High-mobility group box 1 protein plasma concentrations during septic shock.

Abstract:

OBJECTIVE:To investigate plasma high-mobility group box 1 protein (HMGB1) concentration and its relationship with organ dysfunction and outcome in septic shock patients. DESIGN AND SETTING:Prospective, noninterventional study. Medical adult intensive care unit at a university hospital in France. PATIENTS:42 critically ill patients with septic shock. METHODS:Arterial blood was drawn within 12 h of admission for the measurement of plasma HMGB1 concentration by ELISA. Repeated sampling was performed on days 3, 7, and 14. RESULTS:Median HMGB1 concentration was 4.4 ng/ml (IQR 1.2-12.5) at admission, with no difference between survivors and nonsurvivors. A positive correlation was observed between HMGB1 and SOFA score and lactate, and procalcitonin concentrations. There was a progressive but statistically nonsignificant decline in HMGB1 concentration among the survivors, while nonsurvivors showed an increase in HMGB1 level between days 1 and 3. SOFA score and lactate and procalcitonin concentrations did not vary significantly between days 1 and 3. When measured on day 3, HMGB1 discriminated survivors from nonsurvivors with 66% sensitivity and 67% specificity, and concentration greater than 4 ng/ml was associated with an odds ratio of death of 5.5 (95% CI 1.3-23.6).

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Gibot S,Massin F,Cravoisy A,Barraud D,Nace L,Levy B,Bollaert PE

doi

10.1007/s00134-007-0691-2

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

1347-53

issue

8

eissn

0342-4642

issn

1432-1238

journal_volume

33

pub_type

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