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Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis.

Abstract：

PURPOSE:Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition of platelets may improve the outcome of sepsis. In this study we investigated whether chronic antiplatelet therapy impacts on the presentation and outcome of sepsis, and the host response. METHODS:We performed a prospective observational study in 972 patients admitted with sepsis to the mixed intensive care units (ICUs) of two hospitals in the Netherlands between January 2011 and July 2013. Of them, 267 patients (27.5%) were on antiplatelet therapy (95.9% acetylsalicylic acid) before admission. To account for differential likelihoods of receiving antiplatelet therapy, a propensity score was constructed, including variables associated with use of antiplatelet therapy. Cox proportional hazards regression was used to estimate the association of antiplatelet therapy with mortality. RESULTS:Antiplatelet therapy was not associated with sepsis severity at presentation, the primary source of infection, causative pathogens, the development of organ failure or shock during ICU stay, or mortality up to 90 days after admission, in either unmatched or propensity-matched analyses. Antiplatelet therapy did not modify the values of 19 biomarkers providing insight into hallmark host responses to sepsis, including activation of the coagulation system, the vascular endothelium, the cytokine network, and renal function, during the first 4 days after ICU admission. CONCLUSIONS:Pre-existing antiplatelet therapy is not associated with alterations in the presentation or outcome of sepsis, or the host response.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Wiewel MA,de Stoppelaar SF,van Vught LA,Frencken JF,Hoogendijk AJ,Klein Klouwenberg PMC,Horn J,Bonten MJ,Zwinderman AH,Cremer OL,Schultz MJ,van der Poll T,MARS Consortium.

doi

10.1007/s00134-015-4171-9

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

352-360

issue

eissn

0342-4642

issn

1432-1238

pii

10.1007/s00134-015-4171-9

journal_volume

pub_type

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Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis.