A,Schandl A,Verbrugghe W,Aitken LM,van Haren FM,Donders AR,Schoonhoven L,Pickkers P

    更新日期：2015-06-01 00:00:00

  • Application of therapeutic hypothermia in the intensive care unit. Opportunities and pitfalls of a promising treatment modality--Part 2: Practical aspects and side effects.

    abstract：:Induced hypothermia can be used to protect the brain from post-ischemic and traumatic neurological injury. Potential clinical applications and the available evidence are discussed in a separate paper. This review focuses on the practical aspects of cooling and physiological changes induced by hypothermia, as well as t...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00134-003-2151-y

    authors： Polderman KH

    更新日期：2004-05-01 00:00:00

  • Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines.

    abstract：PURPOSE:To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. METHODS:We aimed to compare EEN vs. early parenteral nutrition (PN) and vs. delayed EN. We defined "early" EN as EN started within 48 h independent of type or amount. We listed, a priori, conditions in which EN is o...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,meta分析,实务指引,评审

    doi：10.1007/s00134-016-4665-0

    authors： Reintam Blaser A,Starkopf J,Alhazzani W,Berger MM,Casaer MP,Deane AM,Fruhwald S,Hiesmayr M,Ichai C,Jakob SM,Loudet CI,Malbrain ML,Montejo González JC,Paugam-Burtz C,Poeze M,Preiser JC,Singer P,van Zanten AR,De Waele J

    更新日期：2017-03-01 00:00:00

  • End-of-life decision making in the intensive care unit.

    abstract：:Physicians are increasingly involved in how their critically ill patients die [72]. The more this happens, the more physicians will have to understand not only how their own backgrounds and biases influence their medical management, but also the cultural and religious backgrounds of the patient and surrogate [72, 73]....

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s001340000641

    authors： Nyman DJ,Sprung CL

    更新日期：2000-10-01 00:00:00

  • Rapid diagnosis of alcoholic ketoacidosis by proton NMR.

    abstract：:In alcoholic patients, metabolic acidosis can be related to lactate acidosis associated with sepsis or thiamine deficiency, ketoacidosis, methanol or ethylene glycol poisoning. High resolution proton nuclear magnetic resonance (NMR) can be used to detect abnormal organic acid metabolites in urine or serum from patient...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s001340100892

    authors： Godet C,Hira M,Adoun M,Eugène M,Robert R

    更新日期：2001-04-01 00:00:00

  • A new device to remove obstruction from endotracheal tubes during mechanical ventilation in critically ill patients.

    abstract：OBJECTIVE:To evaluate the efficiency of a new device developed to remove obstructions from endotracheal tubes (ETT) in mechanically ventilated patients. DESIGN:Open study in mechanically ventilated sedated and paralyzed ICU patients. SETTING:General ICU and Laboratory of Respiratory Mechanics of the University of Rom...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01705724

    authors： Conti G,Rocco M,De Blasi RA,Lappa A,Antonelli M,Bufi M,Gasparetto A

    更新日期：1994-11-01 00:00:00

  • Mechanism of injury influences quality of life in survivors of acute respiratory distress syndrome.

    abstract：OBJECTIVE:Growing evidence suggests that acute respiratory distress syndrome (ARDS) occurring as a consequence of primary (direct) lung injury differs from that resulting from secondary (indirect) lung injury in terms of radiographic appearance, response to interventions, and outcomes. We examined whether there are dif...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00134-006-0344-x

    authors： Parker CM,Heyland DK,Groll D,Caeser M

    更新日期：2006-11-01 00:00:00

  • How many patients with severe sepsis are needed to confirm the efficacy of drotrecogin alfa activated? A Bayesian design.

    abstract：OBJECTIVES:Controversies concerning the pivotal trial and negative results from other Drotrecogin alfa activated (DAA) trials have raised questions about its efficacy in severe sepsis patients. Based on all available evidence, our study aimed to respond to: (1) What is the current probability that DAA is not better tha...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-008-1159-8

    authors： Kalil AC,Sun J

    更新日期：2008-10-01 00:00:00

  • Clonidine as a sedative adjunct in intensive care.

    abstract：:A 63-year-old man underwent distal oesophagectomy and proximal gastrectomy. Postoperatively, controlled ventilation was necessary for 53 days because of anastomotic leakage. Multiple sedative regimens proved to be inadequate. By contrast, a fentanyl-midazolam combination with continuous supplementation of clonidine 0....

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/BF01705163

    authors： Böhrer H,Bach A,Layer M,Werning P

    更新日期：1990-01-01 00:00:00

  • Noise exposure during noninvasive ventilation with a helmet, a nasal mask, and a facial mask.

    abstract：OBJECTIVE:To assess noise exposure during noninvasive ventilation (NIV) with different types of interface (helmet, nasal, and facial masks). SUBJECTS AND METHODS:Ten "naive" healthy volunteers underwent NIV at pressure support levels of 10 and 15 cmH2O with: (a) helmet, (b) helmet equipped with HME filters at the junc...

    journal_title：Intensive care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00134-004-2347-9

    authors： Cavaliere F,Conti G,Costa R,Proietti R,Sciuto A,Masieri S

    更新日期：2004-09-01 00:00:00

  • Fellows' in intensive care medicine views on professionalism and how they learn it.

    abstract：INTRODUCTION:The emphasis on the importance of professionalism in a recent CoBaTrICE-IT paper was impressive. However, insight into the elements of professionalism as perceived relevant for intensivists from the fellows' view, and how these are taught and learned, is limited. OBJECTIVES AND METHODS:A nationwide study ...

    journal_title：Intensive care medicine

    pub_type： 杂志文章

    doi：10.1007/s00134-009-1644-8

    authors： van Mook WN,de Grave WS,Gorter SL,Muijtjens AM,Zwaveling JH,Schuwirth LW,van der Vleuten CP

    更新日期：2010-02-01 00:00:00

  • Obesity in the critically ill: a narrative review.

    abstract：:The World Health Organization defines overweight and obesity as the condition where excess or abnormal fat accumulation increases risks to health. The prevalence of obesity is increasing worldwide and is around 20% in ICU patients. Adipose tissue is highly metabolically active, and especially visceral adipose tissue h...

    journal_title：Intensive care medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00134-019-05594-1

    authors： Schetz M,De Jong A,Deane AM,Druml W,Hemelaar P,Pelosi P,Pickkers P,Reintam-Blaser A,Roberts J,Sakr Y,Jaber S

    更新日期：2019-06-01 00:00:00