Abstract：
OBJECTIVES:Critically ill patients often develop anaemia which can be related to a number of factors. However, the exact causes of anaemia in many patients remain unexplained. We hypothesized that the relationship between erythropoietin (EPO) and haematocrit may be altered in critically ill patients. DESIGN:Serum concentrations of EPO were serially determined by the ELISA method in 36 critically ill, non-hypoxaemic patients who stayed more than 7 days in the Intensive Care Unit, including 22 patients with sepsis and 14 without. Eighteen ambulatory patients with iron-deficiency anaemia served as a control group. SETTING:Two University Hospital Intensive Care Departments. RESULTS:A significant inverse correlation between serum EPO and haematocrit levels was found in the control patients (r = -0.81, p < 0.001), but not in the critically ill patients (r = -0.09, NS), except in a subgroup of non-septic patients without renal failure (r = -0.61, p < 0.01). CONCLUSIONS:EPO levels can be inappropriately low in critically ill patients, so that EPO deficiency may contribute to the development of anaemia in these patients. This phenomenon is observed not only in the presence of acute renal failure, but also in the presence of sepsis.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Rogiers P,Zhang H,Leeman M,Nagler J,Neels H,Mélot C,Vincent JLdoi
10.1007/s001340050310subject
Has Abstractpub_date
1997-02-01 00:00:00pages
159-62issue
2eissn
0342-4642issn
1432-1238journal_volume
23pub_type
杂志文章,多中心研究abstract：OBJECTIVE:To test the hypothesis that the rate of degradation of exogenously administered albumin is faster with bolus administration than with continuous infusion and thus that a bolus administration is less efficacious in restoring blood albumin concentration (BAC) in the hypoalbuminemic critically ill pediatric pati...
journal_title：Intensive care medicine
pub_type： 临床试验,杂志文章
doi：10.1007/BF01712175
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To study the wishes of a sample of French patients about medical information and surrogacy, at a time when the French Ministry of Health is supporting increased patient autonomy. DESIGN:A cohort of competent patients with non-critical illnesses or injuries completed an intention-to-act questionnaire on the a...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050011
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:To describe changes in hemodynamic variables, sedation, and pain score after discontinuation of prolonged infusions of dexmedetomidine in a pediatric population of critically ill cardiac patients. METHODS:Retrospective case series of patients who received continuous infusions of dexmedetomidine for longer than...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2441-8
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVES:Controversy over the optimal intravenous fluid for volume resuscitation continues unabated. Our objectives were to characterize the demographics of physicians who prescribe intravenous colloids and determine factors that enter into their decision to choose a colloid. DESIGN:Questionnaire with 61 items. PAR...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1337-z
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:This study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and their relationship to sepsis mortality. DESIGN AND SETTING:Prospective animal study in a university laboratory for experimental. SUBJECTS:140 male Wis...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-003-1789-9
更新日期：2003-10-01 00:00:00
abstract：:In alcoholic patients, metabolic acidosis can be related to lactate acidosis associated with sepsis or thiamine deficiency, ketoacidosis, methanol or ethylene glycol poisoning. High resolution proton nuclear magnetic resonance (NMR) can be used to detect abnormal organic acid metabolites in urine or serum from patient...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340100892
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:The interchangeability of continuous measurement of cardiac output (CO) with the traditional bolus method in patients after cardiopulmonary bypass (CPB) is uncertain. DESIGN:Prospective observational clinical study. SETTING:A 20-bed surgical ICU at a university hospital. PATIENTS:Fourteen deeply sedated, v...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0161-2
更新日期：2006-06-01 00:00:00
abstract：:Risk of critical illness is determined both by genetic and environmental influences, particularly those relating to infectious and cardiovascular diseases. Physiologically-based scoring systems cannot measure prior risk because they do not quantify physiological reserve independently of the acute illness. Genetic prof...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s001340051120
更新日期：2000-01-01 00:00:00
abstract：:Values obtained for cardiac output (CO) were compared using thermodilution (TD) with those obtained using bioimpedance (Bi) as measured using the Bomed NCCOM3 (Revision 6) in 28 consecutive patients in the first 24 h after coronary artery bypass surgery (CABS). In 46 paired measurements made in the first 12 h after CA...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01720674
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:Reporting neurodevelopmental outcome of 8-year-old children treated with neonatal extracorporeal membrane oxygenation (ECMO). METHODS:In a follow-up study in 135 8-year-old children who received neonatal ECMO between 1996 and 2001 we assessed intelligence (Revised Amsterdam Intelligence Test), concentration (B...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-013-2973-1
更新日期：2013-09-01 00:00:00
abstract：: ...
journal_title：Intensive care medicine
pub_type： 社论
doi：10.1007/s00134-018-5129-5
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the impact of two different comorbidity measures on the 6-month mortality of severely ill cancer patients. DESIGN AND SETTING:Prospective cohort study in a ten-bed oncological medical-surgical intensive care unit (ICU). PATIENTS:A total of 772 consecutive patients were included over a 45-month p...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-005-2554-z
更新日期：2005-03-01 00:00:00
abstract：INTRODUCTION:Approximately 20 years have passed since we reported our results of histologically proven cytomegalovirus (CMV) pneumonia in non-immunocompromised ICU patients. Even if there are more recent reports suggesting that CMV may worsen the outcomes for ICU patients, there is no definite answer to this question: ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-015-4066-9
更新日期：2016-01-01 00:00:00
abstract：:The Editor-in-Chief has retracted this article [1] because a number of studies included in this review [2, 3, 4] (originally cited as references 98, 128, 129) have since been retracted. Consequently, this has rendered the content of the review unreliable. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,撤回出版物
doi：10.1007/s00134-020-06068-5
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:To analyse the clinical value of procalcitonin (PCT), C-reactive protein (CRP) and leucocyte count in the diagnosis of paediatric sepsis and in the stratification of patients according to severity. DESIGN:Prospective, observational study. SETTING:Paediatric intensive care unit (PICU). PATIENTS:Ninety-four...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-006-0509-7
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:To implement delirium monitoring, test reliability, and monitor compliance of performing the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) in trauma patients. DESIGN AND SETTING:Prospective, observational study in a level 1 trauma unit of a tertiary care, university-based medical center. ...
