Susceptibility to critical illness: reserve, response and therapy.

abstract：OBJECTIVES:To establish priorities for research in critical care medicine in the UK using survey and nominal group (NG) techniques. DESIGN:The senior doctor and nurse from 325 intensive care units (ICUs) in the UK were invited to contribute up to ten research questions relevant to intensive care organisation, practice...

journal_title：Intensive care medicine

authors： Goldfrad C,Vella K,Bion JF,Rowan KM,Black NA

更新日期：2000-10-01 00:00:00

abstract：:Specific regulations regarding oversight of research in children vary from country to country, but most share common principles derived from major consensus documents. Whereas the permissibility of research on adults depends heavily upon the informed consent of the subject, the regulation of research in pediatrics is ...

journal_title：Intensive care medicine

authors： Truog RD

更新日期：2008-01-01 00:00:00

abstract：:A 16-month old baby developed severe respiratory failure because of acute laryngitis and required mechanical ventilation. Intubation was complicated by aspiration and development of chemical pneumonia. Following 4 days of treatment the child was successfully extubated. Thirty six hours after extubation the patient aga...

journal_title：Intensive care medicine

authors： Lotan C,Boneh A,Tamir I,Goitein KJ

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to identify risk factors and to describe epidemiological patterns for early-(EOB) and late-onset bacteremias (LOB) after trauma. DESIGN:A prospective study conducted on 141 consecutive trauma patients. SETTING:A general intensive care unit (ICU) of a university hospital. PATIENTS:...

journal_title：Intensive care medicine

authors： Antonelli M,Moro ML,D'Errico RR,Conti G,Bufi M,Gasparetto A

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:To assess the reproducibility of respiratory dead space measurements in ventilated children. DESIGN:Prospective study. SETTING:University pediatric intensive care unit. PATIENTS:Thirty-two mechanically ventilated children (0.13-15.4 years) who were clinically stable. METHODS:The single-breath CO(2) test ...

journal_title：Intensive care medicine

authors： Riou Y,Leclerc F,Neve V,Dupuy L,Noizet O,Leteurtre S,Sadik A

更新日期：2004-07-01 00:00:00

abstract：:The purpose of this study was noninvasive assessment of respiratory compliance and resistance in mechanically ventilated patients with acute respiratory failure (ARF). To this end, flow, change in lung volume, and airway pressure were measured at the proximal tip of the endotracheal tubes in twenty nine critically ill...

journal_title：Intensive care medicine

authors： Bernasconi M,Ploysongsang Y,Gottfried SB,Milic-Emili J,Rossi A

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:a) to describe a non-barotraumatic ventilatory setting for independent lung ventilation (ILV); b) to determine the utility of single lung end-tidal CO(2) (EtCO(2)) monitoring to evaluate the ventilation to perfusion (V/Q) matching in each lung during ILV and for ILV weaning. DESIGN:prospective study. SETTIN...

journal_title：Intensive care medicine

authors： Cinnella G,Dambrosio M,Brienza N,Giuliani R,Bruno F,Fiore T,Brienza A

更新日期：2001-12-01 00:00:00

abstract：:We report the intensive care management of 23 children (age 3-15 years) following orthotopic heart (HT) and combined heart and lung transplantation (HLT) performed at our 2 institutes between February 1985 and August 1989. Cyclosporin A, azathioprine and steroids were given as routine immunosuppression, whilst anti-th...

journal_title：Intensive care medicine

authors： Whitehead B,James I,Helms P,Scott JP,Smyth R,Higenbottam TW,McGoldrick J,English TA,Wallwork J,Elliott M

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the usefulness of early transcranial Doppler ultrasound (TCD) goal-directed therapy after severe traumatic brain injury initiated before invasive cerebral monitoring is available. DESIGN:Prospective, observational clinical study. SETTING:Surgical intensive care unit, university hospital. PATIEN...

journal_title：Intensive care medicine

authors： Ract C,Le Moigno S,Bruder N,Vigué B

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection. METHODS:All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrom...

journal_title：Intensive care medicine

authors： Helms J,Tacquard C,Severac F,Leonard-Lorant I,Ohana M,Delabranche X,Merdji H,Clere-Jehl R,Schenck M,Fagot Gandet F,Fafi-Kremer S,Castelain V,Schneider F,Grunebaum L,Anglés-Cano E,Sattler L,Mertes PM,Meziani F,CRICS TR