journal_title：Intensive care medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00134-008-1031-x
更新日期：2008-07-01 00:00:00
abstract：:We examined the incidence, diagnosis and therapy of acute adrenal insufficiency, secondary to adrenal hemorrhage. This insufficiency resulted in temperature irregularities. hemodynamic instability, and a large volume resuscitation requirement post-operatively. The case illustrates that a high level of suspicion should...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01704704
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:Chronic pulmonary hypertension (PH) therapy is poorly investigated in intensive care. Our aim was to evaluate haemodynamic and neuroendocrine effects of the dual endothelin-1 (ET-1) blocker tezosentan in monocrotaline (MCT)-induced PH. METHODS:Male Wistar rats (180-200 g, n = 194) randomly received 60 mg kg(-1...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-012-2484-5
更新日期：2012-06-01 00:00:00
abstract：:Pneumonia caused by herpes simplex virus type 1 (HSV1) is rare and occurs in severely immunosuppressed patients. HSV1 can be detected in bronchoalveolar lavage (BAL) from patients presenting with respiratory failure, but its direct effect on disease is difficult to prove. We demonstrate the causative role of HSV1 in t...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340050339
更新日期：1997-03-01 00:00:00
abstract：:The use of ultrasonography has become increasingly popular in the everyday management of critically ill patients. It has been demonstrated to be a safe and handy bedside tool that allows rapid hemodynamic assessment and visualization of the thoracic, abdominal and major vessels structures. More recently, M-mode ultras...
journal_title：Intensive care medicine
pub_type： 杂志文章,评审
doi：10.1007/s00134-013-2823-1
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To present our observation of the development of a rare nail deformity in the prolonged course of disease of a critically ill patient with a pulmonary abscess. DESIGN:Case report. SETTING:Tertiary referral, 16-bed, level I surgical ICU in an academic hospital. PATIENT:A 48-year-old Caucasian male was treat...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000679
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:Do-not-resuscitate orders (DNR orders) and advance directives (AD) have been developed and their use by patients is increasing. The objective of the study was to evaluate the compliance with patient's wishes and doctors' and nurses' agreement on decision-making in the treatment of elderly patients from a cros...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s001340000602
更新日期：2000-09-01 00:00:00
abstract：:Since the introduction of synchronized intermittent mandatory ventilation (SIMV) several advantages have been attributed to this ventilatory mode, one of them being a more homogeneous distribution of ventilation and perfusion than during controlled mechanical ventilation (CMV). Up to now no data are available to confi...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/BF01704716
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:To provide recommendations and standard operating procedures for intensive care units and hospital preparedness for an influenza pandemic. METHODS:Based on a literature review and expert opinion, a Delphi process was used to define the essential topics. RESULTS:Key recommendations include: Hospitals should in...
journal_title：Intensive care medicine
pub_type： 指南,杂志文章,评审
doi：10.1007/s00134-010-1759-y
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:The association of acute-phase reaction and outcome of patients with acute vascular diseases is controversial. The prognostic value of admission C-reactive protein (CRP) in patients with acute aortic aneurysm or dissection has not yet been investigated. DESIGN AND SETTING:Cohort study including 255 consecuti...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-002-1299-1
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:Recalibration and determining discriminative power, internationally, of the existing delirium prediction model (PRE-DELIRIC) for intensive care patients. METHODS:A prospective multicenter cohort study was performed in eight intensive care units (ICUs) in six countries. The ten predictors (age, APACHE-II, urgen...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s00134-013-3202-7
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:We determined the effects of two antibiotic policies (predominance of either beta-lactam antibiotics or fluroquinolones) on acquisition with third-generation cephalosporin-resistant Enterobacteriaceae (CRE) and fluoroquinolone-resistant CRE (FCRE) in two ICUs, with monitoring of other variables that may infl...
journal_title：Intensive care medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00134-009-1714-y
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:Pseudomonas aeruginosa-induced lung injury is characterized not only by the alteration in lung fluid movement but also by apoptosis of lung epithelial and endothelial cells. We studied whether inhibition of apoptosis using a broad spectrum caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp fluoromethylketone (Z...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-004-2165-0
更新日期：2004-06-01 00:00:00
abstract：PURPOSE:A retrieval program was developed in New South Wales (NSW), Australia to provide extracorporeal membrane oxygenation support (ECMO) for the safe transport of adults with severe, acute respiratory or cardiac failure. We describe the development and results of this program and the impact of the 2009 H1N1 epidemic...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-011-2158-8
更新日期：2011-05-01 00:00:00
abstract：INTRODUCTION:Microcirculatory abnormalities are frequently observed in patients with severe heart failure and correlate to worse outcomes. We tested the hypothesis that nitroglycerin dose-dependently improves perfusion in severe heart failure and that this could be monitored by measuring central-peripheral temperature ...
journal_title：Intensive care medicine
pub_type： 杂志文章
doi：10.1007/s00134-009-1591-4
更新日期：2009-11-01 00:00:00