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:The Sonoclot analyser provides global measurement of haemostasis, including plasma coagulation, platelet function and fibrinolysis. Benefits of its use in cardiovascular and hepatic surgery are well-documented and it may be useful in managing obstetric complications. The aim of this study was to determine ran...

journal_title：Intensive care medicine

authors： Kjellberg U,Hellgren M

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition of platelets may improve the outcome of sepsis. In this study we investigated whether chronic antiplatelet therapy impacts on the presentation and outcome of seps...

journal_title：Intensive care medicine

authors： Wiewel MA,de Stoppelaar SF,van Vught LA,Frencken JF,Hoogendijk AJ,Klein Klouwenberg PMC,Horn J,Bonten MJ,Zwinderman AH,Cremer OL,Schultz MJ,van der Poll T,MARS Consortium.

更新日期：2016-03-01 00:00:00

abstract：:A case of brainstem encephalitis complicated by torsade de pointes is described. The possible occurrence of ventricular arrhythmias may contribute to the mortality in this condition. We recommend the admission of patients with brainstem encephalitis to an intensive care unit, for a period of electrocardiographic monit...

journal_title：Intensive care medicine

authors： De Keyser J,De Boel S,Ceulemans L,Ebinger G

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To assess the role of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance. DESIGN:Prospective cohort study. SETTING:Two medical intensive care units. PATIENTS AND PARTICIPANTS:346 patients admitted for >or= 48 h. INTERVENTION:Analysis of data from an 8-month study c...

journal_title：Intensive care medicine

authors： Martínez JA,Delgado E,Martí S,Marco F,Vila J,Mensa J,Torres A,Codina C,Trilla A,Soriano A,Alquezar A,Castro P,Nicolás JM

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Invasive candidiasis (IC) outcomes in intensive care units (ICUs) could be improved by the early administration of antifungals. The Candida Score (CS) prediction rule has been proposed for the selection of patients who could develop IC. Procalcitonin (PCT) levels allow prompt identification of sepsis, but the...

journal_title：Intensive care medicine

authors： Charles PE,Castro C,Ruiz-Santana S,León C,Saavedra P,Martín E

更新日期：2009-12-01 00:00:00

abstract：:The influence of varying cardiac output (CO) on thermal-dye extravascular lung water (EVLW) was investigated in a total of 40 cardiac surgery patients before the onset of the operation. EVLW was measured by means of the double indicator dilution technique with indocyanine green as the non-diffusible indicator and a mi...

journal_title：Intensive care medicine

authors： Boldt J,Kling D,von Bormann B,Scheld HH,Hempelmann G

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Inhalation of high concentrations of nitric oxide (NO) has been shown to improve gas exchange and to reduce pulmonary vascular resistance in individuals with ischemia-reperfusion injury following orthotopic lung transplantation. We assessed the cardiopulmonary effects of low doses of NO in early allograft dys...

journal_title：Intensive care medicine

authors： Kemming GI,Merkel MJ,Schallerer A,Habler OP,Kleen MS,Haller M,Briegel J,Vogelmeier C,Fürst H,Reichart B,Zwissler B

更新日期：1998-11-01 00:00:00

abstract：:Results of the relationships between oxygen supply, demand, and uptake can be used to interpret cardiac output values, identify types of acute circulatory failure, guide attempts to improve cellular function, and thus prevent the development of multiple organ failure and death. Five steps in the interpretation of card...

journal_title：Intensive care medicine

authors： Vincent JL

更新日期：1990-01-01 00:00:00

abstract：:The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenance of blood fluidity and the growth of new vessels. During severe sepsis, the endothelium becomes proadhesive, procoagulan...

journal_title：Intensive care medicine

authors： Ait-Oufella H,Maury E,Lehoux S,Guidet B,Offenstadt G

更新日期：2010-08-01 00:00:00

abstract：: ...

journal_title：Intensive care medicine

authors： Varkila MRJ,Cremer OL

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:The intravenous fluid 6% hydroxyethyl starch (130/0.4) (6% HES 130/0.4) is used widely for resuscitation but there is limited information on its efficacy and safety. A large-scale multi-centre randomised controlled trial (CHEST) in critically ill patients is currently underway comparing fluid resuscitation with...

journal_title：Intensive care medicine

authors： Crystalloid versus Hydroxyethyl Starch Trial (CHEST) Management Committee.

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To assess the feasibility of remifentanil-based sedation in hypoxemic acute respiratory failure (HARF) patients refusing to continue noninvasive ventilation (NPPV) for intolerance to two different interfaces-helmet and total face mask. DESIGN AND SETTING:Prospective uncontrolled clinical investigation in a 14-...

journal_title：Intensive care medicine

authors： Rocco M,Conti G,Alessandri E,Morelli A,Spadetta G,Laderchi A,Di Santo C,Francavilla S,Pietropaoli P

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of different infusion pump models on continuity of drug delivery during vertical displacement of syringe pumps. DESIGN:Zero-drug delivery time (ZDDT), retrograde aspiration volume, and infusion bolus were recorded using the same syringe in three different models of syringe pump after l...

journal_title：Intensive care medicine

authors： Neff TA,Fischer JE,Schulz G,Baenziger O,Weiss M

更新日期：2001-01-01 00:00:00

abstract：:Dynamic vectorcardiography (VCG) is increasingly employed for ischaemia monitoring with the use of a computerized method for recording and on-line analysis by the calculation of trend parameters. To elucidate how well the derived electrocardiogram (dECG), calculated from the VCG, compares with the simultaneously regis...

journal_title：Intensive care medicine

authors： Gannedahl PE,Ljungqvist OH,Lundin P,Edner M

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:We assessed outcomes in brain-injured patients after implementation of a multi-faceted approach to reduce respiratory complications in intensive care units. METHODS:Prospective nationwide before-after trial. Consecutive adults with acute brain injury requiring mechanical ventilation for ≥24 h in 20 French inte...

journal_title：Intensive care medicine

authors： Asehnoune K,Mrozek S,Perrigault PF,Seguin P,Dahyot-Fizelier C,Lasocki S,Pujol A,Martin M,Chabanne R,Muller L,Hanouz JL,Hammad E,Rozec B,Kerforne T,Ichai C,Cinotti R,Geeraerts T,Elaroussi D,Pelosi P,Jaber S,Dalicha

更新日期：2017-07-01 00:00:00

abstract：:A young woman with long-standing systemic lupus erythematosus and rheumatic fever presented with deteriorating renal function. She had severe gastritis treated with cimetidine and received methylprednisolone when her blood cultures were repeatedly negative. She developed spontaneous bruising and bleeding from venepunc...

journal_title：Intensive care medicine

authors： Bloxham CA,Carr S,Ryan DW,Kesteven PJ,Bexton RS,Griffiths ID,Richards J

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Angiopoietin-2 (Ang-2) is a potent regulator of vascular permeability and inflammation in acute lung injury and acute respiratory distress syndrome (ARDS). Genetic variants in the Ang-2 gene may lead to altered activities of Ang-2 (or ANGPT2) gene. The aim of this study was to assess if genetic variants of An...

journal_title：Intensive care medicine

authors： Su L,Zhai R,Sheu CC,Gallagher DC,Gong MN,Tejera P,Thompson BT,Christiani DC

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the perceived health and cognitive status in survivors of chronic obstructive pulmonary disease (COPD) exacerbations requiring mechanical ventilation. DESIGN AND SETTING:Prospective controlled cohort study in a respiratory intermediate intensive care unit. PATIENTS:Sixty-three COPD patients at t...

journal_title：Intensive care medicine

authors： Ambrosino N,Bruletti G,Scala V,Porta R,Vitacca M

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that levosimendan increases systemic and intestinal oxygen delivery (DO(2)) and prevents intramucosal acidosis in septic shock. DESIGN:Prospective, controlled experimental study. SETTING:University-based research laboratory. SUBJECTS:Nineteen anesthetized, mechanically ventilated she...

journal_title：Intensive care medicine

authors： Dubin A,Murias G,Sottile JP,Pozo MO,Barán M,Edul VS,Canales HS,Etcheverry G,Maskin B,Estenssoro E

更新日期：2007-03-01 00:00:00

abstract：:A 46-year-old man was diagnosed clinically brain dead after sustaining head trauma. The patient was in deep coma, brain nerves were unresponsive and spontaneous breathing was absent. However, EEG showed well preserved activity, but no reactivity to external stimuli. EEG activity disappeared within 40 h. BAEP were high...

journal_title：Intensive care medicine

authors： Kaukinen S,Mäkelä K,Häkkinen VK,Martikainen K

更新日期：1995-01-01 00:00:00